Zheng‐Xiong Xi

Also affiliated with Molecular Discovery (United Kingdom)

NeuroscienceBiochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 50 papers. Top paper: “Current Perspectives on Selective Dopamine D3 Receptor Antagonists/Partial Agonists as Pharmacotherapeutics for Opioid and Psychostimulant Use Disorders”.

Current Perspectives on Selective Dopamine D3 Receptor Antagonists/Partial Agonists as Pharmacotherapeutics for Opioid and Psychostimulant Use Disorders

Current topics in behavioral neurosciences(2022)10.1007/7854_2022_347

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0.529DataRank · unranked

33 citations

Zheng‐Xiong Xi, Christian Heidbreder, Amy Hauck Newman

Modafinil and its structural analogs as atypical dopamine uptake inhibitors and potential medications for psychostimulant use disorder

Current Opinion in Pharmacology(2020)10.1016/j.coph.2020.07.007

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0.529DataRank · unranked

33 citations

Melinda Hersey, Briana J. Hempel, Zheng‐Xiong Xi, Amy Hauck Newman, Gianluigi Tanda

Dissecting the role of CB1 and CB2 receptors in cannabinoid reward versus aversion using transgenic CB1- and CB2-knockout mice

European Neuropsychopharmacology(2020)10.1016/j.euroneuro.2020.11.019

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0.529DataRank · unranked

33 citations

Briana J. Hempel, Hong-Ju Yang, Xiao Han, Guo‐Hua Bi, Eliot L. Gardner +2 more

A highly D3R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D3R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder

Neuropsychopharmacology(2022)10.1038/s41386-022-01379-1

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0.470DataRank · unranked

22 citations

Guo‐Hua Bi, Benjamin Klein, Briana J. Hempel, Anver Basha Shaik, Emma Gogarnoiu +12 more

Pharmacological targeting of G protein-coupled receptor heteromers

Pharmacological Research(2022)10.1016/j.phrs.2022.106476

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0.464DataRank · unranked

21 citations

Nil Casajuana-Martín, Michael Coyle, Baruc Campos, Ewa Galaj, Claudia Llinás del Torrent +13 more

(±)VK4‐40, a novel dopamine D3 receptor partial agonist, attenuates cocaine reward and relapse in rodents

British Journal of Pharmacology(2020)10.1111/bph.15244

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0.449DataRank · unranked

19 citations

Yi He, Guo‐Hua Bi, Zhi‐Bing You, Jianjing Cao, Zheng‐Xiong Xi +2 more

GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice

Translational Psychiatry(2024)10.1038/s41398-024-02820-3

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0.416DataRank · unranked

15 citations

Hui Shen, Guo‐Hua Bi, Hai‐Ying Zhang, Omar Soler‐Cedeño, Hannah Alton +3 more

GPR55 is expressed in glutamate neurons and functionally modulates nicotine taking and seeking in rats and mice

Research Square(2023)10.21203/rs.3.rs-3222344/v1

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0.114DataRank · unranked

1 citations

Yi He, Hui Shen, Guo‐Hua Bi, Hai‐Ying Zhang, Omar Soler‐Cedeño +3 more

Optogenetic brain‐stimulation reward: A new procedure to re‐evaluate the rewarding versus aversive effects of cannabinoids in dopamine transporter‐Cre mice

Addiction Biology(2021)10.1111/adb.13005

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30 citations

Chloe J. Jordan, Hai‐Ying Zhang, Hui Shen, Xiao Han, Guo‐Hua Bi +5 more

Increased novelty-induced locomotion, sensitivity to amphetamine, and extracellular dopamine in striatum of Zdhhc15-deficient mice

Translational Psychiatry(2021)10.1038/s41398-020-01194-6

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25 citations

Juan José Rodríguez Gotor, Minae Niwa, Irina N. Krasnova, Abby Adamczyk, Mei Han +8 more

Repeated cocaine administration upregulates CB2 receptor expression in striatal medium-spiny neurons that express dopamine D1 receptors in mice

Acta Pharmacologica Sinica(2021)10.1038/s41401-021-00712-6

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21 citations

Lindsay De Biase, Ramesh Chandra, Hui Shen, Qing‐Rong Liu, Eliot L. Gardner +3 more

Effects of the selective dopamine D3 receptor antagonist PG01037 on morphine-induced hyperactivity and antinociception in mice

Behavioural Brain Research(2021)10.1016/j.bbr.2021.113506

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17 citations

Stephanie L. Foster, Desta M. Pulley, Briana J. Hempel, Guo‐Hua Bi, Zheng‐Xiong Xi +4 more

Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior

Translational Psychiatry(2021)10.1038/s41398-021-01693-0

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9 citations

Jordi Bonaventura, Jacqueline D. Keighron, Kelsey M. Wright, Dondre L. Marable, Lionel A. Rodriguez +12 more

Deletion of VGLUT2 in midbrain dopamine neurons attenuates dopamine and glutamate responses to methamphetamine in mice

Pharmacology Biochemistry and Behavior(2021)10.1016/j.pbb.2021.173104

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11 citations

Kai Chen, Rosa Anna Maria Marino, Ross A. McDevitt, Zheng‐Xiong Xi, Hui Shen

Pharmacology in the age of circuit neuroscience: Illuminating the neural mechanisms of reward, drug use and addiction and enlightening the future of translational research

Pharmacology Biochemistry and Behavior(2021)10.1016/j.pbb.2021.173187

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2 citations

Roy A. Wise, Zheng‐Xiong Xi, Chloe J. Jordan

Mitochondrial Clk1-iron-DAT regulation pathway: a possible new therapeutic target for methamphetamine use disorder

Acta Pharmacologica Sinica(2021)10.1038/s41401-021-00821-2

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1 citations

Zheng‐Xiong Xi, Briana J. Hempel

Cannabinoid CB1 Receptors Are Expressed in a Subset of Dopamine Neurons and Underlie Cannabinoid-Induced Aversion, Hypoactivity, and Anxiolytic Effects in Mice

Journal of Neuroscience(2022)10.1523/jneurosci.1493-22.2022

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38 citations

Ying Liang, Briana J. Hempel, Chloe J. Jordan, Hui Shen, Guo‐Hua Bi +3 more

A red nucleus–VTA glutamate pathway underlies exercise reward and the therapeutic effect of exercise on cocaine use

Science Advances(2022)10.1126/sciadv.abo1440

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27 citations

Graziella Madeo, Ying Liang, Cindy Zhang, Briana J. Hempel, Xiaojie Liu +11 more

Receptor mechanisms underlying the CNS effects of cannabinoids: CB1 receptor and beyond

Advances in pharmacology(2022)10.1016/bs.apha.2021.10.006

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26 citations

Zheng‐Xiong Xi, Briana J. Hempel

Identification of the Risk Genes Associated With Vulnerability to Addiction: Major Findings From Transgenic Animals

Frontiers in Neuroscience(2022)10.3389/fnins.2021.811192

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20 citations

Zheng‐Xiong Xi, Chloe J. Jordan

Involvement of the ghrelin system in the maintenance of oxycodone self-administration: converging evidence from endocrine, pharmacologic and transgenic approaches

Molecular Psychiatry(2022)10.1038/s41380-022-01438-5

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14 citations

Eliot L. Gardner, Ewa Galaj, Allamar Moore, Tristram Buck, Chloe J. Jordan +5 more

Elevation of Extracellular Glutamate by Blockade of Astrocyte Glutamate Transporters Inhibits Cocaine Reinforcement in Rats via a NMDA-GluN2B Receptor Mechanism

Journal of Neuroscience(2022)10.1523/jneurosci.1432-21.2022

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15 citations

Briana J. Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L. Gardner +2 more

Therapeutic potential of PIMSR, a novel CB1 receptor neutral antagonist, for cocaine use disorder: evidence from preclinical research

Translational Psychiatry(2022)10.1038/s41398-022-02059-w

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11 citations

Briana J. Hempel, Allamar Moore, Benjamin Klein, Guo‐Hua Bi, Eliot L. Gardner +3 more

PPARα and PPARγ are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice

Molecular Psychiatry(2023)10.1038/s41380-023-02182-0

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28 citations

Madeline E. Crissman, Sruti Pari, Benjamin Klein, Guo‐Hua Bi, Hannah Alton +2 more

Dopamine D3/D2 Receptor Ligands Based on Cariprazine for the Treatment of Psychostimulant Use Disorders That May Be Dual Diagnosed with Affective Disorders

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.2c01624

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18 citations

Caleb D. Vogt, Julie Sanchez, Alessandro Bonifazi, Elizabeth Saab, Anver Basha Shaik +7 more

Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c02037

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8 citations

Gisela Andrea Camacho‐Hernandez, Kristine Salomon, Kuo Hao Lee, Therese Ku, Jianjing Cao +11 more

The selective D3-Receptor antagonist VK4-116 effectively treats behavioral inflexibility in rats caused by self-administration and withdrawal from cocaine

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.03.556083

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2 citations

Shohan Shetty, Micaela Porod, Lisette Bahena, Zheng‐Xiong Xi, Amy Hauck Newman +2 more

PPARα and PPARγ are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice

Research Square(2023)10.21203/rs.3.rs-2614714/v1

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0 citations

Briana J. Hempel, Madeline E. Crissman, Sruti Pari, Benjamin Klein, Guo‐Hua Bi +2 more

Presynaptic and Postsynaptic Mesolimbic Dopamine D3 Receptors Play Distinct Roles in Cocaine Versus Opioid Reward in Mice

Biological Psychiatry(2024)10.1016/j.biopsych.2024.05.020

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13 citations

Miriam E. Bocarsly, Ewa Galaj, Briana J. Hempel, Catherine E. Teresi, Marlisa Shaw +9 more

AM6527, a neutral CB1 receptor antagonist, suppresses opioid taking and seeking, as well as cocaine seeking in rodents without aversive effects

Neuropsychopharmacology(2024)10.1038/s41386-024-01861-y

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12 citations

Hannah Alton, Guo‐Hua Bi, Emily Linz, Lipin Ji, Alexandros Makriyannis +2 more

Involvement of dopamine D3 receptor in impulsive choice decision-making in male rats

Neuropharmacology(2024)10.1016/j.neuropharm.2024.110051

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10 citations

Zilu Ma, Emma Hans, Ying Duan, Guo-Hua Bi, Yurim Chae +6 more

The selective D3Receptor antagonist VK4-116 reverses loss of insight caused by self-administration of cocaine in rats

Neuropsychopharmacology(2024)10.1038/s41386-024-01858-7

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5 citations

Shohan Shetty, Micaela Porod, Lisette Bahena, Zheng‐Xiong Xi, Amy Hauck Newman +2 more

Optical Intracranial Self-Stimulation (oICSS): A New Behavioral Model for Studying Drug Reward and Aversion in Rodents

International Journal of Molecular Sciences(2024)10.3390/ijms25063455

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2 citations

Omar Soler‐Cedeño, Zheng‐Xiong Xi, Rui Song

Optical Intracranial Self-Stimulation (oICSS): A New Behavioral Model for Studying Drug Reward and Aversion

Preprints.org(2024)10.20944/preprints202401.1465.v1

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1 citations

Omar Soler‐Cedeño, Zheng‐Xiong Xi, Rui Song

ESG-1-60 and ESG-1-61: novel dopamine D3 receptor-preferring partial agonists/antagonists that inhibit cocaine taking and seeking without motor effect

(2024)10.22541/au.172777949.94104264/v1

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0 citations

Bradley M. Keegan, Hannah Alton, Guo‐Hua Bi, Emily Linz, Caleb D. Vogt +5 more

Novel potential pharmacological approaches in treating eating disorders comorbid with substance use disorders

Biomedicine & Pharmacotherapy(2025)10.1016/j.biopha.2025.118327

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4 citations

Ewa Galaj, Zheng‐Xiong Xi

Brain CB2 receptor: a new target in medication development for treating opioid use disorder in rodents

Molecular Psychiatry(2025)10.1038/s41380-025-03377-3

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2 citations

Hai‐Ying Zhang, Emma Xiong, Guo‐Hua Bi, Hannah Alton, Maia Maras +5 more

RDS-04-010: a novel atypical DAT inhibitor that inhibits cocaine taking and seeking and itself has low abuse potential in experimental animals

Translational Psychiatry(2025)10.1038/s41398-025-03391-7

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3 citations

Ewa Galaj, Benjamin Klein, Jianjing Cao, Guo-Hua Bi, Amy Hauck Newman +2 more

Cannabinoid CB1 receptor and mu-opioid receptor interaction: new insights from conditional knockout mice

Neuropsychopharmacology(2025)10.1038/s41386-025-02245-6

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1 citations

Emily Linz, Guo‐Hua Bi, Omar Soler‐Cedeño, Maia Maras, Zheng‐Xiong Xi +1 more

ESG‐1‐60 and ESG‐1‐61: Novel dopamine D3 receptor‐preferring partial agonists/antagonists that inhibit cocaine taking and seeking in rodents

British Journal of Pharmacology(2025)10.1111/bph.70021

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4 citations

Bradley M. Keegan, Hannah Alton, Guo‐Hua Bi, Emily Linz, Caleb D. Vogt +5 more

Cocaine Self-Administration Increases Impulsive Decision-Making in Low-Impulsive Rats Associated with Impaired Functional Connectivity in the Mesocorticolimbic System

eNeuro(2025)10.1523/eneuro.0408-24.2025

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3 citations

Zilu Ma, Emma Hans, Ying Duan, Guo‐Hua Bi, Yurim Chae +4 more

Dissecting the Role of GABA Neurons in the VTAversusSNr in Opioid Reward

Journal of Neuroscience(2020)10.1523/jneurosci.0988-20.2020

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99 citations

Xiao Han, Hui Shen, Chloe J. Jordan, Yi He, Bree A. Humburg +3 more

Neuronal versus Glial CB2 Receptors: Insights from a Novel CB2-KO-eGFP Reporter Mouse Line

Research Square(2025)10.21203/rs.3.rs-8297538/v1

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0 citations

Emily Linz, Hai-Ying Zhang, Christopher J. Dunn, Guo-Hua Bi, Ewa Galaj +5 more

Dopamine D3 receptor-based medication development for the treatment of opioid use disorder: Rationale, progress, and challenges

Neuroscience & Biobehavioral Reviews(2020)10.1016/j.neubiorev.2020.04.024

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54 citations

Amy Hauck Newman, Zheng‐Xiong Xi, Ewa Galaj

Xie2-64, a novel CB2 receptor inverse agonist, reduces cocaine abuse-related behaviors in rodents

Neuropharmacology(2020)10.1016/j.neuropharm.2020.108241

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19 citations

Zhiwei Feng, Ewa Galaj, Guo‐Hua Bi, Ying Xue, Ying Liang +4 more

Neurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms

Psychopharmacology(2020)10.1007/s00213-020-05513-z

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25 citations

Caitlin Burzynski, Subramaniam Jayanthi, Bruce Ladenheim, Jean Lud Cadet, Eliot L. Gardner +5 more

Modafinil potentiates cocaine self-administration by a dopamine-independent mechanism: possible involvement of gap junctions

Neuropsychopharmacology(2020)10.1038/s41386-020-0680-5

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18 citations

Takato Hiranita, Chloe J. Jordan, Lauren E. Chun, Jessica P. Lopez, Mark A. Coggiano +8 more

Progress in opioid reward research: From a canonical two-neuron hypothesis to two neural circuits

Pharmacology Biochemistry and Behavior(2020)10.1016/j.pbb.2020.173072

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28 citations

Zheng‐Xiong Xi, Ewa Galaj

New Drugs, Old Targets: Tweaking the Dopamine System to Treat Psychostimulant Use Disorders

The Annual Review of Pharmacology and Toxicology(2021)10.1146/annurev-pharmtox-030220-124205

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58 citations

Therese Ku, Chloe J. Jordan, Alessandro Bonifazi, Zheng‐Xiong Xi, Amy Hauck Newman

Cannabinoid CB2 receptors are expressed in glutamate neurons in the red nucleus and functionally modulate motor behavior in mice

Neuropharmacology(2021)10.1016/j.neuropharm.2021.108538

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39 citations

Hui Shen, Ming Gao, Zegang Ma, Briana J. Hempel, Guo‐Hua Bi +4 more