Vamsi K. Mootha

Also affiliated with Howard Hughes Medical Institute, Harvard University, MGH Institute of Health Professions, Massachusetts General Hospital, Center for Systems Biology

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 1%percentile

10.3Author DataRank

Indexed papers

3in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 3 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations

Nucleic Acids Research(2020)10.1093/nar/gkaa1011

Top 3%

6.0DataRank

Top 3%2013 citations

Rohit Sharma, Rahul Gupta, Tslil Ast, Connie Chan, Timothy Durham +27 more

Papers

Driven by 52 papers — median percentile 94. Top paper: “MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations”.

MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations

Nucleic Acids Research(2020)10.1093/nar/gkaa1011

Top 3%

6.0DataRank

Top 3%2013 citations

Rohit Sharma, Rahul Gupta, Tslil Ast, Connie Chan, Timothy Durham +27 more

Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell

eLife(2020)10.7554/elife.49178

N/A

4.5DataRank · unranked

261 citations

Denis V. Titov, Owen S. Skinner, Rohit Sharma, Alexis A. Jourdain, Vamsi K. Mootha +1 more

Mitochondrial DNA variation across 56,434 individuals in gnomAD

Genome Research(2022)10.1101/gr.276013.121

Top 6%

3.6DataRank

Top 6%156 citations

Nicole J. Lake, Nicholas A. Watts, Megan Shand, Andrea Haessly, Laura D. Gauthier +12 more

Purifying Selection against Pathogenic Mitochondrial DNA in Human T Cells

New England Journal of Medicine(2020)10.1056/nejmoa2001265

N/A

2.6DataRank · unranked

100 citations

Caleb A. Lareau, Leif S. Ludwig, Amel Karaa, Vijay G. Sankaran, Aviv Regev +2 more

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Proceedings of the National Academy of Sciences(2005)10.1073/pnas.0506580102

N/A

1.6DataRank · unranked

55906 citations

Pablo Tamayo, Vamsi K. Mootha, Sayan Mukherjee, Benjamin L. Ebert, Michael A. Gillette +6 more

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Nature Genetics(2003)10.1038/ng1180

N/A

1.4DataRank · unranked

10534 citations

Cecilia M. Lindgren, Karl-Fredrik Eriksson, Aravind Subramanian, Smita Sihag, Joseph Lehar +19 more

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

eLife(2016)10.7554/elife.10575

N/A

0.917DataRank · unranked

452 citations

Shao-En Ong, Olga Goldberger, Jun Peng, Rohit Sharma, Scott B. Vafai +11 more

Human genetic analyses of organelles highlight the nucleus in age-related trait heritability

eLife(2021)10.7554/elife.68610

N/A

0.809DataRank · unranked

26 citations

Konrad J. Karczewski, Daniel P. Howrigan, Benjamin M. Neale, Vamsi K. Mootha, Rahul Gupta

CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA

Nature Biotechnology(2022)10.1038/s41587-022-01256-8

N/A

0.803DataRank · unranked

210 citations

Anna V. Kotrys, Aditya Raguram, Tony P. Huang, Vamsi K. Mootha, David R. Liu +1 more

SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication

Nature Communications(2021)10.1038/s41467-021-21903-z

N/A

0.760DataRank · unranked

158 citations

Rui Guo, Sharon H. Kim, Hardik Shah, Shuting Zhang, Jin Hua Liang +8 more

Mitochondrial DNA variation across 56,434 individuals in gnomAD

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.07.23.453510

Top 27%

0.757DataRank

Top 27%20 citations

Nicole J. Lake, Nicholas A. Watts, Megan Shand, Andrea Haessly, Laura D. Gauthier +12 more

Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS

Molecular Cell(2021)10.1016/j.molcel.2021.02.033

N/A

0.686DataRank · unranked

96 citations

Bridget E. Begg, Eran Mick, Hardik Shah, Sarah E. Calvo, Owen S. Skinner +6 more

METTL17 is an Fe-S cluster checkpoint for mitochondrial translation

Molecular Cell(2024)10.1016/j.molcel.2023.12.016

N/A

0.598DataRank · unranked

53 citations

Yuzuru Itoh, Shayan Sadre, Jason G. McCoy, Gil Namkoong, Jordan Wengrod +7 more

ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits

Cell Metabolism(2023)10.1016/j.cmet.2023.11.010

N/A

0.564DataRank · unranked

42 citations

Byungchang Jin, Nirajan Shrestha, Andrew L. Markhard, Apekshya Panda, Sarah E. Calvo +17 more

Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism

Cell(2024)10.1016/j.cell.2023.12.010

N/A

0.529DataRank · unranked

33 citations

María Miranda, Owen S. Skinner, Presli P. Wiesenthal, S. Wellner, Alexis A. Jourdain +3 more

Discovery and molecular basis of subtype-selective cyclophilin inhibitors

Nature Chemical Biology(2022)10.1038/s41589-022-01116-1

N/A

0.524DataRank · unranked

32 citations

Aziz M. Rangwala, Manish Thakur, Patrick S. Ward, Christie Hung, Ian R Outhwaite +6 more

Multi-omics identifies large mitoribosomal subunit instability caused by pathogenic MRPL39 variants as a cause of pediatric onset mitochondrial disease

Human Molecular Genetics(2023)10.1093/hmg/ddad069

N/A

0.505DataRank · unranked

28 citations

Daniella H. Hock, Nicole J. Lake, Sarah E. Calvo, Sabine Grønborg, Emma Krzesinski +14 more

Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU

Life Science Alliance(2020)10.26508/lsa.202000718

N/A

0.497DataRank · unranked

15 citations

Andrew L. Markhard, Mert Bozbeyoglu, Forrest Bradford, Olga Goldberger, Vamsi K. Mootha +2 more

Continuous, but not intermittent, regimens of hypoxia prevent and reverse ataxia in a murine model of Friedreich’s ataxia

Human Molecular Genetics(2023)10.1093/hmg/ddad091

N/A

0.373DataRank · unranked

11 citations

Hong Wang, Eizo Marutani, Fumiaki Nagashima, Rajeev Malhotra, Fumito Ichinose +2 more

METTL17 is an Fe-S cluster checkpoint for mitochondrial translation

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.24.517765

N/A

0.373DataRank · unranked

11 citations

Yuzuru Itoh, Shayan Sadre, Jason G. McCoy, Gil Namkoong, Ivan Chicherin +6 more

Differential utilization of vitamin B12-dependent and independent pathways for propionate metabolism across human cells

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.107662

N/A

0.371DataRank · unranked

9 citations

Yuanyuan Ji, Sneha Rath, David Watkins, David S. Rosenblatt, Vamsi K. Mootha +3 more

PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics

Nature Metabolism(2024)10.1038/s42255-024-00994-0

N/A

0.292DataRank · unranked

6 citations

Jason G. McCoy, Naomi K. Ostriker, L Sandler, Carmen A. Mannella, Vamsi K. Mootha +1 more

Insulin Sensitivity and Insulin Secretion in Adults With Friedreich's Ataxia: The Role of Skeletal Muscle

The Journal of Clinical Endocrinology & Metabolism(2024)10.1210/clinem/dgae545

N/A

0.257DataRank · unranked

4 citations

Sara Nguyen, Neil Wilson, Darko Stefanovski, Rui Xiao, Theresa Scattergood +15 more

Salvage of Ribose from Uridine or RNA Supports Glycolysis when Glucose is Limiting

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.06.10.447789

N/A

0.241DataRank · unranked

4 citations

Owen S. Skinner, Akinori Kawakami, Russel P. Goodman, Hongying Shen, Lajos V. Kemény +6 more

Hypoxia ameliorates brain hyperoxia and NAD+ deficiency in a murine model of Leigh syndrome

Molecular Genetics and Metabolism(2021)10.1016/j.ymgme.2021.03.005

N/A

0DataRank · unranked

31 citations

Rohit Sharma, Hardik Shah, Bryn Reinstadler, Olga Goldberger, Marissa K. Cooper +14 more

Mitochondrial depolarization stabilizes the vitamin B12 chaperone MMADHC in the cytosol to increase MTR activity

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.64898/2025.12.31.697091

N/A

0DataRank · unranked

0 citations

Zhu Li, Arkajit Guha, Fangcong Dong, Ruma Banerjee, Vamsi K. Mootha +1 more

A natural fusion of flavodiiron, rubredoxin, and NADH:rubredoxin oxidoreductase domains is the highly efficient water-forming oxidase of T. vaginalis

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.02.02.478753

N/A

0DataRank · unranked

0 citations

Tristan A. Bell, Bazlur Rashid, Mina Heacock, Owen S. Skinner, Mohammad A. Yaseen +5 more

Nuclear genetic control of mtDNA copy number and heteroplasmy in humans

Nature(2023)10.1038/s41586-023-06426-5

N/A

0DataRank · unranked

182 citations

Masahiro Kanai, Timothy Durham, Kristin Tsuo, Jason G. McCoy, Anna V. Kotrys +7 more

Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions

Nature Metabolism(2023)10.1038/s42255-023-00774-2

N/A

0DataRank · unranked

109 citations

Joan Blanco-Fernández, Russell P. Goodman, Akinori Kawakami, Hongying Shen, Lajos V. Kemény +7 more

Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity

Journal of Clinical Investigation(2021)10.1172/jci136055

N/A

0DataRank · unranked

202 citations

Bryn Reinstadler, Kristin Engelstad, Owen S. Skinner, Erin Stackowitz, Ronald G. Haller +12 more

Fatal Perinatal Mitochondrial Cardiac Failure Caused by Recurrent De Novo Duplications in the ATAD3 Locus

Med(2020)10.1016/j.medj.2020.06.004

N/A

0DataRank · unranked

72 citations

Alison G. Compton, Yoshihito Kishita, Daniella H. Hock, AnneMarie E. Welch, Sumudu S. C. Amarasekera +40 more

Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism

Cell(2020)10.1016/j.cell.2020.03.029

N/A

0DataRank · unranked

231 citations

Sarah E. Calvo, Andrew L. Markhard, Owen S. Skinner, Tsz‐Leung To, Tslil Ast +2 more

An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance

Nature Biotechnology(2020)10.1038/s41587-019-0377-7

N/A

0DataRank · unranked

152 citations

Owen S. Skinner, Yusuke Miyazaki, Grigorij Schleifer, Eizo Marutani, Hardik Shah +8 more

Mitochondrial genome copy number variation across tissues in mice and humans

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2402291121

N/A

0DataRank · unranked

40 citations

Rahul Gupta, Ellen Todres, Hong Wang, Alexis A. Jourdain, Kristin G. Ardlie +3 more

Hepatic NADH reductive stress underlies common variation in metabolic traits

Nature(2020)10.1038/s41586-020-2337-2

N/A

0DataRank · unranked

209 citations

Andrew L. Markhard, Hardik Shah, Rohit Sharma, Owen S. Skinner, Clary B. Clish +12 more

Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation

Cell Metabolism(2024)10.1016/j.cmet.2024.07.016

N/A

0DataRank · unranked

24 citations

Brandon T. Hubbard, Mateus T. Guerra, Ali Nasiri, Ikki Sakuma, Mario Kahn +8 more

Therapeutic hypoxia for mitochondrial disease via enhancement of hemoglobin affinity and inhibition of HIF-2α

Journal of Clinical Investigation(2024)10.1172/jci185569

N/A

0DataRank · unranked

9 citations

María Miranda, Eizo Marutani, Paul Lichtenegger, Gregory R. Wojtkiewicz, Fumito Ichinose +2 more

T cell activation contributes to purifying selection against the MELAS‐associated m.3243A>G pathogenic variant in blood

Journal of Inherited Metabolic Disease(2024)10.1002/jimd.12726

N/A

0DataRank · unranked

6 citations

Shuqiang Li, Kenneth J. Livak, Amel Karaa, Catherine J. Wu, Vamsi K. Mootha +1 more

CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene

Current Biology(2024)10.1016/j.cub.2024.04.079

N/A

0DataRank · unranked

6 citations

Presli P. Wiesenthal, Vamsi K. Mootha, Gary Ruvkun, Joshua D. Meisel

Mechanism of Action and Translational Potential of ( S )-Meclizine in Preemptive Prophylaxis Against Stroke

Stroke(2024)10.1161/strokeaha.123.044397

N/A

0DataRank · unranked

2 citations

Vishal M. Gohil, Pedram Heidari, Jessica L. Seidel, Mohammad Zulkifli, Ying Wei +7 more

Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9

Research Square(2024)10.21203/rs.3.rs-4413958/v1

N/A

0DataRank · unranked

2 citations

Matthew Lim, Hardik Shah, Joao A. Paulo, Yuchen Zhang, Haopeng Yang +18 more

Hypoxia as a medicine

Science Translational Medicine(2025)10.1126/scitranslmed.adr4049

N/A

0DataRank · unranked

22 citations

Vamsi K. Mootha, Robert S. Rogers

Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease

Nature Neuroscience(2025)10.1038/s41593-025-02010-4

N/A

0DataRank · unranked

16 citations

María Miranda, Timothy Durham, Sharon H. Kim, Drèson L. Russell, Presli P. Wiesenthal +10 more

Multiomic analysis reveals a key BCAT1 role in mTOR activation by B cell receptor and TLR9

Journal of Clinical Investigation(2025)10.1172/jci186258

N/A

0DataRank · unranked

5 citations

Yizhe Sun, Matthew Lim, Hardik Shah, Joao A Paulo, R.G. Ahmed +22 more

Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency

Nature(2025)10.1038/s41586-025-09821-2

N/A

0DataRank · unranked

4 citations

Pallavi R. Joshi, Amy N. Spelbring, Hong Wang, S. Wellner, Presli P. Wiesenthal +6 more

Hydrogen sulfide–dependent activation of human sulfide quinone oxidoreductase

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110681

N/A

0DataRank · unranked

3 citations

Yashvi Shukla, David A. Hanna, Mackenzie Mackson, Tsz‐Leung To, Vamsi K. Mootha +2 more

The proton motive force maintains mtDNA euploidy by balancing mtDNA replication with cell proliferation

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.10.27.684790

N/A

0DataRank · unranked

1 citations

Vamsi K. Mootha, Sneha Rath

Combinatorial G x G x E CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transport

Research Square(2021)10.21203/rs.3.rs-955541/v1

N/A

0DataRank · unranked

1 citations

Bryn Reinstadler, Hardik Shah, Tsz‐Leung To, Katie Byrne, Luanna Summer +6 more

Human genetic analyses of organelles highlight the nucleus in age-related trait heritability

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.01.22.427431

N/A

0DataRank · unranked

1 citations

Konrad J. Karczewski, Daniel Howrigan, Benjamin M. Neale, Vamsi K. Mootha, Rahul Gupta

Combinatorial G x G x E CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transport

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.09.22.461361

N/A

0DataRank · unranked

3 citations

Bryn Reinstadler, Hardik Shah, Tsz‐Leung To, Katie Byrne, Luanna Summer +6 more

Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS

Nature Communications(2022)10.1038/s41467-022-30126-9

N/A

0DataRank · unranked

102 citations

Bryn Reinstadler, Hardik Shah, Tsz‐Leung To, Katie Byrne, Luanna Summer +6 more

A natural fusion of flavodiiron, rubredoxin, and rubredoxin oxidoreductase domains is a self-sufficient water-forming oxidase of Trichomonas vaginalis

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.102210

N/A

0DataRank · unranked

7 citations

Tristan A. Bell, Bazlur Rashid, Mina Heacock, Tarik Begic, Owen S. Skinner +6 more

Vamsi K. Mootha

Indexed papers

Top data-sharing exemplar

Papers