Keli Agama

Also affiliated with Center for Cancer Research

Biochemistry, Genetics and Molecular BiologyPharmacology, Toxicology and PharmaceuticsChemistry

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 16 papers. Top paper: “DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks”.

DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks

Cell Reports(2020)10.1016/j.celrep.2020.108569

N/A

0DataRank · unranked

55 citations

Yilun Sun, Shar-yin N. Huang, Simone A. Baechler, Lőrinc Sándor Pongor, Keli Agama +5 more

Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.1920165117

N/A

0DataRank · unranked

32 citations

Mitsuo Wakasugi, Salma Akter, Rajendra Prasad, Samuel H. Wilson, Naoto Shimizu +11 more

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

Nature Communications(2021)10.1038/s41467-021-25252-9

N/A

0DataRank · unranked

75 citations

Jiji Chen, Shar-yin N. Huang, Yijun Su, Wenjie Wang, Keli Agama +5 more

Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity

European Journal of Medicinal Chemistry(2021)10.1016/j.ejmech.2021.113261

N/A

0DataRank · unranked

57 citations

Wagdy M. Eldehna, Wenjie Wang, Keli Agama, Yves Pommier, Manabu Abe +1 more

2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights

Journal of Enzyme Inhibition and Medicinal Chemistry(2021)10.1080/14756366.2021.2015344

N/A

0DataRank · unranked

41 citations

Wagdy M. Eldehna, Amer Ali Abd El‐Hafeez, Warda R. Somaa, Amgad Albohy, Sara T. Al‐Rashood +6 more

Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00318

N/A

0DataRank · unranked

28 citations

Wen-Lin Tang, Yu Zhang, Hao Yang, Wenjie Wang, Keli Agama +3 more

Design and synthesis of C-aryl angular luotonins via a one-pot aza-Nazarov–Friedlander sequence and their Topo-I inhibition studies along with C-aryl vasicinones and luotonins

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.127998

N/A

0DataRank · unranked

13 citations

Vamshikrishna Reddy Sammeta, Zachary F. Murphy, James A. Golen, Keli Agama, Yves Pommier +2 more

The synthesis of furoquinolinedione and isoxazoloquinolinedione derivatives as selective Tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors

Bioorganic Chemistry(2021)10.1016/j.bioorg.2021.104881

N/A

0DataRank · unranked

11 citations

Xiaoqing Zhu, Wenjie Wang, Yu Chen, Zhu Hu, Yu Zhang +6 more

Resolution of R-loops by topoisomerase III-β (TOP3B) in coordination with the DEAD-box helicase DDX5

Cell Reports(2022)10.1016/j.celrep.2022.111067

N/A

0DataRank · unranked

72 citations

Xi Yang, Shar-yin N. Huang, Keli Agama, Simone A. Baechler, Yilun Sun +7 more

TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor

Molecular Cancer Therapeutics(2022)10.1158/1535-7163.mct-21-1000

N/A

0DataRank · unranked

55 citations

Yasuhisa Murai, Keli Agama, Yilun Sun, Liton Kumar Saha, Xi Yang +11 more

Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states

Nature Communications(2022)10.1038/s41467-021-27686-7

N/A

0DataRank · unranked

30 citations

Danièle Gadelle, Keli Agama, Evgeny Kiselev, Hongliang Zhang, Emilie Yab +5 more

Synthesis of 11-aminoalkoxy substituted benzophenanthridine derivatives as tyrosyl-DNA phosphodiesterase 1 inhibitors and their anticancer activity

Bioorganic Chemistry(2022)10.1016/j.bioorg.2022.105789

N/A

0DataRank · unranked

11 citations

Fang‐Ting Wang, Min Wu, Wenjie Wang, Keli Agama, Yves Pommier +2 more

Synthesis and Biological Activities of 11‐ and 12‐Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB and Tyrosyl‐DNA Phosphodiesterase 1 Inhibitors

ChemMedChem(2023)10.1002/cmdc.202200593

N/A

0DataRank · unranked

10 citations

Chao Qin, Min Wu, Fang‐Ting Wang, Wenjie Wang, Keli Agama +4 more

Targeted sulfur(VI) fluoride exchange-mediated covalent modification of a tyrosine residue in the catalytic pocket of tyrosyl-DNA phosphodiesterase 1

Communications Chemistry(2024)10.1038/s42004-024-01298-w

N/A

0DataRank · unranked

7 citations

I Barakat, G.T. Lountos, Wenjie Wang, Keli Agama, Md Rasel Al Mahmud +5 more

Application of a bivalent “click” approach to target tyrosyl-DNA phosphodiesterase 1 (TDP1)

RSC Medicinal Chemistry(2025)10.1039/d4md00824c

N/A

0DataRank · unranked

4 citations

Wenjie Wang, Md Rasel Al Mahmud, Keli Agama, Yves Pommier, Terrence R. Burke +1 more

Potent β-lactam-based tyrosyl-DNA phosphodiesterase 1 inhibitors identified by a virtual screen

Scientific Reports(2025)10.1038/s41598-025-12503-8

N/A

0DataRank · unranked

1 citations

Wenjie Wang, Kiall F. Suazo, Md Rasel Al Mahmud, Keli Agama, G.T. Lountos +4 more