Edward P. O’Brien

Biochemistry, Genetics and Molecular BiologyMaterials Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 29 papers. Top paper: “Forcing the ribosome to change its message”.

Forcing the ribosome to change its message

Journal of Biological Chemistry(2020)10.1074/jbc.h120.013747

N/A

0.104DataRank · unranked

1 citations

Carol Deutsch, Edward P. O’Brien, Sarah E. Leininger

Pairs of amino acids at the P- and A-sites of the ribosome predictably and causally modulate translation-elongation rates

Journal of Molecular Biology(2020)10.1016/j.jmb.2020.10.030

N/A

0DataRank · unranked

14 citations

Ulrike Friedrich, Pietro Sormanni, Prajwal Ciryam, Naomi Altman, Bernd Bukau +3 more

Hierarchical Markov State Model Building to Describe Molecular Processes

Journal of Chemical Theory and Computation(2020)10.1021/acs.jctc.9b00955

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0DataRank · unranked

7 citations

Joseph R. Persichetti, Ajeet K. Sharma, Phillip S. Hudson, H. Lee Woodcock, Edward P. O’Brien +1 more

Pairs of amino acids at the P- and A-sites of the ribosome predictably and causally modulate translation-elongation rates

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.04.20.051839

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0DataRank · unranked

1 citations

Ulrike Friedrich, Pietro Sormanni, Prajwal Ciryam, Naomi Altman, Bernd Bukau +3 more

Combinations of slow-translating codon clusters can increase mRNA half-life in Saccharomyces cerevisiae

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2026362118

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0DataRank · unranked

12 citations

Johannes Venezian, Ayala Shiber, Günter Krämer, Bernd Bukau, Edward P. O’Brien +1 more

The driving force for co-translational protein folding is weaker in the ribosome vestibule due to greater water ordering

Chemical Science(2021)10.1039/d1sc01008e

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0DataRank · unranked

11 citations

Yang Jiang, Mai Suan Li, Edward P. O’Brien, Quyen V. Vu

Genomic and experimental evidence that ALKATI does not predict single agent sensitivity to ALK inhibitors

iScience(2021)10.1016/j.isci.2021.103343

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0DataRank · unranked

7 citations

Ivan Sokirniy, Yiyun Rao, Anushka Shah, Farnaz Naeemikia, Edward P. O’Brien +4 more

RiboA: a web application to identify ribosome A-site locations in ribosome profiling data

BMC Bioinformatics(2021)10.1186/s12859-021-04068-w

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0DataRank · unranked

6 citations

Nabeel Ahmed, Nishant Soni, Edward P. O’Brien, Danying Shao

How synonymous mutations alter enzyme structure and function over long time scales

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.08.18.456802

N/A

0DataRank · unranked

12 citations

Syam Sundar Neti, Ian Sitarik, Priya Pradhan, Philip To, Yingzi Xia +4 more

Subpopulations of soluble, misfolded proteins commonly bypass chaperones: How it happens at the molecular level

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.08.18.456736

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0DataRank · unranked

4 citations

Daniel A. Nissley, Ian Sitarik, Edward P. O’Brien, Ritaban Halder

Ribosome elongation kinetics of consecutively charged residues are coupled to electrostatic force

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.08.04.455055

N/A

0DataRank · unranked

1 citations

Judith Rodríguez, Quyen V. Vu, Yang Jiang, Mai Suan Li, Carol Deutsch +2 more

How synonymous mutations alter enzyme structure and function over long timescales

Nature Chemistry(2022)10.1038/s41557-022-01091-z

N/A

0DataRank · unranked

93 citations

Syam Sundar Neti, Ian Sitarik, Priya Pradhan, Philip To, Yingzi Xia +4 more

Universal protein misfolding intermediates can bypass the proteostasis network and remain soluble and less functional

Nature Communications(2022)10.1038/s41467-022-30548-5

N/A

0DataRank · unranked

58 citations

Yang Jiang, Fabio Trovato, Ian Sitarik, Karthik Narayan, Philip To +4 more

Pulse labeling reveals the tail end of protein folding by proteome profiling

Cell Reports(2022)10.1016/j.celrep.2022.111096

N/A

0DataRank · unranked

17 citations

Erich R. Kuechler, Ryan Wong, Gaetano Calabrese, Ian Sitarik, Viraj Rana +5 more

A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments

Nature Communications(2022)10.1038/s41467-022-28045-w

N/A

0DataRank · unranked

8 citations

Yiyun Rao, Scott M. Leighow, Edward P. O’Brien, Luke A. Gilbert, Justin R. Pritchard +1 more

A Newly Identified Class of Protein Misfolding in All-atom Folding Simulations Consistent with Limited Proteolysis Mass Spectrometry

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.07.19.500586

N/A

0DataRank · unranked

11 citations

Ian Sitarik, Yang Jiang, Divya Yadav, Piyoosh Sharma, Stephen D. Fried +3 more

MutSigCVsyn: Identification of Thirty Synonymous Cancer Drivers

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.16.476507

N/A

0DataRank · unranked

1 citations

Nabeel Ahmed, Justin R. Pritchard, Edward P. O’Brien, Yiyun Rao

How soluble misfolded proteins bypass chaperones at the molecular level

Nature Communications(2023)10.1038/s41467-023-38962-z

N/A

0DataRank · unranked

18 citations

Daniel A. Nissley, Ian Sitarik, Yang Jiang, Yiyun Rao, Quyen V. Vu +4 more

Incorporating mutational heterogeneity to identify genes that are enriched for synonymous mutations in cancer

BMC Bioinformatics(2023)10.1186/s12859-023-05521-8

N/A

0DataRank · unranked

1 citations

Nabeel Ahmed, Justin R. Pritchard, Edward P. O’Brien, Yiyun Rao

Is Posttranslational Folding More Efficient Than Refolding from a Denatured State: A Computational Study

The Journal of Physical Chemistry B(2023)10.1021/acs.jpcb.3c01694

N/A

0DataRank · unranked

2 citations

Daniel A. Nissley, Yang Jiang, Edward P. O’Brien, Mai Suan Li, Quyen V. Vu

Synonymous Mutations Can Alter Protein Dimerization Through Localized Interface Misfolding Involving Self-entanglements

Journal of Molecular Biology(2024)10.1016/j.jmb.2024.168487

N/A

0DataRank · unranked

16 citations

Daniel A. Nissley, Ian Sitarik, Quyen V. Vu, Yang Jiang, Philip To +5 more

Non-covalent Lasso Entanglements in Folded Proteins: Prevalence, Functional Implications, and Evolutionary Significance

Journal of Molecular Biology(2024)10.1016/j.jmb.2024.168459

N/A

0DataRank · unranked

12 citations

Ian Sitarik, Justin Petucci, Yang Jiang, Hyebin Song, Edward P. O’Brien +1 more

Pulling Forces Differentially Affect Refolding Pathways Due to Entangled Misfolded States in SARS-CoV-1 and SARS-CoV-2 Receptor Binding Domain

Biomolecules(2024)10.3390/biom14101327

N/A

0DataRank · unranked

0 citations

Edward P. O’Brien, Mai Suan Li, Pham Dang Lan

A widespread protein misfolding mechanism is differentially rescued in vitro by chaperones based on gene essentiality

Nature Communications(2025)10.1038/s41467-025-66236-3

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0DataRank · unranked

5 citations

Quyen V. Vu, Justin Petucci, Pilar Frutos, Hyebin Song, Edward P. O’Brien +1 more

Noncovalent Lasso Entanglements are Common in Experimentally Derived Intrinsically Disordered Protein Ensembles and Strongly Influenced by Protein Length and Charge

The Journal of Physical Chemistry B(2025)10.1021/acs.jpcb.5c01260

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0DataRank · unranked

1 citations

Ian Sitarik, Mai Suan Li, Edward P. O’Brien, Quyen V. Vu

Properties Governing Native State Entanglements and Relationships to Protein Function

Journal of Molecular Biology(2025)10.1016/j.jmb.2025.169342

N/A

0DataRank · unranked

1 citations

Ian Sitarik, Yang Jiang, Viraj Rana, Hyebin Song, Edward P. O’Brien +1 more

HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA

Molecular Cell(2025)10.1016/j.molcel.2025.11.017

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0DataRank · unranked

1 citations

Ziyi Fan, Inayat Ullah Irshad, Edward P. O’Brien, Ajeet K. Sharma, Rachel Green +2 more

Electrostatic Interactions Govern Extreme Nascent Protein Ejection Times from Ribosomes and Can Delay Ribosome Recycling

Journal of the American Chemical Society(2020)10.1021/jacs.9b12264

N/A

0DataRank · unranked

58 citations

Quyen V. Vu, Fabio Trovato, Nabeel Ahmed, Yang Jiang, Mai Suan Li +2 more

A widespread protein misfolding mechanism is differentially rescued by chaperones based on gene essentiality

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.18.677077

N/A

0DataRank · unranked

0 citations

Quyen V. Vu, Justin Petucci, Pilar Frutos, Hyebin Song, Edward P. O’Brien +1 more