Nancy L. Heard‐Costa

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 1%percentile

12.2Author DataRank

Indexed papers

11in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 11 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

Nature(2021)10.1038/s41586-021-03205-y

Top 3%

7.0DataRank

Top 3%2322 citations

Daniel Harris, Michael D. Kessler, Jedidiah Carlson, Zachary A. Szpiech, Raúl Torres +95 more

Papers

Driven by 58 papers — median percentile 62. Top paper: “Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data”.

Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

Nature Genetics(2022)10.1038/s41588-021-00997-7

N/A

7.2DataRank · unranked

363 citations

Deepti Jain, Zhili Zheng, TOPMed Anthropometry Working Group, Stella Aslibekyan, Diane M. Becker +95 more

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

Nature(2021)10.1038/s41586-021-03205-y

Top 3%

7.0DataRank

Top 3%2322 citations

Daniel Harris, Michael D. Kessler, Jedidiah Carlson, Zachary A. Szpiech, Raúl Torres +95 more

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Nature Genetics(2022)10.1038/s41588-022-01165-1

N/A

4.4DataRank · unranked

242 citations

Andrew Emmerich, Nicolas J. Pillon, Timothy M. Moore, Daiane Hemerich, Marilyn C. Cornelis +95 more

De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.1902766117

N/A

3.0DataRank · unranked

112 citations

Douglas P. Loesch, James A. Perry, Nancy L. Heard‐Costa, Daniel Taliun, Brian E. Cade +93 more

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

Nature Communications(2021)10.1038/s41467-021-23556-4

N/A

2.7DataRank · unranked

110 citations

Moriel Singer‐Berk, Rachel G. Son, Abigail Sveden, Jordan C. Wood, Eleina England +95 more

Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss

The American Journal of Human Genetics(2022)10.1016/j.ajhg.2022.04.010

N/A

1.6DataRank · unranked

76 citations

Maxim B. Freidin, Linda Broer, Berthe C. Oosterloo, Shuyang Yao, Yitian Zhou +65 more

Whole genome sequence analysis of blood lipid levels in >66,000 individuals

Nature Communications(2022)10.1038/s41467-022-33510-7

N/A

1.6DataRank · unranked

75 citations

Xihao Li, Zilin Li, Akhil Pampana, David Zhang, Joseph Park +95 more

Genetic modification of inflammation- and clonal hematopoiesis–associated cardiovascular risk

Journal of Clinical Investigation(2023)10.1172/jci168597

N/A

1.5DataRank · unranked

77 citations

Trevor P. Fidler, Yunfeng Ruan, Caitlyn Vlasschaert, Tetsushi Nakao, Md Mesbah Uddin +23 more

Whole-Genome Sequencing Association Analyses of Stroke and Its Subtypes in Ancestrally Diverse Populations From Trans-Omics for Precision Medicine Project

Stroke(2021)10.1161/strokeaha.120.031792

Top 16%

1.3DataRank

Top 16%38 citations

Jeffrey W. Haessler, Regina Manansala, Kerri L. Wiggins, Arden Moscati, Alexa Beiser +34 more

Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes

The American Journal of Human Genetics(2021)10.1016/j.ajhg.2021.11.021

N/A

1.3DataRank · unranked

70 citations

Peter Dornbos, Mark Chaffin, Dajiang J. Liu, Minxian Wang, Margaret Sunitha Selvaraj +95 more

Defining the role of common variation in the genomic and biological architecture of adult human height

Nature Genetics(2014)10.1038/ng.3097

N/A

1.1DataRank · unranked

2093 citations

Emilio Rodríguez-Ruiz, The PAGE Consortium, Diana O. Perkins, Tonu Esko, Jian Yang +479 more

Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality

Nature Communications(2023)10.1038/s41467-023-41785-7

N/A

1.1DataRank · unranked

44 citations

Stephanie L. Battle, Wen Shi, Daniela Puiu, Vamsee Pillalamarri, Jiaqi Xie +21 more

Whole genome sequence analysis of platelet traits in the NHLBI Trans-Omics for Precision Medicine (TOPMed) initiative

Human Molecular Genetics(2021)10.1093/hmg/ddab252

Top 28%

0.724DataRank

Top 28%20 citations

Yao Hu, Quan Sun, Deepti Jain, Jai Broome, Ming‐Huei Chen +62 more

Methylome-Wide Association Study of Central Adiposity Implicates Genes Involved in Immune and Endocrine Systems

Epigenomics(2020)10.2217/epi-2019-0276

Top 29%

0.694DataRank

Top 29%16 citations

Geetha Chittoor, Rahul Gondalia, Phillip E. Melton, Elise Lim, Megan L. Grove +23 more

Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study

Scientific Reports(2023)10.1038/s41598-023-39936-3

Top 31%

0.641DataRank

Top 31%32 citations

Helena Bui, Roby Joehanes, Jiantao Ma, Chunyu Liu, Tianxiao Huan +31 more

A System for Phenotype Harmonization in the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Program

American Journal of Epidemiology(2021)10.1093/aje/kwab115

N/A

0.631DataRank · unranked

66 citations

Leslie S. Emery, Jai Broome, Erin Buth, Alyna Khan, Cecelia Laurie +67 more

Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood

The American Journal of Human Genetics(2025)10.1016/j.ajhg.2024.12.014

N/A

0.605DataRank · unranked

14 citations

Xiaolong Ma, Adrienne M. Stilp, Fulong Yu, Jason Bacon, Justin Wong +64 more

Rare coding variants in 35 genes associate with circulating lipid levels – a multi-ancestry analysis of 170,000 exomes

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.22.423783

N/A

0.534DataRank · unranked

11 citations

Peter Dornbos, Mark Chaffin, Dajiang J. Liu, Minxian X. Wang, Margaret Sunitha Selvaraj +95 more

Rare variant contribution to the heritability of coronary artery disease

Nature Communications(2024)10.1038/s41467-024-52939-6

N/A

0.513DataRank · unranked

16 citations

Shoa L. Clarke, Gaëlle Auguste, Natalie R. Hasbani, Alanna C. Morrison, Adam S. Heath +95 more

Whole genome DNA and RNA sequencing of whole blood elucidates the genetic architecture of gene expression underlying a wide range of diseases

Scientific Reports(2022)10.1038/s41598-022-24611-w

Top 38%

0.509DataRank

Top 38%21 citations

Roby Joehanes, Jiantao Ma, Yuxuan Wang, Xianbang Sun, Amena Keshawarz +15 more

Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program

The American Journal of Human Genetics(2021)10.1016/j.ajhg.2021.08.007

N/A

0.494DataRank · unranked

26 citations

Caitlin McHugh, Linda M. Polfus, Laura M. Raffield, Meher Preethi Boorgula, Thomas W. Blackwell +88 more

Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus

Clinical Epigenetics(2023)10.1186/s13148-023-01589-4

N/A

0.449DataRank · unranked

19 citations

Tianxiao Huan, Yiyi Ma, Roby Joehanes, Alexa Beiser, Charles DeCarli +15 more

Investigating Gene–Diet Interactions Impacting the Association Between Macronutrient Intake and Glycemic Traits

Diabetes(2023)10.2337/db22-0851

N/A

0.425DataRank · unranked

16 citations

Maura E. Walker, Sheila M. Gaynor, Jennifer Wessel, Daniel DiCorpo, Jiantao Ma +66 more

Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study

The American Journal of Human Genetics(2023)10.1016/j.ajhg.2023.09.003

N/A

0.416DataRank · unranked

15 citations

Margaret Sunitha Selvaraj, Xihao Li, Zilin Li, Jacob A. Holdcraft, Donna K. Arnett +69 more

Genetic modification of inflammation and clonal hematopoiesis-associated cardiovascular risk

medRxiv(2022)10.1101/2022.12.08.22283237

N/A

0.416DataRank · unranked

8 citations

Trevor P. Fidler, Yunfeng Ruan, Caitlyn Vlasschaert, Tetsushi Nakao, Md Mesbah Uddin +23 more

A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

Nature Computational Science(2025)10.1038/s43588-024-00764-8

N/A

0.393DataRank · unranked

10 citations

Han Chen, Margaret Sunitha Selvaraj, Eric Van Buren, Hufeng Zhou, Yuxuan Wang +95 more

Whole Genome DNA and RNA Sequencing of Whole Blood Elucidates the Genetic Architecture of Gene Expression Underlying a Wide Range of Diseases

medRxiv(2022)10.1101/2022.04.13.22273841

Top 48%

0.379DataRank

Top 48%9 citations

Roby Joehanes, Jiantao Ma, Yuxuan Wang, Xianbang Sun, Amena Keshawarz +15 more

Whole genome sequencing association analysis of quantitative red blood cell phenotypes: the NHLBI TOPMed program

medRxiv(2020)10.1101/2020.12.09.20246736

N/A

0.360DataRank · unranked

10 citations

Adrienne M. Stilp, Caitlin McHugh, Shuquan Rao, Deepti Jain, Xiuwen Zheng +74 more

Epigenome-wide DNA methylation association study of CHIP provides insight into perturbed gene regulation

Nature Communications(2025)10.1038/s41467-025-59333-w

N/A

0.345DataRank · unranked

9 citations

Tianxiao Huan, Joseph C. Van Amburg, Roby Joehanes, Md Mesbah Uddin, Ngoc Quynh Nguyen +22 more

Whole genome sequence analysis of blood lipid levels in >66,000 individuals

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.10.11.463514

N/A

0.277DataRank · unranked

3 citations

Xihao Li, Zilin Li, Akhil Pampana, David Y Zhang, Joseph Park +80 more

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.06.18.146423

N/A

0.269DataRank · unranked

5 citations

Leslie S. Emery, Jai Broome, Erin Buth, Alyna Khan, Cecelia Laurie +67 more

Key variants via Alzheimer’s Disease Sequencing Project whole genome sequence data

medRxiv(2023)10.1101/2023.08.28.23294631

Top 59%

0.257DataRank

Top 59%4 citations

Chloé Sarnowski, Honghuang Lin, Achilleas Pitsillides, Nancy L. Heard‐Costa, Seung Hoan Choi +14 more

Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: The Framingham Heart Study

medRxiv(2022)10.1101/2022.04.13.22273839

Top 60%

0.253DataRank

Top 60%4 citations

Helena Bui, Roby Joehanes, Jiantao Ma, Chunyu Liu, Tianxiao Huan +32 more

Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood

medRxiv(2024)10.1101/2024.04.16.24305851

N/A

0.241DataRank · unranked

4 citations

Xiaolong Ma, Adrienne M. Stilp, Fulong Yu, Jason Bacon, Justin Wong +61 more

Integrating Genetic and Transcriptomic Data to Identify Genes Underlying Obesity Risk Loci

medRxiv(2024)10.1101/2024.06.11.24308730

Top 61%

0.236DataRank

Top 61%3 citations

Shreyash Gupta, Ian Dinsmore, Abbey Kollu, Anne Marie Cawley, Mohammad Yaser Anwar +23 more

Epigenome-wide DNA Methylation Association Study of CHIP Provides Insight into Perturbed Gene Regulation

Research Square(2024)10.21203/rs.3.rs-4656898/v1

N/A

0.208DataRank · unranked

3 citations

Tianxiao Huan, Joseph C. Van Amburg, Roby Joehanes, Md Mesbah Uddin, Ngoc Quynh Nguyen +21 more

Integrating whole genome and transcriptome sequencing to characterize the genetic architecture of isoform variation

Nature Communications(2025)10.1038/s41467-025-64336-8

Top 70%

0.165DataRank

Top 70%2 citations

Roby Joehanes, Jiantao Ma, Jiuyong Xie, Jian Yang, Mengyao Wang +20 more

Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk

medRxiv(2023)10.1101/2023.08.14.23294063

N/A

0.165DataRank · unranked

2 citations

Rainer Malik, Omar El Bounkari, Natalie R. Hasbani, Jiang Li, Jennifer E. Huffman +60 more

Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed Whole Genome Sequencing Study

medRxiv(2023)10.1101/2023.06.28.23291966

N/A

0.146DataRank · unranked

1 citations

Margaret Sunitha Selvaraj, Xihao Li, Zilin Li, Jacob A. Holdcraft, Donna K. Arnett +69 more

Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci

International Journal of Obesity(2025)10.1038/s41366-025-01898-z

N/A

0.104DataRank · unranked

1 citations

Shreyash Gupta, Ian Dinsmore, Abbey Kollu, Anne Marie Cawley, Mohammad Yaser Anwar +23 more

DNA Methylation Signatures of Cardiovascular Health Provide Insights into Diseases

medRxiv(2024)10.1101/2024.11.19.24317587

N/A

0.104DataRank · unranked

1 citations

Yi Li, Yishu Qu, Yinan Zheng, Alexis C. Wood, Mengyao Wang +43 more

Genome-wide gene by sleepiness interaction analysis for sleep apnea

SLEEP(2025)10.1093/sleep/zsaf212

N/A

0.104DataRank · unranked

1 citations

Nuzulul Kurniansyah, Jiwon Lee, Sina A. Gharib, Yushan Xu, Yiyan Zhang +80 more

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

medRxiv(2020)10.1101/2020.09.22.20195529

N/A

0DataRank · unranked

11 citations

Moriel Singer‐Berk, Rachel G. Son, Abigail Sveden, Jordan C. Wood, Eleina England +95 more

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

UNC Libraries(2020)10.17615/166s-st97

N/A

0DataRank · unranked

0 citations

Weihua Zhang, Joban Sehmi, John C. Chambers, Larry D. Atwood, Liming Liang +27 more

Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course

UNC Libraries(2020)10.17615/t89h-5q09

N/A

0DataRank · unranked

0 citations

Alexander Teumer, Carlo Sidore, Julius S. Ngwa, Mary L. Marazita, Richard J. Crout +27 more

NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium

UNC Libraries(2020)10.17615/svd7-zw53

N/A

0DataRank · unranked

0 citations

Lenore J. Launer, Barbara McKnight, Alan R. Shuldiner, Tamara B. Harris, Ulf Gyllensten +27 more

A system for phenotype harmonization in the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) program

UNC Libraries(2024)10.17615/0ea7-3v47

N/A

0DataRank · unranked

0 citations

Nicola L. Hawley, May E. Montasser, P.A. Peyser, Daniel E. Weeks, Braxton D. Mitchell +67 more

Gene-Excessive Sleepiness Interactions Suggest Treatment Targets for Obstructive Sleep Apnea Subtype

medRxiv(2024)10.1101/2024.10.25.24316158

N/A

0DataRank · unranked

0 citations

Nuzulul Kurniansyah, Jiwon Lee, Sina A. Gharib, Yushan Xu, Yiyan Zhang +31 more

cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

Nature Methods(2025)10.1038/s41592-025-02919-5

N/A

0DataRank · unranked

0 citations

Yi Zhang, Xihao Li, Margaret Sunitha Selvaraj, Zilin Li, Hufeng Zhou +544 more

Elucidating the genetic architecture of DNA methylation to identify promising molecular mechanisms of disease

medRxiv(2022)10.1101/2022.04.13.22273848

N/A

0DataRank · unranked

1 citations

Roby Joehanes, Chunyu Liu, Amena Keshawarz, Shih-Jen Hwang, Helena Bui +13 more

Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation

UNC Libraries(2020)10.17615/frhz-yk87

N/A

0DataRank · unranked

0 citations

Juan M. Peralta, Olivia Weeks, Gudnason, Vilmunder, Kurt Lohman, Andrew D. Johnson +63 more

Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals

Genome biology(2025)10.1186/s13059-025-03698-0

N/A

0DataRank · unranked

2 citations

Xihao Li, Zilin Li, Eric Van Buren, Sara Haidermota, Darina Postupaka +95 more

Elucidating the genetic architecture of DNA methylation to identify promising molecular mechanisms of disease

Scientific Reports(2022)10.1038/s41598-022-24100-0

N/A

0DataRank · unranked

30 citations

Roby Joehanes, Chunyu Liu, Amena Keshawarz, Shih‐Jen Hwang, Helena Bui +13 more

Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study

UNC Libraries(2025)10.17615/408w-ez13

N/A

0DataRank · unranked

0 citations

Jessica Lundin, Dawn L. DeMeo, Daniel Levy, Ramachandran S. Vasan, Shih‐Jen Hwang +31 more

Frequency of Variants in Mendelian Alzheimer’s Disease Genes within the Alzheimer’s Disease Sequencing Project (ADSP)

medRxiv(2023)10.1101/2023.10.24.23297227

N/A

0DataRank · unranked

6 citations

Alexandra Scalici, Yanbing Wang, Honghuang Lin, Achilleas Pitsillides, Nancy L. Heard‐Costa +16 more

Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood

UNC Libraries(2025)10.17615/5tss-f273

N/A

0DataRank · unranked

0 citations

Eric Boerwinkle, Yash Pershad, K.E. North, Fulong Yu, Center, Regeneron Genetics +66 more

Association of Severe Hypercholesterolemia and Familial Hypercholesterolemia Genotype With Risk of Coronary Heart Disease

Circulation(2023)10.1161/circulationaha.123.064168

N/A

0DataRank · unranked

12 citations

Jacqueline S. Dron, Brandon K. Bellows, Amit V. Khera, Junxiu Liu, Pallavi Balte +27 more

FTO genotype is associated with phenotypic variability of body mass index

UNC Libraries(2020)10.17615/yvv7-bx40

N/A

0DataRank · unranked

0 citations

Ayşe Demirkan, David Hadley, Cameron D. Palmer, Sarah E. Medland, Ruth J. F. Loos +27 more

Nancy L. Heard‐Costa

Indexed papers

Top data-sharing exemplar

Papers