Jay P. McLaughlin

Also affiliated with Torrey Pines Institute For Molecular Studies, Florida College

NeuroscienceBiochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 29 papers. Top paper: “Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR”.

Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR

ACS Central Science(2024)10.1021/acscentsci.4c00525

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0.517DataRank · unranked

13 citations

Nokomis Ramos‐Gonzalez, Qiongyu Li, Briana L. Sobecks, Deniz Aydın, Alexander S. Powers +14 more

Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles

Molecules(2020)10.3390/molecules25173999

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19 citations

Sanjeewa N. Senadheera, Michelle L. Ganno, Shainnel O. Eans, Tanvir Khaliq, Thomas F. Murray +3 more

Design, Synthesis, and Characterization of the Macrocyclic Tetrapeptide cyclo[Pro-Sar-Phe-d-Phe]: A Mixed Opioid Receptor Agonist–Antagonist Following Oral Administration

ACS Chemical Neuroscience(2020)10.1021/acschemneuro.0c00086

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19 citations

Ariana C. Brice‐Tutt, Jeremy S. Coleman, Grant G. Simpson, Lisa Wilson, Shainnel O. Eans +5 more

HIV-1 Tat and cocaine impact mitochondrial epigenetics: effects on DNA methylation

Epigenetics(2020)10.1080/15592294.2020.1834919

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30 citations

Venkatesh Jeganathan, Jay P. McLaughlin, Thangavel Samikkannu, Mayur Doke

[3H]Dopamine Uptake through the Dopamine and Norepinephrine Transporters is Decreased in the Prefrontal Cortex of Transgenic Mice Expressing HIV-1 Transactivator of Transcription Protein

Journal of Pharmacology and Experimental Therapeutics(2020)10.1124/jpet.120.266023

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25 citations

Bernadette O’Donovan, Yizhi Ma, Ziyu Xiao, Steven Lin, Michael T. Bardo +4 more

Peripheral kappa opioid receptor activation drives noxious cold hypersensitivity in mice

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.04.325118

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7 citations

Loc V. Thang, Priyanka Chilukuri, Sree Palanisamy, Joel Arackal, Tayler D. Sheahan +6 more

HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF-Transcriptional Mediated Neurodegeneration

Research Square(2020)10.21203/rs.3.rs-38931/v1

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1 citations

Thomas J. Cirino, Jay P. McLaughlin, SAMIKKANNU THANGAVEL, Kalaiselvi Sivalingam

A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c01273

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75 citations

Jeffrey F. DiBerto, Abdelfattah Faouzi, Sarah M. Bernhard, Anna M. Gutridge, Steven Ramsey +19 more

Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

eLife(2021)10.7554/elife.56519

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66 citations

Tao Che, Saheem A. Zaidi, Steven G. Grinnell, Balázs R. Varga, Abdelfattah Faouzi +19 more

In vivo proton magnetic resonance spectroscopy detection of metabolite abnormalities in aged Tat-transgenic mouse brain

GeroScience(2021)10.1007/s11357-021-00354-w

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13 citations

Xi Chen, Joseph Anderson, Alaa N. Qrareya, Fakhri Mahdi, Fei Du +3 more

Mini review: Promotion of substance abuse in HIV patients: Biological mediation by HIV-1 Tat protein

Neuroscience Letters(2021)10.1016/j.neulet.2021.135877

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10 citations

Jay P. McLaughlin, Thomas J. Cirino

Binge ethanol consumption-associated behavioral impairments in male mice using a gelatin-based drinking-in-the dark model

Alcohol(2021)10.1016/j.alcohol.2021.05.001

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7 citations

Jasmin Tawfic, Aziza Abrorkhujaeva, Sam Sowell, Sara Wu, Shainnel O. Eans +5 more

A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.22.440994

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6 citations

Jeffrey F. DiBerto, Abdelfattah Faouzi, Sarah M. Bernhard, Anna M. Gutridge, Steven Ramsey +19 more

Structure-based design of bitopic ligands for the µ-opioid receptor

Nature(2022)10.1038/s41586-022-05588-y

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128 citations

Haoqing Wang, Saheem A. Zaidi, Jeffrey F. DiBerto, Tao Che, Qianhui Qu +21 more

SRI-32743, a novel allosteric modulator, attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter and alleviates the potentiation of cocaine reward in HIV-1 Tat transgenic mice

Neuropharmacology(2022)10.1016/j.neuropharm.2022.109239

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22 citations

Pamela M. Quizon, Yingying Wang, Charles Adeniran, Matthew J. Strauss, Ana Catya Jiménez-Torres +17 more

Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infection

Molecular Brain(2022)10.1186/s13041-022-00946-3

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2 citations

Jay P. McLaughlin, Thangavel Samikkannu, Vaishnavi Sundar

Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration

Molecules(2023)10.3390/molecules28041822

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8 citations

Annika Tiller, Shahayra A. Majumder, Heather M. Stacy, Shainnel O. Eans, Aleksandra Nedovic +3 more

Tryptophan Substitution in CJ-15,208 (cyclo[Phe-D-Pro-Phe-Trp]) Introduces δ-Opioid Receptor Antagonism, Preventing Antinociceptive Tolerance and Stress-Induced Reinstatement of Extinguished Cocaine-Conditioned Place Preference

Pharmaceuticals(2023)10.3390/ph16091218

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4 citations

Shainnel O. Eans, Jéssica Medina, Sanjeewa N. Senadheera, Tanvir Khaliq, Thomas F. Murray +3 more

Circadian disruption and psychostimulants dysregulates plasma acute-phase proteins and circulating cell-free mitochondrial DNA

Brain Behavior & Immunity - Health(2023)10.1016/j.bbih.2023.100659

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1 citations

Mayur Doke, Jay P. McLaughlin, Thangavel Samikkannu, Ramasamy Tamizhselvi

SRI-30827, a novel allosteric modulator of the dopamine transporter, alleviates HIV-1 Tat-induced potentiation of cocaine conditioned place preference in mice

NeuroImmune Pharmacology and Therapeutics(2023)10.1515/nipt-2023-0022

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0 citations

Shainnel O. Eans, Thomas J. Cirino, Subramaniam Ananthan, Ana Catya Jiménez-Torres, Jun Zhu +2 more

Impact of HIV-1 tat protein on methamphetamine-induced inhibition of vesicular monoamine transporter2-mediated dopamine transport and methamphetamine conditioned place preference in HIV-1 tat transgenic mice

European Journal of Pharmacology(2024)10.1016/j.ejphar.2024.177030

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6 citations

Abagail Brenda Cirincione, Matthew J. Strauss, Sarah E. Davis, Shainnel O. Eans, Danielle K Tribbitt +3 more

Structure-Guided Design of Partial Agonists at an Opioid Receptor

Research Square(2024)10.21203/rs.3.rs-4664764/v1

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0 citations

Balázs R. Varga, Sarah M. Bernhard, Amal El Daibani, Saheem A. Zaidi, Jordy Homing Lam +12 more

Structure-guided design of partial agonists at an opioid receptor

Nature Communications(2025)10.1038/s41467-025-57734-5

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14 citations

Sarah M. Bernhard, Amal El Daibani, Saheem A. Zaidi, Jordy Homing Lam, Jhoan Aguilar +16 more

Epigenetics and Mitochondrial Biogenesis: The Role of Sirtuins in HIV Neuropathogenesis

Molecular Neurobiology(2025)10.1007/s12035-025-04885-7

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3 citations

Hemavathi Iyappan, Malaroviyam Samikkannu, Karthick Chennakesavan, Jay P. McLaughlin, Thangavel Samikkannu +1 more

Total synthesis and biological activity of “carbamorphine”: O-to-CH 2 replacement in the E-ring of the morphine core structure

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2425438122

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3 citations

Rohini S. Ople, Alexander Kremsmair, Nokomis Ramos‐Gonzalez, Thomas Nedungadan, Brandon J. Kennedy +9 more

Synthesis and Pharmacology of a Morphinan-Derived Dual Mu–Kappa Opioid Receptor Agonist Analgesic

ACS Chemical Neuroscience(2025)10.1021/acschemneuro.5c00312

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2 citations

Rajendra Uprety, Barnali Paul, Alois Knoll, Nokomis Ramos‐Gonzalez, Kevin Appourchaux +26 more

Dual Opioid–Neuropeptide FF Small Molecule Ligands Demonstrate Analgesia with Reduced Tolerance Liabilities

Molecules(2025)10.3390/molecules30132851

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0 citations

V. Blair Journigan, Samuel Obeng, Victoria L.C. Pallares, Christophe Mѐsangeau, Coco N. Kapanda +12 more

Preventing Morphine-Seeking Behavior through the Re-Engineering of Vincamine’s Biological Activity

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.9b01924

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48 citations

Ariana C. Brice‐Tutt, Shainnel O. Eans, Heather M. Stacy, Guqin Shi, Ranjala Ratnayake +7 more

Optimization of the Macrocyclic Tetrapeptide [D-Trp]CJ-15,208 to Prevent Stress-Induced Relapse of Cocaine-Seeking Behavior

Molecules(2025)10.3390/molecules30193993

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0 citations

Dmitry Yakovlev, Jeremy S. Coleman, Sanjeewa N. Senadheera, Heather M. Stacy, Shainnel O. Eans +4 more