James C. Sacchettini

MedicineMaterials ScienceBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

2in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 2 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 29 papers. Top paper: “Biochemical and Structural Studies of Malate Synthase fromMycobacterium tuberculosis”.

Biochemical and Structural Studies of Malate Synthase fromMycobacterium tuberculosis

Journal of Biological Chemistry(2003)10.1074/jbc.m209248200

N/A

7.2DataRank · unranked

151 citations

Chih-chin Huang, Andras Miczak, David G. Russell, James C. Sacchettini, Kerstin Höner zu Bentrup +1 more

The Copper-Responsive RicR Regulon Contributes to Mycobacterium tuberculosis Virulence

mBio(2014)10.1128/mbio.00876-13

N/A

0.678DataRank · unranked

91 citations

Richard A. Festa, Thomas R. Ioerger, Susan Butler-Wu, James C. Sacchettini, K. Heran Darwin +2 more

CinA mediates multidrug tolerance in Mycobacterium tuberculosis

Nature Communications(2022)10.1038/s41467-022-29832-1

N/A

0.596DataRank · unranked

52 citations

Robert S. Jansen, Travis Hartman, Alexandre Gouzy, Ruojun Wang, Inna V. Krieger +10 more

Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c01586

N/A

0.546DataRank · unranked

37 citations

Peter C. Ray, Fabio Zuccotto, Jorge Hernández, Anup Aggarwal, Claire J. Mackenzie +35 more

SuFEx-based antitubercular compound irreversibly inhibits Pks13

Nature(2025)10.1038/s41586-025-09286-3

N/A

0.457DataRank · unranked

20 citations

Paridhi Sukheja, Baiyuan Yang, Su Tang, Daniel Selle, Ashley Woods +40 more

An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo

Cell Reports(2024)10.1016/j.celrep.2024.114929

N/A

0.398DataRank · unranked

10 citations

Su Tang, Xuelin Bian, Maloy Kumar Parai, Inna V. Krieger, Armando Flores +27 more

Mycobacterium tuberculosis MutT4 is an RNA pyrophosphohydrolase that forms biomolecular condensates and sensitizes mRNAs to degradation

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.05.13.653832

N/A

0.208DataRank · unranked

3 citations

Junpei Xiao, Irene Lepori, Abigail R. Rapiejko, Manchi Reddy, Louis A. Roberts +4 more

Thioquinazolinones as Antituberculosis Agents Targeting Phosphopantetheinyl Transferase

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c00856

N/A

0.104DataRank · unranked

1 citations

Logan T. Zwerneman, Kyle Planck, Takushi Kaneko, Andrew J. Perkowski, Christine M. Suh +18 more

Mutations in fbiD (Rv2983) as a novel determinant of resistance to pretomanid and delamanid in Mycobacterium tuberculosis

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.09.10.292508

N/A

0DataRank · unranked

1 citations

Si‐Yang Li, Thomas R. Ioerger, Keshav V. Shah, Jean‐Philippe Lanoix, Jin Lee +4 more

A Sec14-like Phosphatidylinositol Transfer Protein Paralog Defines a Novel Class of Heme-binding Proteins With An Unusual Heme Coordination Mechanism

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.03.19.999003

N/A

0DataRank · unranked

0 citations

Dongju Lee, Gülçin Gülten, Anup Aggarwal, Joshua D. Wofford, Inna V. Krieger +8 more

Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2

UNC Libraries(2020)10.17615/pz1p-j351

N/A

0DataRank · unranked

0 citations

Brittany K. Miller, Nathan W. Rigel, Stephanie Swanson, James C. Sacchettini, Thomas R. Ioerger +1 more

The Tuberculosis Drug Accelerator at year 10: what have we learned?

Nature Medicine(2021)10.1038/s41591-021-01442-2

N/A

0DataRank · unranked

62 citations

David Barros-Aguirre, Clifton E. Barry, Robert H. Bates, Steven J. Berthel, Helena I. Boshoff +32 more

Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis

Microbiology Spectrum(2021)10.1128/spectrum.00928-21

N/A

0DataRank · unranked

2 citations

A.D. Singh, Guangli Yang, Felipe B. d’Andrea, Xiuju Jiang, Travis Hartman +12 more

Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice

Science(2020)10.1126/science.aaz8899

N/A

0DataRank · unranked

191 citations

Shivatheja Soma, Sai Yuan, Andres Silva, Mohammad Zulkifli, Thomas Snavely +12 more

Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis

Nature Communications(2022)10.1038/s41467-022-28078-1

N/A

0DataRank · unranked

34 citations

Xiaojun Li, Joonyoung Shin, Howard Gamper, Ya-Ming Hou, James C. Sacchettini +2 more

Structural Basis of Agonist Capture by Regulatory C1 Domain of PKC

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.l8086

N/A

0DataRank · unranked

0 citations

Inna V. Krieger, James C. Sacchettini, Tatyana I. Igumenova, Sachin Katti

Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents

Cell(2023)10.1016/j.cell.2023.01.043

N/A

0DataRank · unranked

24 citations

Christine Lair, Christine Roubert, Kwame Amaning, María Belén Pascual Barrio, Yannick Benedetti +26 more

DAIKON: A Data Acquisition, Integration, and Knowledge Capture Web Application for Target-Based Drug Discovery

ACS Pharmacology & Translational Science(2023)10.1021/acsptsci.3c00034

N/A

0DataRank · unranked

6 citations

Saswati Panda, James C. Sacchettini, Steven J. Berthel, Shree Rath

Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin

Nature Communications(2024)10.1038/s41467-024-48448-1

N/A

0DataRank · unranked

9 citations

Peng Ge, Laure Botella, Sae Woong Park, Ha-Na Lee, Natalie Thornton +7 more

Identification of a copper-responsive small molecule inhibitor of uropathogenic Escherichia coli

Journal of Bacteriology(2024)10.1128/jb.00112-24

N/A

0DataRank · unranked

4 citations

Amanuel Hailemariam, Yongjian Yang, Faras Mohamed, George L. Donati, Dwight Baker +4 more

An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo

UNC Libraries(2024)10.17615/wwq1-b853

N/A

0DataRank · unranked

0 citations

Maloy Kumar Parai, Timothy P. Sheahan, Jeremy P. Wood, Bian, Xuelin, Inna V. Krieger +27 more

Crystal Structure of Monoclonal 6B5 Fab Complexed with Phencyclidine

UNC Libraries(2021)10.17615/2q77-1x18

N/A

0DataRank · unranked

0 citations

D. Scott Linthicum, Kap Lim, James C. Sacchettini, S.M. Owens, Larry Arnold

Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis

Nature Communications(2020)10.1038/s41467-020-19959-4

N/A

0DataRank · unranked

94 citations

Dirk A. Lamprecht, Rukaya Asmal, John Adamson, Khushboo Borah, Dany J. V. Beste +8 more

Mutations in fbiD ( Rv2983 ) as a Novel Determinant of Resistance to Pretomanid and Delamanid in Mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy(2020)10.1128/aac.01948-20

N/A

0DataRank · unranked

88 citations

Si-Yang Li, Thomas R. Ioerger, Keshav V. Shah, Jean‐Philippe Lanoix, Jin Lee +4 more

Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis

Nature Communications(2020)10.1038/s41467-020-15876-8

N/A

0DataRank · unranked

74 citations

Lungelo Mandyoli, Ryan Hughes, Shoko Wakabayashi, Jessica T. Pinkham, Bruna P. Selbach +5 more

The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD

Nature Communications(2020)10.1038/s41467-019-14238-3

N/A

0DataRank · unranked

72 citations

Xiaojun Li, Lisa M. Pérez, Wanliang Shi, Ying Zhang, James C. Sacchettini +1 more

Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases

Frontiers in Microbiology(2020)10.3389/fmicb.2020.01248

N/A

0DataRank · unranked

20 citations

Robert L. Smith, Tania J. Lupoli, Zainab Edoo, Xiaojun Li, Ben Gold +12 more

The Structural Basis of T4 Phage Lysis Control: DNA as the Signal for Lysis Inhibition

Journal of Molecular Biology(2020)10.1016/j.jmb.2020.06.013

N/A

0DataRank · unranked

33 citations

Vladimir A. Kuznetsov, Jeng-Yih Chang, Junjie Zhang, Samir H. Moussa, Ry Young +2 more

Ternary complex structure of human hgprtase, prpp, mg 2+ , and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding

PubMed Central(2020)10.17615/2hn2-px64

N/A

0DataRank · unranked

3 citations

Ann E. Eakin, JOSÉ A. Molina, Robert Stevens, Sydney P. Craig, James C. Sacchettini +4 more