James M. Cook

Pharmacology, Toxicology and PharmaceuticsChemistry

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 47 papers. Top paper: “Rationalizing the binding and α subtype selectivity of synthesized imidazodiazepines and benzodiazepines at GABAA receptors by using molecular docking studies”.

Rationalizing the binding and α subtype selectivity of synthesized imidazodiazepines and benzodiazepines at GABAA receptors by using molecular docking studies

Bioorganic & Medicinal Chemistry Letters(2022)10.1016/j.bmcl.2022.128637

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0.425DataRank · unranked

16 citations

Md Yeunus Mian, Taukir Ahmed, Kamal Prakash Pandey, Prithu Mondal, Dishary Sharmin +4 more

Nanocrystal dispersion of DK-I-56–1, a poorly soluble pyrazoloquinolinone positive modulator of α6 GABAA receptors: Formulation approach toward improved in vivo performance

European Journal of Pharmaceutical Sciences(2020)10.1016/j.ejps.2020.105432

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8 citations

Branka Divović, Daniel E. Knutson, Jelena Đoković, Predrag Vulić, Danijela Randjelović +6 more

Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation

Cerebral Cortex(2020)10.1093/cercor/bhaa310

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44 citations

Akiko Sumitomo, Toshifumi Tomoda, Daniel E. Knutson, Guanguan Li, Prithu Mondal +4 more

α6GABAA Receptor Positive Modulators Alleviate Migraine-like Grimaces in Mice via Compensating GABAergic Deficits in Trigeminal Ganglia

Neurotherapeutics(2020)10.1007/s13311-020-00951-1

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28 citations

Ming Tatt Lee, Pi‐Chuan Fan, Daniel E. Knutson, Tzu-Hsuan Lai, Werner Sieghart +3 more

Design, synthesis and characterization of novel gamma‑aminobutyric acid type A receptor ligands

ARKIVOC(2020)10.24820/ark.5550190.p011.398

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7 citations

Md Zubair Ahmed Khan, Lalit K. Golani, Prithu Mondal, Md Yeunus Mian, Farjana Rashid +10 more

Search for α3β2/3γ2 subtype selective ligands that are stable on human liver microsomes

UNC Libraries(2020)10.17615/v82z-qp09

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0 citations

James M. Cook, Yun-Teng Johnson, Samarpan Majumder, Edward M. Johnson, Zdravko Varagić +8 more

Antiseizure Activity of Novel γ-Aminobutyric Acid (A) Receptor Subtype-Selective Benzodiazepine Analogues in Mice and Rat Models

Figshare(2020)10.17615/3252-n144

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0 citations

Bryan L. Roth, Lauren J. Murphree, Chitra R. Edwankar, Subramanian Sankar, Shengming Huang +10 more

GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors

Pharmacology & Therapeutics(2021)10.1016/j.pharmthera.2021.108035

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85 citations

Arnold Lippa, Michael M. Poe, Jodi L. Smith, Xiaoming Jin, Xingjie Ping +4 more

The α6 GABAA Receptor Positive Allosteric Modulator DK-I-56-1 Reduces Tic-Related Behaviors in Mouse Models of Tourette Syndrome

Biomolecules(2021)10.3390/biom11020175

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23 citations

Daniel E. Knutson, Laura J. Mosher, Stefanos Loizou, Karen Odeh, Janet L. Fisher +3 more

Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach

Pharmaceutics(2021)10.3390/pharmaceutics13081188

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11 citations

Branka Divović, Daniel E. Knutson, Jelena Đoković, Aleksandar Kremenović, Vladimir Dobričić +6 more

Positive modulation of α5GABAA receptors leads to dichotomous effects in rats on memory pattern and GABRA5 expression in prefrontal cortex and hippocampus

Behavioural Brain Research(2021)10.1016/j.bbr.2021.113578

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9 citations

Bojan Batinić, Tamara Timić Stamenić, Jovana Aranđelović, Dishary Sharmin, Daniel E. Knutson +3 more

Vasodilatory effects of a variety of positive allosteric modulators of GABAA receptors on rat thoracic aorta

European Journal of Pharmacology(2021)10.1016/j.ejphar.2021.174023

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7 citations

Lidija Todorović, Anja Santrač, Md Yeunus Mian, Dishary Sharmin, James M. Cook +2 more

Identification and Quantification of MIDD0301 Metabolites

Current Drug Metabolism(2021)10.2174/1389200222666211202093841

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2 citations

Nicolas M. Zahn, Brandon N. Mikulsky, Daniel A. Webb, Md Yeunus Mian, Daniel E. Knutson +5 more

The stereospecific and enantiospecific synthesis of indole alkaloids which culminated in the ambidextrous Pictet–Spengler reaction for the C-19 methyl–substituted sarpagine family

Progress in heterocyclic chemistry(2021)10.1016/b978-0-323-89812-6.00001-8

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1 citations

Ojas A. Namjoshi, James M. Cook, Md Toufiqur Rahman

Positive modulation of cerebellar α6GABA A receptors for treating essential tremor: a proof-of-concept study in harmaline-treated mice

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.19.440397

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3 citations

Ming Tatt Lee, Werner Sieghart, Daniel E. Knutson, Laurin Wimmer, Dishary Sharmin +4 more

Effects of α5 GABAA receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease

CNS Neuroscience & Therapeutics(2022)10.1111/cns.13914

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17 citations

Anja Santrač, Bojan Batinić, Lidija Todorović, Vladimir D. Stevanović, V. V. N. Phani Babu Tiruveedhula +6 more

Hippocampal α5-GABAA Receptors Modulate Dopamine Neuron Activity in the Rat Ventral Tegmental Area

Biological Psychiatry Global Open Science(2022)10.1016/j.bpsgos.2021.12.010

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27 citations

Alexandra M. McCoy, Thomas D. Prévot, Md Yeunus Mian, Flavia Carreño, Alan Frazer +4 more

Positive Allosteric Modulation of α5-GABAA Receptors Reverses Stress-Induced Alterations in Dopamine System Function and Prepulse Inhibition of Startle

The International Journal of Neuropsychopharmacology(2022)10.1093/ijnp/pyac035

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18 citations

Thomas D. Prévot, Md Yenus Mian, James M. Cook, Alan Frazer, Etienne Sibille +3 more

Postweaning positive modulation of α5GABAA receptors improves autism‐like features in prenatal valproate rat model in a sex‐specific manner

Autism Research(2022)10.1002/aur.2699

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9 citations

Dunja Bijelić, Vladimir D. Stevanović, Marija Banićević, Jovana Aranđelović, Bojan Batinić +4 more

Targeting α6GABAA receptors as a novel therapy for schizophrenia: A proof-of-concept preclinical study using various animal models

Biomedicine & Pharmacotherapy(2022)10.1016/j.biopha.2022.113022

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17 citations

Akihiro Mouri, Hisayoshi Kubota, Hsin‐Jung Lee, Man‐Hsin Chang, Chen-Yi Wu +7 more

Completion of the Total Synthesis of Several Bioactive Sarpagine/Macroline Alkaloids including the Important NF-κB Inhibitor N4-Methyltalpinine

Molecules(2022)10.3390/molecules27051738

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5 citations

V. V. N. Phani Babu Tiruveedhula, Michael Rajesh Stephen, Sundari Rallapalli, Kamal Prakash Pandey, James M. Cook +1 more

Behavioural interaction of pyrazoloquinolinone positive allosteric modulators at α6GABAA receptors and diazepam in rats: Anti‐diazepam‐induced ataxia action as a structure‐dependent feature

Basic & Clinical Pharmacology & Toxicology(2022)10.1111/bcpt.13801

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5 citations

Dan Knutson, Jelena R. Mitrović, Vladimir D. Stevanović, Boban Stanojević, Snežana Savić +3 more

Metabolism, pharmacokinetics, and anticonvulsant activity of a deuterated analog of the α2/3‐selective GABAkine KRM‐II‐81

Biopharmaceutics & Drug Disposition(2022)10.1002/bdd.2313

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7 citations

Branka Divović, Dishary Sharmin, Kamal Prakash Pandey, Md Yeunus Mian, Rok Cerne +13 more

An efficient debromination technique using PMHS with a number of ligands containing different functional groups

ARKIVOC(2022)10.24820/ark.5550190.p011.712

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0 citations

Prithu Mondal, Dishary Sharmin, Kamal Prakash Pandey, Farjana Rashid, Sepideh Rezvanian +8 more

Assessing the synergistic effects of morphine and MP‐III‐024 co‐administration: enhanced antinociception with reduced side effects

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.r5946

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0 citations

Eric DiDomenico, Christa Donegan, Yulista Tapia, Jason Conviser, Rohit R. Nambiar +9 more

Cerebellar α6GABAA Receptors as a Therapeutic Target for Essential Tremor: Proof-of-Concept Study with Ethanol and Pyrazoloquinolinones

Neurotherapeutics(2023)10.1007/s13311-023-01342-y

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17 citations

Ming Tatt Lee, Han-Yun Hsueh, Daniel E. Knutson, James M. Cook, Marko D. Mihovilovič +3 more

High amount of lecithin facilitates oral delivery of a poorly soluble pyrazoloquinolinone ligand formulated in lipid nanoparticles: Physicochemical, structural and pharmacokinetic performances

International Journal of Pharmaceutics(2023)10.1016/j.ijpharm.2023.122613

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13 citations

Branka Divović, Daniel E. Knutson, Miloš Petković, Djordje Djorović, Danijela Randjelović +7 more

Synthesis and Receptor Binding Studies of α5 GABAAR Selective Novel Imidazodiazepines Targeted for Psychiatric and Cognitive Disorders

Molecules(2023)10.3390/molecules28124771

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9 citations

Md Yeunus Mian, Michael Marcotte, Thomas D. Prévot, Etienne Sibille, Jeffrey M. Witkin +2 more

Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study

European Journal of Pharmaceutical Sciences(2023)10.1016/j.ejps.2023.106557

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5 citations

Maja Bjelošević Žiberna, Aleksandar Vukadinović, Daniel E. Knutson, Dishary Sharmin, Aleksandar Kremenović +7 more

GL-II-73, a Positive Allosteric Modulator of α5GABAA Receptors, Reverses Dopamine System Dysfunction Associated with Pilocarpine-Induced Temporal Lobe Epilepsy

International Journal of Molecular Sciences(2023)10.3390/ijms241411588

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2 citations

Thomas D. Prévot, Dishary Sharmin, James M. Cook, Etienne Sibille, Daniel J. Lodge +1 more

GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.11.29.569295

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3 citations

Riccardo Barille, Donatien Kamdem Toukam, Vaibhavkumar S. Gawali, Laura Kallay, Taukir Ahmed +15 more

Extrasynaptic localization is essential for α5GABA A receptor modulation of dopamine system function

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.12.548744

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1 citations

Thomas D. Prévot, Md Yeunus Mian, Dishary Sharmin, Adeeba N. Ahmad, James M. Cook +3 more

An alpha 5-GABAa receptor positive allosteric modulator attenuates social and cognitive deficits without changing dopamine system hyperactivity in an animal model for autism

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.24.554679

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1 citations

Dishary Sharmin, James M. Cook, Francisco Silveira Guimarães, Felipe V. Gomes, Adriana Jesus Souza

α5-GABAA receptor modulation reverses behavioral and neurophysiological correlates of psychosis in rats with ventral hippocampal Alzheimer’s Disease-like pathology

Research Square(2023)10.21203/rs.3.rs-2809328/v1

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0 citations

Nicole Eassa, Angela M. Boley, Hannah B. Elam, Dishary Sharmin, James M. Cook +2 more

An alpha 5‐GABAA receptor positive allosteric modulator attenuates social and cognitive deficits without changing dopamine system hyperactivity in rats exposed to valproic acid in utero

Autism Research(2024)10.1002/aur.3178

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10 citations

Icaro da Silva Freitas, Dishary Sharmin, James M. Cook, Francisco Silveira Guimarães, Felipe V. Gomes +1 more

GABA(A) Receptor Activation Drives GABARAP–Nix Mediated Autophagy to Radiation-Sensitize Primary and Brain-Metastatic Lung Adenocarcinoma Tumors

Cancers(2024)10.3390/cancers16183167

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9 citations

Riccardo Barrile, Donatien Kamdem Toukam, Vaibhavkumar S. Gawali, Laura Kallay, Taukir Ahmed +17 more

Antinociceptive Effects of α2/α3-Subtype-Selective GABAA Receptor Positive Allosteric Modulators KRM-II-81 and NS16085 in Male Rats: Behavioral Specificity

Journal of Pharmacology and Experimental Therapeutics(2024)10.1124/jpet.123.002070

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7 citations

Kristen Woodhouse, V. V. N. Phani Babu Tiruveedhula, James M. Cook, Jun‐Xu Li, Lakeisha Lewter

The deuterated pyrazoloquinolinone targeting α6 subunit-containing GABAA receptor as novel candidate for inhibition of trigeminovascular system activation: implication for migraine therapy

Frontiers in Pharmacology(2024)10.3389/fphar.2024.1451634

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6 citations

Lih‐Chu Chiou, Tzu-Hsuan Lai, Dishary Sharmin, James M. Cook, Ming Tatt Lee +1 more

Extrasynaptic Localization Is Essential for α5GABA A Receptor Modulation of Dopamine System Function

eNeuro(2024)10.1523/eneuro.0344-23.2023

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3 citations

Thomas D. Prévot, Md Yeunus Mian, Dishary Sharmin, Adeeba N. Ahmad, James M. Cook +3 more

New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy

ACS Chemical Neuroscience(2024)10.1021/acschemneuro.3c00555

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2 citations

Branka Divović, Xingjie Ping, Rok Cerne, Jodi L. Smith, Sepideh Rezvanian +16 more

Development of non-sedating antischistosomal benzodiazepines

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.01.26.577323

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1 citations

Dishary Sharmin, Prithu Mondal, Jawad Bin Belayet, M. Mahmun Hossain, Paul McCusker +9 more

Parenteral Nanoemulsion for Optimized Delivery of GL-II-73 to the Brain—Comparative In Vitro Blood–Brain Barrier and In Vivo Neuropharmacokinetic Evaluation

Pharmaceutics(2025)10.3390/pharmaceutics17030354

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6 citations

Jelena Đoković, Ivan Jančić, Jela Milić, Biljana Bufan, Bojan Marković +10 more

Intravenous Nanoemulsions Loaded with Phospholipid Complex of a Novel Pyrazoloquinolinone Ligand for Enhanced Brain Delivery

Pharmaceutics(2025)10.3390/pharmaceutics17020232

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4 citations

Jela Milić, Branka Divović, Miloš Petković, Vladimir Dobričić, Ivan Jančić +10 more

α6GABAA receptor positive allosteric modulators targeting trigeminal ganglia for preventing and aborting chronic periorbital allodynia and cephalic pain in both sexes: A mechanistic and comparative preclinical study

Biomedicine & Pharmacotherapy(2025)10.1016/j.biopha.2025.118344

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2 citations

Chen‐Jiun Yeh, Yi-Ting Pan, Yueh-Peng Chen, Dishary Sharmin, James M. Cook +3 more

KRM-II-81, a β3-Preferring GABAA Receptor Potentiator, Blocks Handling-Induced Seizures in Theiler’s Murine Encephalomyelitis Virus-Infected Mice

Future Pharmacology(2025)10.3390/futurepharmacol5020025

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0 citations

Kamal Prakash Pandey, Lalit K. Golani, Sepideh Rezvanian, Md Yeunus Mian, Janet L. Fisher +8 more

Mice lacking spinal α2GABAA receptors: Altered GABAergic neurotransmission, diminished GABAergic antihyperalgesia, and potential compensatory mechanisms preventing a hyperalgesic phenotype

Brain Research(2020)10.1016/j.brainres.2020.146889

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11 citations

Mario A. Acuña, Gioele W. Albisetti, Elena Neumann, William T. Ralvenius, Louis Scheurer +5 more

Prolonged blockade of NMDA receptors and positive modulation of a5 GABA A receptors: No changes in depressive-like behavior, while the former slightly increased emotional reactivity in unstressed rats

Medicinska istrazivanja(2025)10.5937/medi0-57913

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0 citations

Jana Ivanović, Kristina Jezdić, Dishary Sharmin, Jovana Aranđelović, James M. Cook +2 more