Lothar Hennighausen

Also affiliated with National Institute of Diabetes and Digestive and Kidney Diseases

MedicineBiochemistry, Genetics and Molecular BiologyImmunology and Microbiology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

3in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 3 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 56 papers. Top paper: “The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER‐positive breast cancers”.

The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER‐positive breast cancers

Molecular Carcinogenesis(2015)10.1002/mc.22188

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0.619DataRank · unranked

61 citations

Kyung Hyun Yoo, Ji Shin Lee, Young Kim, Ik‐Joo Chung, Min Ho Park +4 more

Cytokine-Regulated GADD45G Induces Differentiation and Lineage Selection in Hematopoietic Stem Cells

Stem Cell Reports(2014)10.1016/j.stemcr.2014.05.010

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0.550DataRank · unranked

38 citations

Susanne Wingert, Pangrazio De Giacomo, Nadine Haetscher, Maike Rehage, Boris Brill +5 more

Functional assessment of CTCF sites at cytokine-sensing mammary enhancers using CRISPR/Cas9 gene editing in mice

Nucleic Acids Research(2017)10.1093/nar/gkx185

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0.489DataRank · unranked

25 citations

Michaela Willi, Chaochen Wang, Chul Min Yang, Harold E. Smith, Chengyu Liu +2 more

Cell-Specific Activity of the Human Immunodeficiency Virus Enhancer Repeat In Vitro

AIDS Research and Human Retroviruses(1988)10.1089/aid.1988.4.381

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0.434DataRank · unranked

17 citations

Peter Ghazal, Jay A. Nelson, Lothar Hennighausen, Henryk Lubon

Disease-Associated Mutations of the STAT5B SH2 Domain Regulate Cytokine-Driven Enhancer Function and Mammary Development

Journal of Mammary Gland Biology and Neoplasia(2025)10.1007/s10911-025-09582-8

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0.241DataRank · unranked

4 citations

Jakub Jankowski, Chengyu Liu, Lothar Hennighausen, Hye‐Kyung Lee

Cytokine-regulated GADD45G induces differentiation and lineage selection in hematopoietic stem cells

Experimental Hematology(2014)10.1016/j.exphem.2014.07.215

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0.104DataRank · unranked

1 citations

Susanne Wingert, Pangrazio De Giacomo, Nadine Haetscher, Boris Brill, Lothar Hennighausen +4 more

Activation of the SARS-CoV-2 receptor Ace2 by cytokines through pan JAK-STAT enhancers

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.11.089045

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0DataRank · unranked

18 citations

Hye‐Kyung Lee, Lothar Hennighausen

Activation of Interferon-Stimulated Transcriptomes and ACE2 Isoforms in Human Airway Epithelium Is Curbed by Janus Kinase Inhibitors

Research Square(2020)10.21203/rs.3.rs-119695/v1

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9 citations

Olive Jung, Lothar Hennighausen, Hye‐Kyung Lee

Regulation of the ACE2 locus in human airways cells

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.04.325415

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0DataRank · unranked

3 citations

Olive Jung, Lothar Hennighausen, Hye‐Kyung Lee

The transcription factor STAT5 binds to distinct super-enhancer sites and controls Lrrc32 expression in a prominent autoimmune and allergic disease risk locus

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.06.13.150177

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0DataRank · unranked

1 citations

Hye‐Kyung Lee, Lothar Hennighausen

Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community

PubMed(2020)10.21203/rs.3.rs-69657/v1

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0DataRank · unranked

1 citations

Ludwig Knabl, Lisa Pipperger, André Volland, Priscilla A. Furth, Keunsoo Kang +10 more

Regulatory plasticity within a complex cytokine-sensing mammary enhancer during lactation

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.06.04.134429

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0DataRank · unranked

0 citations

Chengyu Liu, Lothar Hennighausen, Hye‐Kyung Lee

JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells

Communications Biology(2021)10.1038/s42003-021-02167-1

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0DataRank · unranked

32 citations

Olive Jung, Lothar Hennighausen, Hye‐Kyung Lee

Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community

Scientific Reports(2021)10.1038/s41598-021-83110-6

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0DataRank · unranked

28 citations

Ludwig Knabl, Lisa Pipperger, André Volland, Priscilla A. Furth, Keunsoo Kang +10 more

Redundant and non-redundant cytokine-activated enhancers control Csn1s2b expression in the lactating mouse mammary gland

Nature Communications(2021)10.1038/s41467-021-22500-w

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0DataRank · unranked

16 citations

Michaela Willi, Tyler Kuhns, Chengyu Liu, Lothar Hennighausen, Hye‐Kyung Lee

Robust immune response to the BNT162b mRNA vaccine in an elderly population vaccinated 15 months after recovery from COVID-19

medRxiv(2021)10.1101/2021.09.08.21263284

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0DataRank · unranked

16 citations

Ludwig Knabl, Sebastian Kapferer, Birgit Pateter, Mary Walter, Priscilla A. Furth +2 more

Impact of BNT162b First Vaccination on the Immune Transcriptome of Elderly Patients Infected with the B.1.351 SARS-CoV-2 Variant

Research Square(2021)10.21203/rs.3.rs-509143/v1

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0DataRank · unranked

8 citations

Hye‐Kyung Lee, Manuel Wieser, Anna Mur, August Zabernigg, Simon Rauch +6 more

Interferon-regulated genetic programs and JAK/STAT pathway activate the intronic promoter of the short ACE2 isoform in renal proximal tubules

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.01.15.426908

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0DataRank · unranked

3 citations

Hye‐Kyung Lee, Julia Wilflingseder, Lothar Hennighausen, Jakub Jankowski

Immune transcriptomes from hospitalized patients infected with the SARS-CoV-2 variants B.1.1.7 and B.1.1.7 carrying the E484K escape mutation

medRxiv(2021)10.1101/2021.05.27.21257952

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0DataRank · unranked

3 citations

Ludwig Knabl, Manuel Wieser, Anna Mur, August Zabernigg, Jana Schumacher +4 more

Impact of BNT162b first vaccination on the immune transcriptome of elderly patients infected with the B.1.351 SARS-CoV-2 variant

medRxiv(2021)10.1101/2021.05.11.21256862

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0DataRank · unranked

2 citations

Hye‐Kyung Lee, Manuel Wieser, Anna Mur, August Zabernigg, Simon Rauch +6 more

A central role for STAT5 in the transcriptional programing of T helper cell metabolism

Science Immunology(2022)10.1126/sciimmunol.abl9467

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0DataRank · unranked

54 citations

Arian Laurence, Fred P. Davis, Luis Nivelo, Stephen R. Brooks, Hong‐Wei Sun +7 more

mRNA vaccination in octogenarians 15 and 20 months after recovery from COVID-19 elicits robust immune and antibody responses that include Omicron

Cell Reports(2022)10.1016/j.celrep.2022.110680

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0DataRank · unranked

43 citations

Ludwig Knabl, Juan I. Moliva, Anne P. Werner, Seyhan Boyoglu-Barnum, Sebastian Kapferer +6 more

Prior Vaccination Exceeds Prior Infection in Eliciting Innate and Humoral Immune Responses in Omicron Infected Outpatients

Frontiers in Immunology(2022)10.3389/fimmu.2022.916686

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0DataRank · unranked

41 citations

Ludwig Knabl, Mary Walter, Yuhai Dai, Magdalena Füßl, Yasemin Caf +10 more

BNT162b2 vaccination enhances interferon-JAK-STAT-regulated antiviral programs in COVID-19 patients infected with the SARS-CoV-2 Beta variant

Communications Medicine(2022)10.1038/s43856-022-00083-x

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0DataRank · unranked

36 citations

Hye‐Kyung Lee, Manuel Wieser, Anna Mur, August Zabernigg, Simon Rauch +6 more

Immune transcriptome analysis of COVID-19 patients infected with SARS-CoV-2 variants carrying the E484K escape mutation identifies a distinct gene module

Scientific Reports(2022)10.1038/s41598-022-06752-0

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0DataRank · unranked

19 citations

Ludwig Knabl, Manuel Wieser, Anna Mur, August Zabernigg, Jana Schumacher +5 more

Limited cross-variant immune response from SARS-CoV-2 Omicron BA.2 in naïve but not previously infected outpatients

iScience(2022)10.1016/j.isci.2022.105369

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0DataRank · unranked

15 citations

Ludwig Knabl, Mary Walter, Priscilla A. Furth, Lothar Hennighausen, Hye‐Kyung Lee

Genetic immune response and antibody repertoire of heterologous ChAdOx1-BNT162b2 vaccination in a Korean cohort

medRxiv(2022)10.1101/2022.02.07.22270617

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0DataRank · unranked

3 citations

Jinyoung Go, Heungsup Sung, Seong Who Kim, Mary Walter, Ludwig Knabl +4 more

Differences in transcriptional response underlie why prior vaccination exceeds prior infection in eliciting robust immune responses in Omicron infected outpatients

medRxiv(2022)10.1101/2022.03.24.22272837

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0DataRank · unranked

2 citations

Ludwig Knabl, Mary Walter, Yuhai Dai, Magdalena Füßl, Yasemin Caf +10 more

Limited cross-variant immune response from SARS-CoV-2 Omicron BA.2 in naïve but not previously infected outpatients

medRxiv(2022)10.1101/2022.04.07.22273565

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0DataRank · unranked

2 citations

Ludwig Knabl, Mary Walter, Priscilla A. Furth, Lothar Hennighausen, Hye‐Kyung Lee

Comprehensive analysis of immune responses in CLL patients after heterologous COVID-19 vaccination

medRxiv(2022)10.1101/2022.09.21.22280205

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0DataRank · unranked

1 citations

Manuela A. Hoechstetter, Maike Buchner, Trang Thu Pham, Jin Won Huh, Katharina Müller +10 more

Cell-specific and shared regulatory elements control a multigene locus active in mammary and salivary glands

Nature Communications(2023)10.1038/s41467-023-40712-0

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0DataRank · unranked

19 citations

Michaela Willi, Chengyu Liu, Lothar Hennighausen, Hye‐Kyung Lee

Analysis of immune responses in patients with CLL after heterologous COVID-19 vaccination

Blood Advances(2023)10.1182/bloodadvances.2022008445

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0DataRank · unranked

13 citations

Manuela A. Hoechstetter, Maike Buchner, Trang Thu Pham, Jin Won Huh, Katharina Müller +10 more

T cell intrinsic STAT1 signaling prevents aberrant Th1 responses during acute toxoplasmosis

Frontiers in Immunology(2023)10.3389/fimmu.2023.1212190

N/A

0DataRank · unranked

5 citations

David Kugler, Luis Nivelo, Nicolas Vitari, Laura P. Doyle, Svetlana Ristin +5 more

Cell-specific and shared enhancers control a high-density multi-gene locus active in mammary and salivary glands

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.06.527373

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0DataRank · unranked

2 citations

Michaela Willi, Chengyu Liu, Lothar Hennighausen, Hye‐Kyung Lee

A cytokine-responsive promoter is required for distal enhancer function mediating the hundreds-fold increase in milk protein gene expression during lactation

Research Square(2023)10.21203/rs.3.rs-2533546/v1

N/A

0DataRank · unranked

0 citations

Hye‐Kyung Lee, Chengyu Liu, Lothar Hennighausen

Cell-specific and shared enhancers control a high-density multi-gene locus active in mammary and salivary glands

Research Square(2023)10.21203/rs.3.rs-2533579/v1

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0DataRank · unranked

0 citations

Hye‐Kyung Lee, Michaela Willi, Chengyu Liu, Lothar Hennighausen

A cytokine-responsive promoter is required for distal enhancer function mediating the hundreds-fold increase in milk protein gene expression during lactation

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.06.527375

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0DataRank · unranked

0 citations

Chengyu Liu, Lothar Hennighausen, Hye‐Kyung Lee

Sexually dimorphic renal expression of mouse Klotho is directed by a kidney-specific distal enhancer responsive to HNF1b

Communications Biology(2024)10.1038/s42003-024-06855-6

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0DataRank · unranked

2 citations

Hye‐Kyung Lee, Chengyu Liu, Julia Wilflingseder, Lothar Hennighausen, Jakub Jankowski

STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.12.20.629685

N/A

0DataRank · unranked

3 citations

Jichun Chen, Rachael L. Philips, Sung‐Gwon Lee, Xingmin Feng, Zhijie Wu +12 more

Sexually dimorphic renal expression of Klotho is directed by a kidney-specific distal enhancer responsive to HNF1b

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.29.582831

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0DataRank · unranked

2 citations

Hye‐Kyung Lee, Chengyu Liu, Julia Wilflingseder, Lothar Hennighausen, Jakub Jankowski

STAT5B SH2 variants disrupt mammary enhancers and the stability of genetic programs during pregnancy

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.05.06.592736

N/A

0DataRank · unranked

2 citations

Chengyu Liu, Lothar Hennighausen, Hye‐Kyung Lee

Sexually dimorphic renal expression of Klotho is directed by a kidney-specific distal enhancer responsive to HNF1b

Research Square(2024)10.21203/rs.3.rs-4188774/v1

N/A

0DataRank · unranked

1 citations

Hye‐Kyung Lee, Chengyu Liu, Julia Wilflingseder, Lothar Hennighausen, Jakub Jankowski

STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs

Life Science Alliance(2025)10.26508/lsa.202503222

N/A

0DataRank · unranked

5 citations

Jichun Chen, Rachael L. Philips, Sung‐Gwon Lee, Xingmin Feng, Zhijie Wu +14 more

Spotlight on amino acid changing mutations in the JAK-STAT pathway: from disease-specific mutation to general mutation databases

Scientific Reports(2025)10.1038/s41598-025-90788-5

N/A

0DataRank · unranked

7 citations

Lothar Hennighausen, Markus Hoffmann

Rare germline JAK/STAT variants in a Korean cohort amplify innate immune responses to vaccination

iScience(2025)10.1016/j.isci.2025.114110

N/A

0DataRank · unranked

2 citations

Gyuhyeok Cho, Jin Won Huh, Priscilla A. Furth, Jungwook Kim, Lothar Hennighausen +1 more

Noncanonical EZH2 activity cooperates with FOXM1 to drive tumorigenesis and advanced progression in HCC

Clinical and Molecular Hepatology(2026)10.3350/cmh.2025.1379

N/A

0DataRank · unranked

0 citations

Hyun Jin Bang, Myong-Suk Park, Kyung Hwa Lee, Lothar Hennighausen, Kyung Hyun Yoo +2 more

Impact of rare JAK/STAT germline mutations on vaccination-induced innate immune responses in a Tyrolian population

International Journal of Biological Sciences(2025)10.7150/ijbs.124098

N/A

0DataRank · unranked

2 citations

Gyuhyeok Cho, Sung‐Gwon Lee, Yasmin Caf, Jungwook Kim, Ludwig Knabl +3 more

Mouse Model of STAT3 Mutation Resulting in Job’s Syndrome Diverges from Human Pathology

International Journal of Molecular Sciences(2025)10.3390/ijms26167675

N/A

0DataRank · unranked

0 citations

Jichun Chen, Gyuhyeok Cho, Sung‐Gwon Lee, Chengyu Liu, Neal S. Young +3 more

Y665F variant of mouse Stat5b protects against acute kidney injury through transcriptomic shifts in renal gene expression

Scientific Reports(2025)10.1038/s41598-025-15812-0

N/A

0DataRank · unranked

0 citations

Hye‐Kyung Lee, Lothar Hennighausen, Jakub Jankowski

Heritability and transcriptional impact of JAK3, STAT5A and STAT6 variants in a Tyrolean family

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.64898/2025.12.14.694240

N/A

0DataRank · unranked

0 citations

T. Haikarainen, Yasmin Caf, Priscilla A. Furth, Ludwig Knabl, Olli Silvennoinen +2 more

Data-driven projections of candidate enhancer-activating SNPs in immune regulation

BMC Genomics(2025)10.1186/s12864-025-11374-7

N/A

0DataRank · unranked

3 citations

Tiago A. Vaz, Shreeti Chhatrala, Lothar Hennighausen, Markus Hoffmann

Extrinsically regulated Gadd45γ balances hematopoietic stem cell self-renewal and differentiation

Experimental Hematology(2013)10.1016/j.exphem.2013.05.162

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0DataRank · unranked

0 citations

Susanne Wingert, Pangrzio De Giacomo, Andreas Kowarsch, Lothar Hennighausen, Oliver Hilsenbeck +3 more

Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury

Nature Communications(2020)10.1038/s41467-020-17205-5

N/A

0DataRank · unranked

103 citations

Michaela Willi, Hye‐Kyung Lee, Hannes Olauson, Jakub Jankowski, Takaharu Ichimura +5 more

Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2

PLoS Genetics(2020)10.1371/journal.pgen.1008796

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0DataRank · unranked

74 citations

Woo Kyun Bae, Lothar Hennighausen, David J Waxman, Dana Lau-Corona

Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos

Communications Biology(2020)10.1038/s42003-019-0745-3

N/A

0DataRank · unranked

53 citations

Harold E. Smith, Chengyu Liu, Michaela Willi, Lothar Hennighausen, Hye‐Kyung Lee

The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy

Experimental & Molecular Medicine(2020)10.1038/s12276-020-0425-x

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0DataRank · unranked

2 citations

Hye‐Kyung Lee, Chaochen Wang, Precious Achikeh, Chengyu Liu, Lothar Hennighausen +1 more