Lei Guo

Also affiliated with The University of Texas Southwestern Medical Center

Pharmacology, Toxicology and PharmaceuticsBiochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 26 papers. Top paper: “FREMSA: A Method That Provides Direct Evidence of the Interaction between microRNA and mRNA”.

FREMSA: A Method That Provides Direct Evidence of the Interaction between microRNA and mRNA

Methods in molecular biology(2020)10.1007/978-1-0716-0223-2_30

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18 citations

Si Chen, Dongying Li, Bridgett Knox, Lei Guo, Baitang Ning +1 more

Identification of Translational microRNA Biomarker Candidates for Ketoconazole-Induced Liver Injury Using Next-Generation Sequencing

Toxicological Sciences(2020)10.1093/toxsci/kfaa162

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15 citations

Bridgett Knox, Binsheng Gong, Si Chen, Lei Guo, Zhichao Liu +3 more

Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells

Archives of Toxicology(2020)10.1007/s00204-020-02706-5

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23 citations

Weida Tong, Bridgett Knox, Si Chen, William H. Tolleson, Fang Liu +5 more

Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines

Food and Chemical Toxicology(2020)10.1016/j.fct.2020.111662

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20 citations

Xiaobo He, Si Chen, Xiaoqing Guo, Matthew Bryant, Lei Guo +5 more

A mechanism of perhexiline's cytotoxicity in hepatic cells involves endoplasmic reticulum stress and p38 signaling pathway

Chemico-Biological Interactions(2020)10.1016/j.cbi.2020.109353

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17 citations

Si Chen, Sery Pak, Lei Guo, Zhen Ren

The role of hepatic cytochrome P450s in the cytotoxicity of sertraline

Archives of Toxicology(2020)10.1007/s00204-020-02753-y

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33 citations

Qiangen Wu, Xilin Li, Dongying Li, Michelle Fan, Zhen Ren +5 more

Development and Application of TK6-derived Cells Expressing Human Cytochrome P450s for Genotoxicity Testing

Toxicological Sciences(2020)10.1093/toxsci/kfaa035

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29 citations

Si Chen, Xiaoqing Guo, Qiangen Wu, Ji‐Eun Seo, Lei Guo +5 more

Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline

Toxicology in Vitro(2020)10.1016/j.tiv.2020.104987

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25 citations

Si Chen, Ji‐Eun Seo, Xiaoqing Guo, Dongying Li, Baitang Ning +2 more

Methods for Establishing and Using a Stable Cell Line Expressing Both Gaussia Luciferase and Firefly Luciferase to Screen for Endoplasmic Reticulum Stress

Methods in molecular biology(2020)10.1007/978-1-0716-0223-2_29

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4 citations

Si Chen, Lei Guo, Zhen Ren

Using a Lentivirus-Based Inducible RNAi Vector to Silence a Gene

Methods in molecular biology(2020)10.1007/978-1-0716-0223-2_10

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3 citations

Dongying Li, Zhen Ren, Dianke Yu, Baitang Ning, Nan Mei +2 more

The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells

Toxicology Letters(2021)10.1016/j.toxlet.2021.03.006

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49 citations

Xiaobo He, Si Chen, Yuan Le, Matthew Bryant, Lei Guo +3 more

Roles of CYP3A4, CYP3A5 and CYP2C8 drug-metabolizing enzymes in cellular cytostatic resistance

Chemico-Biological Interactions(2021)10.1016/j.cbi.2021.109448

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43 citations

Dimitrios Vagiannis, Si Chen, Lei Guo, Jakub Hofman

Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity

Journal of Environmental Science and Health Part C(2021)10.1080/26896583.2021.1880242

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42 citations

Qiangen Wu, Xilin Li, Dongying Li, Nan Mei, Baitang Ning +5 more

In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells

Food and Chemical Toxicology(2021)10.1016/j.fct.2021.112722

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33 citations

Qiangen Wu, Xilin Li, Linda S. Von Tungeln, Frederick A. Beland, Dayton M. Petibone +5 more

Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells

Toxicological Sciences(2022)10.1093/toxsci/kfac131

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27 citations

Xilin Li, Patrick Cournoyer, Supratim Choudhuri, Xiaozhong Yu, Lei Guo +2 more

The expression of Phase II drug-metabolizing enzymes in human B-lymphoblastoid TK6 cells

Journal of Environmental Science and Health Part C(2022)10.1080/26896583.2022.2044242

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5 citations

Yuxi Li, Kylie Ning, Si Chen, Lei Guo, Jessica A. Bonzo +2 more

Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells

Archives of Toxicology(2023)10.1007/s00204-023-03609-x

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17 citations

Xilin Li, Patrick Cournoyer, Supratim Choudhuri, Lei Guo, Si Chen +1 more

Metabolism and liver toxicity of cannabidiol

Journal of Environmental Science and Health Part C(2024)10.1080/26896583.2024.2366741

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20 citations

Yuxi Li, Xilin Li, Qiangen Wu, Montserrat Puig, Frederic Moulin +3 more

Investigation of cannabidiol-induced cytotoxicity in human hepatic cells

Toxicology(2024)10.1016/j.tox.2024.153884

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12 citations

Xilin Li, Qiangen Wu, Yuxi Li, Montserrat Puig, Frederic Moulin +4 more

Hepatotoxicity of usnic acid and underlying mechanisms

Journal of Environmental Science and Health Part C(2024)10.1080/26896583.2024.2366737

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7 citations

Zhen Ren, Lei Guo, Si Chen

Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells

Toxicology Letters(2024)10.1016/j.toxlet.2024.01.012

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2 citations

Yuan Le, Yuxi Li, Si Chen, Lei Guo, Xin Fu +3 more

Mechanistic study of pexidartinib-induced toxicity in human hepatic cells

Chemico-Biological Interactions(2025)10.1016/j.cbi.2025.111641

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4 citations

Yuxi Li, Xilin Li, Nan Mei, Xiaobo He, Matthew Bryant +4 more

Potential anticancer effects and toxicity of flavones luteolin and apigenin in vivo

Journal of Environmental Science and Health Part C(2025)10.1080/26896583.2025.2527437

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2 citations

Yuxi Li, Si Chen, Lei Guo, Nan Mei, Xilin Li

Characterizing the metabolites of the tyrosine-kinase inhibitor pexidartinib in mouse feces, urine, plasma, and liver

Journal of Pharmaceutical and Biomedical Analysis(2025)10.1016/j.jpba.2025.117034

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1 citations

Si Chen, John M. Hakenjos, Jian Wang, Lei Guo, Ashish Dogra +4 more

Comparing the cannabidiol-induced transcriptomic profiles in human and mouse Sertoli cells

Toxicology(2025)10.1016/j.tox.2025.154068

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2 citations

Xilin Li, Patrick Cournoyer, Supratim Choudhuri, Lei Guo, Si Chen +1 more

7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells

Archives of Toxicology(2025)10.1007/s00204-025-04001-7

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1 citations

Xilin Li, Qiangen Wu, Montserrat Puig, Frederic Moulin, Supratim Choudhuri +4 more