Christina D. Orrú

National Institute of Allergy and Infectious Diseases

Biochemistry, Genetics and Molecular BiologyMedicineNeuroscience

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 23 papers. Top paper: “Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies”.

Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies

Acta Neuropathologica(2020)10.1007/s00401-020-02160-8

N/A

0DataRank · unranked

479 citations

Niccolò Candelise, Simone Baiardi, Sabina Capellari, Giulia Giannini, Christina D. Orrú +10 more

Ring trial of 2nd generation RT‐QuIC diagnostic tests for sporadic CJD

Annals of Clinical and Translational Neurology(2020)10.1002/acn3.51219

N/A

0DataRank · unranked

56 citations

Bradley R. Groveman, Aaron Foutz, Matilde Bongianni, Franco Cardone, Neil McKenzie +17 more

High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease

Acta Neuropathologica Communications(2021)10.1186/s40478-021-01282-8

N/A

0DataRank · unranked

261 citations

Christina D. Orrú, Luis Concha‐Marambio, Simone Giaisi, Bradley R. Groveman, Carly M. Farris +13 more

Alpha-synuclein seeds in olfactory mucosa and cerebrospinal fluid of patients with dementia with Lewy bodies

Brain Communications(2021)10.1093/braincomms/fcab045

N/A

0DataRank · unranked

79 citations

Matilde Bongianni, Giovanni Novi, Francesco Janes, Valentina Bessi, Stefano Capaldi +23 more

Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases

Molecular Brain(2021)10.1186/s13041-021-00864-w

N/A

0DataRank · unranked

59 citations

Benjamin Schwarz, Bradley R. Groveman, Ryan O. Walters, Natalia Ferreira, Christina D. Orrú +10 more

Detection of chronic wasting disease in mule and white-tailed deer by RT-QuIC analysis of outer ear

Scientific Reports(2021)10.1038/s41598-021-87295-8

N/A

0DataRank · unranked

44 citations

Jorge M. Charco, Jakob Plagenz, Christina D. Orrú, Nathanial D. Denkers, Michael A. Metrick +9 more

Performance of αSynuclein RT-QuIC in relation to neuropathological staging of Lewy body disease

Acta Neuropathologica Communications(2022)10.1186/s40478-022-01388-7

N/A

0DataRank · unranked

123 citations

Christina D. Orrú, Geidy E. Serrano, Douglas Galasko, Andrew G. Hughson, Bradley R. Groveman +5 more

Real-Time Quaking- Induced Conversion Assays for Prion Diseases, Synucleinopathies, and Tauopathies

Frontiers in Aging Neuroscience(2022)10.3389/fnagi.2022.853050

N/A

0DataRank · unranked

42 citations

Christina D. Orrú, Byron Caughey, Sarah Vascellari

PERFORMANCE OF αSYNUCLEIN RT-QUIC IN RELATION TO NEUROPATHOLOGICAL STAGING OF LEWY BODY DISEASE

medRxiv(2022)10.1101/2022.05.05.22274567

N/A

0DataRank · unranked

4 citations

Christina D. Orrú, Geidy E. Serrano, Douglas Galasko, Andrew G. Hughson, Bradley R. Groveman +5 more

Trajectories of neurodegeneration and seed amplification biomarkers prior to disease onset in individuals at risk of prion disease

medRxiv(2022)10.1101/2022.10.30.22281644

N/A

0DataRank · unranked

0 citations

Akın Nihat, Nour K. Majbour, Danielle Sequeira, Leah Holm-Mercer, Thomas Coysh +28 more

Tau seeds occur before earliest Alzheimer’s changes and are prevalent across neurodegenerative diseases

Acta Neuropathologica(2023)10.1007/s00401-023-02574-0

N/A

0DataRank · unranked

35 citations

Heidi G. Standke, Danielle F. Browne, Mikayla L. Huntley, Olivia R. Thomas, Christina D. Orrú +10 more

α-Synuclein seeding activity in duodenum biopsies from Parkinson’s disease patients

PLoS Pathogens(2023)10.1371/journal.ppat.1011456

N/A

0DataRank · unranked

33 citations

Christina D. Orrú, Bradley R. Groveman, Sabiha Parveen, Giuseppe Fenu, Giada Pisano +12 more

A novel subtype of sporadic Creutzfeldt–Jakob disease with PRNP codon 129MM genotype and PrP plaques

Acta Neuropathologica(2023)10.1007/s00401-023-02581-1

N/A

0DataRank · unranked

28 citations

Christina D. Orrú, Rabail Aslam, Yvonne Cohen, Amelia Silva-Rohwer, Seongki Lee +9 more

Altered energy metabolism in Fatal Familial Insomnia cerebral organoids is associated with astrogliosis and neuronal dysfunction

PLoS Genetics(2023)10.1371/journal.pgen.1010565

N/A

0DataRank · unranked

23 citations

Anna L. Smith, Benjamin Schwarz, Eric Bohrnsen, Catharine M. Bosio, Katie Williams +5 more

Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection

PLoS Pathogens(2023)10.1371/journal.ppat.1011487

N/A

0DataRank · unranked

3 citations

Adela Malik, Daniel R. Sandoval, Christopher V. Barback, Christina D. Orrú, Heidi G. Standke +15 more

Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.19.545528

N/A

0DataRank · unranked

0 citations

Adela Malik, Daniel R. Sandoval, Christopher V. Barback, Christina D. Orrú, Heidi G. Standke +15 more

Enhanced quantitation of pathological α-synuclein in patient biospecimens by RT-QuIC seed amplification assays

PLoS Pathogens(2024)10.1371/journal.ppat.1012554

N/A

0DataRank · unranked

27 citations

Qinlu Wang, Christina D. Orrú, Manel Fernández, Yaroslau Compta, Bernardino Ghetti +5 more

Sensitive detection of pathological seeds of α-synuclein, tau and prion protein on solid surfaces

PLoS Pathogens(2024)10.1371/journal.ppat.1012175

N/A

0DataRank · unranked

15 citations

Bradley R. Groveman, Andrew G. Hughson, Tomás Barrio, Kachi Isiofia, Brent Race +9 more

Large-scale validation of skin prion seeding activity as a biomarker for diagnosis of prion diseases

Acta Neuropathologica(2024)10.1007/s00401-023-02661-2

N/A

0DataRank · unranked

18 citations

Christina D. Orrú, Aaron Foutz, Mingxuan Ding, Jue Yuan, Syed Zahid Ali Shah +21 more

A same day α-synuclein RT-QuIC seed amplification assay for synucleinopathy biospecimens

npj Biosensing(2025)10.1038/s44328-024-00023-w

N/A

0DataRank · unranked

25 citations

Parvez Alam, Christina D. Orrú, Sarah Vascellari, Andrew G. Hughson, Wen‐Quan Zou +9 more

Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice

Journal of Clinical Investigation(2025)10.1172/jci186432

N/A

0DataRank · unranked

6 citations

Julia A. Callender, Joshua E. Mayfield, Daniel B. McClatchy, Daniel Ojeda-Juárez, Mahsa Pourhamzeh +26 more

Prions and protein aggregates as pathogens, self-propagating structures, biomarkers, and therapeutic targets

Microbiology and Molecular Biology Reviews(2025)10.1128/mmbr.00007-25

N/A

0DataRank · unranked

2 citations

Efrosini Artikis, Daniel Shoup, Christina D. Orrú, Parvez Alam, Sabiha Parveen +5 more

Infecting human brain organoids with FFI or sCJD preserves prion traits regardless of host genotype

npj Dementia(2025)10.1038/s44400-025-00029-9

N/A

0DataRank · unranked

1 citations

Simote T. Foliaki, Katie Williams, Christina D. Orrú, Brent Race, Gianluigi Zanusso +2 more