Matthew Hassler

Biochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 18 papers. Top paper: “2′-O-Methyl at 20-mer Guide Strand 3′ Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA”.

2′-O-Methyl at 20-mer Guide Strand 3′ Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA

Molecular Therapy — Nucleic Acids(2020)10.1016/j.omtn.2020.05.010

N/A

0DataRank · unranked

21 citations

Jacquelyn Sousa, Lorenc Vangjeli, Matthew Hassler, Dimas Echeverria, Emily G. Knox +4 more

Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference

Molecular Therapy — Nucleic Acids(2020)10.1016/j.omtn.2020.06.006

N/A

0DataRank · unranked

35 citations

Dimas Echeverria, Matthew Hassler, Socheata Ly, Anastasia Khvorova, Chantal Ferguson

An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis

Molecular Therapy(2021)10.1016/j.ymthe.2021.11.007

N/A

0DataRank · unranked

46 citations

Nicole Wetoska, Mark Kelly, Dimas Echeverria, Kyounghee Min, Lawrence M. Lifshitz +13 more

Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep

JCI Insight(2021)10.1172/jci.insight.152203

N/A

0DataRank · unranked

29 citations

Bruno M.D.C. Godinho, Julia F. Alterman, Andrew H. Coles, Matthew Hassler, Dimas Echeverria +13 more

Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity

Nucleic Acids Research(2021)10.1093/nar/gkab1126

N/A

0DataRank · unranked

20 citations

Samuel Hildebrand, Sarah M. Davis, Rachael Miller, Faith Conroy, Ellen Sapp +10 more

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington’s disease models

Nature Communications(2022)10.1038/s41467-022-33061-x

N/A

0DataRank · unranked

49 citations

Rachael Miller, Julia F. Alterman, Matthew Hassler, Dimas Echeverria, Bruno M.D.C. Godinho +12 more

PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs

Molecular Therapy — Nucleic Acids(2022)10.1016/j.omtn.2022.06.005

N/A

0DataRank · unranked

27 citations

Emily G. Knox, Samuel Hildebrand, James W. Gilbert, Dimas Echeverria, Zachary Kennedy +9 more

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in vivo in CNS

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.29.498088

N/A

0DataRank · unranked

0 citations

Rachael Miller, Julia F. Alterman, Matthew Hassler, Dimas Echeverria, Bruno M.D.C. Godinho +12 more

Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors

Molecular Therapy — Nucleic Acids(2023)10.1016/j.omtn.2023.102088

N/A

0DataRank · unranked

16 citations

Jillian Caiazzi, Annabelle Biscans, Julia F. Alterman, Dimas Echeverria, Nicholas McHugh +7 more

Challenges of Assessing Exon 53 Skipping of the Human DMD Transcript with Locked Nucleic Acid-Modified Antisense Oligonucleotides in a Mouse Model for Duchenne Muscular Dystrophy

Nucleic Acid Therapeutics(2023)10.1089/nat.2023.0038

N/A

0DataRank · unranked

14 citations

Daniel O’Reilly, David van de Vijver, Ingrid E.C. Verhaart, Maaike van Putten, Vignesh Hariharan +5 more

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.26.542506

N/A

0DataRank · unranked

7 citations

Vignesh Hariharan, Jillian Caiazzi, Rachael Miller, Chantal Furguson, Ellen Sapp +18 more

Extended Nucleic Acid (exNA): A Novel, Biologically Compatible Backbone that Significantly Enhances Oligonucleotide Efficacy in vivo

Research Square(2023)10.21203/rs.3.rs-2987323/v1

N/A

0DataRank · unranked

4 citations

Jillian Caiazzi, Rachael Miller, Chantal Ferguson, Ellen Sapp, Hassan Fakih +18 more

Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in rodent and swine photoreceptors

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.20.558641

N/A

0DataRank · unranked

0 citations

Jillian Caiazzi, Annabelle Biscans, Julia F. Alterman, Dimas Echeverria, Nicholas McHugh +7 more

Silencing Apoe with divalent‐siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease

Alzheimer s & Dementia(2024)10.1002/alz.13703

N/A

0DataRank · unranked

33 citations

Samuel Hildebrand, Bruno M.D.C. Godinho, Julianna Buchwald, Dimas Echeverria, Andrew H. Coles +10 more

A combinatorial approach for achieving CNS-selective RNAi

Nucleic Acids Research(2024)10.1093/nar/gkae100

N/A

0DataRank · unranked

11 citations

Bruno M.D.C. Godinho, Dimas Echeverria, Matthew Hassler, Lorenc Vangjeli, Jacquelyn Sousa +8 more

Identification of selective and non-selective C9ORF72 targeting in vivo active siRNAs

Molecular Therapy — Nucleic Acids(2024)10.1016/j.omtn.2024.102291

N/A

0DataRank · unranked

9 citations

Zachary Kennedy, Bruno M.D.C. Godinho, Ashley Summers, Alexandra Weiss, Dimas Echeverria +10 more

RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.20.599943

N/A

0DataRank · unranked

6 citations

James W. Gilbert, Iris Valeria Rivera Flores, Jillian Belgrad, Chantal Ferguson, Elif O. Dogan +18 more

RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice

Molecular Therapy(2025)10.1016/j.ymthe.2025.05.010

N/A

0DataRank · unranked

8 citations

James W. Gilbert, Iris Valeria Rivera Flores, Jillian Belgrad, Chantal Ferguson, Elif O. Dogan +19 more