Jamie B. Spangler

Also affiliated with Johns Hopkins University, Johns Hopkins Medicine, Sidney Kimmel Cancer Center, Sidney Kimmel Comprehensive Cancer Center, University of Baltimore

MedicineImmunology and Microbiology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 47 papers. Top paper: “Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection”.

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

Cell Reports(2022)10.1016/j.celrep.2022.111478

N/A

1.0DataRank · unranked

44 citations

Marcos Iglesias, Jakub Tomala, Arabella Young, Jennifer Smith, Joseph A. Perry +20 more

Molecular Engineering of Interleukin-2 for Enhanced Therapeutic Activity in Autoimmune Diseases

BioDrugs(2023)10.1007/s40259-023-00635-0

N/A

0.764DataRank · unranked

21 citations

Kathy Liu, Derek VanDyke, Charina S. Fabilane, Jamie B. Spangler, Luke M. Tomasovic

Preclinical proof of principle for orally delivered Th17 antagonist miniproteins

Cell(2024)10.1016/j.cell.2024.05.052

N/A

0.673DataRank · unranked

88 citations

Franziska Seeger, Ta-Yi Yu, Merve Aydin, Yang Hui-lin, Daniel Rosenblum +21 more

Strategies for Glycoengineering Therapeutic Proteins

Frontiers in Chemistry(2022)10.3389/fchem.2022.863118

N/A

0.624DataRank · unranked

63 citations

Paige Epler, Stanley Zhu, Zachary J. Bernstein, Paul R. Stabach, Demetrios T. Braddock +3 more

IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function

JCI Insight(2022)10.1172/jci.insight.158362

N/A

0.606DataRank · unranked

56 citations

David R. Thiemann, Felipe Andrade, Maria Isabel Trejo‐Zambrano, Elissa K. Leonard, Jamie B. Spangler +33 more

IgM autoantibodies recognizing ACE2 are associated with severe COVID-19

medRxiv(2020)10.1101/2020.10.13.20211664

N/A

0.571DataRank · unranked

44 citations

David R. Thiemann, Felipe Andrade, Maria Isabel Trejo Zambrano, Jody E. Hooper, Elissa K. Leonard +20 more

Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity

JCI Insight(2024)10.1172/jci.insight.173469

N/A

0.495DataRank · unranked

13 citations

Jakub Tomala, Joseph R. Gould, Michael I. Leff, Jian-Xin Lin, Peng Li +16 more

Nanoparticle-based modulation of CD4+ T cell effector and helper functions enhances adoptive immunotherapy

Nature Communications(2022)10.1038/s41467-022-33597-y

N/A

0.494DataRank · unranked

26 citations

Aliyah B. Silver, Hawley C. Pruitt, Michal Mass, Emma H. Elias, Gohta Aihara +13 more

Discovery of antibodies targeting multipass transmembrane proteins using a suspension cell-based evolutionary approach

Cell Reports Methods(2023)10.1016/j.crmeth.2023.100429

N/A

0.442DataRank · unranked

18 citations

Justyn Fine, Yang Hui-lin, Derek VanDyke, Zhiwei Ang, Kook Bum Kim +3 more

Massively parallel encapsulation of single cells with structured microparticles and secretion-based flow sorting

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.03.09.984245

N/A

0.360DataRank · unranked

10 citations

Robert Dimatteo, Maani M. Archang, Mark van Zee, Doyeon Koo, Sohyung Lee +13 more

Designed Endocytosis-Triggering Proteins mediate Targeted Degradation

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.19.553321

N/A

0.312DataRank · unranked

7 citations

Mohamad H. Abedi, Green Ahn, Brian Coventry, Isaac Sappington, Rong Wang +38 more

Engineering growth factor ligands and receptors for therapeutic innovation

Trends in cancer(2024)10.1016/j.trecan.2024.09.006

N/A

0.276DataRank · unranked

5 citations

Justin Paoloni, Yuseong Oh, Jamie B. Spangler, Xinran An

Emerging approaches for T cell-stimulating platform development

Cell Systems(2024)10.1016/j.cels.2024.11.007

N/A

0.269DataRank · unranked

5 citations

N. Espinoza, A Carson Stephenson, Jamie B. Spangler, Emily Ariail

NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas

Cell Reports(2025)10.1016/j.celrep.2025.116099

N/A

0.269DataRank · unranked

5 citations

Ammar S. Naqvi, Makenna Higgins, Jia‐Geng Liu, Kyra Harvey, Julien Jarroux +25 more

Full speed AHEAD in antibody discovery

Nature Chemical Biology(2021)10.1038/s41589-021-00838-y

N/A

0.208DataRank · unranked

3 citations

Jamie B. Spangler, Paul R. Sargunas

An engineered Treg selective immunocytokine induces sustained immune modulation in a preclinical model of hemophilia A

Journal of Thrombosis and Haemostasis(2025)10.1016/j.jtha.2025.02.032

N/A

0.165DataRank · unranked

2 citations

Derek VanDyke, Maite Muñoz-Melero, Charina S. Fabilane, Senthilkumar Thirumurugan, Sreevani Arisa +4 more

Regulating IL-2 Immune Signaling Function Via A Core Allosteric Structural Network

Journal of Molecular Biology(2024)10.1016/j.jmb.2024.168892

N/A

0.104DataRank · unranked

1 citations

Shahlo Solieva, Daniel Hwang, Viviane S. De Paula, Charina Fabilane, Michael C. Young +7 more

Mechanistic computational modeling of monospecific and bispecific antibodies targeting interleukin-6/8 receptors

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.18.570445

N/A

0.104DataRank · unranked

1 citations

Yang Hui-lin, Jamie B. Spangler, Feilim Mac Gabhann, Christina M.P. Ray

Engineered cytokine/antibody fusion proteins improve delivery of IL-2 to pro-inflammatory cells and promote antitumor activity

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.05.03.539272

N/A

0DataRank · unranked

4 citations

Jakub Tomala, Joseph R. Gould, Michael I. Leff, Jian-Xin Lin, Peng Li +11 more

In Vivo Stimulation of Therapeutic Antigen‐Specific T Cells in an Artificial Lymph Node Matrix

Advanced Materials(2024)10.1002/adma.202310043

N/A

0DataRank · unranked

21 citations

John W. Hickey, Hajin Sim, Sebastian F. Salathe, Joseph Choy, Jiayuan Kong +17 more

Cytokine/Antibody Fusion Protein Design and Evaluation

Current Protocols(2024)10.1002/cpz1.1061

N/A

0DataRank · unranked

6 citations

A Carson Stephenson, Elissa K. Leonard, Derek VanDyke, Jamie B. Spangler, Charina S. Fabilane

Production of site-specific antibody conjugates using metabolic glycoengineering and novel Fc glycovariants

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.108005

N/A

0DataRank · unranked

4 citations

Taylor Gierke, Kris Dammen‐Brower, Stephany Y. Tzeng, Stanley Zhu, Sabrina S. Chen +5 more

Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1

Cell chemical biology(2024)10.1016/j.chembiol.2024.02.014

N/A

0DataRank · unranked

2 citations

Bunyarit Meksiriporn, Jiacheng Tan, Rakeeb Kureshi, Akhilesh Mishra, Kyle J. Kaeo +12 more

Single-chain variable fragment affinity tuning can optimize anti-AML CAR-NK cell functionality

Journal for ImmunoTherapy of Cancer(2025)10.1136/jitc-2024-010763

N/A

0DataRank · unranked

10 citations

Monika Kizerwetter, Yang Huilin, Ilias Christodoulou, Christian Guaraca, Natalie J. Holl +11 more

Temporal optimization of CD25-biased IL-2 agonists and immune checkpoint blockade leads to synergistic anticancer activity despite robust regulatory T cell expansion

Journal for ImmunoTherapy of Cancer(2025)10.1136/jitc-2024-010465

N/A

0DataRank · unranked

4 citations

Petra Weberova, Derek VanDyke, Milada Šírová, Katerina Kubesova, Charina S. Fabilane +8 more

Bispecific receptor decoy proteins block ocular neovascularization via simultaneous blockade of vascular endothelial growth factor A and C

Molecular Therapy(2025)10.1016/j.ymthe.2025.03.027

N/A

0DataRank · unranked

2 citations

Emily Ariail, Raquel Lima e Silva, Akash Patil, Mingliang Zhang, Jikui Shen +9 more

Screening of a pooled library of chimeric antigen receptor T cells based on secretory function

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.07.02.662376

N/A

0DataRank · unranked

1 citations

Anna Mei, Rocío Castellanos-Rueda, N. Espinoza, Monika Kizerwetter, Jamie B. Spangler +3 more

Adapting antibody–invertase fusion protein immunoassays to multiwell plates for infectious disease antibody quantification

Sensors & Diagnostics(2025)10.1039/d5sd00117j

N/A

0DataRank · unranked

0 citations

Xinran An, Jamie B. Spangler, Netzahualcóyotl Arroyo‐Currás, Elysse Ornelas‐Gatdula

Structure-Guided Molecular Engineering of a Vascular Endothelial Growth Factor Antagonist to Treat Retinal Diseases

Cellular and Molecular Bioengineering(2020)10.1007/s12195-020-00641-0

N/A

0DataRank · unranked

4 citations

Angela Y. Zhu, Jikui Shen, Stephany Y. Tzeng, Leilani R. Astrab, Paul R. Sargunas +4 more

A CD25–chemokine receptor complex initiates noncanonical IL-2 signaling

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110981

N/A

0DataRank · unranked

0 citations

Sarah Hyun Ji Kim, Javid Aceil, Amelia Meecham, Alexandre R. Gingras, Klaus Ley +3 more

Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells

Cell(2021)10.1016/j.cell.2021.01.018

N/A

0DataRank · unranked

180 citations

Yamuna Kalyani Mathiharan, Kevin M. Jude, Leon Su, Ouliana Panova, Patrick J. Lupardus +6 more

Insights into the anticancer mechanisms of interleukin-15 from engineered cytokine therapies

Journal of Clinical Investigation(2021)10.1172/jci152857

N/A

0DataRank · unranked

10 citations

Jamie B. Spangler, Zachary J. Bernstein

Poly(beta-amino ester)s as high-yield transfection reagents for recombinant protein production

Dove Medical Press (Taylor and Francis Group)(2021)10.22541/au.161822876.60446320/v1

N/A

0DataRank · unranked

1 citations

Stephen Lee, Yang Hui-lin, Wentao Wang, Seth D. Ludwig, Haley E. Tarbox +4 more

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy

Nature Biotechnology(2022)10.1038/s41587-022-01510-z

N/A

0DataRank · unranked

78 citations

M. Aladdin Bhuiyan, Huilin Yang, Isabel Leung, Elisa Bello, Lestat R. Ali +14 more

Biologics-based degraders — an expanding toolkit for targeted-protein degradation

Current Opinion in Biotechnology(2022)10.1016/j.copbio.2022.102807

N/A

0DataRank · unranked

30 citations

Jonathan D. Taylor, Kyle J. Kaeo, James Hunt, Jamie B. Spangler, Derek VanDyke

Engineered bispecific antibodies targeting the interleukin-6 and -8 receptors potently inhibit cancer cell migration and tumor metastasis

Molecular Therapy(2022)10.1016/j.ymthe.2022.07.008

N/A

0DataRank · unranked

29 citations

Michelle N. Karl, Wentao Wang, Bartholomew Starich, Haotian Tan, Ashley Kiemen +9 more

Poly(Beta-Amino Ester)s as High-Yield Transfection Reagents for Recombinant Protein Production

International Journal of Nanomedicine(2022)10.2147/ijn.s377371

N/A

0DataRank · unranked

12 citations

Yang Hui-lin, Stephen J. Lee, Wentao Wang, Seth D. Ludwig, Haley E. Tarbox +4 more

Supramolecular filaments for concurrent ACE2 docking and enzymatic activity silencing enable coronavirus capture and infection prevention

Matter(2022)10.1016/j.matt.2022.11.027

N/A

0DataRank · unranked

13 citations

Qiong Wang, David Stern, Elissa K. Leonard, Boran Sun, Kyle J. Fergie +8 more

Empowering gene delivery with protein engineering platforms

Gene Therapy(2022)10.1038/s41434-022-00379-6

N/A

0DataRank · unranked

9 citations

Kevin Pietz, Luke M. Tomasovic, Jamie B. Spangler, Monika Kizerwetter

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.05.29.493918

N/A

0DataRank · unranked

1 citations

Marcos Iglesias, Jakub Tomala, Arabella Young, Jennifer Smith, Joseph A. Perry +20 more

Lung tumor-infiltrating T reg have divergent transcriptional profiles and function linked to checkpoint blockade response

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.12.13.520329

N/A

0DataRank · unranked

0 citations

Jiajia Zhang, Boyang Zhang, Laurene S. Cheung, Zhen Zeng, Christopher Cherry +32 more

Lung tumor–infiltrating Treghave divergent transcriptional profiles and function linked to checkpoint blockade response

Science Immunology(2023)10.1126/sciimmunol.adg1487

N/A

0DataRank · unranked

75 citations

Jiajia Zhang, Laurene S. Cheung, Sydney Connor, Boyang Zhang, Zhen Zeng +34 more

Bioengineered particles expand myelin-specific regulatory T cells and reverse autoreactivity in a mouse model of multiple sclerosis

Science Advances(2023)10.1126/sciadv.add8693

N/A

0DataRank · unranked

33 citations

Stephany Y. Tzeng, Marcos Iglesias, Dongwoo Lee, Kaitlyn Storm, Sarah Y. Neshat +6 more

IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function

Cell Reports(2023)10.1016/j.celrep.2023.112996

N/A

0DataRank · unranked

32 citations

Ho Sup Lee, S H Kim, Mikhael Fernandes de Lima, Alexandre R. Gingras, Qinyi Du +10 more

Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds

Nature Chemical Biology(2023)10.1038/s41589-023-01313-6

N/A

0DataRank · unranked

28 citations

Umut Y. Ulge, Alfredo Quijano‐Rubio, Zachary J. Bernstein, David R. Maestas, Jung-Ho Chun +20 more

Redirecting the specificity of tripartite motif containing-21 scaffolds using a novel discovery and design approach

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.105381

N/A

0DataRank · unranked

7 citations

Linda Xu, Paul R. Sargunas, Ryan Gilbreth, Manuel Baca, Changshou Gao +3 more

An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2

Cell Reports Medicine(2023)10.1016/j.xcrm.2023.101289

N/A

0DataRank · unranked

7 citations

Stephany Y. Tzeng, Mallory Lager, Jeremy Wang, Jun Ishihara, Jordan J. Green +2 more