Hengming Ke

Biochemistry, Genetics and Molecular BiologyMedicineChemistryMaterials Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 35 papers. Top paper: “Cyclic nucleotide phosphodiesterases as drug targets”.

Cyclic nucleotide phosphodiesterases as drug targets

Pharmacological Reviews(2025)10.1016/j.pharmr.2025.100042

N/A

0.510DataRank · unranked

29 citations

Viacheslav O. Nikolaev, Leila Gobejishvili, Claire Lugnier, Christian Heßlinger, Peter Nickolaus +24 more

Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors

UNC Libraries(2020)10.17615/1va5-s052

N/A

0.269DataRank · unranked

5 citations

Huanchen Wang, Jie Geng, Hengming Ke, Thomas Seebeck, Stefan Kunz +1 more

Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis

UNC Libraries(2020)10.17615/4qfw-xn22

N/A

0.165DataRank · unranked

2 citations

Huanchen Wang, Xuan Luo, Hengming Ke, Mengchun Ye, Howard Robinson +1 more

An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies

UNC Libraries(2020)10.17615/v110-8g62

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0.104DataRank · unranked

1 citations

Gong Chen, Huanchen Wang, Howard Robinson, Jiwen Cai, Yiqian Wan +1 more

The Molecular Basis for Different Recognition of Substrates by Phosphodiesterase Families 4 and 10

UNC Libraries(2021)10.17615/4pyb-jc31

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0.104DataRank · unranked

1 citations

Hengming Ke, Huanchen Wang, Howard Robinson

Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity † ‡

UNC Libraries(2020)10.17615/4qyq-qs72

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0DataRank · unranked

2 citations

Howard Robinson, Hengming Ke, Jiwen Cai, Huanchen Wang, SERENA YANG +1 more

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

UNC Libraries(2020)10.17615/8w7g-wn12

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0DataRank · unranked

0 citations

Myung K. Kim, Keith Baar, Tishan Williams, Sung Jun Park, Ronald Taussig +10 more

The MDM2 RING Domain and Central Acidic Domain Play Distinct Roles in MDM2 Protein Homodimerization and MDM2-MDMX Protein Heterodimerization

UNC Libraries(2020)10.17615/sr4p-jn12

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0DataRank · unranked

0 citations

Hengming Ke, Patrick L. Leslie, Yanping Zhang

Identification of overlapping but distinct cAMP and cGMP interaction sites with cyclic nucleotide phosphodiesterase 3A by site-directed mutagenesis and molecular modeling based on crystalline PDE4B

UNC Libraries(2020)10.17615/n0ng-9p67

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0DataRank · unranked

0 citations

Bradford A. Jameson, Robert W. Colman, Wei Zhang, Hengming Ke, Anna P. Tretiakova

Structural Asymmetry of Phosphodiesterase-9, Potential Protonation of a Glutamic Acid, and Role of the Invariant Glutamine

UNC Libraries(2020)10.17615/x5qj-2y69

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0DataRank · unranked

0 citations

Jie Xu, Hai‐Bin Luo, Ruizhi Zhao, Ming Liu, Hengming Ke +1 more

p53 Oligomerization Is Essential for Its C-terminal Lysine Acetylation

UNC Libraries(2020)10.17615/yvhm-8e55

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0DataRank · unranked

0 citations

Yoko Itahana, Hengming Ke, Yanping Zhang

Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK

UNC Libraries(2020)10.17615/ynv7-pw65

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0DataRank · unranked

0 citations

Alexandra L. Brown, Hengming Ke, Xuesong Feng, Myung K. Kim, Vittorio Sartorelli +9 more

A Phosphomimetic Mutation Stabilizes SOD1 and Rescues Cell Viability in the Context of an ALS-Associated Mutation

UNC Libraries(2020)10.17615/38be-7s73

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0DataRank · unranked

0 citations

Wenjun Cui, Yazhong Tao, Nikolay V. Dokholyan, James M. Fay, Elizabeth A. Proctor +2 more

Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase †

UNC Libraries(2020)10.17615/83jp-9g80

N/A

0DataRank · unranked

0 citations

Zheng Huang, Dwight Macdonald, Renée Aspiotis, Howard Robinson, Huanchen Wang +3 more

Conformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain

UNC Libraries(2020)10.17615/gzjh-6479

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0DataRank · unranked

5 citations

Hengming Ke, Huanchen Wang, Howard Robinson

Dual Specificity and Novel Structural Folding of Yeast Phosphodiesterase-1 for Hydrolysis of Second Messengers Cyclic Adenosine and Guanosine 3′,5′-Monophosphate

UNC Libraries(2020)10.17615/nmjb-bt54

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0DataRank · unranked

0 citations

Yiqian Wan, Hengming Ke, Yousheng Wang, Howard Robinson, Manna Huang +2 more

Phosphodiesterase inhibitors as a new generation of antiprotozoan drugs: exploiting the benefit of enzymes that are highly conserved between host and parasite

UNC Libraries(2020)10.17615/n6a0-4563

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0DataRank · unranked

0 citations

Geert Jan Sterk, Hengming Ke, Thomas Seebeck

Refolding and kinetic characterization of the phosphodiesterase-8A catalytic domain

UNC Libraries(2020)10.17615/w3ew-1a89

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0DataRank · unranked

0 citations

Jiwen Cai, Huanchen Wang, Zier Yan, Hengming Ke

Computer-Based Redesign of a β Sandwich Protein Suggests that Extensive Negative Design Is Not Required for De Novo β Sheet Design

UNC Libraries(2020)10.17615/c6db-b739

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0DataRank · unranked

0 citations

Xiaozhen Hu, Brian Kuhlman, Hengming Ke, Huanchen Wang

A Potential Substrate Binding Conformation of β-Lactams and Insight into the Broad Spectrum of NDM-1 Activity

UNC Libraries(2020)10.17615/v8h4-x027

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0DataRank · unranked

0 citations

Qinghui Yuan, Hengming Ke, Lin He

Biological and Structural Characterization of Trypanosoma cruzi Phosphodiesterase C and Implications for Design of Parasite Selective Inhibitors

UNC Libraries(2020)10.17615/absz-fh35

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0DataRank · unranked

0 citations

Thomas Seebeck, Stefan Kunz, Sibylla Martinelli, Huanchen Wang, Gong� Chen +3 more

Purification and crystallization of cyclin-dependent kinase inhibitor p21

UNC Libraries(2020)10.17615/qk59-qc51

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0DataRank · unranked

0 citations

Yue Xiong, Dale R. Mayrose, Hengming Ke, Michael A. Nichols

Essential Role of the B23/NPM Core Domain in Regulating ARF Binding and B23 Stability

UNC Libraries(2021)10.17615/b2f7-8z10

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0DataRank · unranked

6 citations

Yanping Zhang, Hengming Ke, Mikael S. Lindström, Takeharu Enomoto, Aiwen Jin

Multiple Conformations of Phosphodiesterase-5: IMPLICATIONS FOR ENZYME FUNCTION AND DRUG DEVELOPMENT

UNC Libraries(2021)10.17615/7e9p-e025

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0DataRank · unranked

6 citations

Hengming Ke, Yudong Liu, Guiting Lin, Qing Huai, Zhong-Cheng Xin +6 more

Cyclophilin A complexed with a fragment of HIV-1 gag protein: insights into HIV-1 infectious activity

UNC Libraries(2021)10.17615/r866-gv64

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0DataRank · unranked

4 citations

Mike Schutkowski, Hengming Ke, Gunter Fischer, Yingdong Zhao, Yong Q. Chen

Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function

UNC Libraries(2021)10.17615/7p2v-4235

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0DataRank · unranked

0 citations

Howard D. Rees, Hengming Ke, Keith Brown, Lih Shen Chin, Keith D. Wilkinson +4 more

Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte

UNC Libraries(2021)10.17615/m8g3-vn28

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0DataRank · unranked

0 citations

Laurinda A. Jaffe, Huanchen Wang, Rachael P. Norris, Matthew A. Movsesian, Marina Freudzon +5 more

Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity

UNC Libraries(2021)10.17615/6xnd-fd71

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0DataRank · unranked

0 citations

Jackie D. Corbin, Sharron H. Francis, Hengming Ke, Qing Huai, Yudong Liu

Structures of the N-Terminal and Middle Domains of E. coli Hsp90 and Conformation Changes upon ADP Binding

UNC Libraries(2021)10.17615/5thf-mm48

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0DataRank · unranked

0 citations

Yudong Liu, Hengming Ke, Qing Huai, Hwa-Young Kim, DAVID O. TOFT +1 more

Advances in targeting cyclic nucleotide phosphodiesterases

UNC Libraries(2021)10.17615/9zdd-pf10

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0DataRank · unranked

0 citations

Donald H. Maurice, Yousheng Wang, Jay H. Chung, Faiyaz Ahmad, Vincent C. Manganiello +1 more

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

UNC Libraries(2020)10.17615/6hnz-p812

N/A

0DataRank · unranked

0 citations

Coral González‐García, Nuria E. Campillo, Javier Hernández, Jimena Cuenca, Hengming Ke +10 more

Structure-Based Discovery of Highly Selective Phosphodiesterase-9A Inhibitors and Implications for Inhibitor Design

Figshare(2020)10.17615/0wt9-3m65

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0DataRank · unranked

3 citations

Hengming Ke, Yiqian Wan, Fei Meng, Jing Hou, Yongxian Shao +8 more

Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure

INDIGO (University of Illinois at Chicago)(2020)10.17615/xprs-ew59

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0DataRank · unranked

4 citations

Hengming Ke, Huanchen Wang, Chimed Jansen, Thomas Seebeck, Iwan J. P. de Esch +6 more

Crystallographic and Nuclear Magnetic Resonance Evaluation of the Impact of Peptide Binding to the Second PDZ Domain of Protein Tyrosine Phosphatase 1E

Figshare(2020)10.17615/yvka-hg40

N/A

0DataRank · unranked

1 citations

Huanchen Wang, Sarah R Hengel, Hengming Ke, Andrew L. Lee, Jun Zhang +3 more

Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors

UNC Libraries(2020)10.17615/w9qr-pa69

N/A

0DataRank · unranked

1 citations

Yi Chen, Hengming Ke, Miles D. Houslay, Howard Robinson, Jie Geng +3 more