L. David Sibley

Also affiliated with Washington University in St. Louis

Immunology and MicrobiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 42 papers. Top paper: “Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma–dependent pathogen restriction in human cells”.

Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma–dependent pathogen restriction in human cells

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2315865120

N/A

1.0DataRank · unranked

33 citations

Hinissan P. Kohio, Pallavi Chandra, Adam Brown, John G. Doench, Jennifer A. Philips +3 more

Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection

eLife(2021)10.7554/elife.73137

N/A

0.836DataRank · unranked

25 citations

Michael E. Abrams, Sumit K. Matta, John W. Schoggins, Neal M. Alto, L. David Sibley +1 more

Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.31.275339

N/A

0DataRank · unranked

5 citations

L. David Sibley, Alex Rosenberg

Gut metabolites influence susceptibility of neonatal mice to cryptosporidiosis

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.09.11.294462

N/A

0DataRank · unranked

0 citations

Lisa J. Funkhouser-Jones, Marianna E. Akey, Deborah A. Schaefer, Kevin Ackman, Michael W. Riggs +3 more

Insulinase like protease 1 contributes to macrogamont formation in Cryptosporidium parvum

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.03.411165

N/A

0DataRank · unranked

0 citations

Yaoyu Feng, Lihua Xiao, L. David Sibley, Rui Xu

Commensal Cryptosporidium colonization elicits a cDC1-dependent Th1 response that promotes intestinal homeostasis and limits other infections

Immunity(2021)10.1016/j.immuni.2021.10.002

N/A

0DataRank · unranked

56 citations

Jisun Jung, Aidan T. Miller, Shannon Young, Jaeu Yi, Alec Wehmeier +15 more

Toxoplasma bradyzoites exhibit physiological plasticity of calcium and energy stores controlling motility and egress

eLife(2021)10.7554/elife.73011

N/A

0DataRank · unranked

28 citations

Kevin M Brown, Nathaniel G Jones, Silvia N.J. Moreno, L. David Sibley, Yong Fu

Autophagy gene-dependent intracellular immunity triggered by interferon-γ

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.10.443539

N/A

0DataRank · unranked

1 citations

Jaya Bhushan, Dale R. Balce, Anthony Orvedahl, Arnold Park, Seungmin Hwang +4 more

Toxoplasma bradyzoites exhibit physiological plasticity of calcium and energy stores controlling motility and egress

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.17.444531

N/A

0DataRank · unranked

1 citations

Kevin M. Brown, Nathaniel G Jones, Silvia N.J. Moreno, L. David Sibley, Yong Fu

Intrinsically disordered pathogen effector alters the STAT1 dimer to prevent recruitment of co-transcriptional activators CBP/p300

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.08.09.455663

N/A

0DataRank · unranked

1 citations

Hejun Liu, Jay C. Nix, Catherine R. Knoverek, Gregory R. Bowman, Gaya K. Amarasinghe +2 more

The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment

Nature Communications(2022)10.1038/s41467-022-31720-7

N/A

0DataRank · unranked

39 citations

Hejun Liu, Jay C. Nix, Rui Xu, Catherine R. Knoverek, Gregory R. Bowman +3 more

Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase

Nature Communications(2022)10.1038/s41467-022-28108-y

N/A

0DataRank · unranked

26 citations

Bruno Melillo, Payal Mittal, Manmohan Sharma, Amit Sharma, Yong Fu +8 more

Interactions of Autophagy and the Immune System in Health and Diseases

Autophagy Reports(2022)10.1080/27694127.2022.2119743

N/A

0DataRank · unranked

23 citations

Xiaomin Yao, Aude Lavedrine, Christophe Viret, Jacob Dockterman, Swati Chauhan +11 more

Molecular Basis for Interferon-mediated Pathogen Restriction in Human Cells

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.10.21.513197

N/A

0DataRank · unranked

8 citations

Hinissan P. Kohio, Pallavi Chandra, Adam Brown, John G. Doench, Jennifer A. Philips +3 more

Microbiota-produced indole metabolites disrupt mitochondrial function and inhibit Cryptosporidium parvum growth

Cell Reports(2023)10.1016/j.celrep.2023.112680

N/A

0DataRank · unranked

48 citations

Rui Xu, Georgia Wilke, Yong Fu, Lawrence A. Schriefer, Heyde Makimaa +7 more

Apical Secretory Glycoprotein Complex Contributes to Cell Attachment and Entry by Cryptosporidium parvum

mBio(2023)10.1128/mbio.03064-22

N/A

0DataRank · unranked

18 citations

Rui Xu, Soumya Ravindran, Lisa J. Funkhouser-Jones, L. David Sibley, Marianna E. Akey

Autophagy gene-dependent intracellular immunity triggered by interferon-γ

mBio(2023)10.1128/mbio.02332-23

N/A

0DataRank · unranked

15 citations

Jaya Bhushan, Dale R. Balce, Anthony Orvedahl, Arnold Park, Seungmin Hwang +4 more

Susceptibility of Toxoplasma gondii to autophagy in human cells relies on multiple interacting parasite loci

mBio(2023)10.1128/mbio.02595-23

N/A

0DataRank · unranked

7 citations

Alex Rosenberg, Joshua B. Radke, Jaya Bhushan, Tadakimi Tomita, Louis M. Weiss +2 more

Dendritic Cells and Cryptosporidium: From Recognition to Restriction

Microorganisms(2023)10.3390/microorganisms11041056

N/A

0DataRank · unranked

6 citations

L. David Sibley, Iti Saraav

Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.27.546703

N/A

0DataRank · unranked

3 citations

Wandy L. Beatty, Valentin Greigert, William H. Witola, L. David Sibley, Rui Xu

Microbiota produced indole metabolites disrupt host cell mitochondrial energy production and inhibit Cryptosporidium parvum growth

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.25.542157

N/A

0DataRank · unranked

2 citations

Rui Xu, Georgia Wilke, Yong Fu, Lawrence A. Shriefer, Heyde Makimaa +7 more

A Combination of Four Nuclear Targeted Effectors Protects Toxoplasma Against Interferon Gamma Driven Human Host Cell Death During Acute Infection

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.24.573224

N/A

0DataRank · unranked

1 citations

L. David Sibley, Alex Rosenberg, Brittany Henry

Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum

Nature Communications(2024)10.1038/s41467-024-44696-3

N/A

0DataRank · unranked

47 citations

Wandy L. Beatty, Valentin Greigert, William H. Witola, L. David Sibley, Rui Xu

Cryptosporidium infection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus

Gut Microbes(2024)10.1080/19490976.2023.2297897

N/A

0DataRank · unranked

31 citations

Iti Saraav, Juhee Son, Yinxing Zhu, Denise Dayao, Avan Antia +6 more

Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum

PLoS Genetics(2024)10.1371/journal.pgen.1011162

N/A

0DataRank · unranked

12 citations

Lisa J. Funkhouser-Jones, Wanyi Huang, Rui Xu, William H. Witola, L. David Sibley +1 more

A combination of four Toxoplasma gondii nuclear-targeted effectors protects against interferon gamma-driven human host cell death

mBio(2024)10.1128/mbio.02124-24

N/A

0DataRank · unranked

6 citations

Aubrey J. Phillips, L. David Sibley, Alex Rosenberg, Brittany Henry

Bicyclic Pyrrolidine Inhibitors of Toxoplasma gondii Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure

ACS Infectious Diseases(2024)10.1021/acsinfecdis.4c00170

N/A

0DataRank · unranked

3 citations

Taher Uddin, Julien Borrel, Payal Mittal, Han Xie, Jochen Zoller +7 more

Constitutive upregulation of transcription factors underlies permissive bradyzoite differentiation in a natural isolate of Toxoplasma gondii

mBio(2024)10.1128/mbio.00641-24

N/A

0DataRank · unranked

8 citations

Yong Fu, Wanyi Huang, Taher Uddin, L. David Sibley, Jing Xia

Function of the alternative electron transport chain in the Cryptosporidium parvum mitosome

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.10.01.616074

N/A

0DataRank · unranked

3 citations

L. David Sibley, Silu Deng

Constitutive upregulation of transcription factors underlies permissive bradyzoite differentiation in a natural isolate of Toxoplasma gondii

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.28.582596

N/A

0DataRank · unranked

2 citations

Yong Fu, Wanyi Huang, L. David Sibley, Jing Xia

Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.02.578536

N/A

0DataRank · unranked

0 citations

Lisa J. Funkhouser-Jones, Wanyi Huang, Rui Xu, William H. Witola, L. David Sibley +1 more

Bicyclic pyrrolidine inhibitors of Toxoplasma gondii phenylalanine t-RNA synthetase with antiparasitic potency in vitro and brain exposure

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.28.582607

N/A

0DataRank · unranked

0 citations

Taher Uddin, Julien Borrel, Payal Mittal, Han Xie, Jochen Zoller +7 more

High Throughput Repurposing Screen Reveals Compounds with Activity Against Toxoplasma gondii Bradyzoites

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.07.01.601569

N/A

0DataRank · unranked

0 citations

Jing Xia, Yong Fu, Case W. McNamara, Arnab K. Chatterjee, L. David Sibley +1 more

SAMD9 senses cytosolic double-stranded nucleic acids in epithelial and mesenchymal cells to induce antiviral immunity

Nature Communications(2025)10.1038/s41467-025-59090-w

N/A

0DataRank · unranked

16 citations

Wandy L. Beatty, Lili Ren, Yaw Shin Ooi, Juhee Son, Yinxing Zhu +12 more

Cryptosporidium parvum multidrug resistance protein confers resistance to toxic gut microbial metabolite

Cell Host & Microbe(2025)10.1016/j.chom.2025.07.024

N/A

0DataRank · unranked

13 citations

Rui Xu, Abigail K. Kimball, William H. Witola, Megan T. Baldridge, Yaoyu Feng +3 more

Toxoplasma chitinase-like protein orchestrates cyst wall glycosylation to facilitate effector export and cyst turnover

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2416870122

N/A

0DataRank · unranked

3 citations

Tadakimi Tomita, Louis M. Weiss, Christopher M. West, L. David Sibley, Yong Fu

Phospho-relay feedback loops control egress vs. intracellular development in Toxoplasma gondii

Cell Reports(2025)10.1016/j.celrep.2025.115260

N/A

0DataRank · unranked

3 citations

Yong Fu, L. David Sibley, Ja E. Claywell

High-Throughput Repurposing Screen Reveals Compounds with Activity against Toxoplasma gondii Bradyzoites

ACS Infectious Diseases(2025)10.1021/acsinfecdis.4c00689

N/A

0DataRank · unranked

2 citations

Jing Xia, Yong Fu, Case W. McNamara, Arnab K. Chatterjee, L. David Sibley +1 more

Assessing the function of the alternative electron transport chain in the Cryptosporidium parvum mitosome

mBio(2025)10.1128/mbio.01120-25

N/A

0DataRank · unranked

2 citations

Wandy L. Beatty, L. David Sibley, Silu Deng

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells

mBio(2020)10.1128/mbio.00852-20

N/A

0DataRank · unranked

63 citations

Joshua B. Radke, Yi-Chieh Perng, Michael R. McAllaster, Deborah J. Lenschow, Herbert W. Virgin +2 more

Structure‐Based Drug Design of Novel Heterocyclic Scaffolds as TgCDPK1 Inhibitors

ChemMedChem(2025)10.1002/cmdc.202500440

N/A

0DataRank · unranked

1 citations

Mariah Norman, Igi Vilza, Michael P. Mannino, Mary Savari Dhason, Jon Helander +4 more

An Important Role for CD4 + T Cells in Adaptive Immunity to Toxoplasma gondii in Mice Lacking the Transcription Factor Batf3

mSphere(2020)10.1128/msphere.00634-20

N/A

0DataRank · unranked

11 citations

Michael S. Behnke, Nicole M. Kretzer, Gary E. Grajales‐Reyes, Theresa L. Murphy, Robert D. Schreiber +3 more