Dennis E. Discher

Also affiliated with Bioengineering Center, University of Pennsylvania, Philadelphia University

Biochemistry, Genetics and Molecular BiologyMedicineImmunology and MicrobiologyChemistry

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 22 papers. Top paper: “Matrix Elasticity Directs Stem Cell Lineage Specification”.

Matrix Elasticity Directs Stem Cell Lineage Specification

Cell(2006)10.1016/j.cell.2006.06.044

N/A

1.4DataRank · unranked

13616 citations

Shamik Sen, H. Lee Sweeney, Dennis E. Discher, Adam J. Engler

Macrophage checkpoint blockade: results from initial clinical trials, binding analyses, and CD47-SIRPα structure–function

Antibody Therapeutics(2020)10.1093/abt/tbaa006

N/A

0.713DataRank · unranked

115 citations

Jason C. Andrechak, Dennis E. Discher, AbdelAziz Jalil

Cooperative phagocytosis of solid tumours by macrophages triggers durable anti-tumour responses

Nature Biomedical Engineering(2023)10.1038/s41551-023-01031-3

N/A

0.626DataRank · unranked

64 citations

Jason C. Andrechak, Brandon H. Hayes, Siddhant Kadu, William Zhang, Ruby Pan +6 more

CD47-SIRPα Checkpoint Disruption in Metastases Requires Tumor-Targeting Antibody for Molecular and Engineered Macrophage Therapies

Cancers(2022)10.3390/cancers14081930

N/A

0.434DataRank · unranked

17 citations

Lawrence J. Dooling, Michael P. Tobin, William W. Zhang, Brandon H. Hayes, Justine Y. Lee +4 more

Chromosomal instability induced in cancer can enhance macrophage-initiated immune responses that include anti-tumor IgG

eLife(2023)10.7554/elife.88054

N/A

0.367DataRank · unranked

7 citations

Mai Wang, Hui Zhu, Steven H. Phan, Lawrence J. Dooling, Jason C. Andrechak +6 more

Differences in cell shape, motility, and growth reflect chromosomal number variations that can be visualized with live-cell ChReporters

Molecular Biology of the Cell(2023)10.1091/mbc.e23-06-0207

N/A

0.245DataRank · unranked

3 citations

Charlotte R. Pfeifer, Peter Kuangzheng Zhu, Brandon H. Hayes, Mai Wang, Manasvita Vashisth +6 more

Titrating CD47 by mismatch CRISPRi reveals incomplete repression can eliminate IgG-opsonized tumors but CD47 heterogeneity limits induction of anti-tumor IgG

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.27.509740

N/A

0.165DataRank · unranked

2 citations

Hui Zhu, Jason C. Andrechak, Dennis E. Discher, Brandon H. Hayes

Pan-tissue scaling of stiffness versus fibrillar collagen reflects contractility-driven strain that inhibits fibril degradation

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.27.559759

N/A

0.165DataRank · unranked

2 citations

S. Cho, Manu Tewari, A. Jalil, M. Wang, A.J. Kasznel +4 more

Chromosomal instability can favor macrophage-mediated immune response and induce a broad, vaccination-like anti-tumor IgG response

(2023)10.7554/elife.88054.1

N/A

0.111DataRank · unranked

1 citations

Mai Wang, Hui Zhu, Steven H. Phan, Jason C. Andrechak, Alexander H. Chang +5 more

Chromosomal instability can favor macrophage-mediated immune response and induce a broad, vaccination-like anti-tumor IgG response

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.02.535275

N/A

0.104DataRank · unranked

1 citations

Mai Wang, Hui Zhu, Steven H. Phan, Lawrence J. Dooling, Jason C. Andrechak +6 more

Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape Without Side Effects

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.04.16.589801

N/A

0DataRank · unranked

50 citations

Yufei Wang, Manthan N. Patel, Eno‐Obong Essien, Mengwen Shen, Aparajeeta Majumdar +24 more

Chromosomal instability induced in cancer can enhance macrophage-initiated immune responses that include anti-tumor IgG

eLife(2024)10.7554/elife.88054.3

N/A

0DataRank · unranked

0 citations

Mai Wang, Hui Zhu, Steven H. Phan, Lawrence J. Dooling, Jason C. Andrechak +6 more

Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape

Nature Nanotechnology(2025)10.1038/s41565-025-01974-5

N/A

0DataRank · unranked

61 citations

Yufei Wang, Manthan N. Patel, Aleksa Milosavljevic, Daniel W. Zuschlag, Subhajit Poddar +34 more

Macrophages show higher levels of engulfment after disruption of cis interactions between CD47 and the checkpoint receptor SIRPα

Journal of Cell Science(2020)10.1242/jcs.237800

N/A

0DataRank · unranked

63 citations

Richard Tsai, Lawrence J. Dooling, Siddhant Kadu, Justine Y. Lee, Diego A. Pantano +5 more

Heterogeneous strains in tissue collagen show that high strains locally suppress degradation by collagenase

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.02.07.430141

N/A

0DataRank · unranked

5 citations

Mukesh Tiwari, S. Cho, A. Jalil, Manasvita Vashisth, Jerome Irianto +8 more

Challenges and opportunities for the next generation of cardiovascular tissue engineering

Nature Methods(2022)10.1038/s41592-022-01591-3

N/A

0DataRank · unranked

171 citations

Dennis E. Discher, Kam W. Leong, Gordana Vunjak‐Novakovic, Joseph C. Wu, Sang-Kyun Cho

Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues

Matrix Biology(2022)10.1016/j.matbio.2022.06.006

N/A

0DataRank · unranked

46 citations

Karanvir Saini, Alişya A. Anlaş, Dennis E. Discher, Lawrence J. Dooling

Cooperative phagocytosis underlies macrophage immunotherapy of solid tumours and initiates a broad anti-tumour IgG response

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.01.474150

N/A

0DataRank · unranked

5 citations

Lawrence J. Dooling, Brandon H. Hayes, Siddhant Kadu, William Zhang, Ruby Pan +5 more

Small lipid droplets are rigid enough to indent a nucleus, dilute the lamina, and cause rupture

The Journal of Cell Biology(2023)10.1083/jcb.202208123

N/A

0DataRank · unranked

39 citations

Michael P. Tobin, Tianyi Bai, Lawrence J. Dooling, Dennis E. Discher, Irena L. Ivanovska

Titrating CD47 by mismatch CRISPR-interference reveals incomplete repression can eliminate IgG-opsonized tumors but limits induction of antitumor IgG

PNAS Nexus(2023)10.1093/pnasnexus/pgad243

N/A

0DataRank · unranked

10 citations

Hui Zhu, Jason C. Andrechak, Lawrence J. Dooling, Dennis E. Discher, Brandon H. Hayes

Genetic heterogeneity in p53-null leukemia increases transiently with spindle assembly checkpoint inhibition and is not rescued by p53

Chromosoma(2023)10.1007/s00412-023-00800-y

N/A

0DataRank · unranked

7 citations

Steven Phan, Brandon H. Hayes, Dennis E. Discher, Mai Wang

Confinement plus myosin-II suppression maximizes heritable loss of chromosomes, as revealed by live-cell ChReporters

Journal of Cell Science(2023)10.1242/jcs.260753

N/A

0DataRank · unranked

13 citations

Peter Kuangzheng Zhu, Mai Wang, Charlotte R. Pfeifer, Yuntao Xia, Steven Phan +10 more