Benjamin L. Handen

Also affiliated with Pittsburg State University

MedicineNeurosciencePsychology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 3%percentile

0.958Author DataRank

Indexed papers

3in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 3 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS) study

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring(2020)10.1002/dad2.12039

Top 30%

0.674DataRank

Top 30%23 citations

Fan Zhang, Nicole Schupf, Sharon J. Krinsky‐McHale, James Hall, Mark Mapstone +18 more

Papers

Driven by 54 papers — median percentile 57. Top paper: “Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS) study”.

Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS) study

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring(2020)10.1002/dad2.12039

Top 30%

0.674DataRank

Top 30%23 citations

Fan Zhang, Nicole Schupf, Sharon J. Krinsky‐McHale, James Hall, Mark Mapstone +18 more

Characterizing the emergence of amyloid and tau burden in Down syndrome

Alzheimer s & Dementia(2023)10.1002/alz.13444

N/A

0.628DataRank · unranked

65 citations

Tobey J. Betthauser, Andrew K McVea, Charles M. Laymon, Dana Tudorascu, Sterling C. Johnson +12 more

Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer’s Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome

Journal of Alzheimer s Disease(2020)10.3233/jad-201167

N/A

0.598DataRank · unranked

53 citations

Michael S. Rafii, Fan Zhang, James Hall, David Julovich, Beau M. Ances +20 more

PET measurement of longitudinal amyloid load identifies the earliest stages of amyloid-beta accumulation during Alzheimer's disease progression in Down syndrome

NeuroImage(2021)10.1016/j.neuroimage.2021.117728

N/A

0.581DataRank · unranked

47 citations

Dana Tudorascu, Charles M. Laymon, Sigan L. Hartley, Shahid Zaman, Beau M. Ances +8 more

Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study

The Lancet Neurology(2024)10.1016/s1474-4422(24)00084-x

N/A

0.542DataRank · unranked

36 citations

Nicole S. McKay, Anna H. Boerwinkle, James L. Kennedy, Shaney Flores, Benjamin L. Handen +86 more

Markers of early changes in cognition across cohorts of adults with Down syndrome at risk of Alzheimer's disease

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring(2021)10.1002/dad2.12184

N/A

0.515DataRank · unranked

30 citations

R. Asaad Baksh, Bessy Benejam, Jessica Beresford‐Webb, Antonia Coppus, Juan Fortea +14 more

Cerebrovascular disease is associated with Alzheimer’s plasma biomarker concentrations in adults with Down syndrome

Brain Communications(2024)10.1093/braincomms/fcae331

N/A

0.510DataRank · unranked

29 citations

Patrick J. Lao, Mohamad J. Alshikho, Olivia M. Ericsson, Batool Rizvi, Melissa Petersen +70 more

Timeline to symptomatic Alzheimer's disease in people with Down syndrome as assessed by amyloid-PET and tau-PET: a longitudinal cohort study

The Lancet Neurology(2024)10.1016/s1474-4422(24)00426-5

N/A

0.505DataRank · unranked

28 citations

Matthew Zammit, Jiebiao Wang, Benjamin L. Handen, Tobey J. Betthauser, Charles M. Laymon +71 more

Postmortem Neocortical 3H-PiB Binding and Levels of Unmodified and Pyroglutamate Aβ in Down Syndrome and Sporadic Alzheimer’s Disease

Frontiers in Aging Neuroscience(2021)10.3389/fnagi.2021.728739

N/A

0.292DataRank · unranked

6 citations

Tamara Racic, Eric E. Abrahamson, Victor L. Villemagne, Benjamin L. Handen, Ira T. Lott +3 more

Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer's continuum in adults with Down syndrome

Alzheimer s & Dementia(2025)10.1002/alz.70679

Top 57%

0.283DataRank

Top 57%5 citations

Natalie Edwards, Lisi Flores Aguilar, Mohamad J. Alshikho, Anna Smith, Rachel LeMay +13 more

The tau biomarker cascade is condensed in Down syndrome compared with sporadic Alzheimer’s disease

Brain(2025)10.1093/brain/awaf428

N/A

0.165DataRank · unranked

2 citations

Hailey Bruzzone, Karly Alex Cody, Jacob Morse, Rachael E. Wilson, Brecca Bettcher +65 more

Innovating Therapies for Down Syndrome: An International Virtual Conference of the T21 Research Society

Molecular Syndromology(2022)10.1159/000526021

N/A

0.104DataRank · unranked

1 citations

Lisi Flores Aguilar, Benjamin L. Handen, Marie‐Claude Potier, Ann‐Charlotte Granholm, Stephanie L. Sherman +8 more

A modified Cued Recall Test for detecting prodromal AD in adults with Down syndrome

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring(2022)10.1002/dad2.12361

N/A

0DataRank · unranked

27 citations

Sigan L. Hartley, Christy Hom, Margaret B. Pulsifer, I. C. H. Clare, Benjamin L. Handen +4 more

Impact of the COVID-19 pandemic on daily life, mood, and behavior of adults with Down syndrome

Disability and health journal(2022)10.1016/j.dhjo.2022.101278

N/A

0DataRank · unranked

20 citations

Victoria Fleming, Brianna Piro‐Gambetti, Annie Cohen, Beau M. Ances, Michael A. Yassa +13 more

Weight Loss and Alzheimer’s Disease in Down Syndrome

Journal of Alzheimer s Disease(2022)10.3233/jad-220865

N/A

0DataRank · unranked

12 citations

Brian C. Helsel, Lauren T. Ptomey, H. Diana Rosas, Benjamin L. Handen, Charles M. Laymon +10 more

Physical activity, memory function, and hippocampal volume in adults with Down syndrome

Frontiers in Integrative Neuroscience(2022)10.3389/fnint.2022.919711

N/A

0DataRank · unranked

9 citations

Benjamin L. Handen, Charles M. Laymon, Victoria Fleming, Brianna Piro‐Gambetti, Bradley Christian +5 more

Cognitive outcome measures for tracking Alzheimer's disease in Down syndrome

International review of research in developmental disabilities(2022)10.1016/bs.irrdd.2022.05.006

N/A

0DataRank · unranked

5 citations

Christy Hom, I. C. H. Clare, Shemaya L. Hurd-Thomas, Sharon J. Krinsky‐McHale, Benjamin L. Handen +2 more

AT(N) biomarker profiles and Alzheimer's disease symptomology in Down syndrome

Alzheimer s & Dementia(2023)10.1002/alz.13446

N/A

0DataRank · unranked

21 citations

Benjamin L. Handen, Dana Tudorascu, Laisze Lee, Annie Cohen, Emily K. Schworer +11 more

Plasma NT1‐tau and Aβ42 correlate with age and cognitive function in two large Down syndrome cohorts

Alzheimer s & Dementia(2023)10.1002/alz.13382

N/A

0DataRank · unranked

9 citations

Kathryn L. Van Pelt, Lei Liu, Amirah K. Anderson, Beth L. Ostaszewski, Mark Mapstone +8 more

Cerebrovascular disease drives Alzheimer plasma biomarker concentrations in adults with Down syndrome

medRxiv(2023)10.1101/2023.11.28.23298693

N/A

0DataRank · unranked

10 citations

Patrick J. Lao, Mohamad J. Alshikho, Olivia M. Ericsson, Batool Rizvi, Melissa Petersen +20 more

Plasma NT1-tau and Aβ 42 correlate with age and cognitive function in two large Down syndrome cohorts

medRxiv(2023)10.1101/2023.03.10.23287109

N/A

0DataRank · unranked

2 citations

Kathryn L. Van Pelt, Lei Liu, Amirah K. Anderson, Beth L. Ostaszewski, Mark Mapstone +8 more

Cerebrovascular disease emerges with age and Alzheimer’s disease in adults with Down syndrome

Scientific Reports(2024)10.1038/s41598-024-61962-y

N/A

0DataRank · unranked

28 citations

Natalie Edwards, Lisi Flores Aguilar, Mohamad J. Alshikho, Batool Rizvi, Dana Tudorascu +11 more

Whole genome‐wide sequence analysis of long‐lived families (Long‐Life Family Study) identifies MTUS2 gene associated with late‐onset Alzheimer's disease

Alzheimer s & Dementia(2024)10.1002/alz.13718

N/A

0DataRank · unranked

17 citations

Stephanie Cosentino, Badri N. Vardarajan, Richard Mayeux, Thomas T. Perls, Stacy L. Andersen +14 more

Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring(2024)10.1002/dad2.12582

N/A

0DataRank · unranked

16 citations

Benjamin L. Handen, Melissa Petersen, Sid E. O’Bryant, Jamie C. Peven, Dana Tudorascu +17 more

The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndrome

EBioMedicine(2024)10.1016/j.ebiom.2024.105433

N/A

0DataRank · unranked

6 citations

Lam‐Ha T. Dang, Alice Lee, Sharon J. Krinsky‐McHale, Deborah Pang, Lisa Melilli +72 more

The Alzheimer's Biomarker Consortium–Down Syndrome (ABC‐DS): A 10‐year report

Alzheimer s & Dementia(2025)10.1002/alz.70294

N/A

0DataRank · unranked

21 citations

Mark Mapstone, Sigan L. Hartley, Howard Andrews, Brad T. Christian, Joseph H. Lee +20 more

The striatum is an early, accurate indicator of amyloid burden using [ 11 C]PiB in Down syndrome: Comparison of two radiotracers

Alzheimer s & Dementia(2025)10.1002/alz.70141

N/A

0DataRank · unranked

12 citations

Brecca Bettcher, Andrew K McVea, Alexandra H DiFilippo, Matthew Zammit, Lisette LeMerise +21 more

Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer’s disease and related neurodegenerative pathologies using 7T postmortem MRI

Journal of Neuropathology & Experimental Neurology(2025)10.1093/jnen/nlaf010

N/A

0DataRank · unranked

6 citations

Jinghang Li, Jacob Berardinelli, Hecheng Jin, Tales Santini, Jaehoon Noh +69 more

PET‐measured amyloid beta accumulates at an accelerated rate in Down syndrome compared to neurotypical populations

Alzheimer s & Dementia(2025)10.1002/alz.70357

N/A

0DataRank · unranked

4 citations

Alexandra H DiFilippo, Max McLachlan, Brecca Betcher, Matthew Zammit, Tobey J. Betthauser +20 more

Lifestyle Composite and Resilience to Alzheimer's Disease Pathology in Down Syndrome

Journal of Applied Research in Intellectual Disabilities(2025)10.1111/jar.70109

N/A

0DataRank · unranked

4 citations

Matthew Zammit, Benjamin L. Handen, Brianna Piro‐Gambetti, Melissa Jenkins, Courtney E Brothers +6 more

Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome

Alzheimer s & Dementia(2025)10.1002/alz.70726

N/A

0DataRank · unranked

4 citations

Patrick J. Lao, Mohamad J. Alshikho, Olivia M. Ericsson, Batool Rizvi, Melissa Petersen +20 more

Examination of metabolic syndrome in Down syndrome and association with dementia

Alzheimer s & Dementia(2025)10.1002/alz.70799

N/A

0DataRank · unranked

3 citations

Lam‐Ha T. Dang, Laura Xicota, Sharon J. Krinsky‐McHale, Balaji Kannappan, Adam M. Brickman +8 more

Development and evaluation of image preprocessing pipelines for the Centiloid method on Down Syndrome data

Alzheimer s & Dementia(2025)10.1002/alz.70712

N/A

0DataRank · unranked

2 citations

Davneet Minhas, Ethan D Rubenstein, David N Situ, Sarah K. Royse, Beau M. Ances +8 more

Eye Tracking as a Tool for Detecting Alzheimer's Disease in People With Down Syndrome

Journal of Intellectual Disability Research(2025)10.1111/jir.13214

N/A

0DataRank · unranked

6 citations

Sharon J. Krinsky‐McHale, Cynthia Kovacs, Benjamin L. Handen, Bradley T. Christian, Charles M. Laymon +8 more

Longitudinal diffusion tensor imaging correlates with amyloid burden in Down syndrome

Alzheimer s & Dementia(2025)10.1002/alz.70572

N/A

0DataRank · unranked

2 citations

José Guerrero-González, Andrew K McVea, Matthew Zammit, Steven Kecskemeti, Sigan L. Hartley +7 more

A comparison of multiple amyloid PET radiotracers for Down syndrome clinical trials

Brain Communications(2025)10.1093/braincomms/fcaf406

N/A

0DataRank · unranked

2 citations

Julie C. Price, Bradley T. Christian, Michael S. Rafii, Beau M. Ances, Howard Andrews +51 more

Imaging and plasma biomarkers for pathological accumulation in Down syndrome

Brain(2025)10.1093/brain/awaf418

N/A

0DataRank · unranked

2 citations

Ziqiao Jiao, James T. Kennedy, Ann D. Cohen, Zinayida Schlachetzki, Melissa Petersen +21 more

Genetically determined Alzheimer's disease research advances: The Down Syndrome & Autosomal Dominant Alzheimer's Disease 2024 Conference

Alzheimer s & Dementia(2025)10.1002/alz.70309

N/A

0DataRank · unranked

4 citations

Lucía Maure-Blesa, Beau M. Ances, Lisi Flores Aguilar, Sigan L. Hartley, Jason Hassenstab +54 more

Preliminary investigation of obstructive sleep apnea and Alzheimer’s disease in down syndrome

SLEEP Advances(2025)10.1093/sleepadvances/zpaf044

N/A

0DataRank · unranked

1 citations

David T. Plante, Victoria Fleming, Benjamin L. Handen, Patrick J. Lao, Jamie C. Peven +8 more

Genome‐wide association analyses identify candidate loci for amyloid imaging and plasma biomarkers in adults with Down syndrome

Alzheimer s & Dementia(2025)10.1002/alz.70358

N/A

0DataRank · unranked

0 citations

Lam‐Ha T. Dang, Ruyu Shi, Kang-Hsien Fan, Asma Naseer Cheema, Laura Xicota +16 more

Stressful life experiences and mental health symptoms in adults with down syndrome

Research in Developmental Disabilities(2025)10.1016/j.ridd.2025.105152

N/A

0DataRank · unranked

0 citations

Jessica L. Greenlee, Melissa Jenkins, Emily K. Schworer, Courtney E Brothers, Christy Hom +3 more

The Alzheimer's Biomarker Consortium‐Down Syndrome: Rationale and methodology

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring(2020)10.1002/dad2.12065

N/A

0DataRank · unranked

122 citations

Ira T. Lott, Bradley T. Christian, Nicole Schupf, Sid E. O’Bryant, Mark Mapstone +17 more

IC‐P‐004: AMYLOID BURDEN AND CORTICAL ATROPHY IN NON‐DEMENTED DOWN SYNDROME

Alzheimer's & Dementia(2018)10.1016/j.jalz.2018.06.2068

N/A

0DataRank · unranked

0 citations

Tobey J. Betthauser, Patrick J. Lao, Annie Cohen, Dana L. Tudorascu, Charles M. Laymon +5 more

Amyloid accumulation in Down syndrome measured with amyloid load

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring(2020)10.1002/dad2.12020

N/A

0DataRank · unranked

44 citations

Charles M. Laymon, Tobey J. Betthauser, Karly Alex Cody, Dana Tudorascu, Davneet Minhas +9 more

Association of sleep with cognition and beta amyloid accumulation in adults with Down syndrome

Neurobiology of Aging(2020)10.1016/j.neurobiolaging.2020.04.018

N/A

0DataRank · unranked

36 citations

Brianna Piro‐Gambetti, Matthew Zammit, Bradley T. Christian, Benjamin L. Handen, William E. Klunk +5 more

Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring(2020)10.1002/dad2.12028

N/A

0DataRank · unranked

23 citations

Thomas Groß, Fabìo Macciardi, Amrita K. Cheema, Melissa Petersen, Elizabeth Head +7 more

Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study

The Lancet Neurology(2021)10.1016/s1474-4422(21)00139-3

N/A

0DataRank · unranked

71 citations

Rachel L. Henson, Yan Li, Anna H. Boerwinkle, Chengjie Xiong, Randall J. Bateman +29 more

Physical activity and cognitive and imaging biomarkers of Alzheimer's disease in down syndrome

Neurobiology of Aging(2021)10.1016/j.neurobiolaging.2021.07.016

N/A

0DataRank · unranked

40 citations

Brianna Piro‐Gambetti, Austin L. Patrick, Matthew Zammit, Andrew L. Alexander, Bradley T. Christian +9 more

Neurofibrillary tau depositions emerge with subthreshold cerebral beta-amyloidosis in down syndrome

NeuroImage Clinical(2021)10.1016/j.nicl.2021.102740

N/A

0DataRank · unranked

28 citations

Dana Tudorascu, Charles M. Laymon, Sigan L. Hartley, Paul A. Ellison, Shahid Zaman +10 more

White matter microstructure associations with episodic memory in adults with Down syndrome: a tract-based spatial statistics study

Journal of Neurodevelopmental Disorders(2021)10.1186/s11689-021-09366-1

N/A

0DataRank · unranked

26 citations

Matthew Zammit, Minjie Wu, Douglas Dean, Sterling C. Johnson, Dana Tudorascu +11 more

White matter microstructure associations to amyloid burden in adults with Down syndrome

NeuroImage Clinical(2021)10.1016/j.nicl.2021.102908

N/A

0DataRank · unranked

6 citations

Matthew Zammit, Minjie Wu, Patrick J. Lao, Douglas Dean, Sterling C. Johnson +12 more

Markers of early changes in cognition across cohorts of adults with Down syndrome at risk of Alzheimer's disease.

Apollo (University of Cambridge)(2021)10.17863/cam.71177

N/A

0DataRank · unranked

0 citations

R. Asaad Baksh, Bessy Benejam, Jessica Beresford‐Webb, Antonia Coppus, Juan Fortea +14 more

Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study

The Lancet Neurology(2022)10.1016/s1474-4422(22)00408-2

N/A

0DataRank · unranked

56 citations

Brian A. Gordon, Julie K. Wisch, Shaney Flores, Rachel L. Henson, Omar H. Butt +95 more

Conducting clinical trials in persons with Down syndrome: summary from the NIH INCLUDE Down syndrome clinical trials readiness working group

Journal of Neurodevelopmental Disorders(2022)10.1186/s11689-022-09435-z

N/A

0DataRank · unranked

40 citations

Mara L. Becker, George T. Capone, Kathleen M. Egan, Juan Fortea, Benjamin L. Handen +7 more

Benjamin L. Handen

Indexed papers

Top data-sharing exemplar

Papers