🏆 Finalist — NIH Data Sharing Index (“S-Index”) Challenge

Tina Pesaran

Ambry Genetics (United States)

ORCID: 0000-0001-9807-4304
Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 2%percentile
3.2Author DataRank

Indexed papers

3in pilot corpus
datarank_citation_only_1hop_v6· scope data_onlyMethodology
Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 3 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Top data-sharing exemplar

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

The Contribution of Germline Predisposition Gene Mutations to Clinical Subtypes of Invasive Breast Cancer From a Clinical Genetic Testing Cohort

JNCI Journal of the National Cancer Institute(2020)10.1093/jnci/djaa023
Top 7%
3.2DataRank
Top 7%108 citations

Eric C. Polley, Siddhartha Yadav, Jenna Lilyquist, Hermela Shimelis, Jie Na +8 more

Papers

Driven by 37 papers — median percentile 0. Top paper: “The Contribution of Germline Predisposition Gene Mutations to Clinical Subtypes of Invasive Breast Cancer From a Clinical Genetic Testing Cohort”.

The Contribution of Germline Predisposition Gene Mutations to Clinical Subtypes of Invasive Breast Cancer From a Clinical Genetic Testing Cohort

JNCI Journal of the National Cancer Institute(2020)10.1093/jnci/djaa023
Top 7%
3.2DataRank
Top 7%108 citations

Eric C. Polley, Siddhartha Yadav, Jenna Lilyquist, Hermela Shimelis, Jie Na +8 more

Gene-specific ACMG/AMP classification criteria for germline APC variants: Recommendations from the ClinGen InSiGHT Hereditary Colorectal Cancer/Polyposis Variant Curation Expert Panel

Genetics in Medicine(2023)10.1016/j.gim.2023.100992
N/A
1.0DataRank · unranked
33 citations

Xiaoyu Yin, Marcy E. Richardson, Marta Pineda, Andreas Laner, Deborah Ritter +27 more

Optimising clinical care through CDH1-specific germline variant curation: improvement of clinical assertions and updated curation guidelines

Journal of Medical Genetics(2022)10.1136/jmg-2022-108807
N/A
0.745DataRank · unranked
24 citations

Jamie L. Maciaszek, Bryony A. Thompson, Huei San Leong, Katherine Dixon, Sónia Sousa +19 more

Functional evaluation and clinical classification of BRCA2 variants

Nature(2025)10.1038/s41586-024-08388-8
N/A
0.606DataRank · unranked
56 citations

Chunling Hu, Jie Na, Steven N. Hart, Rohan Gnanaolivu, Mohamed Abozaid +39 more

Suggested application of HER2+ breast tumor phenotype for germline TP53 variant classification within ACMG/AMP guidelines

Human Mutation(2020)10.1002/humu.24060
N/A
0.477DataRank · unranked
23 citations

Jessica L. Mester, Tina Pesaran, Jeffrey N. Weitzel, Jill S. Dolinsky, Amal Yussuf +13 more

Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline ATM sequence variants

The American Journal of Human Genetics(2024)10.1016/j.ajhg.2024.08.022
N/A
0.434DataRank · unranked
17 citations

Megan Holdren, Terra Brannan, Miguel de la Hoya, Amanda B. Spurdle, Sean V. Tavtigian +16 more

Assessment of the evidence yield for the calibrated PP3/BP4 computational recommendations

Genetics in Medicine(2024)10.1016/j.gim.2024.101213
N/A
0.434DataRank · unranked
17 citations

Vikas Pejaver, Timothy Bergquist, Leslie G. Biesecker, Alicia B. Byrne, Emily A.W. Nadeau +21 more

Saturation genome editing-based functional evaluation and clinical classification of BRCA2 single nucleotide variants

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.14.571597
N/A
0.269DataRank · unranked
5 citations

Chunling Hu, Jie Na, Steven N. Hart, Rohan Gnanaolivu, Mohamed Abozaid +18 more

Assigning credit where it’s due: An information content score to capture the clinical value of Multiplexed Assays of Variant Effect

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.20.562794
N/A
0.104DataRank · unranked
1 citations

Carolyn Horton, Tina Pesaran, Shawn Fayer, Lea M. Starita, Brian H. Shirts +1 more

Calibration of computational tools for missense variant pathogenicity classification and ClinGen recommendations for PP3/BP4 criteria

The American Journal of Human Genetics(2022)10.1016/j.ajhg.2022.10.013
N/A
0DataRank · unranked
548 citations

Alicia B. Byrne, Bing Feng, Kymberleigh A. Pagel, Sean D. Mooney, Rachel Karchin +20 more

An integrative model for the comprehensive classification of BRCA1 and BRCA2 variants of uncertain clinical significance

npj Genomic Medicine(2022)10.1038/s41525-022-00302-3
N/A
0DataRank · unranked
5 citations

Gary Lipton, Steven N. Hart, Kun Y. Lee, Chunling Hu, Eric C. Polley +9 more

Using the ACMG/AMP framework to capture evidence related to predicted and observed impact on splicing: Recommendations from the ClinGen SVI Splicing Subgroup

The American Journal of Human Genetics(2023)10.1016/j.ajhg.2023.06.002
N/A
0DataRank · unranked
315 citations

Miguel de la Hoya, George A. R. Wiggins, Amanda Lindy, Lisa M. Vincent, Michael T. Parsons +28 more

ClinGen guidance for use of the PP1/BS4 co-segregation and PP4 phenotype specificity criteria for sequence variant pathogenicity classification

The American Journal of Human Genetics(2023)10.1016/j.ajhg.2023.11.009
N/A
0DataRank · unranked
87 citations

Alicia B. Byrne, Steven M Harrison, Tina Pesaran, Alejandro A. Schäffer, Brian H. Shirts +3 more

Recommendations for risk allele evidence curation, classification, and reporting from the ClinGen Low Penetrance/Risk Allele Working Group

Genetics in Medicine(2023)10.1016/j.gim.2023.101036
N/A
0DataRank · unranked
70 citations

Marcie Steeves, Pınar Bayrak‐Toydemir, Katherine A. Benson, Bradley P. Coe, Laura K. Conlin +42 more

APPLICATION OF THE ACMG/AMP FRAMEWORK TO CAPTURE EVIDENCE RELEVANT TO PREDICTED AND OBSERVED IMPACT ON SPLICING: RECOMMENDATIONS FROM THE CLINGEN SVI SPLICING SUBGROUP

medRxiv(2023)10.1101/2023.02.24.23286431
N/A
0DataRank · unranked
17 citations

Miguel de la Hoya, George A. R. Wiggins, Amanda Lindy, Lisa M. Vincent, Michael T. Parsons +11 more

Saturation genome editing-based functional evaluation and clinical classification of BRCA2 single nucleotide variants

Research Square(2023)10.21203/rs.3.rs-3736200/v1
N/A
0DataRank · unranked
0 citations

Huaizhi Huang, Chunling Hu, Jie Na, Steven N. Hart, Rohan Gnanaolivu +18 more

Functional analysis and clinical classification of 462 germline BRCA2 missense variants affecting the DNA binding domain

The American Journal of Human Genetics(2024)10.1016/j.ajhg.2024.02.002
N/A
0DataRank · unranked
17 citations

Huaizhi Huang, Jie Na, Carolyn A. Lumby, Mohamed Abozaid, Megan Holdren +21 more

Large-scale application of ClinGen-InSiGHT APC-specific ACMG/AMP variant classification criteria leads to substantial reduction in VUS

The American Journal of Human Genetics(2024)10.1016/j.ajhg.2024.09.002
N/A
0DataRank · unranked
15 citations

Marcy E. Richardson, Andreas Laner, Xuemei Shi, Elisabet Ognedal, Valeria Vasta +27 more

Pathogenic Variants in Cancer Susceptibility Genes Predispose to Ductal Carcinoma In Situ of the Breast

Clinical Cancer Research(2024)10.1158/1078-0432.ccr-24-1884
N/A
0DataRank · unranked
11 citations

Ronan E. Couch, Rachid Karam, Chunling Hu, Nicholas Boddicker, Eric C. Polley +37 more

Challenges and approaches to calibrating patient phenotype as evidence for cancer gene variant classification under ACMG/AMP guidelines

Human Molecular Genetics(2024)10.1093/hmg/ddae009
N/A
0DataRank · unranked
7 citations

Kyriaki Michailidou, Michael T. Parsons, Jill S. Dolinsky, Tina Pesaran, Amal Yussuf +11 more

Assigning credit where it is due: an information content score to capture the clinical value of multiplexed assays of variant effect

BMC Bioinformatics(2024)10.1186/s12859-024-05920-5
N/A
0DataRank · unranked
1 citations

Carolyn Horton, Tina Pesaran, Shawn Fayer, Lea M. Starita, Brian H. Shirts +1 more

Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline ATM sequence variants

medRxiv(2024)10.1101/2024.05.28.24307502
N/A
0DataRank · unranked
2 citations

Megan Holdren, Terra Brannan, Miguel de la Hoya, Amanda B. Spurdle, Sean V. Tavtigian +16 more

Saturation genome editing-based functional evaluation and clinical classification of BRCA2 single nucleotide variants.

Journal of Clinical Oncology(2024)10.1200/jco.2024.42.16_suppl.10511
N/A
0DataRank · unranked
0 citations

Huaizhi Huang, Tina Pesaran, Rachid Karam, Siddhartha Yadav, Susan M. Domchek +6 more

Calibration of additional computational tools expands ClinGen recommendation options for variant classification with PP3/BP4 criteria

Genetics in Medicine(2025)10.1016/j.gim.2025.101402
N/A
0DataRank · unranked
45 citations

Sarah L. Stenton, Emily A.W. Nadeau, Alicia B. Byrne, Marc S. Greenblatt, Steven M. Harrison +20 more

Association of gene variant type and location with breast cancer risk in the general population

Annals of Oncology(2025)10.1016/j.annonc.2025.04.010
N/A
0DataRank · unranked
8 citations

Nicholas Boddicker, Siddhartha Yadav, Cai-Xia Hu, Steven N. Hart, Christine B. Ambrosone +40 more

A quantitative, Bayesian-informed approach to gene-specific variant classification: Updated Expert Panel recommendations improve classification of TP53 germline variants for Li-Fraumeni syndrome

Genome Medicine(2025)10.1186/s13073-025-01536-3
N/A
0DataRank · unranked
5 citations

Megan N. Frone, Jessica L. Mester, Miguel de la Hoya, Phuong L. Mai, Tina Pesaran +32 more

Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline PALB2 sequence variants

The American Journal of Human Genetics(2025)10.1016/j.ajhg.2025.08.020
N/A
0DataRank · unranked
4 citations

Megan F.H. Bishop, Megan Holdren, Miguel de la Hoya, Amanda B. Spurdle, Sean V. Tavtigian +15 more

Specifications of the ACMG/AMP variant interpretation guidelines for germline TP53 variants

Human Mutation(2020)10.1002/humu.24152
N/A
0DataRank · unranked
166 citations

Kristy Lee, Magali Olivier, Tina Pesaran, Phuong L. Mai, Kelvin C. de Andrade +19 more

Data Supplement 1 from Pathogenic Variants in Cancer Susceptibility Genes Predispose to Ductal Carcinoma In Situ of the Breast

Figshare(2025)10.1158/1078-0432.28141741
Top 100%
0DataRank
Top 100%0 citations

Ronan E. Couch, Rachid Karam, Chunling Hu, Nicholas Boddicker, Eric C. Polley +37 more

Racial and Ethnic Differences in Multigene Hereditary Cancer Panel Test Results for Women With Breast Cancer

JNCI Journal of the National Cancer Institute(2020)10.1093/jnci/djaa167
N/A
0DataRank · unranked
39 citations

Holly LaDuca, Eric C. Polley, Chunling Hu, Nancy Niguidula, Hermela Shimelis +13 more

Curated multiple sequence alignment for the Adenomatous Polyposis Coli (APC) gene and accuracy of in silico pathogenicity predictions

PLoS ONE(2020)10.1371/journal.pone.0233673
N/A
0DataRank · unranked
3 citations

Dylan J. Martini, David J. Hermel, Dana Solcz, Marcy E. Richardson, Tina Pesaran +3 more

Specifications of the ACMG/AMP variant interpretation guidelines for germline TP53 variants

medRxiv(2020)10.1101/2020.04.25.20078931
N/A
0DataRank · unranked
5 citations

Kristy Lee, Magali Olivier, Tina Pesaran, Phuong L. Mai, Kelvin C. de Andrade +18 more

Closing the gap: Systematic integration of multiplexed functional data resolves variants of uncertain significance in BRCA1, TP53, and PTEN

The American Journal of Human Genetics(2021)10.1016/j.ajhg.2021.11.001
N/A
0DataRank · unranked
128 citations

Carolyn Horton, Jennifer N. Dines, Alan F. Rubin, Marcy E. Richardson, Kelly McGoldrick +7 more

Strong functional data for pathogenicity or neutrality classify BRCA2 DNA-binding-domain variants of uncertain significance

The American Journal of Human Genetics(2021)10.1016/j.ajhg.2021.02.005
N/A
0DataRank · unranked
63 citations

Chunling Hu, Kun Y. Lee, Holly LaDuca, Kelly Fulk, Kate Durda +10 more

Germline Pathogenic Variants in Cancer Predisposition Genes Among Women With Invasive Lobular Carcinoma of the Breast

Journal of Clinical Oncology(2021)10.1200/jco.21.00640
N/A
0DataRank · unranked
51 citations

Chunling Hu, Katherine L. Nathanson, Jeffrey N. Weitzel, David E. Goldgar, Peter Kraft +37 more

ClinGen CDH1 specifications for the ACMG/AMP guidelines: improvement of germline variant clinical assertions and updated curation guidelines

medRxiv(2021)10.1101/2021.11.01.21265332
N/A
0DataRank · unranked
0 citations

Jamie L. Maciaszek, Bryony A. Thompson, Huei San Leong, Katherine Dixon, Sónia Sousa +19 more

Germline pathogenic variants in cancer predisposition genes among women with invasive lobular cancer of breast.

Journal of Clinical Oncology(2021)10.1200/jco.2021.39.15_suppl.10581
Top 100%
0DataRank
Top 100%0 citations

Chunling Hu, Susan M. Domchek, Jeffrey N. Weitzel, David E. Goldgar, Peter Kraft +11 more