Steven E. Brenner

Biochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 1%percentile

7.8Author DataRank

Indexed papers

7in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 7 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

SCOPe: improvements to the structural classification of proteins – extended database to facilitate variant interpretation and machine learning

Nucleic Acids Research(2021)10.1093/nar/gkab1054

Top 5%

4.6DataRank

Top 5%206 citations

Lindsey Guan, Shiangyi Lin, Changhua Yu, Naomi K. Fox, Steven E. Brenner +1 more

Papers

Driven by 39 papers — median percentile 46. Top paper: “Calibration of computational tools for missense variant pathogenicity classification and ClinGen recommendations for PP3/BP4 criteria”.

Calibration of computational tools for missense variant pathogenicity classification and ClinGen recommendations for PP3/BP4 criteria

The American Journal of Human Genetics(2022)10.1016/j.ajhg.2022.10.013

N/A

9.9DataRank · unranked

560 citations

Alicia B. Byrne, Bing Feng, Kymberleigh A. Pagel, Sean D. Mooney, Rachel Karchin +20 more

Using the ACMG/AMP framework to capture evidence related to predicted and observed impact on splicing: Recommendations from the ClinGen SVI Splicing Subgroup

The American Journal of Human Genetics(2023)10.1016/j.ajhg.2023.06.002

N/A

6.1DataRank · unranked

324 citations

Miguel de la Hoya, George A. R. Wiggins, Amanda Lindy, Lisa M. Vincent, Michael T. Parsons +28 more

SCOPe: improvements to the structural classification of proteins – extended database to facilitate variant interpretation and machine learning

Nucleic Acids Research(2021)10.1093/nar/gkab1054

Top 5%

4.6DataRank

Top 5%206 citations

Lindsey Guan, Shiangyi Lin, Changhua Yu, Naomi K. Fox, Steven E. Brenner +1 more

Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE

Science(2010)10.1126/science.1198374

Top 9%

2.4DataRank

Top 9%1089 citations

Sushmita Roy, Jason Ernst, Peter V. Kharchenko, Yanxiao Zhang, Richard S. Sandstrom +172 more

WebLogo: A Sequence Logo Generator: Figure 1

Genome Research(2004)10.1101/gr.849004

N/A

1.4DataRank · unranked

12930 citations

Gary Hon, John-Marc Chandonia, Steven E. Brenner, Gary C. Hon, John‐Marc Chandonia +1 more

The Bioperl Toolkit: Perl Modules for the Life Sciences

Genome Research(2002)10.1101/gr.361602

N/A

1.1DataRank · unranked

1704 citations

David Block, Kris Boulez, Steven E. Brenner, Stephen A. Chervitz, Chris Dagdigian +21 more

The role of exome sequencing in newborn screening for inborn errors of metabolism

Nature Medicine(2020)10.1038/s41591-020-0966-5

N/A

0.835DataRank · unranked

261 citations

Renata C. Gallagher, Yaqiong Wang, Robert J. Currier, George S. Amatuni, Laia Bassaganyas +19 more

Comparative analysis of regulatory information and circuits across distant species

Nature(2014)10.1038/nature13668

N/A

0.818DataRank · unranked

232 citations

Carlos L. Araya, Cathleen Brdlik, Philip Cayting, Chao Cheng, Yong Cheng +40 more

Opportunities and challenges for the computational interpretation of rare variation in clinically important genes

The American Journal of Human Genetics(2021)10.1016/j.ajhg.2021.03.003

N/A

0.686DataRank · unranked

96 citations

Andrew G. Sharo, Megan L. Koleske, Julia E. H. Brown, Matthew Norstad, Aashish N. Adhikari +9 more

Application of full-genome analysis to diagnose rare monogenic disorders

npj Genomic Medicine(2021)10.1038/s41525-021-00241-5

N/A

0.598DataRank · unranked

53 citations

Monica Penon‐Portmann, K. Wong, Michal Levy‐Sakin, Michelle Verghese, Anne Slavotinek +15 more

Critical assessment of missense variant effect predictors on disease-relevant variant data

Human Genetics(2025)10.1007/s00439-025-02732-2

N/A

0.596DataRank · unranked

24 citations

Ryan Chung, Sindy Li, Chang Li, Kyoungyeul Lee, Junwoo Woo +31 more

ClinVar and HGMD genomic variant classification accuracy has improved over time, as measured by implied disease burden

Genome Medicine(2023)10.1186/s13073-023-01199-y

N/A

0.593DataRank · unranked

51 citations

Yangyun Zou, Aashish N. Adhikari, Steven E. Brenner, Andrew G. Sharo

Calibration of additional computational tools expands ClinGen recommendation options for variant classification with PP3/BP4 criteria

Genetics in Medicine(2025)10.1016/j.gim.2025.101402

N/A

0.590DataRank · unranked

50 citations

Sarah L. Stenton, Emily A.W. Nadeau, Alicia B. Byrne, Marc S. Greenblatt, Steven M. Harrison +20 more

Variant Impact Predictor database (VIPdb), version 2: trends from three decades of genetic variant impact predictors

Human Genomics(2024)10.1186/s40246-024-00663-z

Top 36%

0.546DataRank

Top 36%14 citations

Arul S. Menon, Zhiqiang Hu, Steven E. Brenner, Yu-Jen Lin

Evidence-based calibration of computational tools for missense variant pathogenicity classification and ClinGen recommendations for clinical use of PP3/BP4 criteria

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.03.17.484479

N/A

0.533DataRank · unranked

34 citations

Alicia B. Byrne, Bing Feng, Kymberleigh A. Pagel, Sean D. Mooney, Rachel Karchin +9 more

Assessment of the evidence yield for the calibrated PP3/BP4 computational recommendations

Genetics in Medicine(2024)10.1016/j.gim.2024.101213

N/A

0.434DataRank · unranked

17 citations

Vikas Pejaver, Timothy Bergquist, Leslie G. Biesecker, Alicia B. Byrne, Emily A.W. Nadeau +21 more

Networks of Splice Factor Regulation by Unproductive Splicing Coupled With Nonsense Mediated mRNA Decay

10.1101/2020.05.20.107375

N/A

0.385DataRank · unranked

12 citations

Zhiqiang Hu, Courtney E. French, James P. B. Lloyd, Steven E. Brenner, Anna Desai

StrVCTVRE: A supervised learning method to predict the pathogenicity of human genome structural variants

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.15.097048

N/A

0.360DataRank · unranked

10 citations

Zhiqiang Hu, Shamil R. Sunyaev, Steven E. Brenner, Andrew G. Sharo

Investigation of the causal etiology in a patient with T-B+NK+ immunodeficiency

Frontiers in Immunology(2022)10.3389/fimmu.2022.928252

N/A

0.241DataRank · unranked

4 citations

Jian‐Xin Lin, Esteban Martı́nez, Sadhna Rana, Andrew G. Sharo, Majid Kazemian +13 more

Ten Years of PLoS‡ Computational Biology: A Decade of Appreciation and Innovation

PLOS Computational Biology(2015)10.1371/journal.pcbi.1004317

N/A

0.172DataRank · unranked

2 citations

Steven E. Brenner, Michael B. Eisen, Philip E. Bourne

ClinVar and HGMD genomic variant classification accuracy has improved over time, as measured by implied disease burden

medRxiv(2022)10.1101/2022.10.26.22281567

Top 71%

0.120DataRank

Top 71%1 citations

Yangyun Zou, Aashish N. Adhikari, Steven E. Brenner, Andrew G. Sharo

Evaluating predictors of kinase activity of STK11 variants identified in primary human non-small cell lung cancers

Human Genetics(2025)10.1007/s00439-025-02726-0

Top 78%

0.104DataRank

Top 78%1 citations

Kyoungyeul Lee, Junwoo Woo, Dong Wook Kim, Changwon Keum, Giulia Babbi +18 more

Session Introduction: TOWARDS ETHICAL BIOMEDICAL INFORMATICS: LEARNING FROM OLELO NOEAU, HAWAIIAN PROVERBS

PubMed(2022)10.1142/9789811270611_0042

N/A

0.104DataRank · unranked

1 citations

Noelani Puniwai, Martina Kamaka, Gamze Gürsoy, Nicholas P. Tatonetti, Steven E. Brenner +2 more

Opportunities and Challenges for Interpreting Rare Variation in Clinically Important Genes

Preprints.org(2020)10.20944/preprints202011.0599.v1

N/A

0.104DataRank · unranked

1 citations

Andrew G. Sharo, Megan L. Koleske, Julia E. H. Brown, Matthew Norstad, Aashish N. Adhikari +9 more

Newborn Sequencing in Genomic Medicine and Public Health

UNC Libraries(2020)10.17615/p3y4-3s09

N/A

0DataRank · unranked

0 citations

Stacey Pereira, Sean D. Mooney, Anastasia L. Wise, Jennifer M. Puck, Timothy W. Yu +37 more

Transcriptome analysis of alternative splicing-coupled nonsense-mediated mRNA decay in human cells reveals broad regulatory potential

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.01.183327

N/A

0DataRank · unranked

11 citations

Gang Wei, James P. B. Lloyd, Zhiqiang Hu, Angela N. Brooks, Steven E. Brenner +1 more

Assessing predictions on fitness effects of missense variants in HMBS in CAGI6

Human Genetics(2024)10.1007/s00439-024-02680-3

N/A

0DataRank · unranked

2 citations

Lisa N. Kinch, Panagiotis Katsonis, Olivier Lichtarge, Milind Jagota, Yun S. Song +26 more

Calibration of additional computational tools expands ClinGen recommendation options for variant classification with PP3/BP4 criteria

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.09.17.611902

N/A

0DataRank · unranked

13 citations

Sarah L. Stenton, Emily A.W. Nadeau, Alicia B. Byrne, Marc S. Greenblatt, Steven M. Harrison +8 more

Variant Impact Predictor database (VIPdb), version 2: Trends from 25 years of genetic variant impact predictors

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.25.600283

Top 100%

0DataRank

Top 100%0 citations

Arul S. Menon, Zhiqiang Hu, Steven E. Brenner, Yu-Jen Lin

Genomic Analysis of Historical Cases with Positive Newborn Screens for Short-Chain Acyl-CoA Dehydrogenase Deficiency Shows That a Validated Second-Tier Biochemical Test Can Replace Future Sequencing

International Journal of Neonatal Screening(2020)10.3390/ijns6020041

N/A

0DataRank · unranked

19 citations

Robert J. Currier, Hao Tang, Coleman Turgeon, Robert L. Nussbaum, Rajgopal Srinivasan +7 more

Developing Computational Biology

PLoS Computational Biology(2007)10.1371/journal.pcbi.0030157

N/A

0DataRank · unranked

0 citations

Steven E. Brenner, Philip E. Bourne

Disruption of the moonlighting function of CTF18 in a patient with T-lymphopenia

Frontiers in Immunology(2025)10.3389/fimmu.2025.1539848

N/A

0DataRank · unranked

0 citations

Billy Truong, Manoj Kumar Singh, Susan A. Shinton, Rachael Price, Andrew G. Sharo +10 more

Application of Full Genome Analysis to Diagnose Rare Monogenic Disorders

medRxiv(2020)10.1101/2020.10.22.20216531

N/A

0DataRank · unranked

9 citations

Monica Penon‐Portmann, K. Wong, Michal Levy‐Sakin, Michelle Verghese, Anne Slavotinek +15 more

Perturbation robustness analyses reveal important parameters in variant interpretation pipelines

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.06.29.173815

N/A

0DataRank · unranked

2 citations

Aashish N. Adhikari, Uma Sunderam, Mark Kvale, Robert J. Currier, Renata C. Gallagher +5 more

Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome

Cell Reports(2021)10.1016/j.celrep.2021.109321

N/A

0DataRank · unranked

14 citations

Zhiqiang Hu, Martina Rama, Emily N. Devericks, Jacob Weiss, Gary G. Chiang +6 more

DNA from dried blood spots yields high quality sequences for exome analysis

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.19.105304

N/A

0DataRank · unranked

2 citations

Aashish N. Adhikari, Kunal Kundu, Jennifer M. Puck, Robert J. Currier, Pui–Yan Kwok +3 more

StrVCTVRE: A supervised learning method to predict the pathogenicity of human genome structural variants

The American Journal of Human Genetics(2022)10.1016/j.ajhg.2021.12.007

N/A

0DataRank · unranked

73 citations

Zhiqiang Hu, Shamil R. Sunyaev, Steven E. Brenner, Andrew G. Sharo

Dysregulation of hippocampal adult-born immature neurons disrupts a brain-wide network for spatial memory

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.09.02.273649

N/A

0DataRank · unranked

4 citations

Zhiqiang Hu, Sung‐Ho Lee, Ramya Kolagani, Tzu-Hao Harry Chao, Yan‐Jia Luo +11 more

Meta-Align: A Novel HMM-based Algorithm for Pairwise Alignment of Error-Prone Sequencing Reads

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.11.087676

N/A

0DataRank · unranked

4 citations

Shravan Kumar, Degui Zhi, Steven E. Brenner, Kentaro Tomii

Steven E. Brenner

Indexed papers

Top data-sharing exemplar

Papers