Ulf Dettmer

MedicineBiochemistry, Genetics and Molecular BiologyNeuroscience

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 37 papers. Top paper: “The role of alpha-synuclein in synucleinopathy: Impact on lipid regulation at mitochondria–ER membranes”.

The role of alpha-synuclein in synucleinopathy: Impact on lipid regulation at mitochondria–ER membranes

npj Parkinson s Disease(2025)10.1038/s41531-025-00960-x

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0.385DataRank · unranked

12 citations

Cristina Guardia‐Laguarta, Taekyung yun, Zena K. Chatila, Xena Flowers, Chantel Wong +14 more

Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson’s disease

Cell Reports(2025)10.1016/j.celrep.2025.115636

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0.292DataRank · unranked

6 citations

Katelyn VanderSleen, Jiya Mody, Neha Patel, Benjamin N. Sacks, Mahsa Darestani Farahani +25 more

Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor

International Journal of Molecular Sciences(2020)10.3390/ijms21155193

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37 citations

Arati Tripathi, Thibaut Imberdis, Zachary M. LaVoie, Gary P. H. Ho, Dennis J. Selkoe +4 more

Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100271

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28 citations

Ulf Dettmer, Nagendran Ramalingam

Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicity

Human Molecular Genetics(2021)10.1093/hmg/ddab188

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17 citations

Andrew J Newman, Thibaut Imberdis, Lisa Brontesi, Arati Tripathi, Nagendran Ramalingam +4 more

Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?

Biomolecules(2021)10.3390/biom12010040

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8 citations

Saranna Fanning, Ulf Dettmer, Arati Tripathi

Brain region-specific spread of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.

Research Square(2021)10.21203/rs.3.rs-294515/v1

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0DataRank · unranked

0 citations

Laura de Boni, Aurelia Hays Watson, Ludovica Zaccagnini, Nora Kim, John Sanderson +10 more

Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy

npj Parkinson s Disease(2022)10.1038/s41531-022-00335-6

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24 citations

Haley Cirka, Jennifer L. Thies, Jooyoung Jeong, Sarah M. Niemi, Joon Yoon +12 more

Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons

npj Parkinson s Disease(2022)10.1038/s41531-022-00380-1

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30 citations

Jonathan M. S. Stricker, Stephanie Soriano-Cruz, Beatrice Weykopf, Ulf Dettmer, Christina Muratore +3 more

Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis

Journal of Neuroscience(2022)10.1523/jneurosci.1881-21.2022

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26 citations

Heba Alnakhala, Elizabeth Terry-Kantor, Andrew Newman, Lei Liu, Thibaut Imberdis +6 more

A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity

Neurotherapeutics(2022)10.1007/s13311-022-01199-7

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25 citations

Chee Yeun Chung, Daniel F. Tardiff, Pascal A. Bechade, Thomas D. McCaffery, Kazuma Shimanaka +14 more

Anti-fibrillization effects of sulfonamide derivatives on α-synuclein and hyperphosphorylated tau isoform 1N4R

Journal of Molecular Structure(2022)10.1016/j.molstruc.2022.133574

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14 citations

Kazuma Shimanaka, A. Prasanth Saraswati, Mengyu Liu, Kuang‐Wei Wang, Hsiao-Tien Hagar +8 more

Rapid iPSC inclusionopathy models shed light on formation, consequence and molecular subtype of α-synuclein inclusions

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.08.515615

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9 citations

Alain Ndayisaba, Amanda J. Lewis, YuHong Fu, Giselle T. Sagredo, Ludovica Zaccagnini +44 more

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity

npj Parkinson s Disease(2023)10.1038/s41531-023-00444-w

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150 citations

Shan‐Xue Jin, Tim E. Moors, Luis Fonseca‐Ornelas, Kazuma Shimanaka, Lei Shi +18 more

Dynamic reversibility of α‐synuclein serine‐129 phosphorylation is impaired in synucleinopathy models

EMBO Reports(2023)10.15252/embr.202357145

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24 citations

Lisa Brontesi, Shan‐Xue Jin, Dennis J. Selkoe, Ulf Dettmer, Nagendran Ramalingam

α-Synuclein serine129 phosphorylation – the physiology of pathology

Molecular Neurodegeneration(2023)10.1186/s13024-023-00680-x

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19 citations

Ulf Dettmer, Nagendran Ramalingam

5-Nitro-1,2-benzothiazol-3-amine and N-Ethyl-1-[(ethylcarbamoyl)(5-nitro-1,2-benzothiazol-3-yl)amino]formamide Modulate α-Synuclein and Tau Aggregation

ACS Omega(2023)10.1021/acsomega.3c02668

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11 citations

Susantha K. Ganegamage, Ahmed A. Elbatrawy, Heba Alnakhala, Kazuma Shimanaka, Arati Tripathi +5 more

Discovery of 4-aminoindole carboxamide derivatives to curtail alpha-synuclein and tau isoform 2N4R oligomer formation

Results in Chemistry(2023)10.1016/j.rechem.2023.100938

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7 citations

Se-Hong Min, Susantha K. Ganegamage, Kazuma Shimanaka, Magaly Guzman Sosa, Ulf Dettmer +3 more

The effects of KTKEGV repeat motif and intervening ATVA sequence on α‐synuclein solubility and assembly

Journal of Neurochemistry(2023)10.1111/jnc.15763

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4 citations

Thibaut Imberdis, Nagendran Ramalingam, Ulf Dettmer, Lisa Brontesi

Adding hydrophobicity or positive charges to the cytosolic half of the α‐synuclein 3–11 helix increases membrane association and S129 phosphorylation

FEBS Letters(2023)10.1002/1873-3468.14773

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0DataRank · unranked

2 citations

Bryan Shi, Lisa Brontesi, Heba Alnakhala, Vidyashree Jayanthi, Kanagaraj Subramanian +4 more

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions

Neuron(2024)10.1016/j.neuron.2024.06.002

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0DataRank · unranked

31 citations

Alain Ndayisaba, Amanda J. Lewis, YuHong Fu, Giselle T. Sagredo, Anastasia Kuzkina +49 more

Physiological roles of α-synuclein serine-129 phosphorylation – not an oxymoron

Trends in Neurosciences(2024)10.1016/j.tins.2024.05.005

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26 citations

Christian Haass, Ulf Dettmer, Nagendran Ramalingam

Discovery of small molecule benzothiazole and indole derivatives tackling tau 2N4R and α-synuclein fibrils

Bioorganic & Medicinal Chemistry(2024)10.1016/j.bmc.2024.117613

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19 citations

Taiwo A. Ademoye, Heba Alnakhala, Arati Tripathi, Ashique Zami, Raluca Ostafe +3 more

RXR nuclear receptor signaling modulates lipid metabolism and triggers lysosomal clearance of alpha-synuclein in neuronal models of synucleinopathy

Cellular and Molecular Life Sciences(2024)10.1007/s00018-024-05373-2

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8 citations

Heba Alnakhala, Lisa Brontesi, Dennis J. Selkoe, Ulf Dettmer, Arati Tripathi

A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons

npj Parkinson s Disease(2024)10.1038/s41531-024-00725-y

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6 citations

Karis A. Clark, Kellianne D. Alexander, Nagendran Ramalingam, Tracy L. Young‐Pearse, Ulf Dettmer +3 more

Interactions of alpha-synuclein with membranes in Parkinson's disease: Mechanisms and therapeutic strategies

Neurobiology of Disease(2024)10.1016/j.nbd.2024.106646

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9 citations

Ulf Dettmer, Baoyi Li

Exploring the rhodanine universe: Design and synthesis of fluorescent rhodanine-based derivatives as anti-fibrillar and anti-oligomer agents against α-synuclein and 2N4R tau

Bioorganic & Medicinal Chemistry(2024)10.1016/j.bmc.2024.117990

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3 citations

Taiwo A. Ademoye, Heba Alnakhala, Arati Tripathi, Germán Plascencia‐Villa, Xiongwei Zhu +4 more

The Role of Alpha-Synuclein in Synucleinopathy: Impact on Lipid Regulation at Mitochondria–ER Membranes

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.17.599406

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5 citations

Cristina Guardia‐Laguarta, Taekyung yun, Zena K. Chatila, Xena Flowers, Bruno Santos +12 more

Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson’s disease

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.08.30.610195

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0DataRank · unranked

0 citations

Katelyn VanderSleen, Jiya Mody, Neha Patel, Benjamin N. Sacks, Mahsa Darestani Farahani +22 more

Inhibition of hippocampal mossy fiber plasticity and episodic memory by human Aβ oligomers is prevented by enhancing cAMP signaling in Alzheimer's mice

Alzheimer s & Dementia(2025)10.1002/alz.70194

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9 citations

Jean‐Pierre Bellier, Adrienne R. Wells, Paula Montero LIopis, Praju Vikas Anekal, Jason S. Tresback +7 more

A Novel α‐Synuclein K58N Missense Variant in a Patient with Parkinson's Disease

Movement Disorders(2025)10.1002/mds.70030

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0DataRank · unranked

3 citations

Sandrina Weber, Nagendran Ramalingam, Maria Ramón, Liana Shvachiy, Gonçalo Mestre +20 more

A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features

Molecular Neurodegeneration(2025)10.1186/s13024-025-00889-y

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3 citations

Mohammed Al‐Azzani, Nagendran Ramalingam, Maria Ramón, Rita L. Sousa, Fiamma A. Buratti +15 more

In Vitro Evaluation of Amide-Linked Coumarin Scaffolds for the Inhibition of α-Synuclein and Tau Aggregation

ACS Omega(2025)10.1021/acsomega.5c02435

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2 citations

Susantha K. Ganegamage, Behrad Masoudi, Omnia M. H. Ibrahium, Heba Alnakhala, Arati Tripathi +5 more

Acute lipid droplet accumulation induced by the inhibition of the phospholipase DDHD2 does not affect the level, solubility, or phosphoserine-129 status of α-synuclein

Metabolic Brain Disease(2025)10.1007/s11011-025-01534-9

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0 citations

Tim E. Moors, Lisa Brontesi, Silke Nuber, Ulf Dettmer, Nagendran Ramalingam +1 more

Parkinson’s disease: proteinopathy or lipidopathy?

npj Parkinson s Disease(2020)10.1038/s41531-019-0103-7

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241 citations

Dennis J. Selkoe, Ulf Dettmer, Saranna Fanning

Lipid droplets promote the aberrant liquid-liquid phase separation of alpha-synuclein leading to impaired energy homeostasis

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.11.20.689615

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0DataRank · unranked

0 citations

Elena Eubanks, Sung-Hoo Jung, Yiming Huang, Elyse Guadagno, Neeharika Rao Suvvari +9 more

A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α‐Synuclein Mice

Annals of Neurology(2020)10.1002/ana.25920

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0DataRank · unranked

67 citations

Alice Y. Nam, Molly M. Rajsombath, Haley Cirka, Xiaoping Hronowski, Junmin Wang +11 more