Barbara S. Slusher

Also affiliated with Johns Hopkins Medicine, Behavioral Pharma (United States), H. L. Snyder Medical Foundation, Sidney Kimmel Comprehensive Cancer Center

Biochemistry, Genetics and Molecular BiologyNeuroscienceImmunology and Microbiology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 64 papers. Top paper: “Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells”.

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells

Journal of Clinical Investigation(2020)10.1172/jci131859

N/A

6.6DataRank · unranked

443 citations

Im‐Hong Sun, Liang Zhao, Robert D. Leone, Im-Meng Sun, Wei Xu +15 more

Targeting Glutamine Metabolism to Enhance Immunoprevention of EGFR‐Driven Lung Cancer

Advanced Science(2022)10.1002/advs.202105885

N/A

0.644DataRank · unranked

72 citations

Donghai Xiong, Jing Pan, Qi Zhang, Shizuko Sei, Robert H. Shoemaker +6 more

The glutamine antagonist prodrug JHU-083 slows malignant glioma growth and disrupts mTOR signaling

Neuro-Oncology Advances(2020)10.1093/noajnl/vdaa149

N/A

0.606DataRank · unranked

56 citations

Marina da Costa Rosa, Vittorio Stumpo, Rana Rais, Barbara S. Slusher, Gregory J. Riggins +1 more

Neutral sphingomyelinase 2 is required for HIV-1 maturation

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2219475120

N/A

0.599DataRank · unranked

17 citations

Yanan Zhu, Eva L. Agostino, Lwar Naing, Yuta Hikichi, Ferri Soheilian +7 more

Astrocytes deliver CK1 to neurons via extracellular vesicles in response to inflammation promoting the translation and amyloidogenic processing of APP

Journal of Extracellular Vesicles(2020)10.1002/jev2.12035

N/A

0.590DataRank · unranked

50 citations

Mohammed Moniruzzaman, Raha Dastgheyb, Seung‐Wan Yoo, Meina Wang, Hongbo Hao +7 more

Metabolic Reprogramming of Tumor-Associated Macrophages Using Glutamine Antagonist JHU083 Drives Tumor Immunity in Myeloid-Rich Prostate and Bladder Cancers

Cancer Immunology Research(2024)10.1158/2326-6066.cir-23-1105

N/A

0.590DataRank · unranked

50 citations

Fan Shen, Alex J. Lee, Liang Zhao, Thomas R. Nirschl, Debebe Theodros +18 more

Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer’s Disease

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c00278

N/A

0.581DataRank · unranked

47 citations

Kristen R. Hollinger, Ajit G. Thomas, Ranjeet Prasad Dash, Carolyn Tallon, Vijayabhaskar Veeravalli +12 more

The Psychiatric Impact of HIV

ACS Chemical Neuroscience(2017)10.1021/acschemneuro.7b00169

N/A

0.581DataRank · unranked

47 citations

Arena A. Manning, Svetlana Semenova, Charlene Gamaldo, Norman J. Haughey, Barbara S. Slusher +1 more

Neuroprotective effects of a dendrimer-based glutamate carboxypeptidase inhibitor on superoxide dismutase transgenic mice after neonatal hypoxic-ischemic brain injury

Neurobiology of Disease(2020)10.1016/j.nbd.2020.105201

N/A

0.557DataRank · unranked

40 citations

Zhi Zhang, Elizabeth Smith Khoury, R. Ann Sheldon, Anjali Sharma, Fan Zhang +5 more

Inhibition of glutamate-carboxypeptidase-II in dorsolateral prefrontal cortex: potential therapeutic target for neuroinflammatory cognitive disorders

Molecular Psychiatry(2022)10.1038/s41380-022-01656-x

N/A

0.538DataRank · unranked

35 citations

Dibyadeep Datta, Elizabeth Woo, Alvaro Duque, Yury M. Morozov, Jon I. Arellano +4 more

Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance

Frontiers in Aging Neuroscience(2021)10.3389/fnagi.2021.760270

N/A

0.510DataRank · unranked

29 citations

Shannon Leslie, Elizabeth Woo, Nishita Amancharla, Ayah Elmansy, Miguel Lepe +5 more

Regulatory T cells reduce endothelial neutral sphingomyelinase 2 to prevent T‐cell migration into tumors

European Journal of Immunology(2021)10.1002/eji.202149208

N/A

0.509DataRank · unranked

9 citations

Louis Szeponik, Veronica Langenes, Viktoria Karlsson, Patrik Sundström, Elinor Bexe Lindskog +4 more

Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome

Theranostics(2020)10.7150/thno.41714

N/A

0.505DataRank · unranked

28 citations

Anjali Sharma, Rajasekhar R. Ramireddy, Ajit G. Thomas, Jesse Alt, Amanda Fowler +7 more

A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis

Science Translational Medicine(2023)10.1126/scitranslmed.abn7491

N/A

0.434DataRank · unranked

17 citations

Lauren Norris, Lukáš Tenora, Ivan Šnajdr, András K. Ponti, Xiaolei Zhu +10 more

Aged fibroblast-derived extracellular vesicles promote angiogenesis in melanoma

Cell Reports(2024)10.1016/j.celrep.2024.114721

N/A

0.434DataRank · unranked

17 citations

Yash Chhabra, Олеся Гололобова, Vania Wang, Guanshu Liu, Agrani Dixit +13 more

Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker

Bioorganic & Medicinal Chemistry(2020)10.1016/j.bmc.2020.115698

N/A

0.416DataRank · unranked

15 citations

Sarah C. Zimmermann, Run-Duo Gao, Ajit G. Thomas, Filip Kalčic, Vijayabhaskar Veeravalli +7 more

Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c00734

N/A

0.407DataRank · unranked

10 citations

Ashley N. Nilson, Rebekah Placide, Mimi L. Pham, Franziska M. Jakobs, Noelia Boldizsar +30 more

Empirical Analysis of Drug Targets for Nervous System Disorders

ACS Chemical Neuroscience(2024)10.1021/acschemneuro.3c00676

N/A

0.312DataRank · unranked

7 citations

Barbara S. Slusher, Takashi Tsukamoto, Louis G. Mueller

Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement

Current Drug Metabolism(2021)10.2174/1389200222666210831125041

N/A

0.312DataRank · unranked

7 citations

Sadakatali S. Gori, Kathryn M. Lemberg, Arindom Pal, Vijayabhaskar Veeravalli, Ying Wu +8 more

Development of a high‐throughput dual‐stream liquid chromatography–tandem mass spectrometry method to screen for inhibitors of glutamate carboxypeptidase II

Rapid Communications in Mass Spectrometry(2024)10.1002/rcm.9772

N/A

0.292DataRank · unranked

6 citations

Yixuan Qiu, Stephen C. Kales, Rick Schneider, Xin Hu, Anu Dalal +8 more

Inhibition of microglial glutaminase alleviates chronic stress-induced neurobehavioral and cognitive deficits

Neurotherapeutics(2025)10.1016/j.neurot.2025.e00759

N/A

0.208DataRank · unranked

3 citations

Yannan Li, Ajit G. Thomas, A. Sharma, Wathsala Liyanage, Tomáš Tichý +13 more

Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold

European Journal of Medicinal Chemistry(2023)10.1016/j.ejmech.2023.115674

N/A

0.208DataRank · unranked

3 citations

Ajit G. Thomas, Ondřej Štěpánek, Brennan A. Murphy, Niyada Hin, Jan Skácel +10 more

Bioisosteric Replacement of Amides with 1,2,3-Triazoles Improves Dopamine D4 Receptor Ligand Pharmacokinetics

ChemRxiv(2025)10.26434/chemrxiv-2024-0z6jk-v2

N/A

0.104DataRank · unranked

1 citations

Franziska M. Jacobs, John Hanson, Ashley N. Nilson, Amy E. Moritz, Tian Li +20 more

Prodrugs 2-(Phosphonomethyl)pentanedioic Acid (2-PMPA) as Orally Available Glutamate Carboxypeptidase II Inhibitors

ACS Medicinal Chemistry Letters(2025)10.1021/acsmedchemlett.5c00384

N/A

0.104DataRank · unranked

1 citations

Chae Bin Lee, Sadakatali S. Gori, Barbara S. Slusher, Rana Rais, Takashi Tsukamoto +1 more

PSMA-Targeted PET Radiotracer [18F]DCFPyL as an Imaging Biomarker in Inflammatory Bowel Disease

Clinical and Experimental Gastroenterology(2023)10.2147/ceg.s404009

N/A

0DataRank · unranked

6 citations

Diane E. Peters, Steven P. Rowe, Ali Salavati, Sowmya Sharma, Robert A. Anders +4 more

Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor

Molecular Cancer Therapeutics(2023)10.1158/1535-7163.mct-23-0258

N/A

0DataRank · unranked

2 citations

Eunüs S. Ali, Marcela Krečmerová, Joanna Marie H. Aguilar, Jesse Alt, Diane E. Peters +11 more

SIKs Regulate HDAC7 Stabilization and Cytokine Recall in Late-Stage T Cell Effector Differentiation

The Journal of Immunology(2023)10.4049/jimmunol.2300248

N/A

0DataRank · unranked

2 citations

Alberto Marín-González, Chirag H. Patel, Im‐Hong Sun, Jiayu Wen, Robert D. Leone +8 more

Synthesis and Pharmacological Characterization of a Difluorinated Analogue of Reduced Haloperidol as a Sigma-1 Receptor Ligand

ACS Chemical Neuroscience(2023)10.1021/acschemneuro.2c00791

N/A

0DataRank · unranked

2 citations

Michelle Taylor, Tamara R. McInnis, Zhenglan Chen, Sadakatali S. Gori, Heather M. LaPorte +9 more

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in murine Alzheimer’s disease

Research Square(2023)10.21203/rs.3.rs-3131295/v1

N/A

0DataRank · unranked

4 citations

Benjamin J. Bell, Medhinee M. Malvankar, Pragney Deme, Carlos Nogueras‐Ortiz, Erden Eren +12 more

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.23.529704

N/A

0DataRank · unranked

3 citations

Jessica Shen, Shichun Lun, Liang Zhao, Benjamin Koleske, Robert D. Leone +6 more

Brain N-acetyl-aspartyl-glutamate is associated with cognitive function in older virally suppressed people with HIV

AIDS(2024)10.1097/qad.0000000000003871

N/A

0DataRank · unranked

9 citations

Kristin L. Bigos, Raha Dastgheyb, Peter B. Barker, Leah H. Rubin, Barbara S. Slusher +1 more

Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia

Diabetes(2024)10.2337/db24-0175

N/A

0DataRank · unranked

7 citations

Michael P. Ellenberger, Zachary J. Farino, Despoina Aslanoglou, Rana Rais, Sandra Pereira +10 more

GCPII Inhibition Promotes Remyelination after Peripheral Nerve Injury in Aged Mice

International Journal of Molecular Sciences(2024)10.3390/ijms25136893

N/A

0DataRank · unranked

5 citations

Meixiang Huang, Ajit G. Thomas, John Maragakis, Kaitlyn Huizar, Yuxin Zheng +4 more

Dectin-1 as a therapeutic target for inflammatory bowel disease

Advances in pharmacology(2024)10.1016/bs.apha.2024.10.002

N/A

0DataRank · unranked

4 citations

Meixiang Huang, Santiago Cardinale, Yu Su, Diane E. Peters, Barbara S. Slusher +2 more

Development of novel tools for dissection of central versus peripheral dopamine D 2 -like receptor signaling in dysglycemia

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.21.581451

N/A

0DataRank · unranked

0 citations

Michael P. Ellenberger, Zachary J. Farino, Despoina Aslanoglou, Rana Rais, Sandra Pereira +10 more

Discovery of PSMA in the prostate of the common marmoset (Callithrix jacchus)

The Prostate(2024)10.1002/pros.24722

N/A

0DataRank · unranked

0 citations

Michael Brownlee, Donna Layne‐Colon, Barbara S. Slusher, Diane E. Peters

Targeting NAAG metabolism restores cognition and synaptic integrity in EcoHIV-infected mice

Neurotherapeutics(2025)10.1016/j.neurot.2025.e00782

N/A

0DataRank · unranked

2 citations

Meixiang Huang, R. Michael Maragakis, Peter Pietri, Yu Su, Jesse Alt +7 more

Resilient pathways for drug discovery in challenging times

Trends in Pharmacological Sciences(2025)10.1016/j.tips.2025.10.006

N/A

0DataRank · unranked

1 citations

Barbara S. Slusher, Sean Ekins

The potential of academic drug discovery: successes and challenges

Expert Opinion on Drug Discovery(2025)10.1080/17460441.2025.2528125

N/A

0DataRank · unranked

2 citations

Barbara S. Slusher, Matthew Stremlau

Mass spectrometry-guided discovery of novel GCPII inhibitor scaffolds

Frontiers in Pharmacology(2025)10.3389/fphar.2025.1646207

N/A

0DataRank · unranked

0 citations

Ajit G. Thomas, John Janiszewski, Nate Hoxie, Chae Bin Lee, Ying Wu +13 more

Bioisosteric Replacement of Amides with 1,2,3-Triazoles Improves Dopamine D4 Receptor Ligand Pharmacokinetics

ChemRxiv(2024)10.26434/chemrxiv-2024-0z6jk

N/A

0DataRank · unranked

0 citations

Franziska M. Jacobs, John Hanson, Ashley N. Nilson, Li Tian, Afua B. Faibille +19 more

Bioenergetic adaptations to HIV infection. Could modulation of energy substrate utilization improve brain health in people living with HIV-1?

Experimental Neurology(2020)10.1016/j.expneurol.2020.113181

N/A

0DataRank · unranked

11 citations

Camilo Rojas, Barbara S. Slusher, Raina Rais, Zahra Afghah, Jonathan D. Geiger +2 more

Inhibition of neutral sphingomyelinase 2 promotes remyelination

Science Advances(2020)10.1126/sciadv.aba5210

N/A

0DataRank · unranked

37 citations

Amit Agarwal, Matthew D. Smith, Saja S. Khuder, Emily G. Baxi, Ajit G. Thomas +7 more

Microglia-targeted dendrimer-2PMPA therapy robustly inhibits GCPII and improves cognition in a mouse model of multiple sclerosis

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.04.22.055228

N/A

0DataRank · unranked

1 citations

Anjali Sharma, Carolyn Tallon, Lyndah Lovell, Ajit G. Thomas, Xiaolei Zhu +9 more

Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis

Nanotheranostics(2021)10.7150/ntno.63158

N/A

0DataRank · unranked

47 citations

Anjali Sharma, Carolyn Tallon, Lyndah Lovell, Ajit G. Thomas, Xiaolei Zhu +11 more

Inhibition of neutral sphingomyelinase 2 reduces extracellular vesicle release from neurons, oligodendrocytes, and activated microglial cells following acute brain injury

Biochemical Pharmacology(2021)10.1016/j.bcp.2021.114796

N/A

0DataRank · unranked

42 citations

Silvia Picciolini, Seung‐Wan Yoo, Ajit G. Thomas, Arindom Pal, Jesse Alt +7 more

Model studies towards prodrugs of the glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON) containing a diazo precursor

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.128321

N/A

0DataRank · unranked

8 citations

Niyada Hin, Eva Prchalová, Arindom Pal, Jenny Lam, Rana Rais +3 more

Development of EQ-6, a Novel Analogue of Ethoxyquin to Prevent Chemotherapy-Induced Peripheral Neuropathy

Neurotherapeutics(2021)10.1007/s13311-021-01093-8

N/A

0DataRank · unranked

7 citations

Jing Zhu, Xinghua Luan, Jun-Soon Kim, Byoungchol Oh, Cory Brayton +5 more

Clinical development of metabolic inhibitors for oncology

Journal of Clinical Investigation(2022)10.1172/jci148550

N/A

0DataRank · unranked

137 citations

Sadakatali S. Gori, Takashi Tsukamoto, Rana Rais, Barbara S. Slusher, Kathryn M. Lemberg

Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects

Frontiers in Chemistry(2022)10.3389/fchem.2022.889737

N/A

0DataRank · unranked

74 citations

Pavel Majer, Rana Rais, Barbara S. Slusher, Marcela Krečmerová

In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma

Science Advances(2022)10.1126/sciadv.abp8293

N/A

0DataRank · unranked

58 citations

Amy Tarangelo, Lindsey K. Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng‐Yang Wu +24 more

The pathogenesis of, and pharmacological treatment for, Canavan disease

Drug Discovery Today(2022)10.1016/j.drudis.2022.05.019

N/A

0DataRank · unranked

29 citations

John R. Moffett, Man Amanat, Ali Fatemi, Takashi Tsukamoto, Aryan M.A. Namboodiri +2 more

Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice

Pharmaceutics(2022)10.3390/pharmaceutics14102066

N/A

0DataRank · unranked

27 citations

Benjamin J. Bell, Anjali Sharma, Arindom Pal, Medhinee M. Malvankar, Ajit G. Thomas +10 more

Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata

PNAS Nexus(2022)10.1093/pnasnexus/pgac297

N/A

0DataRank · unranked

13 citations

Sadakatali S. Gori, Jesse Alt, Sandhya P. Tiwari, Jitesh Iyer, Rashmi Talwar +25 more

1119 Glutamine antagonist prodrug JHU083 reprograms immunosuppressive tumor-associated macrophages to drives tumor immunity in urologic cancers

Regular and Young Investigator Award Abstracts(2022)10.1136/jitc-2022-sitc2022.1119

N/A

0DataRank · unranked

1 citations

Fan Shen, Thomas R. Nirschl, Alex J. Lee, Xiaoxu Wang, Liang Zhao +15 more

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

Nature Communications(2023)10.1038/s41467-023-43304-0

N/A

0DataRank · unranked

35 citations

Jessica Shen, Shichun Lun, Liang Zhao, Jesse Alt, Benjamin Koleske +7 more

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model

Translational Neurodegeneration(2023)10.1186/s40035-023-00383-9

N/A

0DataRank · unranked

24 citations

Benjamin J. Bell, Medhinee M. Malvankar, Pragney Deme, Carlos Nogueras‐Ortiz, Erden Eren +12 more

T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade

JCI Insight(2023)10.1172/jci.insight.160345

N/A

0DataRank · unranked

23 citations

Elizabeth A. Thompson, Sepideh Gharaie, Chirag H. Patel, Johanna T. Kurzhagen, Phillip M. Pierorazio +6 more

Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2219543120

N/A

0DataRank · unranked

18 citations

Abdül Waheed, Pragney Deme, Şehmus Tohumeken, Rana Rais, Matthew D. Smith +7 more

Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsy

Journal of Controlled Release(2023)10.1016/j.jconrel.2023.04.017

N/A

0DataRank · unranked

16 citations

Zhi Zhang, Jesse Alt, Siva P. Kambhampati, Anjali Sharma, Sarabdeep Singh +8 more

Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-l-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c01681

N/A

0DataRank · unranked

10 citations

Lukáš Tenora, Eva Prchalová, James Paule, Jesse Alt, Vijay Veeravalli +10 more

Neuronal deletion of nSMase2 reduces the production of Aβ and directly protects neurons

Neurobiology of Disease(2023)10.1016/j.nbd.2023.105987

N/A

0DataRank · unranked

7 citations

Pragney Deme, Seung Wan Yoo, Sujasha Gupta, Rana Rais, Barbara S. Slusher +2 more

Dendrimer-Conjugated Glutamate Carboxypeptidase II Inhibitor Restores Microglial Changes in a Rabbit Model of Cerebral Palsy

Developmental Neuroscience(2023)10.1159/000530389

N/A

0DataRank · unranked

7 citations

Zhi Zhang, Alicia Chime, Amanda Fowler, Antonio Mendez-Trendler, A. Sharma +4 more

Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques

Alzheimer s & Dementia Translational Research & Clinical Interventions(2023)10.1002/trc2.12431

N/A

0DataRank · unranked

12 citations

Dibyadeep Datta, Feng Liang, Nicolas R. Barthélemy, Robyn Wiseman, Barbara S. Slusher +13 more