Stephen W. Fesik

Also affiliated with Vanderbilt Health, Institute of Pharmacology

Biochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

3in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 3 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 27 papers. Top paper: “Heteronuclear three-dimensional NMR spectroscopy of the inflammatory protein C5a”.

Heteronuclear three-dimensional NMR spectroscopy of the inflammatory protein C5a

Biochemistry(1989)10.1021/bi00432a008

N/A

0.871DataRank · unranked

332 citations

Stephen W. Fesik, Erik R. P. Zuiderweg

Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c01120

N/A

0.663DataRank · unranked

82 citations

Alex G. Waterson, Chris A. Smethurst, Dirk Kessler, Jark Böttcher, Moriz Mayer +22 more

Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

eLife(2023)10.7554/elife.90683

N/A

0.652DataRank · unranked

18 citations

Jing Wang, Kristie L. Rose, Camden Jones, Purvi Patel, Tina Tsui +15 more

Solution structure of the cytohesin-1 (B2–1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1

Proceedings of the National Academy of Sciences(1998)10.1073/pnas.95.14.7909

N/A

0.546DataRank · unranked

37 citations

Arndt Schnuchel, Hong Wang, Edward T. Olejniczak, Robert P. Meadows, Brian P. Lipsky +4 more

Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c00511

N/A

0.500DataRank · unranked

27 citations

Edward T. Olejniczak, Jason Phan, Jesse A. Coker, Jiqing Sai, Allison L. Arnold +4 more

Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells

NAR Cancer(2022)10.1093/narcan/zcac007

N/A

0.442DataRank · unranked

18 citations

Chase M. Woodley, Jing Wang, Brian C. Grieb, Macey J. Slota, Kiana Guerrazzi +10 more

Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c01188

N/A

0.434DataRank · unranked

17 citations

James M. Salovich, Martin Aichinger, KyuOk Jeon, Nagarathanam Veerasamy, John Sensintaffar +22 more

Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2408889121

N/A

0.385DataRank · unranked

12 citations

Brianna N. Smith, Jing Wang, Kevin B. Teuscher, Brian C. Grieb, Gregory C. Howard +12 more

Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c01529

N/A

0.360DataRank · unranked

10 citations

Jonathan J. Mills, Jianhua Tian, Changho Han, Kenneth M. Meyers, Jiqing Sai +12 more

Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.26.550648

N/A

0.165DataRank · unranked

2 citations

Jing Wang, Kristie L. Rose, Camden Jones, Purvi Patel, Tina Tsui +15 more

Author response: Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

(2024)10.7554/elife.90683.2.sa3

N/A

0DataRank · unranked

0 citations

Jing Wang, Kristie L. Rose, Camden Jones, Purvi Patel, Tina Tsui +15 more

Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

eLife(2024)10.7554/elife.90683.3

N/A

0DataRank · unranked

0 citations

Jing Wang, Kristie L. Rose, Camden Jones, Purvi Patel, Tina Tsui +15 more

Discovery of BI-2493, a Pan-KRAS Inhibitor Showing In Vivo Efficacy

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c00576

N/A

0DataRank · unranked

10 citations

Alex G. Waterson, Timothy R. Hodges, Jason R. Abbott, Allison L. Arnold, Jark Böttcher +20 more

Identification of ligands for E3 ligases with restricted expression using fragment-based methods

RSC Chemical Biology(2025)10.1039/d5cb00198f

N/A

0DataRank · unranked

3 citations

Brian D. Lehmann, Zhenwei Lu, John Sensintaffar, Edward T. Olejniczak, Bin Zhao +5 more

Discovery of Small Molecules that Bind to Son of Sevenless 2 (SOS2)

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.4c02007

N/A

0DataRank · unranked

5 citations

Alex G. Waterson, Leonhard Geist, Nina Braun, Katja Hauer, Klaus Rumpel +14 more

Nuclear Magnetic Resonance ‐based fragment screen of the E3 ligase Fem‐1 homolog B

Protein Science(2025)10.1002/pro.70365

N/A

0DataRank · unranked

1 citations

Kangsa Amporndanai, Ashley J. Taylor, Kristie L. Rose, Peter C. Gareiss, Roberto A. Crespo +4 more

Data from A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia

10.1158/2159-8290.c.6547384.v1

N/A

0DataRank · unranked

0 citations

Melissa A. Fischer, Taekyu Lee, Agnieszka E. Gorska, Maria Pia Arrate, Londa Fuller +9 more

Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

(2023)10.7554/elife.90683.1

N/A

0DataRank · unranked

1 citations

Jing Wang, Kristie L. Rose, Purvi Patel, Tina Tsui, Andrea C. Florian +12 more

Targeting MYC through WDR5

Molecular & Cellular Oncology(2020)10.1080/23723556.2019.1709388

N/A

0DataRank · unranked

32 citations

Clare M. Adams, Stephen W. Fesik, Christine M. Eischen, William P. Tansey, Lance R. Thomas

Drugging the undruggable RAS: Mission Possible?

UNC Libraries(2020)10.17615/2r76-yy91

N/A

0DataRank · unranked

0 citations

Adrienne D. Cox, Ji Luo, Alec Kimmelman, Channing J. Der, Stephen W. Fesik

Impact of WIN site inhibitor on the WDR5 interactome

Cell Reports(2021)10.1016/j.celrep.2020.108636

N/A

0DataRank · unranked

75 citations

Kristie L. Rose, Jing Wang, Bin Zhao, Tessa M. Popay, Christina Wang +13 more

Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2211297120

N/A

0DataRank · unranked

38 citations

Somenath Chowdhury, Kenneth M. Meyers, Jianhua Tian, Jiqing Sai, Mayme Van Meveren +15 more

WIN site inhibition disrupts a subset of WDR5 function

Scientific Reports(2022)10.1038/s41598-022-05947-9

N/A

0DataRank · unranked

38 citations

Jing Wang, Andrea C. Florian, Lance R. Thomas, Joy H. Creighton, Brittany K. Matlock +8 more

Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c00195

N/A

0DataRank · unranked

32 citations

Kenneth M. Meyers, Qiangqiang Wei, Jonathan J. Mills, Jianhua Tian, Joseph Alvarado +11 more

WDR5 is a conserved regulator of protein synthesis gene expression

Nucleic Acids Research(2020)10.1093/nar/gkaa051

N/A

0DataRank · unranked

89 citations

Jing Wang, Gregory C. Howard, Alissa D. Guarnaccia, Chase M. Woodley, Erin R. Aho +10 more

Reviewer #1 (Public Review): Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

(2023)10.7554/elife.90683.1.sa1

N/A

0DataRank · unranked

0 citations

Jing Wang, Kristie L. Rose, Purvi Patel, Tina Tsui, Andrea C. Florian +12 more

WD Repeat Domain 5 Inhibitors for Cancer Therapy: Not What You Think

Journal of Clinical Medicine(2024)10.3390/jcm13010274

N/A

0DataRank · unranked

18 citations

Stephen W. Fesik, William P. Tansey, April M. Weissmiller