Takahisa Kanekiyo

Also affiliated with WinnMed, Institute for Regenerative Medicine & Biotherapy, Mayo Clinic in Florida

MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 51 papers. Top paper: “APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids”.

APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

Nature Communications(2020)10.1038/s41467-020-19264-0

N/A

7.4DataRank · unranked

377 citations

Yuan Fu, Yu Yamazaki, Yingxue Ren, Mary Dabney Davis, Chia‐Chen Liu +18 more

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Mediates Neuronal Aβ42 Uptake and Lysosomal Trafficking

PLoS ONE(2010)10.1371/journal.pone.0011884

N/A

4.1DataRank · unranked

111 citations

Qiang Liu, Juan Zhang, Takahisa Kanekiyo, Xiaoyan Hu, Jin-Moo Lee +3 more

Functionalized nanoparticles for brain targeted BDNF gene therapy to rescue Alzheimer's disease pathology in transgenic mouse model

International Journal of Biological Macromolecules(2022)10.1016/j.ijbiomac.2022.03.203

N/A

1.5DataRank · unranked

62 citations

Takahisa Kanekiyo, Jagdish Singh, Sanjay Arora

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference

Alzheimer s & Dementia(2024)10.1002/alz.13877

N/A

1.1DataRank · unranked

33 citations

Michaël E. Belloy, Elizabeth Blue, Gregory R. Bowman, María C. Carrillo, Xiaoying Chen +55 more

ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism

Molecular Psychiatry(2023)10.1038/s41380-023-02372-w

N/A

1.1DataRank · unranked

51 citations

Marie‐Louise Holm, Skylar C Starling, Yuka A. Martens, Jing Zhao, Wenyan Lü +14 more

APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids

Stem Cell Research & Therapy(2023)10.1186/s13287-023-03444-y

N/A

0.891DataRank · unranked

23 citations

Tadafumi C. Ikezu, Wenyan Lü, Jesse R. Macyczko, Yonghe Li, Laura J. Lewis‐Tuffin +8 more

CSF biomarkers of immune activation and Alzheimer’s disease for predicting cognitive impairment risk in the elderly

Science Advances(2024)10.1126/sciadv.adk3674

N/A

0.851DataRank · unranked

33 citations

Launia J. White, Rachel Hendrix, Jason D. Ulrich, Rachel L. Henson, William D. Knight +19 more

LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4

JCI Insight(2023)10.1172/jci.insight.163822

N/A

0.749DataRank · unranked

24 citations

Yu Yamazaki, Wenhui Qiao, Chen Yuanxin, Yingxue Ren, Aishe Kurti +18 more

ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids

Science Advances(2023)10.1126/sciadv.adi3647

N/A

0.673DataRank · unranked

88 citations

Zhengrong Zhang, Nadia Sultana, Maria Ericsson, Yuka A. Martens, Min Sun +5 more

Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids

Acta Neuropathologica(2021)10.1007/s00401-021-02361-9

N/A

0.614DataRank · unranked

59 citations

Wenyan Lü, Yingxue Ren, Yuan Fu, Yuka A. Martens, Francis Shue +18 more

Nerve Growth Factor Gene Delivery across the Blood–Brain Barrier to Reduce Beta Amyloid Accumulation in AD Mice

Molecular Pharmaceutics(2020)10.1021/acs.molpharmaceut.0c00218

N/A

0.593DataRank · unranked

51 citations

Takahisa Kanekiyo, Jagdish Singh, Bruna dos Santos Rodrigues

Uremic Toxins, CKD, and Cognitive Dysfunction

Journal of the American Society of Nephrology(2025)10.1681/asn.0000000675

N/A

0.562DataRank · unranked

23 citations

Gregory S. Day, Sarosh R. Irani, Takahisa Kanekiyo, LaTonya J. Hickson, Taylor Andrews

In vitro and in vivo characterization of CPP and transferrin modified liposomes encapsulating pDNA

Nanomedicine Nanotechnology Biology and Medicine(2020)10.1016/j.nano.2020.102225

N/A

0.557DataRank · unranked

40 citations

Takahisa Kanekiyo, Jagdish Singh, Bruna dos Santos Rodrigues

Gliovascular transcriptional perturbations in Alzheimer’s disease reveal molecular mechanisms of blood brain barrier dysfunction

Nature Communications(2024)10.1038/s41467-024-48926-6

N/A

0.557DataRank · unranked

40 citations

Xue Wang, Joseph S. Reddy, Yuhao Min, Elanur Yılmaz, Prabesh Bhattarai +36 more

Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins

Molecular Neurodegeneration(2023)10.1186/s13024-022-00592-2

N/A

0.500DataRank · unranked

27 citations

Joseph S. Reddy, Zachary Quicksall, Minerva M. Carrasquillo, Xue Wang, Chia‐Chen Liu +22 more

ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimer’s disease through BDNF/NGFR signaling

Cell Genomics(2024)10.1016/j.xgen.2024.100642

N/A

0.416DataRank · unranked

15 citations

Elanur Yılmaz, Prabesh Bhattarai, Yuhao Min, Xue Wang, Yiyi Ma +23 more

Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer’s disease

Acta Neuropathologica Communications(2024)10.1186/s40478-024-01731-0

N/A

0.406DataRank · unranked

14 citations

Sydney V. Doss, Michael G. Heckman, Emily C. Craver, Zonghua Li, Tadafumi C. Ikezu +17 more

Human iPSC-Derived MSCs Induce Neurotrophic Effects and Improve Metabolic Activity in Acute Neuronal Injury Models

Journal of Neuroscience(2024)10.1523/jneurosci.0606-24.2024

N/A

0.396DataRank · unranked

13 citations

Genesis Omana Suarez, Ralph B. Perkerson, Ephraim E. Parent, Toshihiko Nambara, Joshua A. Knight +11 more

Generation and validation of APOE knockout human iPSC-derived cerebral organoids

STAR Protocols(2021)10.1016/j.xpro.2021.100571

N/A

0.360DataRank · unranked

10 citations

Siming Xu, Richard JR Tait, Gang Li, Xin-Ping Zhao, Wenyan Lü +5 more

Relationships between PET and blood plasma biomarkers in corticobasal syndrome

Alzheimer s & Dementia(2024)10.1002/alz.13914

N/A

0.345DataRank · unranked

9 citations

Alla Alnobani, Jonathan Graff‐Radford, Mary M. Machulda, Michelle M. Mielke, Christopher G. Schwarz +7 more

Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice

Neurobiology of Disease(2025)10.1016/j.nbd.2025.106813

N/A

0.312DataRank · unranked

7 citations

Dmitry Prokopenko, Ni Wang, Tomonori Aikawa, Younjung Choi, Can Zhang +17 more

Impact of APOE on cerebrovascular lipid profile in Alzheimer’s disease

Acta Neuropathologica(2025)10.1007/s00401-025-02949-5

N/A

0.292DataRank · unranked

6 citations

Hu Wang, Michael G. Heckman, Yingxue Ren, Launia J. White, Wenyan Lü +12 more

Partial inhibition of mitochondrial complex I attenuates neurodegeneration and restores energy homeostasis and synaptic function in a symptomatic Alzheimer’s mouse model

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.01.182428

N/A

0.165DataRank · unranked

2 citations

Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li +31 more

Prostaglandin D2-Mediated Microglia/Astrocyte Interaction Enhances Astrogliosis and Demyelination in twitcher

UNC Libraries(2021)10.17615/sj66-aj08

N/A

0DataRank · unranked

2 citations

Keiichi Ozono, Masako Taniike, Kinuko Suzuki, Naomi Eguchi, Hitoshi Sasai +10 more

Upregulation of sFRP1 Is More Profound in Female than Male 5xFAD Mice and Positively Associated with Amyloid Pathology

Journal of Alzheimer s Disease(2023)10.3233/jad-230218

N/A

0DataRank · unranked

12 citations

Na Wang, Wenyan Lü, Suren Jeevaratnam, Francis Shue, Yuka A. Martens +5 more

ABCA7 Regulates Brain Fatty Acid Metabolism During LPS-Induced Acute Inflammation

Frontiers in Neuroscience(2021)10.3389/fnins.2021.647974

N/A

0DataRank · unranked

25 citations

Yingxue Ren, Marie‐Louise Holm, Yan W. Asmann, Amer Alam, Michael L. Fitzgerald +3 more

Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice

Communications Biology(2021)10.1038/s42003-020-01584-y

N/A

0DataRank · unranked

69 citations

Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li +31 more

APOE2 promotes longevity independent of Alzheimer’s disease

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.31.255141

N/A

0DataRank · unranked

0 citations

Takahisa Kanekiyo, Masaya Tachibana, Aishe Kurti, Motoko Shinohara, Yuan Fu +8 more

Secretome from iPSC-derived MSCs exerts proangiogenic and immunosuppressive effects to alleviate radiation-induced vascular endothelial cell damage

Stem Cell Research & Therapy(2024)10.1186/s13287-024-03847-5

N/A

0DataRank · unranked

25 citations

Ralph B. Perkerson, Tammee M. Parsons, Ramacharan Angom, Danilyn Amerna, Jeremy D. Burgess +9 more

Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice

Journal of Alzheimer s Disease(2020)10.3233/jad-201015

N/A

0DataRank · unranked

33 citations

Su-Youne Chang, Jarred J. Nesbitt, Nicholas P. Pichurin, Mark Ostroot, Tomonori Aikawa +3 more

Dual-Modified Liposome for Targeted and Enhanced Gene Delivery into Mice Brain

Journal of Pharmacology and Experimental Therapeutics(2020)10.1124/jpet.119.264127

N/A

0DataRank · unranked

59 citations

Sushant Lakkadwala, Takahisa Kanekiyo, Jagdish Singh, Bruna dos Santos Rodrigues

Alterations of PINK1-PRKN signaling in mice during normal aging

Autophagy Reports(2024)10.1080/27694127.2024.2434379

N/A

0DataRank · unranked

10 citations

Jens O. Watzlawik, Xu Hou, Tyrique Richardson, Nicholas W. Kurchaba, Tingxiang Yan +15 more

Brain-targeting liposome-based APOE2 gene delivery exacerbates soluble amyloid-β accumulation in AppNL−G-F mice

Heliyon(2024)10.1016/j.heliyon.2024.e39607

N/A

0DataRank · unranked

9 citations

Tammee M. Parsons, Yingxue Ren, Yining Pan, Aishe Kurti, Skylar C Starling +4 more

Synthesis and Characterization of Transferrin and Cell-Penetrating Peptide-Functionalized Liposomal Nanoparticles to Deliver Plasmid ApoE2 In Vitro and In Vivo in Mice

Molecular Pharmaceutics(2024)10.1021/acs.molpharmaceut.4c00870

N/A

0DataRank · unranked

9 citations

Avinash Gothwal, Takahisa Kanekiyo, Jagdish Singh, Chinenye Edith Muolokwu

Amyloid pathology and cognitive impairment in hAβ-KI and APPSAA-KI mouse models of Alzheimer's disease

Neurobiology of Aging(2024)10.1016/j.neurobiolaging.2024.10.005

N/A

0DataRank · unranked

7 citations

Francis Shue, Aishe Kurti, Suren Jeevaratnam, Jesse R. Macyczko, Bhaskar Roy +6 more

A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells

Frontiers in Cellular Neuroscience(2024)10.3389/fncel.2024.1368018

N/A

0DataRank · unranked

6 citations

Yingxue Ren, Shuwen Zhang, Michael Bamkole, Naeyma N. Islam, Manikandan Selvaraj +5 more

Comparison of Culturing Methods of Primary Vaginal Fibroblasts

Urogynecology(2024)10.1097/spv.0000000000001612

N/A

0DataRank · unranked

0 citations

Tammee M. Parsons, Jing Zhao, Ralph B. Perkerson, C C Glembotski, Frédéric Zenhausern +4 more

APOE genotype determines cell-type-specific pathological landscape of Alzheimer’s disease

Neuron(2025)10.1016/j.neuron.2025.02.017

N/A

0DataRank · unranked

29 citations

Yuka A. Martens, Yingxue Ren, Yunjung Jin, Hiroaki Sekiya, Sydney V. Doss +25 more

Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function

Neuron(2020)10.1016/j.neuron.2020.11.019

N/A

0DataRank · unranked

74 citations

Chia‐Chen Liu, Akari Yamazaki, Francis Shue, Yuka A. Martens, Yuanxin Chen +13 more

HDAC3 as an Emerging Therapeutic Target for Alzheimer's Disease and other Neurological Disorders

Molecular Neurobiology(2025)10.1007/s12035-025-04866-w

N/A

0DataRank · unranked

14 citations

Taha Izhar, Takahisa Kanekiyo, Yonghe Li

Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer's disease

EBioMedicine(2025)10.1016/j.ebiom.2025.105924

N/A

0DataRank · unranked

6 citations

Thi Kim Oanh Nguyen, Andrea Stojakovic, Mark Ostroot, J. Trey Deason, Su-Youne Chang +7 more

Compromised lipid metabolism, mitochondria respiration and neuroprotective effects in iPSC-derived astrocytes from a Smith-Lemli-Opitz syndrome patient

Human Molecular Genetics(2025)10.1093/hmg/ddaf159

N/A

0DataRank · unranked

3 citations

Samantha K. Baker, Jazmine D. W. Yaeger, Ruthellen H. Anderson, Yingxue Ren, Zonghua Li +5 more

Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer's disease

Alzheimer s & Dementia(2025)10.1002/alz.70112

N/A

0DataRank · unranked

5 citations

Yining Pan, Skylar C Starling, Devon H. Haskell, Astrid Quintero, Keiji Kawatani +18 more

Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer’s disease

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.02.12.637918

N/A

0DataRank · unranked

2 citations

Thi Kim Oanh Nguyen, Andrea Stojakovic, Mark Ostroot, J. Trey Deason, Su-Youne Chang +7 more

Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human brain organoid microphysiological systems

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.02.16.638539

N/A

0DataRank · unranked

2 citations

Zheng Ao, Jonas Cerneckis, Hongwei Cai, Lei Chen, Henyao Niu +7 more

Dual-modified Liposomes Encapsulating Nucleic Acids (pApoE2 or pGFP) for Transport Studies Across a Hydrocortisone-enhanced In Vitro Blood–brain Barrier Model for CNS Therapeutic Screening

Pharmaceutical Research(2025)10.1007/s11095-025-03900-9

N/A

0DataRank · unranked

0 citations

Avinash Gothwal, Takahisa Kanekiyo, Jagdish Singh, Chinenye Edith Muolokwu

Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease

Molecular Neurodegeneration(2023)10.1186/s13024-023-00640-5

N/A

0DataRank · unranked

300 citations

Francis Shue, Guojun Bu, Takahisa Kanekiyo, Yasuteru Inoue

Efficient neuronal targeting and transfection using RVG and transferrin-conjugated liposomes

Brain Research(2020)10.1016/j.brainres.2020.146738

N/A

0DataRank · unranked

75 citations

Sanjay Arora, Takahisa Kanekiyo, Jagdish Singh, Bruna dos Santos Rodrigues

APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.30.498241

N/A

0DataRank · unranked

1 citations

Tadafumi C. Ikezu, Wenyan Lü, Jesse R. Macyczko, Yonghe Li, Laura J. Lewis‐Tuffin +8 more

Mesenchymal stem cell therapy for focal epilepsy: A systematic review of preclinical models and clinical studies

Epilepsia(2022)10.1111/epi.17266

N/A

0DataRank · unranked

13 citations

Carlos Perez‐Vega, Ricardo A. Domingo, Seung Jin Lee, Ralph B. Perkerson, Abba C. Zubair +6 more

LRP1 is a neuronal receptor for α-synuclein uptake and spread

Molecular Neurodegeneration(2022)10.1186/s13024-022-00560-w

N/A

0DataRank · unranked

115 citations

Yuka A. Martens, Axel Meneses, Daniel Ryu, Wenyan Lü, Ana‐Caroline Raulin +14 more