Tracy L. Young‐Pearse

MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 1%percentile

7.7Author DataRank

Indexed papers

3in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 3 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

Nature Neuroscience(2018)10.1038/s41593-018-0154-9

Top 4%

5.2DataRank

Top 4%584 citations

Chris Gaiteri, Sarah E. Sullivan, Charles C. White, Shinya Tasaki, Jishu Xu +17 more

Papers

Driven by 48 papers — median percentile 91. Top paper: “A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease”.

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease

Nature Neuroscience(2018)10.1038/s41593-018-0154-9

Top 4%

5.2DataRank

Top 4%584 citations

Chris Gaiteri, Sarah E. Sullivan, Charles C. White, Shinya Tasaki, Jishu Xu +17 more

Cell subtype-specific effects of genetic variation in the Alzheimer’s disease brain

Nature Genetics(2024)10.1038/s41588-024-01685-y

Top 9%

2.3DataRank

Top 9%179 citations

Zongmei Gao, Lu Zeng, Cristin McCabe, Charles C. White, Bernard Ng +22 more

Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease

Molecular Neurodegeneration(2023)10.1186/s13024-023-00674-9

N/A

1.4DataRank · unranked

89 citations

Tracy L. Young‐Pearse, Gizem Terzioğlu

Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing

Nature Communications(2023)10.1038/s41467-023-43293-0

N/A

1.3DataRank · unranked

52 citations

Zhiyun Wei, M. Catarina Silva, Sergio Barberán-Soler, Jiarui Zhang, Rosalia Rabinovsky +7 more

Cell-subtype specific effects of genetic variation in the aging and Alzheimer cortex

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.07.515446

N/A

0.808DataRank · unranked

35 citations

Zongmei Gao, Lu Zeng, Cristin McCabe, Charles C. White, Bernard Ng +22 more

VLDLR and ApoER2 are receptors for multiple alphaviruses

Nature(2021)10.1038/s41586-021-04326-0

N/A

0.740DataRank · unranked

138 citations

Sarah A. Clark, ChieYu Lin, Jianying Liu, Adrian Coscia, Katherine Nabel Smith +14 more

CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density

Neuron(2025)10.1016/j.neuron.2025.03.034

N/A

0.698DataRank · unranked

41 citations

Elyssa F L Grogan, Courtney R. Benoit, Richard V. Pearse, Sarah E. Heuer, Tain Luquez +14 more

INPP5D regulates inflammasome activation in human microglia

Nature Communications(2023)10.1038/s41467-023-42819-w

N/A

0.652DataRank · unranked

76 citations

Richard V. Pearse, Aimee J. Aylward, Nancy Ashour, Mariko Taga, Gizem Terzioğlu +12 more

Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1

Cell Reports(2023)10.1016/j.celrep.2023.112994

N/A

0.593DataRank · unranked

51 citations

Aimee J. Aylward, Richard V. Pearse, Alexandra M Lish, Yi‐Chen Hsieh, Zachary M. Augur +17 more

RNA-binding protein ELAVL4/HuD ameliorates Alzheimer's disease-related molecular changes in human iPSC-derived neurons

Progress in Neurobiology(2022)10.1016/j.pneurobio.2022.102316

N/A

0.581DataRank · unranked

47 citations

Jacqueline Gerritsen, Mei-Chen Liao, Joanna Widomska, Richard V. Pearse, Forest M. White +4 more

Early lysosome defects precede neurodegeneration with amyloid-β and tau aggregation in NHE6-null rat brain

Brain(2021)10.1093/brain/awab467

N/A

0.564DataRank · unranked

42 citations

Morgan R. Miller, Marty A. Fernandez, Elizabeth L. Berg, Adriana M. Prada, Qing Ouyang +5 more

Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease

Glia(2025)10.1002/glia.24677

N/A

0.525DataRank · unranked

19 citations

Richard V. Pearse, Alexandra M Lish, Cheryl Pan, Zachary M. Augur, Gizem Terzioğlu +12 more

Association of AK4 Protein From Stem Cell–Derived Neurons With Cognitive Reserve

Neurology(2022)10.1212/wnl.0000000000201120

N/A

0.495DataRank · unranked

10 citations

Yi‐Chen Hsieh, Richard V. Pearse, Yanling Wang, Vladislav Petyuk, Julie A. Schneider +6 more

Person‐specific differences in ubiquitin‐proteasome mediated proteostasis in human neurons

Alzheimer s & Dementia(2024)10.1002/alz.13680

N/A

0.483DataRank · unranked

24 citations

Zachary M. Augur, Mason R. Arbery, Nancy Ashour, Katharine Barrett, Richard V. Pearse +8 more

Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity

Molecular Neurodegeneration(2022)10.1186/s13024-022-00558-4

N/A

0.483DataRank · unranked

24 citations

Joseph Negri, Amy He, Richard V. Pearse, Lei Liu, Duc M. Duong +5 more

Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures

Cell Reports(2025)10.1016/j.celrep.2025.115777

N/A

0.483DataRank · unranked

24 citations

Nancy Ashour, Richard V. Pearse, Paige C. Galle, Gwendolyn A Orme, Sarah E. Heuer +10 more

Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer’s disease

Communications Biology(2023)10.1038/s42003-023-04791-5

N/A

0.457DataRank · unranked

20 citations

Kuixi Zhu, Marc Henrion, Syed Shujaat Ali Zaidi, Branden Lau, Sara Moein +7 more

Methods for the isolation and analysis of Aβ from postmortem brain

Frontiers in Neuroscience(2023)10.3389/fnins.2023.1108715

N/A

0.360DataRank · unranked

10 citations

Wen Liu, Alexandra DeSousa, Tracy L. Young‐Pearse, Dominic M. Walsh, Wei Hong

INPP5D/SHIP1 regulates inflammasome activation in human microglia

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.25.530025

N/A

0.360DataRank · unranked

10 citations

Seeley B. Fancher, Richard V. Pearse, Hyo Lee, Matti Lam, Nicholas T. Seyfried +5 more

Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons

Acta Neuropathologica Communications(2025)10.1186/s40478-025-02103-y

N/A

0.269DataRank · unranked

5 citations

Garrett M. Fogo, Mason R. Arbery, Andrew M. Stern, Courtney R. Benoit, Yi‐Chen Hsieh +2 more

Cell-type-specific regulation of APOE levels in human neurons by the Alzheimer’s disease risk gene SORL1

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.25.530017

N/A

0.220DataRank · unranked

3 citations

Aimee J. Aylward, Richard V. Pearse, Yi‐Chen Hsieh, Zachary M. Augur, Courtney R. Benoit +13 more

Amyloid beta binding partners in the brain tissue of older adults

Alzheimer s & Dementia(2025)10.1002/alz.70882

N/A

0.185DataRank · unranked

2 citations

Lei Yu, Yanling Wang, Jingyun Yang, Ricardo A. Vialle, Kátia de Paiva Lopes +8 more

A proteogenomic tool uncovers protein markers for human microglial states

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.03.31.646212

Top 70%

0.165DataRank

Top 70%2 citations

Alex R. Bautista, John F. Tuddenham, Victoria Marshe, Rebecca Chiu, Yunduo Liu +36 more

ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer’s disease

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.21.533654

N/A

0.104DataRank · unranked

1 citations

Elliot H. H. Youth, Shania Hansen, Maria E. Kaufman, Harrison Xiao, So Yeon Koo +15 more

Small Molecule Regulators of microRNAs Identified by High-Throughput Screen Coupled with High-Throughput Sequencing

Research Square(2023)10.21203/rs.3.rs-2617979/v1

N/A

0DataRank · unranked

3 citations

Lien D. Nguyen, Zhiyun Wei, M. Catarina Silva, Sergio Barberán-Soler, Rosalia Rabinovsky +6 more

Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer's disease

Alzheimer s & Dementia(2022)10.1002/alz.12646

N/A

0DataRank · unranked

53 citations

Bianca M. Lauro, Amy He, Hyo Lee, Sanjay Bhattarai, Michael S. Wolfe +6 more

A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons

npj Parkinson s Disease(2024)10.1038/s41531-024-00725-y

N/A

0DataRank · unranked

6 citations

Karis A. Clark, Kellianne D. Alexander, Nagendran Ramalingam, Tracy L. Young‐Pearse, Ulf Dettmer +3 more

Development of a high-throughput, quantitative platform using human cerebral organoids to study virus-induced neuroinflammation in Alzheimer’s disease

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.03.21.585957

N/A

0DataRank · unranked

4 citations

Pepper Dawes, Liam F. Murray, Nathaniel Barton, Jonathan Sundstrom, Adrian R. Orszulak +20 more

Assessment of Spontaneous Neuronal ActivityIn VitroUsing Multi-Well Multi-Electrode Arrays: Implications for Assay Development

eNeuro(2020)10.1523/eneuro.0080-19.2019

N/A

0DataRank · unranked

59 citations

Vilas Menon, Tracy L. Young‐Pearse, Joseph Negri

Plasma TDP-43 is a potential biomarker for advanced limbic-predominant age-related TDP-43 encephalopathy neuropathologic change

medRxiv(2025)10.1101/2025.07.09.25331146

N/A

0DataRank · unranked

1 citations

Julie M. Schneider, David A. Bennett, Nicholas T. Seyfried, Tracy L. Young‐Pearse, Hyun‐Sik Yang +1 more

Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies

Brain Communications(2020)10.1093/braincomms/fcaa010

N/A

0DataRank · unranked

49 citations

Suman De, Haiyang Jiang, Matteo Rovere, Ming Jin, Ludovica Zaccagnini +12 more

Plasma TDP-43 is a potential biomarker for advanced limbic-predominant age-related TDP-43 encephalopathy neuropathologic change

Molecular Neurodegeneration(2025)10.1186/s13024-025-00910-4

N/A

0DataRank · unranked

6 citations

Julie M. Schneider, David Bennett, Nicholas T. Seyfried, Tracy L. Young‐Pearse, Hyun‐Sik Yang +1 more

An improved immunoassay detects Aβ oligomers in human biofluids: their CSF levels rise with tau and phosphotau levels

Alzheimer s Research & Therapy(2025)10.1186/s13195-025-01802-x

N/A

0DataRank · unranked

6 citations

Yi Xu, Shan‐Xue Jin, Nagendran Ramalingam, Jean‐Pierre Bellier, Alexandra M Lish +8 more

Protocol for generating a human iPSC-derived tri-culture model to study interactions between neurons, astrocytes, and microglia

STAR Protocols(2025)10.1016/j.xpro.2025.104152

N/A

0DataRank · unranked

5 citations

Paige C. Galle, Gwendolyn A Orme, Nancy Ashour, Sarah E. Heuer, Annabel J. Curle +3 more

Parkinson disease–associated toxic exposures selectively up-regulate vesicular glutamate transporter vGlut2 in a model of human cortical neurons

Molecular Biology of the Cell(2025)10.1091/mbc.e24-08-0376

N/A

0DataRank · unranked

2 citations

Andrew J. White, Wojciech Pasławski, Kellianne D. Alexander, Shaoning Peng, Tracy L. Young‐Pearse +4 more

Brain Endothelial Soluble ST2 Production and Cerebral Edema in a Rat Model of Ischemic Stroke

Annals of Neurology(2025)10.1002/ana.78006

N/A

0DataRank · unranked

1 citations

Jiaqi An, Arum Yoo, Elle Fietsam, Caroline Booraem, Divya Reddy +11 more

POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population

Brain(2025)10.1093/brain/awaf221

N/A

0DataRank · unranked

3 citations

Lilia B Sattler, Aimee J. Aylward, Olivia Pembridge, Bella Kim, Christina Muratore +9 more

Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis

Acta Neuropathologica(2025)10.1007/s00401-025-02947-7

N/A

0DataRank · unranked

1 citations

Garrett M. Fogo, Mason R. Arbery, Yi‐Chen Hsieh, Nalini R. Rao, Kritika Goyal +6 more

BAG3 coordinates astrocytic proteostasis of Alzheimer’s disease-linked proteins via proteasome, autophagy, and retromer complex interactions

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.20.677505

N/A

0DataRank · unranked

3 citations

Garrett M. Fogo, Courtney R. Benoit, Gizem Terzioğlu, Zachary R. Murphy, Mason R. Arbery +6 more

Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer’s disease

Trends in Neurosciences(2023)10.1016/j.tins.2023.03.005

N/A

0DataRank · unranked

94 citations

Hyo Lee, Yi‐Chen Hsieh, Vicky Chou, Dennis J. Selkoe, Tracy L. Young‐Pearse

Predictive Network Analysis Identifies JMJD6 and Other Novel Key Drivers in Alzheimer’s Disease

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.10.19.512949

N/A

0DataRank · unranked

0 citations

Kuixi Zhu, Marc Henrion, Syed Shujaat Ali Zaidi, Branden Lau, Sara Moein +7 more

3D bioengineered neural tissue generated from patient-derived iPSCs develops time-dependent phenotypes and transcriptional features of Alzheimer’s disease

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.07.21.501004

N/A

0DataRank · unranked

2 citations

Ravi S. Pandey, Nicolas Rouleau, Beatrice Menicacci, WonHee Kim, William Cantley +7 more

Mosaic loss of Chromosome Y in aged human microglia

Genome Research(2022)10.1101/gr.276409.121

N/A

0DataRank · unranked

39 citations

Richard V. Pearse, Tracy L. Young‐Pearse, Sara Mostafavi, Michael Vermeulen

Magnetic resonance elastography to study the effect of amyloid plaque accumulation in a mouse model

Journal of Neuroimaging(2022)10.1111/jon.12996

N/A

0DataRank · unranked

7 citations

Katharina Schregel, Navid Nazari, Julie P. Merchant, Walter M. Taylor, Charles R.G. Guttmann +4 more

Loss of endosomal exchanger NHE6 leads to pathological changes in tau in human neurons

Stem Cell Reports(2022)10.1016/j.stemcr.2022.08.001

N/A

0DataRank · unranked

19 citations

Fatmata Bah, Li Ma, Youjin Lee, M Schmidt, Elizabeth Welch +3 more

3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer’s disease

Molecular Psychiatry(2023)10.1038/s41380-023-02147-3

N/A

0DataRank · unranked

20 citations

Ravi S. Pandey, Nicolas Rouleau, Beatrice Menicacci, WonHee Kim, William Cantley +7 more

Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer’s disease immunotherapeutics

Acta Neuropathologica Communications(2023)10.1186/s40478-023-01511-2

N/A

0DataRank · unranked

13 citations

Ming Jin, Wei Hong, Wen Liu, David Reczek, Valentina N. Lagomarsino +8 more

ZCCHC17 Modulates Neuronal RNA Splicing and Supports Cognitive Resilience in Alzheimer's Disease

Journal of Neuroscience(2023)10.1523/jneurosci.2324-22.2023

N/A

0DataRank · unranked

11 citations

Elliot H. H. Youth, Shania Hansen, Yiyang Wu, Heather Buchanan, Maria E. Kaufman +18 more

Tracy L. Young‐Pearse

Indexed papers

Top data-sharing exemplar

Papers