Dennis J. Selkoe

MedicineBiochemistry, Genetics and Molecular BiologyComputer Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 41 papers. Top paper: “Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease”.

Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease

Nature(2025)10.1038/s41586-025-08852-z

N/A

0.998DataRank · unranked

64 citations

Ayshwarya Subramanian, Zhuoran Yin, Ahad Khalilnezhad, Yufan Wu, Danyang He +38 more

Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor

International Journal of Molecular Sciences(2020)10.3390/ijms21155193

N/A

0.911DataRank · unranked

37 citations

Arati Tripathi, Thibaut Imberdis, Zachary M. LaVoie, Gary P. H. Ho, Dennis J. Selkoe +4 more

Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons

npj Parkinson s Disease(2022)10.1038/s41531-022-00380-1

N/A

0.520DataRank · unranked

31 citations

Jonathan M. S. Stricker, Stephanie Soriano-Cruz, Beatrice Weykopf, Ulf Dettmer, Christina Muratore +3 more

The case for regulatory approval of amyloid‐lowering immunotherapies in Alzheimer's disease based on clearcut biomarker evidence

Alzheimer s & Dementia(2024)10.1002/alz.14342

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0.515DataRank · unranked

30 citations

Randall J. Bateman, Damian C. Crowther, Jeff Cummings, John Dwyer, Takeshi Iwatsubo +7 more

Aβ oligomers from human brain impair mossy fiber LTP in CA3 of hippocampus, but activating cAMP-PKA and cGMP-PKG prevents this

Neurobiology of Disease(2022)10.1016/j.nbd.2022.105816

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0.494DataRank · unranked

26 citations

Lei Liu, Shaomin Li, Angela L. Meunier, Dennis J. Selkoe, Shan‐Xue Jin

A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity

Neurotherapeutics(2022)10.1007/s13311-022-01199-7

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0.489DataRank · unranked

25 citations

Chee Yeun Chung, Daniel F. Tardiff, Pascal A. Bechade, Thomas D. McCaffery, Kazuma Shimanaka +14 more

Dynamic reversibility of α‐synuclein serine‐129 phosphorylation is impaired in synucleinopathy models

EMBO Reports(2023)10.15252/embr.202357145

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0.483DataRank · unranked

24 citations

Lisa Brontesi, Shan‐Xue Jin, Dennis J. Selkoe, Ulf Dettmer, Nagendran Ramalingam

RXR nuclear receptor signaling modulates lipid metabolism and triggers lysosomal clearance of alpha-synuclein in neuronal models of synucleinopathy

Cellular and Molecular Life Sciences(2024)10.1007/s00018-024-05373-2

N/A

0.330DataRank · unranked

8 citations

Heba Alnakhala, Lisa Brontesi, Dennis J. Selkoe, Ulf Dettmer, Arati Tripathi

The pathogenicity of PSEN2 variants is tied to Aβ production and homology to PSEN1

Alzheimer s & Dementia(2024)10.1002/alz.14339

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0.312DataRank · unranked

7 citations

Stephanie A. Schultz, Adriana Saba, Hyun‐Sik Yang, Laam Li, Dennis J. Selkoe +2 more

Neuronal Loss of the Glutamate Transporter GLT-1 Promotes Excitotoxic Injury in the Hippocampus

Frontiers in Cellular Neuroscience(2021)10.3389/fncel.2021.788262

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0DataRank · unranked

39 citations

Shaomin Li, Jens V. Andersen, Emil W. Westi, Alexander Rotenberg, Jianlin Wang +6 more

Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicity

Human Molecular Genetics(2021)10.1093/hmg/ddab188

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0DataRank · unranked

17 citations

Andrew J Newman, Thibaut Imberdis, Lisa Brontesi, Arati Tripathi, Nagendran Ramalingam +4 more

Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer's disease

Alzheimer s & Dementia(2022)10.1002/alz.12646

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0DataRank · unranked

53 citations

Bianca M. Lauro, Amy He, Hyo Lee, Sanjay Bhattarai, Michael S. Wolfe +6 more

Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy

npj Parkinson s Disease(2022)10.1038/s41531-022-00335-6

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0DataRank · unranked

24 citations

Haley Cirka, Jennifer L. Thies, Jooyoung Jeong, Sarah M. Niemi, Joon Yoon +12 more

Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer’s disease brains

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.10.18.512754

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0DataRank · unranked

11 citations

Yang Yang, Angela L. Meunier, Wen Liu, Yuqi Cai, Maria Ericsson +5 more

Health phenome of Parkinson’s patients reveals prominent mood-sleep cluster

medRxiv(2022)10.1101/2022.02.01.22270276

N/A

0DataRank · unranked

0 citations

Joseph J. Locascio, Idil Tuncali, Nada Laroussi, Elena Abatzis, Polina Kamenskaya +18 more

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity

npj Parkinson s Disease(2023)10.1038/s41531-023-00444-w

N/A

0DataRank · unranked

150 citations

Shan‐Xue Jin, Tim E. Moors, Luis Fonseca‐Ornelas, Kazuma Shimanaka, Lei Shi +18 more

Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer’s disease

Trends in Neurosciences(2023)10.1016/j.tins.2023.03.005

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0DataRank · unranked

94 citations

Hyo Lee, Yi‐Chen Hsieh, Vicky Chou, Dennis J. Selkoe, Tracy L. Young‐Pearse

Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer’s disease brains

Neuron(2023)10.1016/j.neuron.2023.04.007

N/A

0DataRank · unranked

92 citations

Yang Yang, Shan‐Xue Jin, Keitaro Yamashita, Angela L. Meunier, Wen Liu +7 more

Palmitoylation of the Parkinson’s disease–associated protein synaptotagmin-11 links its turnover to α-synuclein homeostasis

Science Signaling(2023)10.1126/scisignal.add7220

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0DataRank · unranked

40 citations

Erin C. Wilkie, Andrew J. White, Dennis J. Selkoe, Gary P. H. Ho

The Parkinson-Associated Toxin Paraquat Shifts Physiological α-Synuclein Tetramers toward Monomers That Can Be Calpain-Truncated and Form Oligomers

American Journal Of Pathology(2023)10.1016/j.ajpath.2023.01.010

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0DataRank · unranked

14 citations

Dennis J. Selkoe, Silke Nuber

Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer’s disease immunotherapeutics

Acta Neuropathologica Communications(2023)10.1186/s40478-023-01511-2

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0DataRank · unranked

13 citations

Ming Jin, Wei Hong, Wen Liu, David Reczek, Valentina N. Lagomarsino +8 more

Uncovering elevated tau TPP motif phosphorylation in the brain of Alzheimer's disease patients

Alzheimer s & Dementia(2023)10.1002/alz.13557

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0DataRank · unranked

10 citations

Yuqi Cai, Sarah M. Alam, Thorsten Wiederhold, Arica Aiello, Jonathan Vogelgsang +5 more

Plasma NT1‐tau and Aβ42 correlate with age and cognitive function in two large Down syndrome cohorts

Alzheimer s & Dementia(2023)10.1002/alz.13382

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0DataRank · unranked

9 citations

Kathryn L. Van Pelt, Lei Liu, Amirah K. Anderson, Beth L. Ostaszewski, Mark Mapstone +8 more

Plasma NT1-tau and Aβ 42 correlate with age and cognitive function in two large Down syndrome cohorts

medRxiv(2023)10.1101/2023.03.10.23287109

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0DataRank · unranked

2 citations

Kathryn L. Van Pelt, Lei Liu, Amirah K. Anderson, Beth L. Ostaszewski, Mark Mapstone +8 more

Health phenome of Parkinson’s patients reveals prominent mood-sleep cluster

Research Square(2023)10.21203/rs.3.rs-3683455/v1

N/A

0DataRank · unranked

1 citations

Joseph J. Locascio, Idil Tuncali, Nada Laroussi, Elena Abatzis, Polina Kamenskaya +18 more

γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)

The Lancet Neurology(2024)10.1016/s1474-4422(24)00236-9

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0DataRank · unranked

33 citations

Lei Liu, Aaron P. Schultz, Colleen Fitzpatrick, Raina Levin, Jean‐Pierre Bellier +94 more

A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons

npj Parkinson s Disease(2024)10.1038/s41531-024-00725-y

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0DataRank · unranked

6 citations

Karis A. Clark, Kellianne D. Alexander, Nagendran Ramalingam, Tracy L. Young‐Pearse, Ulf Dettmer +3 more

Identification of fibrinogen as a plasma protein binding partner for lecanemab biosimilar IgG

Annals of Clinical and Translational Neurology(2024)10.1002/acn3.52227

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0DataRank · unranked

4 citations

Andrea M. Román Viera, Caitlyn Christiano, Juliana A. U. Anzai, Stéphanie Moreno, Emily C. Campbell +11 more

Inhibition of hippocampal mossy fiber plasticity and episodic memory by human Aβ oligomers is prevented by enhancing cAMP signaling in Alzheimer's mice

Alzheimer s & Dementia(2025)10.1002/alz.70194

N/A

0DataRank · unranked

9 citations

Jean‐Pierre Bellier, Adrienne R. Wells, Paula Montero LIopis, Praju Vikas Anekal, Jason S. Tresback +7 more

An improved immunoassay detects Aβ oligomers in human biofluids: their CSF levels rise with tau and phosphotau levels

Alzheimer s Research & Therapy(2025)10.1186/s13195-025-01802-x

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0DataRank · unranked

6 citations

Yi Xu, Shan‐Xue Jin, Nagendran Ramalingam, Jean‐Pierre Bellier, Alexandra M Lish +8 more

Parkinson disease–associated toxic exposures selectively up-regulate vesicular glutamate transporter vGlut2 in a model of human cortical neurons

Molecular Biology of the Cell(2025)10.1091/mbc.e24-08-0376

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0DataRank · unranked

2 citations

Andrew J. White, Wojciech Pasławski, Kellianne D. Alexander, Shaoning Peng, Tracy L. Young‐Pearse +4 more

Neurons accumulate disease-specific somatic genomic changes across tau pathologic states in Alzheimer’s disease

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.05.26.656152

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0DataRank · unranked

4 citations

Katherine Sun-Mi Brown, Denis S. Smirnov, S. T. Naik, Samantha L. Kirkham, Elizabeth L. Hennessey +11 more

CNS-Tau Specific Antibodies Illuminate Disease Signatures Across Tauopathies

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.14.676119

N/A

0DataRank · unranked

0 citations

Yin Zheng, Luke Slominski, Qimin Quan, Adriana Saba, Jean‐Pierre Bellier +10 more

A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer’s brain

Journal of Neurochemistry(2020)10.1111/jnc.15007

N/A

0DataRank · unranked

270 citations

Dennis J. Selkoe, Shaomin Li

Parkinson’s disease: proteinopathy or lipidopathy?

npj Parkinson s Disease(2020)10.1038/s41531-019-0103-7

N/A

0DataRank · unranked

241 citations

Dennis J. Selkoe, Ulf Dettmer, Saranna Fanning

A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α‐Synuclein Mice

Annals of Neurology(2020)10.1002/ana.25920

N/A

0DataRank · unranked

67 citations

Alice Y. Nam, Molly M. Rajsombath, Haley Cirka, Xiaoping Hronowski, Junmin Wang +11 more

Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals

Nature Communications(2020)10.1038/s41467-020-19543-w

N/A

0DataRank · unranked

65 citations

Aaron P. Schultz, Yifan Dang, Beth L. Ostaszewski, Lei Liu, Hyun‐Sik Yang +4 more

Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies

Brain Communications(2020)10.1093/braincomms/fcaa010

N/A

0DataRank · unranked

49 citations

Suman De, Haiyang Jiang, Matteo Rovere, Ming Jin, Ludovica Zaccagnini +12 more

An ultra‐sensitive immunoassay detects and quantifies soluble Aβ oligomers in human plasma

Alzheimer s & Dementia(2021)10.1002/alz.12457

N/A

0DataRank · unranked

61 citations

Hyunchang Kwak, Trebor Lawton, Shan‐Xue Jin, Angela L. Meunier, Yifan Dang +5 more

Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100393

N/A

0DataRank · unranked

45 citations

Bianca M. Lauro, Michael S. Wolfe, Dennis J. Selkoe, Lei Liu

Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson’s disease

Cell Reports(2021)10.1016/j.celrep.2021.109333

N/A

0DataRank · unranked

47 citations

Thibault Viennet, Matteo Rovere, Haiyang Jiang, Lei Liu, Silke Nuber +4 more