Jeffery W. Kelly

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 50 papers. Top paper: “A Comprehensive Enumeration of the Human Proteostasis Network. 1. Components of Translation, Protein Folding, and Organelle-Specific Systems”.

A Comprehensive Enumeration of the Human Proteostasis Network. 1. Components of Translation, Protein Folding, and Organelle-Specific Systems

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.08.30.505920

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0.510DataRank · unranked

29 citations

Suzanne Elsasser, Lisa P. Elia, Richard I. Morimoto, Evan T. Powers, Daniel Finley +18 more

A Comprehensive Enumeration of the Human Proteostasis Network. 2. Components of the Autophagy-Lysosome Pathway

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.22.533675

N/A

0.477DataRank · unranked

23 citations

Suzanne Elsasser, Lisa P. Elia, Richard I. Morimoto, Evan T. Powers, Daniel Finley +23 more

The conformational landscape of human transthyretin revealed by cryo-EM

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.01.23.576879

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0.416DataRank · unranked

15 citations

Karina Nugroho, N. Yan, Gabriel M. Kline, Evan T. Powers, Felix J. Tsai +7 more

Autophagy activators normalize aberrant Tau proteostasis and rescue synapses in human familial Alzheimer’s disease iPSC-derived cortical organoids

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.25.661453

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0.241DataRank · unranked

4 citations

Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal +19 more

Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains

Journal of Medicinal Chemistry(2024)10.1021/acs.jmedchem.4c01773

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0.241DataRank · unranked

4 citations

N. Yan, Julian Sanchez, Wen Ren, Carlton E. Ash, Steven J. Wilkens +10 more

PERK Signaling Promotes Mitochondrial Elongation By Remodeling Membrane Phosphatidic Acid

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.02.23.481593

N/A

0.241DataRank · unranked

4 citations

Christian M. Cole, Justine Lebeau, Vivian Dolina, Kelsey R Baron, Aparajita Madhavan +4 more

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

UNC Libraries(2020)10.17615/7bhd-4s41

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0DataRank · unranked

0 citations

Ana P. C. Rodrigues, John R. Riordan, Gergely L. Lukács, Jeffery W. Kelly, William R. Skach +18 more

Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2025847118

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0DataRank · unranked

135 citations

Kristopher L. Nazor, Yvonne S. Eisele, Titas Grabauskas, Nima Dolatabadi, James Parker +12 more

α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss

Journal of Neuroscience(2021)10.1523/jneurosci.1871-20.2020

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0DataRank · unranked

102 citations

Sara Sanz‐Blasco, Yvonne S. Eisele, Swagata Ghatak, Karthik Bodhinathan, Mohd Waseem Akhtar +6 more

Stereoelectronic effects in stabilizing protein–N-glycan interactions revealed by experiment and machine learning

Nature Chemistry(2021)10.1038/s41557-021-00646-w

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0DataRank · unranked

32 citations

Louis Noodleman, Evan T. Powers, Jeffery W. Kelly, Maziar S. Ardejani

Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00339

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0DataRank · unranked

32 citations

Diogo Santos‐Martins, Reji Nair, Alan Chu, Ian A. Wilson, Kristen A. Johnson +5 more

Light Chain Stabilization: A Therapeutic Approach to Ameliorate AL Amyloidosis

Hemato(2021)10.3390/hemato2040042

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0DataRank · unranked

25 citations

Joel N. Buxbaum, Jeffery W. Kelly, Gareth J. Morgan

Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors

Cell & Bioscience(2022)10.1186/s13578-022-00783-w

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0DataRank · unranked

34 citations

Edmund Cotter, Yajuan Wang, Xu Fu, Angela L. Whittsette, Joseph W. Lynch +5 more

Inverse Drug Discovery identifies weak electrophiles affording protein conjugates

Current Opinion in Chemical Biology(2022)10.1016/j.cbpa.2021.102113

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0DataRank · unranked

21 citations

Karina Nugroho, Jeffery W. Kelly, Gabriel M. Kline

Characterising diflunisal as a transthyretin kinetic stabilizer at relevant concentrations in human plasma using subunit exchange

Amyloid(2022)10.1080/13506129.2022.2148094

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0DataRank · unranked

13 citations

Luke T. Nelson, Gabriel M. Kline, Markus Jäger, John L. Berk, Yoshiki Sekijima +3 more

ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors

Cells(2022)10.3390/cells11101661

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0DataRank · unranked

12 citations

Isabelle C. Romine, Ethan M. Smith-Cohen, Julia M. D. Grandjean, Jeffery W. Kelly, Joseph C. Genereux +2 more

Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site

Bioorganic & Medicinal Chemistry Letters(2022)10.1016/j.bmcl.2022.128571

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0DataRank · unranked

9 citations

Reji Nair, Alan Chu, Ian A. Wilson, Kristen Johnson, Gareth J. Morgan +2 more

ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion Through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.04.13.488200

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0DataRank · unranked

4 citations

Isabelle C. Romine, Ethan M. Smith-Cohen, Julia M. D. Grandjean, Jeffery W. Kelly, Joseph C. Genereux +2 more

PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid

The EMBO Journal(2023)10.15252/embj.2023113908

N/A

0DataRank · unranked

63 citations

Christian M. Cole, Justine Lebeau, Vivian Dolina, Kelsey R Baron, Aparajita Madhavan +4 more

Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis

Cell chemical biology(2023)10.1016/j.chembiol.2022.12.004

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0DataRank · unranked

19 citations

Chao Wang, Pei Zhao, Gabe M. Kline, Julia M. D. Grandjean, Xin Jiang +5 more

Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis

Current Opinion in Chemical Biology(2023)10.1016/j.cbpa.2023.102319

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0DataRank · unranked

17 citations

Gareth J. Morgan, H. Michael Petrassi, Ian A. Wilson, Jeffery W. Kelly, N. Yan

Divergent Proteome Reactivity Influences Arm-Selective Activation of the Unfolded Protein Response by Pharmacological Endoplasmic Reticulum Proteostasis Regulators

ACS Chemical Biology(2023)10.1021/acschembio.3c00042

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0DataRank · unranked

14 citations

Ryan J Paxman, Chung‐Yon Lin, Nicole Madrazo, Leonard Yoon, Julia M. D. Grandjean +6 more

Tafamidis concentration required for transthyretin stabilisation in cerebrospinal fluid

Amyloid(2023)10.1080/13506129.2023.2167595

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0DataRank · unranked

9 citations

Marcus Jaeger, Teresa Coelho, Evan T. Powers, Jeffery W. Kelly, Felix J. Tsai

Crystal Structures of Diaryl Hydrazone and Sulfone Stabilizers in Complex with an Amyloidogenic Light Chain Reveal an Alternate Ligand‐Binding Cavity

Israel Journal of Chemistry(2023)10.1002/ijch.202300002

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0DataRank · unranked

4 citations

Ian A. Wilson, Jeffery W. Kelly, N. Yan

Biochemistry and Protein Interactions of the CYREN Microprotein

Biochemistry(2023)10.1021/acs.biochem.3c00397

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0DataRank · unranked

4 citations

M.E. Bowman, Gordon V. Louie, Cheng Zhang, Maziar S. Ardejani, Xuemei Huang +10 more

Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer’s Disease

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.11.29.568318

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0DataRank · unranked

12 citations

Eric B. Dammer, Yong Ran, Wangchen Tsering, Duc M. Duong, Measho Abreha +29 more

Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.01.16.524237

N/A

0DataRank · unranked

1 citations

Ryan J Paxman, Chung‐Yon Lin, Nicole Madrazo, Julia M. D. Grandjean, KyungA Lee +5 more

Activation of XBP1s attenuates disease severity in models of proteotoxic Charcot–Marie–Tooth type 1B

Brain(2024)10.1093/brain/awae407

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0DataRank · unranked

11 citations

Francesca A Veneri, Anke Claessens, Cinzia Ferri, R Mastrangelo, Noémie Sorgiati +11 more

Metabolically activated proteostasis regulators that protect against erastin-induced ferroptosis

RSC Chemical Biology(2024)10.1039/d4cb00027g

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0DataRank · unranked

9 citations

Nicole Madrazo, Christian M. Cole, Meera Pannikkat, Michael J. Bollong, Jessica D. Rosarda +3 more

Advancing Transthyretin Amyloidosis Drug Development in an Evolving Treatment Landscape: Amyloidosis Forum Meeting Proceedings

Advances in Therapy(2024)10.1007/s12325-024-02891-0

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0DataRank · unranked

7 citations

Prem Soman, Adrian F. Hernandez, Pablo García‐Pavía, James Signorovitch, L. J. Wei +54 more

Differential Association of Transthyretin Stability with Variant and Wild-Type Transthyretin Amyloid Cardiomyopathy

JACC Heart Failure(2024)10.1016/j.jchf.2024.06.014

N/A

0DataRank · unranked

5 citations

Sergio Teruya, William S. Blaner, Pierre‐Jacques Brun, Tatiana Prokaeva, Felix J. Tsai +4 more

Conservation of kinetic stability, but not the unfolding mechanism, between human transthyretin and a transthyretin-related enzyme

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2315007121

N/A

0DataRank · unranked

5 citations

Jeffery W. Kelly, Martin Gruebele, Marcus Jäger

Detection of ATTR aggregates in the plasma of polyneuropathic patients with ATTR-V30M amyloidosis

Amyloid(2024)10.1080/13506129.2024.2404073

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0DataRank · unranked

5 citations

Lanie Wang, Justin L. Grodin, Ahmad Masri, Jeffery W. Kelly, Lorena Saelices +1 more

Activation of XBP1s attenuates disease severity in models of proteotoxic Charcot-Marie-Tooth type 1B

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.01.31.577760

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0DataRank · unranked

3 citations

Francesca A Veneri, Anke Claessens, Cinzia Ferri, R Mastrangelo, Noémie Sorgiati +11 more

Transthyretin Kinetic Stabilizers for ATTR Amyloidosis: A Narrative Review of Mechanisms and Therapeutic Benefits

Cardiology and Therapy(2025)10.1007/s40119-025-00423-7

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0DataRank · unranked

11 citations

Leslie Amass, Lori Baylor, Isabel Fernández‐Arias, Steve Riley, Jeffery W. Kelly +1 more

The conformational landscape of human transthyretin revealed by cryo-EM

Nature Structural & Molecular Biology(2025)10.1038/s41594-024-01472-7

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0DataRank · unranked

14 citations

Karina Nugroho, N. Yan, Gabriel M. Kline, Evan T. Powers, Felix J. Tsai +7 more

Autophagy activator AA-20 improves proteostasis and extends Caenorhabditis elegans lifespan

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2423455122

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0DataRank · unranked

5 citations

Nora Lyang, Saam Doroodian, Pablo Sanz-Martinez, Jin Xu, Sviatlana Zaretski +18 more

Transthyretin Kinetic Stabilizers for ATTR Amyloidosis

Cardiology and Therapy(2025)10.1007/s40119-025-00422-8

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0DataRank · unranked

3 citations

Jeffery W. Kelly

AA147 Alleviates Symptoms in a Mouse Model of Multiple Sclerosis by Reducing Oligodendrocyte Loss

Glia(2025)10.1002/glia.70001

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0DataRank · unranked

3 citations

Kevin Kaschke, Joseph R. Podojil, Ming‐Yi Chiang, Ian Steckler, Kody Bruce +8 more

Plasma Proteome Profiling Reveals Inflammation Markers and Tafamidis Effects in V30M Transthyretin Polyneuropathy

International Journal of Molecular Sciences(2025)10.3390/ijms26125534

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0DataRank · unranked

1 citations

Chung‐Yon Lin, Cecília Monteiro, Teresa Coelho, James J. Moresco, Antônio F. M. Pinto +5 more

Lysine carbamoylation during urea denaturation remodels the energy landscape of human transthyretin dissociation linked to unfolding

Protein Science(2025)10.1002/pro.70009

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0DataRank · unranked

0 citations

D.E. Mortenson, Maziar S. Ardejani, Gabriel M. Kline, Maria T. A. Dendle, N. Yan +4 more

Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.04.646800

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0DataRank · unranked

0 citations

Lisa Boinon, Adrian M. Guerrero, Sergei Kutseikin, Gabrielle Cruz, Marnie P Williams +6 more

Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity

eLife(2025)10.7554/elife.107000

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0DataRank · unranked

0 citations

Lisa Boinon, Adrian M. Guerrero, Sergei Kutseikin, Gabrielle Cruz, Marnie P Williams +6 more

Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming

Nature Chemical Biology(2020)10.1038/s41589-020-0584-z

N/A

0DataRank · unranked

185 citations

Aparajita Madhavan, Lauren Čech, Bryan O. Seguinot, Ryan J Paxman, Emery Smith +8 more

Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity

eLife(2025)10.7554/elife.107000.2

N/A

0DataRank · unranked

0 citations

Lisa Boinon, Adrian M. Guerrero, Sergei Kutseikin, Gabrielle Cruz, Marnie P Williams +6 more

Structural Characterization of Cardiac Ex Vivo Transthyretin Amyloid: Insight into the Transthyretin Misfolding Pathway In Vivo

Biochemistry(2020)10.1021/acs.biochem.0c00091

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0DataRank · unranked

13 citations

Ivan Hung, Brian Michael, Zhehong Gan, Jeffery W. Kelly, Lawreen H. Connors +3 more

Disruption of the CD Loop by Enzymatic Cleavage Promotes the Formation of Toxic Transthyretin Oligomers through a Common Transthyretin Misfolding Pathway

Biochemistry(2020)10.1021/acs.biochem.0c00079

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0DataRank · unranked

26 citations

Jenette Arreola, Brian Michael, Robert G. Griffin, Jeffery W. Kelly, Kwang Hun Lim +1 more

Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins

Bioorganic & Medicinal Chemistry Letters(2020)10.1016/j.bmcl.2020.127356

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0DataRank · unranked

23 citations

Diogo Santos‐Martins, Enrico Rennella, Brittany B. Sanchez, Jason S. Chen, Lewis E. Kay +5 more

ER Proteostasis Regulators Reduce Amyloidogenic Light Chain Secretion Through an On-Target, ATF6-Independent Mechanism

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.15.098145

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0DataRank · unranked

1 citations

Jaleh S. Mesgarzadeh, Isabelle C. Romine, Ryan J Paxman, Jeffery W. Kelly, R. Luke Wiseman +1 more

The Endoplasmic Reticulum Proteostasis Regulator ATF6 is Essential for Human Cone Photoreceptor Development

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.04.325019

N/A

0DataRank · unranked

1 citations

Julia M. D. Grandjean, Wei‐Chieh Chiang, Daphne S. Bindels, Rebecca Mastey, Jennifer Okáľová +9 more