Stuart H. Orkin

Also affiliated with Dana-Farber/Boston Children's Cancer and Blood Disorders Center

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 1%percentile

7.9Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

A comparative encyclopedia of DNA elements in the mouse genome

Nature(2014)10.1038/nature13992

Top 2%

7.9DataRank

Top 2%1946 citations

Yong Cheng, Alessandra Breschi, Jost Vielmetter, Weisheng Wu, Tyrone Ryba +150 more

Papers

Driven by 30 papers — median percentile 98. Top paper: “A comparative encyclopedia of DNA elements in the mouse genome”.

A comparative encyclopedia of DNA elements in the mouse genome

Nature(2014)10.1038/nature13992

Top 2%

7.9DataRank

Top 2%1946 citations

Yong Cheng, Alessandra Breschi, Jost Vielmetter, Weisheng Wu, Tyrone Ryba +150 more

PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells

Cell Reports(2015)10.1016/j.celrep.2015.07.053

N/A

3.3DataRank · unranked

77 citations

David A. Hendrix, Effie Apostolou, Alice H. Buchner, Matthew C. Canver, Semir Beyaz +19 more

Congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1

Blood(2022)10.1182/blood.2021013753

N/A

1.1DataRank · unranked

30 citations

Caleb A. Lareau, Erik L. Bao, Nan Liu, Taiju Utsugisawa, Alex M. Tseng +27 more

Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis

Cell Stem Cell(2021)10.1016/j.stem.2021.08.007

N/A

0.716DataRank · unranked

117 citations

Charlie Chung, Haiwei Mou, Khristian E. Bauer-Rowe, Michael E. Xifaras, Ilgin Ergin +33 more

Role of PDGFRA+ cells and a CD55+ PDGFRALo fraction in the gastric mesenchymal niche

Nature Communications(2023)10.1038/s41467-023-43619-y

N/A

0.635DataRank · unranked

16 citations

Guodong Tie, Ermanno Malagola, Davide Seruggia, Shariq Madha, Adrianna Maglieri +9 more

Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture

Nature Communications(2021)10.1038/s41467-021-26574-4

N/A

0DataRank · unranked

47 citations

Özgün Uyan, Kai Yan, Tianxin Liu, Qian Zhu, Zuzana Tóthová +6 more

Mapping the evolving landscape of super-enhancers during cell differentiation

Genome biology(2021)10.1186/s13059-021-02485-x

N/A

0DataRank · unranked

45 citations

Bin E. Li, Ming Zhu, Grace Y. Li, Fei Chen, Yingli Han +6 more

Molecular Medicine: Found in Translation

Med(2021)10.1016/j.medj.2020.12.011

N/A

0DataRank · unranked

33 citations

Stuart H. Orkin

A unified model of human hemoglobin switching through single-cell genome editing

Nature Communications(2021)10.1038/s41467-021-25298-9

N/A

0DataRank · unranked

33 citations

Jeffrey M. Verboon, Yuannyu Zhang, Nan Liu, Yoon Jung Kim, Samantha Marglous +9 more

Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

Nature Communications(2021)10.1038/s41467-021-24158-w

N/A

0DataRank · unranked

17 citations

Adam E. Handel, Hong Ying Teh, Rushika C. Wirasinha, Katrin Hafen, Saulius Žuklys +6 more

Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells

Cell chemical biology(2022)10.1016/j.chembiol.2022.06.007

N/A

0DataRank · unranked

45 citations

Altantsetseg Buyanbat, Kai Yan, Ozge Karayel, Seth Goldman, Davide Seruggia +12 more

Transcriptional Plasticity Drives Leukemia Immune Escape

Blood Cancer Discovery(2022)10.1158/2643-3230.bcd-21-0207

N/A

0DataRank · unranked

22 citations

Taku Harada, Jérémie Kalfon, Monika W. Perez, Yaser Heshmati, Jazmin Ewers +10 more

A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia

Genes & Development(2022)10.1101/gad.349284.121

N/A

0DataRank · unranked

29 citations

Yaser Heshmati, Jérémie Kalfon, Monika W. Perez, Juliana Xavier Ferrucio, Jazmin Ewers +24 more

Integrated genomic analysis of AgRP neurons reveals that IRF3 regulates leptin’s hunger-suppressing effects

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.03.474708

N/A

0DataRank · unranked

2 citations

Nan Liu, Christopher Jacobs, Rachael Ivison, Natalia Machado, Aykut Göktürk Üner +8 more

A cell-permeant nanobody-based degrader that induces fetal hemoglobin

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.07.495197

N/A

0DataRank · unranked

2 citations

Zheng Ge, Mekedlawit Setegne, Karin Tenglin, Manizheh Izada, Henry Xie +4 more

Haig H. Kazazian, Jr. (1937–2022)

Genome Research(2022)10.1101/gr.276712.122

N/A

0DataRank · unranked

0 citations

Stuart H. Orkin, Stylianos E. Antonarakis

Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis

Nature Genetics(2023)10.1038/s41588-023-01424-9

N/A

0DataRank · unranked

37 citations

Silvio Alessandro Di Gioia, Bryn D. Webb, Wai‐Man Chan, Elke de Boer, Sarah J. Garnai +53 more

Evolution of nanobodies specific for BCL11A

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2218959120

N/A

0DataRank · unranked

31 citations

Manizheh Izadi, Karin Tenglin, Thibault Viennet, Liting Zhai, Zheng Ge +4 more

Identifying quantitatively differential chromosomal compartmentalization changes and their biological significance from Hi-C data using DARIC

BMC Genomics(2023)10.1186/s12864-023-09675-w

N/A

0DataRank · unranked

4 citations

Nan Liu, Stuart H. Orkin, Guo‐Cheng Yuan, Kai Yan

Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.13.532438

N/A

0DataRank · unranked

7 citations

Jérémie Kalfon, Monika W. Perez, Kenneth Eagle, Flora Dievenich Braes, Rashad Batley +15 more

Rapid-kinetics degron benchmarking reveals off-target activities and mixed agonism-antagonism of MYB inhibitors

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.07.536032

N/A

0DataRank · unranked

5 citations

Monika W. Perez, Jérémie Kalfon, Flora Dievenich Braes, Rashad Batley, Kenneth Eagle +9 more

Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells

Cell stem cell(2024)10.1016/j.stem.2024.11.001

N/A

0DataRank · unranked

26 citations

My Anh Nguyen, Pengpeng Liu, Lucas Ferreira da Silva, Sébastien Lévesque, Linda Yingqi Lin +28 more

Redirecting E3 ubiquitin ligases for targeted protein degradation with heterologous recognition domains

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.108077

N/A

0DataRank · unranked

10 citations

Ge Zheng, Grace Y. Li, Alia Alshaye, Stuart H. Orkin, Huan Yang

Structural insights into the DNA-binding mechanism of BCL11A: The integral role of ZnF6

Structure(2024)10.1016/j.str.2024.09.022

N/A

0DataRank · unranked

6 citations

Maolu Yin, Abhilash Jayaraj, Woojin Kim, Zhenyu Sun, Yuko Fujiwara +7 more

Structural Insights into the DNA-Binding Mechanism of BCL11A: The Integral Role of ZnF6

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.01.17.576058

N/A

0DataRank · unranked

0 citations

Maolu Yin, Abhilash Jayaraj, Woojin Kim, Zhenyu Sun, Yuko Fujiwara +7 more

Silencing of BCL11A by disrupting enhancer-dependent epigenetic insulation

Blood(2025)10.1182/blood.2025030211

N/A

0DataRank · unranked

3 citations

Juan Wang, Ruopeng Feng, Kseniia Dudnyk, Yoon Jung Kim, Jun Yi Stanley Lim +10 more

Dietary suppression of MHC-II expression in intestinal stem cells enhances intestinal tumorigenesis

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.09.05.284174

N/A

0DataRank · unranked

0 citations

Jatin Roper, Khristian E. Bauer-Rowe, Michael E. Xifaras, Ilgin Ergin, Lenka Dohnalova +29 more

Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation

Nature Genetics(2020)10.1038/s41588-019-0568-7

N/A

0DataRank · unranked

107 citations

Mathias Munschauer, Caleb A. Lareau, Kara E. Montbleau, Jacob C. Ulirsch, Christina R. Hartigan +16 more

Multiplexed capture of spatial configuration and temporal dynamics of locus-specific 3D chromatin by biotinylated dCas9

Genome biology(2020)10.1186/s13059-020-01973-w

N/A

0DataRank · unranked

56 citations

Yong Chen, Yuannyu Zhang, Yuxuan Liu, Nan Liu, Giovanni A. Botten +5 more

Reactivation of a developmentally silenced embryonic globin gene

Nature Communications(2021)10.1038/s41467-021-24402-3

N/A

0DataRank · unranked

51 citations

Duantida Songdej, Damien J. Downes, Robert A. Beagrie, Siyu Liu, Megan Buckley +21 more

Stuart H. Orkin

Indexed papers

Top data-sharing exemplar

Papers