David R. Sibley

Also affiliated with National Institute of Neurological Disorders and Stroke

Biochemistry, Genetics and Molecular BiologyNeuroscience

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 25 papers. Top paper: “A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity”.

A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity

Science Signaling(2020)10.1126/scisignal.aaw5885

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47 citations

Ravi Kumar Verma, Blair K. A. Willette, Elizabeth C. Gonye, Annah M. Moore, Amy E. Moritz +6 more

Evidence for a Stereoselective Mechanism for Bitopic Activity by Extended-Length Antagonists of the D3 Dopamine Receptor

ACS Chemical Neuroscience(2020)10.1021/acschemneuro.0c00425

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15 citations

Alessandro Bonifazi, Adrian M. Guerrero, Vivek Kumar, R. Benjamin Free, J. Robert Lane +5 more

Ligand with Two Modes of Interaction with the Dopamine D2 Receptor–An Induced-Fit Mechanism of Insurmountable Antagonism

ACS Chemical Neuroscience(2020)10.1021/acschemneuro.0c00477

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13 citations

Hugo Zeberg, Tomasz Maciej Stępniewski, R. Benjamin Free, Sean W. Reilly, Robert R. Luedtke +8 more

Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c00424

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25 citations

R. Benjamin Free, Warren S. Weiner, Emmanuel Akano, Disha M. Gandhi, Ara M. Abramyan +10 more

Development of pyrimidone D1 dopamine receptor positive allosteric modulators

Bioorganic & Medicinal Chemistry Letters(2020)10.1016/j.bmcl.2020.127696

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8 citations

Prashi Jain, R. Benjamin Free, Jennie Conroy, Jeffrey Aubé, David R. Sibley +2 more

Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability

Molecular Psychiatry(2021)10.1038/s41380-021-01093-2

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266 citations

Sherry Lam, Meghan L. Carlton, Matthew A. Boehm, Juan L. Gomez, Óscar Solís +9 more

Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors

Translational Psychiatry(2021)10.1038/s41398-020-01171-z

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94 citations

Suzanne Bertera, Marta Sánchez‐Soto, R. Benjamin Free, Jeongkyung Lee, Wei Zong +11 more

Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor

Molecular Pharmacology(2021)10.1124/molpharm.121.000336

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40 citations

Caroline A. Cuoco, Bing Xie, Yoon Namkung, Varun V. Prabhu, Blair K. A. Willette +8 more

Dopamine D5 receptor-mediated decreases in mitochondrial reactive oxygen species production are cAMP and autophagy dependent

Hypertension Research(2021)10.1038/s41440-021-00646-w

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23 citations

Xiaoliang Jiang, Imran Perwaiz, Peiying Yu, Jin Wang, Ying Wang +10 more

Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential

Signal Transduction and Targeted Therapy(2021)10.1038/s41392-021-00630-3

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14 citations

Kathryn D. Luderman, R. Benjamin Free, Lei Shi, David R. Sibley

Target deconvolution studies of (2R,6R)-hydroxynorketamine: an elusive search

Molecular Psychiatry(2022)10.1038/s41380-022-01673-w

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45 citations

Juan L. Gomez, Meghan L. Carlton, Sherry Lam, Marta Sánchez‐Soto, Patrick J. Morris +9 more

Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine

iScience(2022)10.1016/j.isci.2022.104771

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20 citations

Suzanne Bertera, Laura Friggeri, Marta Sánchez‐Soto, Jeongkyung Lee, Xiangning Xue +10 more

Time will tell. Reply to “Comments to pharmacological and behavioral divergence of ketamine enantiomers by Jordi Bonaventura et al.” by Chen et al.

Molecular Psychiatry(2022)10.1038/s41380-022-01480-3

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6 citations

Sherry Lam, Meghan L. Carlton, Matthew A. Boehm, Juan L. Gomez, Óscar Solís +9 more

Identification and Characterization of ML321: A Novel and Highly Selective D 2 Dopamine Receptor Antagonist with Efficacy in Animal Models That Predict Atypical Antipsychotic Activity

ACS Pharmacology & Translational Science(2022)10.1021/acsptsci.2c00202

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5 citations

Ashley N. Nilson, Noelia Boldizsar, Trevor Doyle, Ramona M. Rodriguiz, Vladimir M. Pogorelov +14 more

Novel Dopamine D4 Receptor‐Selective Antagonists For Neuropsychiatric Disorders

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.r5298

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0 citations

Shreya Kelshikar, Nisha K. Shah, Connor McBride, Moises Ximello Sanchez, Diandra Panasis +11 more

Identification and Characterization of ML321: a Novel and Highly Selective D 2 Dopamine Receptor Antagonist with Efficacy in Animal Models that Predict Atypical Antipsychotic Activity

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.14.516475

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0 citations

Ashley N. Nilson, Noelia Boldizsar, Trevor Doyle, Ramona M. Rodriguiz, Vladimir M. Pogorelov +14 more

G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D2 Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation

Biomolecules(2023)10.3390/biom13101552

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14 citations

Noelia Boldizsar, Kayla A. Schardien, Nora S. Madaras, Blair K. A. Willette, Laura R. Inbody +8 more

Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c00734

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10 citations

Ashley N. Nilson, Rebekah Placide, Mimi L. Pham, Franziska M. Jakobs, Noelia Boldizsar +30 more

Dopamine receptor divergence revealed using a common ligand

Trends in Pharmacological Sciences(2023)10.1016/j.tips.2023.08.002

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3 citations

Ashley N. Nilson, Amy E. Moritz, Lei Shi, David R. Sibley

Delineation of G Protein-Coupled Receptor Kinase Phosphorylation Sites within the D1 Dopamine Receptor and Their Roles in Modulating β-Arrestin Binding and Activation

International Journal of Molecular Sciences(2023)10.3390/ijms24076599

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8 citations

Nora S. Madaras, Michele L. Rankin, Laura R. Inbody, David R. Sibley, Amy E. Moritz

Bioisosteric Replacement of Amides Linkers with 1, 2, 3-Triazoles for Improved Pharmacokinetics Without Losing Dopamine D4 Receptor Potency or Selectivity

Journal of Pharmacology and Experimental Therapeutics(2023)10.1124/jpet.122.261980

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0 citations

Mohammad Alkhatib, Julianna Saez, J. B. Hanson, Ashley N. Nilson, Franziska M. Jacobs +10 more

Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors

Nature Neuroscience(2024)10.1038/s41593-024-01819-9

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21 citations

Miguel Arenivar, Héctor E. Yarur, Chloe Noh, Rodolfo J. Flores, Tenley Weil +13 more

Bioisosteric Replacement of Amides with 1,2,3-Triazoles Improves Dopamine D4 Receptor Ligand Pharmacokinetics

ChemRxiv(2024)10.26434/chemrxiv-2024-0z6jk

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0 citations

Franziska M. Jacobs, John Hanson, Ashley N. Nilson, Li Tian, Afua B. Faibille +19 more

Discovery, Characterization, and Optimization of a Novel Positive Allosteric Modulator-Antagonist of the D3 Dopamine Receptor

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c01585

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1 citations

Feijun Wang, Nora S. Madaras, Amber M. Kelley, Kirsten K. Snyder, Disha M. Gandhi +8 more

Bioisosteric Replacement of Amides with 1,2,3-Triazoles Improves Dopamine D4 Receptor Ligand Pharmacokinetics

ChemRxiv(2025)10.26434/chemrxiv-2024-0z6jk-v2

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1 citations

Franziska M. Jacobs, John Hanson, Ashley N. Nilson, Amy E. Moritz, Tian Li +20 more