Alan D. D’Andrea

Also affiliated with Dana-Farber Cancer Institute

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

5in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 5 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Data from Phase 1b Clinical Trial with Alpelisib plus Olaparib for Patients with Advanced Triple-Negative Breast Cancer

(2023)10.1158/1078-0432.c.6532290.v1

Top 100%

0DataRank

Top 100%0 citations

Niya Xiong, Nabihah Tayob, Madeline Polak, Julia Eismann, Lewis C. Cantley +10 more

Papers

Driven by 57 papers — median percentile 0. Top paper: “Biomarker-Guided Development of DNA Repair Inhibitors”.

Biomarker-Guided Development of DNA Repair Inhibitors

Molecular Cell(2020)10.1016/j.molcel.2020.04.035

N/A

6.3DataRank · unranked

230 citations

Andrew J. Aguirre, Geoffrey I. Shapiro, Alan D. D’Andrea, James M. Cleary

Berzosertib plus gemcitabine versus gemcitabine alone in platinum-resistant high-grade serous ovarian cancer: a multicentre, open-label, randomised, phase 2 trial

The Lancet Oncology(2020)10.1016/s1470-2045(20)30180-7

N/A

5.1DataRank · unranked

233 citations

Su-Chun Cheng, Andrea E. Wahner Hendrickson, Richard T. Penson, Susan Schumer, L. Austin Doyle +19 more

Tumour predisposition and cancer syndromes as models to study gene–environment interactions

Nature reviews. Cancer(2020)10.1038/s41568-020-0265-y

N/A

4.6DataRank · unranked

195 citations

Sarah T. Arron, Bruce Beutler, Angela Bononi, Webster K. Cavenee, James E. Cleaver +18 more

Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML

JCI Insight(2020)10.1172/jci.insight.142149

N/A

2.3DataRank · unranked

90 citations

Anne-Laure Valton, Rebecca A. Gorelov, Mounica Vallurupalli, John M. Krill-Burger, Amie L. Holmes +18 more

A Replication stress biomarker is associated with response to gemcitabine versus combined gemcitabine and ATR inhibitor therapy in ovarian cancer

Nature Communications(2021)10.1038/s41467-021-25904-w

N/A

1.9DataRank · unranked

69 citations

Alexandre André Balieiro Anastácio da Costa, D. Gulhan, Elizabeth K. Lee, Su-Chun Cheng, Andrea E. Wahner Hendrickson +14 more

Phase 1b Clinical Trial with Alpelisib plus Olaparib for Patients with Advanced Triple-Negative Breast Cancer

Clinical Cancer Research(2022)10.1158/1078-0432.ccr-21-3045

N/A

1.5DataRank · unranked

64 citations

Niya Xiong, Nabihah Tayob, Madeline Polak, Julia Eismann, Lewis C. Cantley +10 more

Reversion and non-reversion mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2-mutant metastatic breast cancer

Annals of Oncology(2020)10.1016/j.annonc.2020.02.008

N/A

0.759DataRank · unranked

157 citations

Ofir Cohen, Bose Kochupurakkal, D. Kim, Connor E. Dunn, Jorge Buendia +20 more

Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer

Nature Communications(2022)10.1038/s41467-022-28389-3

N/A

0.723DataRank · unranked

123 citations

Nuppu Lyytikäinen, Julia Casado, Ella Anttila, Angéla Szabó, U.-M. Haltia +12 more

Exploiting the Microhomology-Mediated End-Joining Pathway in Cancer Therapy

Cancer Research(2020)10.1158/0008-5472.can-20-1672

N/A

0.680DataRank · unranked

92 citations

Alan D. D’Andrea, Jeffrey Patterson-Fortin

Single-Stranded DNA Gap Accumulation Is a Functional Biomarker for USP1 Inhibitor Sensitivity

Cancer Research(2024)10.1158/0008-5472.can-23-4007

N/A

0.679DataRank · unranked

24 citations

Ozge Somuncu, Ramya Ravindranathan, Sirisha Mukkavalli, David B. Martignetti, Huy Nguyen +11 more

Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20

Molecular Cell(2016)10.1016/j.molcel.2016.05.031

N/A

0.644DataRank · unranked

72 citations

Kah Suan Lim, Hyungjin Kim, Thomas R. Hinds, Ukhyun Jo, Haibin Mao +6 more

Targeting DNA Repair with Combined Inhibition of NHEJ and MMEJ Induces Synthetic Lethality in TP53 -Mutant Cancers

Cancer Research(2022)10.1158/0008-5472.can-22-1124

N/A

0.624DataRank · unranked

63 citations

Arindam Bose, Wei-Chih Tsai, Carter Grochala, Huy Nguyen, Jia Zhou +8 more

Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer

Cancer Discovery(2022)10.1158/2159-8290.cd-21-1181

N/A

0.621DataRank · unranked

62 citations

Tito A. Sandoval, Sung‐Min Hwang, Eun Sil Park, Paolo Giovanelli, Deepika Awasthi +16 more

Clinical Efficacy and Molecular Response Correlates of the WEE1 Inhibitor Adavosertib Combined with Cisplatin in Patients with Metastatic Triple-Negative Breast Cancer

Clinical Cancer Research(2020)10.1158/1078-0432.ccr-20-3089

N/A

0.596DataRank · unranked

52 citations

Tianyu Li, Tuulia Vallius, Jennifer L. Guerriero, Nabihah Tayob, Bose Kochupurakkal +17 more

Heterogeneity and Clonal Evolution of Acquired PARP Inhibitor Resistance in TP53- and BRCA1 -Deficient Cells

Cancer Research(2021)10.1158/0008-5472.can-20-2912

N/A

0.550DataRank · unranked

38 citations

Alfredo Rodríguez, Jaana Oikkonen, D. Gulhan, Huy Nguyen, Julieta Domínguez +13 more

PARG inhibitor sensitivity correlates with accumulation of single-stranded DNA gaps in preclinical models of ovarian cancer

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2413954121

N/A

0.510DataRank · unranked

29 citations

Ozge Somuncu, Alexandre André Balieiro Anastácio da Costa, Sirisha Mukkavalli, Benjamin P. Lamarre, Huy Nguyen +8 more

A Phase I Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-dose Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma

Clinical Cancer Research(2023)10.1158/1078-0432.ccr-23-2005

N/A

0.503DataRank · unranked

14 citations

Hanrong Feng, Kalindi Parmar, Junning Wang, Kevin S. Kapner, Bose Kochupurakkal +23 more

Inhibition of TGFβ1 and TGFβ3 promotes hematopoiesis in Fanconi anemia

Experimental Hematology(2020)10.1016/j.exphem.2020.11.002

N/A

0.477DataRank · unranked

23 citations

Chunyu Yang, Elissa Furutani, Benilde García‐de Teresa, Martha Velázquez, Jessica Filiatrault +16 more

CDK5–cyclin B1 regulates mitotic fidelity

Nature(2024)10.1038/s41586-024-07888-x

N/A

0.477DataRank · unranked

23 citations

Aniruddha Sarkar, Humphrey Lotana, Aleem Syed, Huy Nguyen, Richard G. Ivey +11 more

RETRACTED ARTICLE: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer

Nature Communications(2023)10.1038/s41467-023-37096-6

N/A

0.470DataRank · unranked

22 citations

Heta Jadhav, Constantia Pantelidou, Tin Phan, Carter Grochala, Anita K. Mehta +9 more

A phase 2 study of berzosertib (M6620) in combination with carboplatin compared with docetaxel in combination with carboplatin in metastatic castration-resistant prostate cancer.

Journal of Clinical Oncology(2021)10.1200/jco.2021.39.15_suppl.5034

N/A

0.461DataRank · unranked

8 citations

Wanling Xie, Edmund Folefac, Daniel Lee, Mamta Parikh, David J. Einstein +12 more

Opportunities for Utilization of DNA Repair Inhibitors in Homologous Recombination Repair-Deficient and Proficient Pancreatic Adenocarcinoma

Clinical Cancer Research(2021)10.1158/1078-0432.ccr-21-1367

N/A

0.406DataRank · unranked

14 citations

Brian M. Wolpin, Stephanie K. Dougan, Srivatsan Raghavan, Harshabad Singh, Brandon M. Huffman +6 more

CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair

Nature Communications(2025)10.1038/s41467-025-56834-6

N/A

0.373DataRank · unranked

11 citations

Tianpeng Zhang, Aleem Syed, Amira Elbakry, Noella Holmer, Huy Nguyen +4 more

Disassembly of the Shieldin Complex by TRIP13

Cell Cycle(2020)10.1080/15384101.2020.1758435

N/A

0.373DataRank · unranked

11 citations

Connor S. Clairmont, Alan D. D’Andrea, Prabha Sarangi

Cyclin D1 overexpression induces replication stress and microhomology-mediated end-joining dependence in mantle cell lymphoma

Journal of Clinical Investigation(2025)10.1172/jci193006

N/A

0.330DataRank · unranked

8 citations

Shuhei Asada, Guangli Zhu, Yuna Hirohashi, Lisa A. Moreau, Divya Iyer +15 more

Randomized phase 2 study of gemcitabine with or without ATR inhibitor berzosertib in platinum-resistant ovarian cancer: Final overall survival (OS) and biomarker analyses.

Journal of Clinical Oncology(2023)10.1200/jco.2023.41.16_suppl.5512

N/A

0.292DataRank · unranked

6 citations

Elizabeth Katherine Lee, Su–Chun Cheng, Alexandre André Balieiro Anastácio da Costa, Andrea E. Wahner Hendrickson, D. Gulhan +14 more

Durable clinical benefit from PARP inhibition in a platinum-sensitive, BRCA2-mutated pancreatic cancer patient after earlier progression on placebo treatment on the POLO trial: a case report

Journal of Gastrointestinal Oncology(2021)10.21037/jgo-21-197

N/A

0.241DataRank · unranked

4 citations

Brian M. Wolpin, Ilana S. Warsofsky, David P. Ryan, Kimberly Perez, Osama E. Rahma +7 more

Isolation of human and murine hematopoietic stem cells for DNA damage and DNA repair assays

STAR Protocols(2021)10.1016/j.xpro.2021.100846

N/A

0.241DataRank · unranked

4 citations

Jessica Filiatrault, Patricia Flores-Guzmán, Héctor Mayani, Kalindi Parmar, Alan D. D’Andrea +1 more

Disruption of Microhomology-mediated End-joining in Ewing Sarcoma

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.05.06.651696

N/A

0.165DataRank · unranked

2 citations

Guangli Zhu, Jithma P. Abeykoon, Yutaro Tanaka, Huy Tien Nguyen, Yuna Hirohashi +14 more

Lack of synergy between AR targeted therapies and PARP inhibitors in homologous recombination-proficient prostate cancer

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.02.657429

N/A

0.165DataRank · unranked

2 citations

Esmé Wheeler, Rong Li, Feng Lü, Buraq Ahmed, Alok K. Tewari +8 more

Defective Microhomology-Mediated End-joining in SMARCB1-Deficient Tumors

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.11.20.689563

N/A

0DataRank · unranked

0 citations

Shuhei Asada, Huy Nguyen, Yuna Hirohashi, Lifang Sun, Avneesh Saravanapavan +4 more

Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection

Cell Reports(2020)10.1016/j.celrep.2020.01.052

N/A

0DataRank · unranked

85 citations

Connor E. Dunn, Wenxu Chen, Bose Kochupurakkal, Huy Nguyen, Lisa A. Moreau +5 more

Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair

Nucleic Acids Research(2020)10.1093/nar/gkaa038

N/A

0DataRank · unranked

74 citations

Jian Wang, Susan S. Wallace, Jing Chen, Jia Zhou, Alan D. D’Andrea +1 more

MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia

Cell stem cell(2020)10.1016/j.stem.2020.09.004

N/A

0DataRank · unranked

65 citations

Kaiyang Zhang, Anniina Färkkilä, Jessica Filiatrault, Chunyu Yang, Martha Velázquez +20 more

CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress

Molecular Cell(2020)10.1016/j.molcel.2020.10.008

N/A

0DataRank · unranked

56 citations

David Kozono, Peter Deraska, Timothy B. Branigan, Connor E. Dunn, Xiao-Feng Zheng +7 more

p31 comet promotes homologous recombination by inactivating REV7 through the TRIP13 ATPase

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.2008830117

N/A

0DataRank · unranked

38 citations

Connor S. Clairmont, Lucas D. Galli, Lisa A. Moreau, Alan D. D’Andrea, Prabha Sarangi

Polymerase Theta Inhibition Kills Homologous Recombination Deficient Tumors

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.23.111658

N/A

0DataRank · unranked

17 citations

Camille Gelot, Constantia Pantelidou, Adam Y. Li, Hatice Yücel, Rachel E. Davis +9 more

A phase II study of M6620 in combination with carboplatin compared with docetaxel in combination with carboplatin in metastatic castration-resistant prostate cancer.

Journal of Clinical Oncology(2020)10.1200/jco.2020.38.15_suppl.tps5597

N/A

0DataRank · unranked

3 citations

Wanling Xie, Mamta Parikh, Daniel Lee, Elizabeth R. Kessler, David J. Einstein +8 more

A phase II study of M6620 in combination with carboplatin compared with docetaxel in combination with carboplatin in metastatic castration-resistant prostate cancer.

Journal of Clinical Oncology(2020)10.1200/jco.2020.38.6_suppl.tps252

N/A

0DataRank · unranked

0 citations

Wanling Xie, Mamta Parikh, Daniel Lee, Elizabeth R. Kessler, David J. Einstein +8 more

REV7 directs DNA repair pathway choice

Trends in Cell Biology(2021)10.1016/j.tcb.2021.05.009

N/A

0DataRank · unranked

48 citations

Alan D. D’Andrea, Connor S. Clairmont

The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair

Molecular Cell(2021)10.1016/j.molcel.2021.09.008

N/A

0DataRank · unranked

26 citations

Nicholas A. Willis, Andrew E. H. Elia, Connor S. Clairmont, Shibo Li, Xiaohua Wu +4 more

FANCI functions as a repair/apoptosis switch in response to DNA crosslinks

Developmental Cell(2021)10.1016/j.devcel.2021.06.010

N/A

0DataRank · unranked

20 citations

Jennifer L. Kernan, Anya van Hoogstraten, Kiyohiro Ando, Yuanyuan Li, Alicia L. Belcher +11 more

REV7/FANCV Binds to CHAMP1 and Promotes Homologous Recombination Repair

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.10.04.463067

N/A

0DataRank · unranked

1 citations

Prabha Sarangi, Hanrong Feng, Lisa A. Moreau, Huy Nguyen, Connor S. Clairmont +2 more

REV7/FANCV Binds to CAMP and Promotes Homologous Recombination Repair

Research Square(2021)10.21203/rs.3.rs-757230/v1

N/A

0DataRank · unranked

0 citations

Prabha Sarangi, Hanrong Feng, Lisa A. Moreau, Huy Nguyen, Connor S. Clairmont +2 more

TGFβ pathway is required for viable gestation of Fanconi anemia embryos

PLoS Genetics(2022)10.1371/journal.pgen.1010459

N/A

0DataRank · unranked

16 citations

Michael W. Epperly, Jessica Filiatrault, Martha Velázquez, Chunyu Yang, Kelsey McQueen +12 more

CCAR2 functions downstream of the Shieldin complex to promote double-strand break end-joining

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2214935119

N/A

0DataRank · unranked

15 citations

Naoya Harada, Connor S. Clairmont, Lige Jiang, David B. Martignetti, Huy Nguyen +4 more

Metformin for treatment of cytopenias in children and young adults with Fanconi anemia

Blood Advances(2022)10.1182/bloodadvances.2021006490

N/A

0DataRank · unranked

16 citations

Elissa Furutani, Shanshan Liu, Erica B. Esrick, Laurie E. Cohen, Jacob R. Bledsoe +29 more

Dynamics of the DYNLL1–MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs

Nature Structural & Molecular Biology(2023)10.1038/s41594-023-01074-9

N/A

0DataRank · unranked

28 citations

Rui Zhou, Aleem Syed, Lisa A. Moreau, Bartłomiej Tomasik, John A. Tainer +5 more

Data from Phase 1b Clinical Trial with Alpelisib plus Olaparib for Patients with Advanced Triple-Negative Breast Cancer

(2023)10.1158/1078-0432.c.6532290.v1

Top 100%

0DataRank

Top 100%0 citations

Niya Xiong, Nabihah Tayob, Madeline Polak, Julia Eismann, Lewis C. Cantley +10 more

Data from Phase 1b Clinical Trial with Alpelisib plus Olaparib for Patients with Advanced Triple-Negative Breast Cancer

(2023)10.1158/1078-0432.c.6532290

Top 100%

0DataRank

Top 100%0 citations

Niya Xiong, Nabihah Tayob, Madeline Polak, Julia Eismann, Lewis C. Cantley +10 more

Data from Heterogeneity and Clonal Evolution of Acquired PARP Inhibitor Resistance in TP53- and BRCA1-Deficient Cells

(2023)10.1158/0008-5472.c.6512719.v1

N/A

0DataRank · unranked

0 citations

Alfredo E. Rodríguez, Jaana Oikkonen, D. Gulhan, Huy Nguyen, J. Domı́nguez +13 more

Data from Clinical Efficacy and Molecular Response Correlates of the WEE1 Inhibitor Adavosertib Combined with Cisplatin in Patients with Metastatic Triple-Negative Breast Cancer

(2023)10.1158/1078-0432.c.6530060.v1

Top 100%

0DataRank

Top 100%0 citations

Tianyu Li, Tuulia Vallius, Jennifer L. Guerriero, Nabihah Tayob, Bose Kochupurakkal +17 more

Data from Clinical Efficacy and Molecular Response Correlates of the WEE1 Inhibitor Adavosertib Combined with Cisplatin in Patients with Metastatic Triple-Negative Breast Cancer

(2023)10.1158/1078-0432.c.6530060

Top 100%

0DataRank

Top 100%0 citations

Tianyu Li, Tuulia Vallius, Jennifer L. Guerriero, Nabihah Tayob, Bose Kochupurakkal +17 more

Data from Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer

(2023)10.1158/2159-8290.c.6549535

N/A

0DataRank · unranked

0 citations

Tito A. Sandoval, Sung‐Min Hwang, Eun Sil Park, Paolo Giovanelli, Deepika Awasthi +16 more

Data from Genomic Landscape of Primary and Recurrent Anal Squamous Cell Carcinomas in Relation to HPV Integration, Copy-Number Variation, and DNA Damage Response Genes

(2023)10.1158/1541-7786.c.6545376.v1

Top 100%

0DataRank

Top 100%0 citations

David R. Lorenz, Kent W. Mouw, Alan D. D’Andrea, Dana Gabuzda, Jordan Aldersley

Fork restart: unloading FANCD2 to travel ahead

Molecular Cell(2023)10.1016/j.molcel.2023.09.027

N/A

0DataRank · unranked

0 citations

Alan D. D’Andrea, Divya Iyer

A porcine model of Fanconi anemia

PLoS ONE(2025)10.1371/journal.pone.0335854

N/A

0DataRank · unranked

0 citations

Kristin M. Whitworth, Devorah C. Goldman, Lisa A. Moreau, Kelsey McQueen, Kalindi Parmar +8 more

Alan D. D’Andrea

Indexed papers

Top data-sharing exemplar

Papers