Douglas R. Spitz

Also affiliated with University of Iowa Hospitals and Clinics, University of Iowa Health Care

NursingBiochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 48 papers. Top paper: “Magnetic Resonance Imaging of Iron Metabolism with T2* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM”.

Magnetic Resonance Imaging of Iron Metabolism with T2* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM

Clinical Cancer Research(2023)10.1158/1078-0432.ccr-22-3952

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0.857DataRank · unranked

26 citations

Varun Monga, Kellie L. Bodeker, Michael Kwofie, Chu‐Yu Lee, Kranti A. Mapuskar +23 more

Glutaminase Inhibitors Induce Thiol-Mediated Oxidative Stress and Radiosensitization in Treatment-Resistant Cervical Cancers

Molecular Cancer Therapeutics(2020)10.1158/1535-7163.mct-20-0271

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0DataRank · unranked

47 citations

Kay Jayachandran, Jin Zhang, Vishnu Menon, Naoshad Muhammad, Michael C. Zahner +12 more

Triphenylphosphonium derivatives disrupt metabolism and inhibit melanoma growth in vivo when delivered via a thermosensitive hydrogel

PLoS ONE(2020)10.1371/journal.pone.0244540

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0DataRank · unranked

14 citations

Alora S. Kraus, Devin K. Hedlund, Colette Gnade, Brett A. Wagner, Michael L. McCormick +9 more

Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents

Cancers(2020)10.3390/cancers12082258

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0DataRank · unranked

25 citations

M.M. Hasibuzzaman, Samuel N. Rodman, Jessica E. Goetz, Kranti A. Mapuskar, Michael S. Petronek +9 more

Magnetic resonance imaging (MRI) of pharmacological ascorbate-induced iron redox state as a biomarker in subjects undergoing radio-chemotherapy

Redox Biology(2020)10.1016/j.redox.2020.101804

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0DataRank · unranked

20 citations

Michael S. Petronek, Kellie L. Bodeker, Sandy Vollstedt, Heather A. Brown, Emyleigh Opat +19 more

Combination Therapy with Radiation and PARP Inhibition Enhances Responsiveness to Anti-PD-1 Therapy in Colorectal Tumor Models

International Journal of Radiation Oncology*Biology*Physics(2020)10.1016/j.ijrobp.2020.01.030

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0DataRank · unranked

46 citations

M.M. Hasibuzzaman, Vivan Pham, Michael S. Petronek, Cameron M. Callaghan, Amanda L. Kalen +6 more

Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper

Free Radical Biology and Medicine(2020)10.1016/j.freeradbiomed.2020.01.186

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0DataRank · unranked

43 citations

Aimee L. Butler, Kai Gui, Michael Anderson, Mengshi Li, Jeffrey M. Stolwijk +14 more

Dual Oxidase-Induced Sustained Generation of Hydrogen Peroxide Contributes to Pharmacologic Ascorbate-Induced Cytotoxicity

Cancer Research(2020)10.1158/0008-5472.can-19-3094

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0DataRank · unranked

36 citations

Brianne R. O’Leary, Juan Du, Ehab H. Sarsour, Amanda L. Kalen, Brett A. Wagner +9 more

Iron–Sulfur Cluster Biogenesis as a Critical Target in Cancer

Antioxidants(2021)10.3390/antiox10091458

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0DataRank · unranked

44 citations

Douglas R. Spitz, Bryan G. Allen, Michael S. Petronek

Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy

Redox Biology(2021)10.1016/j.redox.2021.101864

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0DataRank · unranked

34 citations

Jeffrey M. Stolwijk, S. Murray, Emily J. Steinbach, Yousef Zakharia, Garry R. Buettner +3 more

Detection of pro angiogenic and inflammatory biomarkers in patients with CKD

Scientific Reports(2021)10.1038/s41598-021-87710-0

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0DataRank · unranked

28 citations

Bridget Sanford, Brandon Renner, Patrick Ten Eyck, Jennifer Laskowski, James Cooper +8 more

Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy

International Journal of Molecular Sciences(2021)10.3390/ijms221910880

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0DataRank · unranked

21 citations

Michael S. Petronek, Jeffrey M. Stolwijk, Kranti A. Mapuskar, Amanda L. Kalen, Garry R. Buettner +5 more

Quantum chemical insight into the effects of the local electron environment on T2*-based MRI

Scientific Reports(2021)10.1038/s41598-021-00305-7

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10 citations

Joël St‐Aubin, Chu‐Yu Lee, Douglas R. Spitz, Edward G. Gillan, Bryan G. Allen +2 more

The Effects of Benoxacor on the Liver and Gut Microbiome of C57BL/6 Mice

Toxicological Sciences(2021)10.1093/toxsci/kfab142

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0DataRank · unranked

7 citations

Nicole Cady, Chunyun Zhang, Rachel L. Shrode, Michael L. McCormick, Douglas R. Spitz +5 more

Sex Differences in Brain Tumor Glutamine Metabolism Reveal Sex-Specific Vulnerabilities to Treatment

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.09.29.461531

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0DataRank · unranked

9 citations

Jill K. Jones, Cheryl Frankfater, Shanshan Zhang, Olivia Tung, Kevin Cho +16 more

Reply to Petersen et al.: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes

American Journal of Physiology-Endocrinology and Metabolism(2021)10.1152/ajpendo.00119.2021

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0DataRank · unranked

1 citations

Sunny C. Huang, Charles Searby, Benjamin Cassaidy, Michael Miller, Wojciech J. Grzesik +27 more

RETRACTED: Inhibition of CaMKII in mitochondria preserves endothelial barrier function after irradiation

Free Radical Biology and Medicine(2021)10.1016/j.freeradbiomed.2021.09.011

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0DataRank · unranked

0 citations

Olha M. Koval, Sara C. Sebag, Karima Ait‐Aissa, Bryan G. Allen, Douglas R. Spitz +2 more

Elucidating the neurological mechanism of the FLASH effect in juvenile mice exposed to hypofractionated radiotherapy

Neuro-Oncology(2022)10.1093/neuonc/noac248

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0DataRank · unranked

67 citations

Yasaman Alaghband, Enikö A. Kramár, Ning Ru, Benoît Petit, Veljko Grilj +11 more

Sex differences in brain tumor glutamine metabolism reveal sex-specific vulnerabilities to treatment

Med(2022)10.1016/j.medj.2022.08.005

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0DataRank · unranked

48 citations

Jill K. Jones, Cheryl Frankfater, Shanshan Zhang, Olivia Tung, Kevin Cho +16 more

Pharmacological ascorbate improves the response to platinum-based chemotherapy in advanced stage non-small cell lung cancer

Redox Biology(2022)10.1016/j.redox.2022.102318

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0DataRank · unranked

47 citations

Taher Abu Hejleh, Laura Stephens, Stacey M. Hartwig, Sarah L. Mott, Casey Pulliam +22 more

Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging

Arteriosclerosis Thrombosis and Vascular Biology(2022)10.1161/atvbaha.121.317735

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0DataRank · unranked

33 citations

Alicia S. Eustes, Azaj Ahmed, Melissa Jensen, Mitali V. Solanki, Jagadish Swamy +8 more

Pharmacological ascorbate as a novel therapeutic strategy to enhance cancer immunotherapy

Frontiers in Immunology(2022)10.3389/fimmu.2022.989000

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0DataRank · unranked

19 citations

Laura Stephens, Ann M. Miller, Stacey M. Hartwig, Jeffrey M. Stolwijk, Michael S. Petronek +10 more

Oxidative stress and impaired insulin secretion in cystic fibrosis pig pancreas

Advances in Redox Research(2022)10.1016/j.arres.2022.100040

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0DataRank · unranked

18 citations

Mitchell C. Coleman, Xingshen Sun, Junying Lei, Jianrong Yao, Casey Pulliam +9 more

Oxidation of ferumoxytol by ionizing radiation releases iron. An electron paramagnetic resonance study

Journal of Radiation Research(2022)10.1093/jrr/rrac008

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0DataRank · unranked

11 citations

Douglas R. Spitz, Garry R. Buettner, Bryan G. Allen, Michael S. Petronek

Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury

Antioxidants(2023)10.3390/antiox12091728

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34 citations

Casey Pulliam, Diana Zepeda‐Orozco, Benjamin R. Griffin, Muhammad Furqan, Douglas R. Spitz +2 more

Avasopasem manganese (GC4419) protects against cisplatin-induced chronic kidney disease: An exploratory analysis of renal metrics from a randomized phase 2b clinical trial in head and neck cancer patients

Redox Biology(2023)10.1016/j.redox.2022.102599

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0DataRank · unranked

17 citations

G Vasquez Martinez, Casey Pulliam, Michael S. Petronek, Emily J. Steinbach, Varun Monga +20 more

Magnetite nanoparticles as a kinetically favorable source of iron to enhance GBM response to chemoradiosensitization with pharmacological ascorbate

Redox Biology(2023)10.1016/j.redox.2023.102651

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0DataRank · unranked

17 citations

Nahom Teferi, Joseph M. Caster, Jeffrey M. Stolwijk, Amira Zaher, John M. Buatti +10 more

Depletion of Labile Iron Induces Replication Stress and Enhances Responses to Chemoradiation in Non-Small-Cell Lung Cancer

Antioxidants(2023)10.3390/antiox12112005

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0DataRank · unranked

16 citations

Mekhla Singhania, Melissa A. Fath, Charles Searby, Jeffrey M. Stolwijk, John B. Henrich +12 more

Tubular mitochondrial pyruvate carrier disruption elicits redox adaptations that protect from acute kidney injury

Molecular Metabolism(2023)10.1016/j.molmet.2023.101849

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0DataRank · unranked

9 citations

Gabriela Vásquez Martínez, Gabriel Mayoral Andrade, Hsiang Wen, JY Kim, Aaron Simoni +13 more

Differential H2O2 Metabolism among Glioblastoma Subtypes Confers Variable Responses to Pharmacological Ascorbate Therapy Combined with Chemoradiation

International Journal of Molecular Sciences(2023)10.3390/ijms242417158

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0DataRank · unranked

8 citations

Kranti A. Mapuskar, Jann N. Sarkaria, Douglas R. Spitz, Michael S. Petronek, Bryan G. Allen +1 more

Chemokine Receptor CXCR4 Radioligand Targeted Therapy Using 177Lutetium-pentixather for Pulmonary Neuroendocrine Cancers

Radiation Research(2023)10.1667/rade-23-00064.1

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0DataRank · unranked

10 citations

Dijie Liu, Jordan T. Ewald, Claudia Robles-Planells, Ann Tomanek‐Chalkley, Stephen A. Graves +8 more

Evaluating the iron chelator function of sirtinol in non-small cell lung cancer

Frontiers in Oncology(2023)10.3389/fonc.2023.1185715

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9 citations

Khaliunaa Bayanbold, Koffi Amegble, Ann Tomanek‐Chalkley, Bryan G. Allen, Douglas R. Spitz +2 more

Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.01.31.526492

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0DataRank · unranked

3 citations

Gabriela Vásquez Martínez, Gabriel Mayoral Andrade, Hsiang Wen, JY Kim, Aaron Simoni +12 more

Data from Enhancement of Carboplatin-Mediated Lung Cancer Cell Killing by Simultaneous Disruption of Glutathione and Thioredoxin Metabolism

(2023)10.1158/1078-0432.c.6519573

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0DataRank · unranked

0 citations

Iman M. Ahmad, Carmen J. Smith, Jacquelyn Spence, Douglas R. Spitz, Melissa A. Fath

Data from Enhancement of Carboplatin-Mediated Lung Cancer Cell Killing by Simultaneous Disruption of Glutathione and Thioredoxin Metabolism

(2023)10.1158/1078-0432.c.6519573.v1

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0 citations

Iman M. Ahmad, Carmen J. Smith, Jacquelyn Spence, Douglas R. Spitz, Melissa A. Fath

FLASH: New intersection of physics, chemistry, biology, and cancer medicine

Reviews of Modern Physics(2024)10.1103/revmodphys.96.035002

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0DataRank · unranked

41 citations

Billy W. Loo, Sami Tantawi, Peter G. Maxim, Douglas R. Spitz, Claude Bailat +2 more

The antioxidant and anti-inflammatory activities of avasopasem manganese in age-associated, cisplatin-induced renal injury

Redox Biology(2024)10.1016/j.redox.2023.103022

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0DataRank · unranked

30 citations

Casey Pulliam, Ann Tomanek‐Chalkley, Prerna Rastogi, Hsiang Wen, Sanjana Dayal +9 more

Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance

Cell Reports(2024)10.1016/j.celrep.2024.113897

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0DataRank · unranked

28 citations

Diego R. Coelho, Kirthi Pulakanti, Marcelo J. Sakiyama, Yunping Huang, Fernando T. Ogata +10 more

Quantitative MRI Evaluation of Ferritin Overexpression in Non-Small-Cell Lung Cancer

International Journal of Molecular Sciences(2024)10.3390/ijms25042398

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0DataRank · unranked

9 citations

Amira Zaher, Casey Pulliam, Khaliunaa Bayanbold, Charles Searby, Joshua D. Schoenfeld +6 more

Exploratory Analysis of Image-Guided Ionizing Radiation Delivery to Induce Long-Term Iron Accumulation and Ferritin Expression in a Lung Injury Model: Preliminary Results

Bioengineering(2024)10.3390/bioengineering11020182

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3 citations

Bryce Duchman, Marina Ivanovic, Douglas R. Spitz, Muhammad Furqan, Bryan G. Allen +2 more

Superoxide Dismutase Mimetic Avasopasem Manganese Enhances Radiation Therapy Effectiveness in Soft Tissue Sarcomas and Accelerates Wound Healing

Antioxidants(2024)10.3390/antiox13050587

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0DataRank · unranked

2 citations

Kranti A. Mapuskar, Michael S. Petronek, Munir R. Tanas, Alexandra L. Isaacson, Rebecca D. Dodd +7 more

Additive Effects of Cu-ATSM and Radiation on Survival of Diffuse Intrinsic Pontine Glioma Cells

Radiation Research(2024)10.1667/rade-24-00076.1

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0DataRank · unranked

1 citations

Shane R. Solst, Claire H. Graham, Lianna Z. Fiore, Rana Rheem, Ann Tomanek‐Chalkley +5 more

Pharmacological ascorbate combined with rucosopasem selectively radio-chemo-sensitizes NSCLC via generation of H2O2

Redox Biology(2025)10.1016/j.redox.2025.103505

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0DataRank · unranked

5 citations

Melissa A. Fath, Sho S, Susan T. Johnson, Brett A. Wagner, Mekhla Singhania +12 more

Mitochondrial oxidants promote platelet activation and thrombotic susceptibility in prediabetes

Journal of Clinical Investigation(2025)10.1172/jci195662

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0DataRank · unranked

2 citations

Pooja Yadav, Melissa Jensen, Katharine Geasland, Jagadish S. Swamy, Douglas R. Spitz +4 more

Mitoregulin Promotes Cell Cycle Progression in Non-Small Cell Lung Cancer Cells

International Journal of Molecular Sciences(2025)10.3390/ijms26051939

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0DataRank · unranked

2 citations

Connor R. Linzer, Collin D. Heer, Nathan H. Witmer, Jesse D. Cochran, Douglas R. Spitz +2 more

Iron-oxide nanoparticles selectively enhance the toxicity of pharmacological ascorbate through hydrogen peroxide-dependent DNA damage in non-small cell lung cancer (NSCLC)

Free Radical Biology and Medicine(2025)10.1016/j.freeradbiomed.2025.09.013

N/A

0DataRank · unranked

3 citations

Sei Sho, Melissa A. Fath, Adriana Sánchez, Casey Pulliam, Bryan G. Allen +6 more

Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes

Cell Metabolism(2020)10.1016/j.cmet.2020.09.012

N/A

0DataRank · unranked

81 citations

Sunny C. Huang, Charles Searby, Benjamin Cassaidy, Michael J. Miller, Wojciech J. Grzesik +27 more

Xanthine oxidoreductase expression is diminished in breast cancer as a response to uric acid mediated chelation of redox active iron

Free Radical Biology and Medicine(2025)10.1016/j.freeradbiomed.2025.06.019

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0DataRank · unranked

1 citations

Rita King, Zuzana Dean, Ashish Maskey, RM Park, M. Velayutham +6 more