Stephen B. Shears

Also affiliated with National Institutes of Health, National Institute of Environmental Health Sciences, National Institute of Health Sciences

Biochemistry, Genetics and Molecular BiologyAgricultural and Biological SciencesMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 30 papers. Top paper: “Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver”.

Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver

Nature(1984)10.1038/312374a0

N/A

20.6DataRank · unranked

323 citations

Stephen B. Shears, Christopher J. Kirk, Robert H. Michell, Diane J. Storey

Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase

Biochemical Journal(1997)10.1042/bj3280075

N/A

0.617DataRank · unranked

60 citations

William BURKHART, T. Stephen SAFRANY, James J. Caffrey, Stephen T. Safrany, Stephen B. Shears +1 more

Expanding coincident signaling by PTEN through its inositol 1,3,4,5,6‐pentakisphosphate 3‐phosphatase activity

FEBS Letters(2001)10.1016/s0014-5793(01)02500-5

N/A

0.533DataRank · unranked

34 citations

Tom Darden, Markus R. Wenk, Stephen B. Shears, James J. Caffrey

Rapid stimulation of cellular Pi uptake by the inositol pyrophosphate InsP 8 induced by its photothermal release from lipid nanocarriers using a near infra-red light-emitting diode

Chemical Science(2020)10.1039/d0sc02144j

N/A

0.505DataRank · unranked

9 citations

Nikolaus Jork, Tamara Bittner, Huanchen Wang, Henning J. Jessen, Stephen B. Shears +1 more

KIDINS220 and InsP8 safeguard the stepwise regulation of phosphate exporter XPR1

Molecular Cell(2025)10.1016/j.molcel.2025.08.003

N/A

0.391DataRank · unranked

12 citations

Zhongjian Bai, Ciara Wallis, Huanchen Wang, Yaoyao Han, Ruitao Jin +9 more

Biochemical and biophysical characterization of inositol-tetrakisphosphate 1-kinase inhibitors

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.108274

N/A

0.217DataRank · unranked

3 citations

Huanchen Wang, Haibo Zhang, Isabel Prucker, Lalith Perera, Ekaterina I. Goncharova +8 more

New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1

The FASEB Journal(2021)10.1096/fj.202001489r

N/A

0DataRank · unranked

31 citations

Nikolaus Jork, Sarah Hostachy, Dorothea Fiedler, Henning J. Jessen, Stephen B. Shears +2 more

Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca 2+ mobilization and the inflammatory activity of dendritic cells

Science Signaling(2021)10.1126/scisignal.aaz2120

N/A

0DataRank · unranked

27 citations

Francesca Mingozzi, Clara Cigni, Roberta Marzi, Marco Di Gioia, Massimiliano Garrè +16 more

New Structural Insights Reveal an Expanded Reaction Cycle for Inositol Pyrophosphate Hydrolysis by Human DIPP1

The FASEB Journal(2021)10.1096/fasebj.2021.35.s1.00386

N/A

0DataRank · unranked

4 citations

Nikolaus Jork, Sarah Hostachy, Dorothea Fiedler, Henning J. Jessen, Stephen B. Shears +2 more

Signals | The Inositol Pyrophosphate Signaling Family

Elsevier eBooks(2021)10.1016/b978-0-12-819460-7.00309-1

N/A

0DataRank · unranked

0 citations

Stephen B. Shears, Soumyadip Sahu

Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis

UNC Libraries(2021)10.17615/e5hw-rx97

N/A

0DataRank · unranked

0 citations

Stephen B. Shears, Sherif E. Gabriel, Ling Yang, Jeff Reece

Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues

Chemical Science(2022)10.1039/d2sc05147h

N/A

0DataRank · unranked

65 citations

Chunfang Gu, Guizhen Liu, Kevin Ritter, Verena B. Eisenbeis, Tamara Bittner +6 more

Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions

Journal of Medicinal Chemistry(2022)10.1021/acs.jmedchem.2c00220

N/A

0DataRank · unranked

32 citations

Sandip Mukherjee, Daowei Huang, Molee Chakraborty, Chunfang Gu, Guangning Zong +7 more

Structural and catalytic analyses of the InsP 6 kinase activities of higher plant ITPKs

The FASEB Journal(2022)10.1096/fj.202200393r

N/A

0DataRank · unranked

28 citations

Stephen B. Shears, Huanchen Wang, Guangning Zong

A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop

Nature Communications(2022)10.1038/s41467-022-29673-y

N/A

0DataRank · unranked

24 citations

L. Perera, Nikolaus Jork, Guangning Zong, Andrew M. Riley, Barry V. L. Potter +3 more

Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.14.507917

N/A

0DataRank · unranked

10 citations

Chunfang Gu, Guizhen Liu, Kevin Ritter, Verena B. Eisenbeis, Tamara Bittner +6 more

IP8: A quantitatively minor inositol pyrophosphate signaling molecule that punches above its weight

Advances in Biological Regulation(2023)10.1016/j.jbior.2023.101002

N/A

0DataRank · unranked

15 citations

Xingyao Li, Guangning Zong, Huanchen Wang, Stephen B. Shears, Chunfang Gu

Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling

Biomolecules(2023)10.3390/biom13060885

N/A

0DataRank · unranked

8 citations

Barbara Leibiger, Shao-Nian Yang, Stephen B. Shears, Ingo B. Leibiger, Per‐Olof Berggren +2 more

Fluorination Influences the Bioisostery of Myo‐Inositol Pyrophosphate Analogs

Chemistry - A European Journal(2023)10.1002/chem.202302426

N/A

0DataRank · unranked

7 citations

Huanchen Wang, Guangning Zong, Katy Franke, Andrew M. Riley, Peter Schmieder +4 more

Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP7

Biomolecules(2023)10.3390/biom13010153

N/A

0DataRank · unranked

15 citations

Jacob Gordon, Chunfang Gu, Mack Sobhany, Dorothea Fiedler, Robin E. Stanley +2 more

Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8

Cell Reports(2024)10.1016/j.celrep.2024.114316

N/A

0DataRank · unranked

30 citations

Regan B Kirkpatrick, Xiaodong Wang, Charles J. Tucker, Anuj Shukla, Henning J Jessen +4 more

Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus

The EMBO Journal(2024)10.1038/s44318-023-00005-0

N/A

0DataRank · unranked

11 citations

Yann Desfougères, Paloma Portela-Torres, Yong-Uk Kwon, Adolfo Saiardi, Stephen B. Shears +2 more

Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Mthl10

Insect Biochemistry and Molecular Biology(2024)10.1016/j.ibmb.2024.104086

N/A

0DataRank · unranked

4 citations

Takashi Matsumura, Eui Jae Sung, Takashi Koyama, Masanori Ochiai, Stephen B. Shears +2 more

Structural Rationalization of IPMK Inhibitor Potency

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c02314

N/A

0DataRank · unranked

2 citations

Stephen B. Shears, Raymond D. Blind, Huanchen Wang

Proteomic Analysis Provides Insights Into PPIP5K2 Function and Its Impact on Corneal Energy Metabolism

Investigative Ophthalmology & Visual Science(2025)10.1167/iovs.66.15.67

N/A

0DataRank · unranked

1 citations

Caili Hao, Zhong Chen, Xiaowen Lu, Hongfang Yu, Chunfang Gu +6 more

Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry

Nature Communications(2020)10.1038/s41467-020-19928-x

N/A

0DataRank · unranked

173 citations

Miranda Wilson, Verena B. Eisenbeis, Robert K. Harmel, Esther Riemer, Thomas Haas +10 more

An Expanded Biological Repertoire for Ins(3,4,5,6)P4 through its Modulation of ClC-3 Function

UNC Libraries(2020)10.17615/bbq9-j932

N/A

0DataRank · unranked

0 citations

Martina Gentzsch, Stephen B. Shears, Jennifer Mitchell, Guangping Zhang, Xueqing Wang +1 more

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

UNC Libraries(2020)10.17615/m52q-g503

N/A

0DataRank · unranked

0 citations

Stephen V. Frye, Kenneth H. Pearce, Michael A. Stashko, Brandi M. Baughman, Yi An +4 more

The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis

UNC Libraries(2020)10.17615/1xdg-fm72

N/A

0DataRank · unranked

0 citations

Alexandre Hofer, Xuming Dai, Huanchen Wang, Stephen B. Shears, Henning J. Jessen +2 more

Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2020187118

N/A

0DataRank · unranked

34 citations

Juan Liu, Xiaojing Liu, Haibo Zhang, Ji Luo, Huanchen Wang +3 more