Stephen Safe

Environmental ScienceBiochemistry, Genetics and Molecular BiologyNeuroscience

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 56 papers. Top paper: “Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self‐renewal of colonic stem and progenitor cells”.

Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self‐renewal of colonic stem and progenitor cells

The EMBO Journal(2020)10.15252/embj.2019104319

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1.3DataRank · unranked

43 citations

Laurie A. Davidson, Yang‐Yi Fan, Jennifer S. Goldsby, Grace Yoon, Un‐Ho Jin +11 more

Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs)

International Journal of Molecular Sciences(2020)10.3390/ijms21186654

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0DataRank · unranked

133 citations

Un-Ho Jin, Hyejin Park, Robert S. Chapkin, Arul Jayaraman, Stephen Safe

CXCL11-CXCR3 Axis Mediates Tumor Lymphatic Cross Talk and Inflammation-Induced Tumor, Promoting Pathways in Head and Neck Cancers

American Journal Of Pathology(2020)10.1016/j.ajpath.2019.12.004

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0DataRank · unranked

51 citations

Sumeet Pal Singh, Sukanya Roy, Lavanya Venkatasamy, Tori White, Samiran Sinha +4 more

The Histone Methyltransferase Gene G9A Is Regulated by Nuclear Receptor 4A1 in Alveolar Rhabdomyosarcoma Cells

Molecular Cancer Therapeutics(2020)10.1158/1535-7163.mct-20-0474

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0DataRank · unranked

19 citations

Kumaravel Mohankumar, Un-Ho Jin, Gregory G. Martin, Stephen Safe, Rupesh Shrestha

A Bis-Indole–Derived NR4A1 Antagonist Induces PD-L1 Degradation and Enhances Antitumor Immunity

Cancer Research(2020)10.1158/0008-5472.can-19-2314

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0DataRank · unranked

41 citations

Gus A. Wright, Kumaravel Mohankumar, Un-Ho Jin, Xing-Han Zhang, Stephen Safe +1 more

Bis-Indole–Derived Nuclear Receptor 4A1 (NR4A1, Nur77) Ligands as Inhibitors of Endometriosis

Endocrinology(2020)10.1210/endocr/bqaa027

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0DataRank · unranked

32 citations

Xi Li, Nuri Sung, Yeon Jean Cho, Sang Jun Han, Stephen Safe +1 more

Omeprazole Inhibits Glioblastoma Cell Invasion and Tumor Growth

Cancers(2020)10.3390/cancers12082097

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0DataRank · unranked

27 citations

Sharon K. Michelhaugh, Lisa Polin, Rupesh Shrestha, Sandeep Mittal, Stephen Safe +1 more

Hydroxylated Chalcones as Aryl Hydrocarbon Receptor Agonists: Structure-Activity Effects

Toxicological Sciences(2020)10.1093/toxsci/kfaa179

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0DataRank · unranked

4 citations

Un-Ho Jin, Keshav Karki, Clinton D. Allred, Laurie A. Davidson, Robert S. Chapkin +6 more

Faculty Opinions recommendation of Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature(2020)10.3410/f.736906689.793579058

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0DataRank · unranked

0 citations

Stephen Safe

Faculty Opinions recommendation of Association between Exposure to p,p'-DDT and Its Metabolite p,p'-DDE with Obesity: Integrated Systematic Review and Meta-Analysis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature(2020)10.3410/f.731254143.793579050

N/A

0DataRank · unranked

0 citations

Stephen Safe

Faculty Opinions recommendation of Epigenetics as a mechanism linking developmental exposures to long-term toxicity.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature(2020)10.3410/f.732803226.793579044

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0DataRank · unranked

0 citations

Stephen Safe

Faculty Opinions recommendation of DDT and breast cancer: prospective study of induction time and susceptibility windows.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature(2020)10.3410/f.735089316.793579049

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0DataRank · unranked

0 citations

Stephen Safe

Flavonoids: structure–function and mechanisms of action and opportunities for drug development

Toxicological Research(2021)10.1007/s43188-020-00080-z

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0DataRank · unranked

175 citations

Arul Jayaraman, Robert S. Chapkin, Marcell Howard, Kumaravel Mohankumar, Rupesh Shrestha +1 more

Flavonoids kaempferol and quercetin are nuclear receptor 4A1 (NR4A1, Nur77) ligands and inhibit rhabdomyosarcoma cell and tumor growth

Journal of Experimental & Clinical Cancer Research(2021)10.1186/s13046-021-02199-9

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0DataRank · unranked

56 citations

Kumaravel Mohankumar, Greg Martin, Amanuel Hailemariam, Syng‐Ook Lee, Un-Ho Jin +3 more

Loss of Aryl Hydrocarbon Receptor Promotes Colon Tumorigenesis in ApcS580/+; KrasG12D/+ Mice

Molecular Cancer Research(2021)10.1158/1541-7786.mcr-20-0789

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0DataRank · unranked

39 citations

Laurie A. Davidson, Martha E. Hensel, Grace Yoon, Kerstin K. Landrock, Clinton D. Allred +5 more

NR4A1 Ligands as Potent Inhibitors of Breast Cancer Cell and Tumor Growth

Cancers(2021)10.3390/cancers13112682

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0DataRank · unranked

29 citations

Kumaravel Mohankumar, Abigail Schoeller, Gregory G. Martin, Rupesh Shrestha, Stephen Safe +1 more

Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma

Cancer Research Communications(2021)10.1158/2767-9764.crc-21-0073

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18 citations

Rupesh Shrestha, Sneha Johnson, Zuhua Yu, Keshav Karki, Ali Vaziri‐Gohar +6 more

Single-cell RNA Sequencing Reveals How the Aryl Hydrocarbon Receptor Shapes Cellular Differentiation Potency in the Mouse Colon

Cancer Prevention Research(2021)10.1158/1940-6207.capr-21-0378

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0DataRank · unranked

12 citations

Daniel Osorio, Laurie A. Davidson, Huajun Han, D. Mullens, Arul Jayaraman +5 more

Role of the Aryl Hydrocarbon Receptor (AhR) in Mediating the Effects of Coffee in the Colon

Molecular Nutrition & Food Research(2021)10.1002/mnfr.202100539

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0DataRank · unranked

18 citations

Laurie A. Davidson, Hyejin Park, Un‐Ho Jin, Yang‐Yi Fan, Yating Cheng +8 more

Nuclear receptor 4A1 (NR4A1) antagonists target paraspeckle component 1 (PSPC1) in cancer cells

Molecular Carcinogenesis(2021)10.1002/mc.23362

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0DataRank · unranked

14 citations

Rupesh Shrestha, Stephen Safe, Kumaravel Mohankumar

Synergistic effects of methyl 2-cyano-3,11-dioxo-18beta-olean-1,-12-dien-30-oate and erlotinib on erlotinib-resistant non-small cell lung cancer cells

Journal of Pharmaceutical Analysis(2021)10.1016/j.jpha.2021.06.002

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0DataRank · unranked

7 citations

Elizabeth Mazzio, Sunil Kumar Surapaneni, Shallu Kutlehria, Arindam Mondal, Ramesh Badisa +4 more

The Role of the Aryl Hydrocarbon Receptor (AhR) and Its Ligands in Breast Cancer

Cancers(2022)10.3390/cancers14225574

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0DataRank · unranked

46 citations

Lei Zhang, Stephen Safe

Resveratrol Binds Nuclear Receptor 4A1 (NR4A1) and Acts as an NR4A1 Antagonist in Lung Cancer Cells

Molecular Pharmacology(2022)10.1124/molpharm.121.000481

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27 citations

Greg Martin, Kumaravel Mohankumar, J. Trae Hampton, Wenshe Ray Liu, Stephen Safe +1 more

Intestinal epithelium aryl hydrocarbon receptor is involved in stress sensitivity and maintaining depressive symptoms

Behavioural Brain Research(2022)10.1016/j.bbr.2022.114256

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0DataRank · unranked

20 citations

Lauren Hillbrick, Jacob Kuempel, Georgia Lee Albrecht, Kerstin K. Landrock, Stephen Safe +3 more

3,3′-Diindolylmethane and 1,4-dihydroxy-2-naphthoic acid prevent chronic mild stress induced depressive-like behaviors in female mice

Journal of Affective Disorders(2022)10.1016/j.jad.2022.04.106

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0DataRank · unranked

17 citations

Jacob Kuempel, Georgia Lee Albrecht, Lauren Hillbrick, Arul Jayaraman, Stephen Safe +3 more

Sex-dependent differences in the stress mitigating and antidepressant effects of selective aryl hydrocarbon receptor modulators

Journal of Affective Disorders(2022)10.1016/j.jad.2022.09.155

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0DataRank · unranked

13 citations

Roanna A. Debler, Nathan I. Vardeleon, Lauren Hillbrick, Arul Jayaraman, Stephen Safe +3 more

Structure-activity relationships among mono- and dihydroxy flavones as aryl hydrocarbon receptor (AhR) agonists or antagonists in CACO2 cells

Chemico-Biological Interactions(2022)10.1016/j.cbi.2022.110067

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0DataRank · unranked

9 citations

Un-Ho Jin, Gregory G. Martin, Robert S. Chapkin, Laurie A. Davidson, Kyongbum Lee +3 more

Excited about Receptors

Receptors(2022)10.3390/receptors1010001

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0DataRank · unranked

0 citations

Stephen Safe

Health Benefits of Coffee Consumption for Cancer and Other Diseases and Mechanisms of Action

International Journal of Molecular Sciences(2023)10.3390/ijms24032706

N/A

0DataRank · unranked

73 citations

Jainish Kothari, Amanuel Hailemariam, Srijana Upadhyay, Laurie A. Davidson, Robert S. Chapkin +1 more

Specificity Proteins (Sp) and Cancer

International Journal of Molecular Sciences(2023)10.3390/ijms24065164

N/A

0DataRank · unranked

48 citations

Stephen Safe

Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice

Endocrinology(2023)10.1210/endocr/bqad133

N/A

0DataRank · unranked

35 citations

Kumaravel Mohankumar, Greg S. Martin, Fuada Mariyam, Yuri Park, Sang Jun Han +2 more

Bis-indole-derived NR4A1 antagonists inhibit colon tumor and splenic growth and T-cell exhaustion

Cancer Immunology Immunotherapy(2023)10.1007/s00262-023-03530-3

N/A

0DataRank · unranked

21 citations

Gus A. Wright, Subhashree Kumaravel, Rupesh Shrestha, Lei Zhang, Maen Abdelrahim +3 more

Reciprocal Regulation of Hepatic TGF-β1 and Foxo1 Controls Gluconeogenesis and Energy Expenditure

Diabetes(2023)10.2337/db23-0180

N/A

0DataRank · unranked

22 citations

Weiqi Ai, Yunmei Chen, Da Mi Kim, Zheng Shen, Wanbao Yang +5 more

Flavone and Hydroxyflavones Are Ligands That Bind the Orphan Nuclear Receptor 4A1 (NR4A1)

International Journal of Molecular Sciences(2023)10.3390/ijms24098152

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0DataRank · unranked

19 citations

Srijana Upadhyay, Fuada Mariyam, Greg Martin, Amanuel Hailemariam, Kyongbum Lee +5 more

Selective aryl hydrocarbon receptor modulators can act as antidepressants in obese female mice

Journal of Affective Disorders(2023)10.1016/j.jad.2023.04.044

N/A

0DataRank · unranked

11 citations

Caitlin A. Madison, Lauren Hillbrick, Paula L. Gallegos, Stephen Safe, Robert S. Chapkin +2 more

Aryl Hydrocarbon Receptor (AhR) Signaling in Colonic Cells and Tumors

Receptors(2023)10.3390/receptors2010005

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6 citations

Huajun Han, Arul Jayaraman, Laurie A. Davidson, Clinton D. Allred, Ivan Ivanov +4 more

Piperlongumine is a ligand for the orphan nuclear receptor 4A1 (NR4A1)

Frontiers in Pharmacology(2023)10.3389/fphar.2023.1223153

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5 citations

Greg Martin, Kumaravel Mohankumar, Gus A. Wright, Fuada Mariyam, Stephen Safe +1 more

Data from 1,1-Bis(3′-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth

(2023)10.1158/1535-7163.c.6530925

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0DataRank · unranked

0 citations

Sabitha Papineni, Sudhakar Chintharlapalli, Sung‐Dae Cho, Stephen Safe, Ashish M. Kamat +1 more

Data from The nonsteroidal anti-inflammatory drug tolfenamic acid inhibits BT474 and SKBR3 breast cancer cell and tumor growth by repressing erbB2 expression

(2023)10.1158/1535-7163.c.6531750

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0DataRank · unranked

0 citations

Maen Abdelrahim, Ala Abudayyeh, Ping Lei, Stephen Safe, Xinyi Liu

Data from The nonsteroidal anti-inflammatory drug tolfenamic acid inhibits BT474 and SKBR3 breast cancer cell and tumor growth by repressing erbB2 expression

(2023)10.1158/1535-7163.c.6531750.v1

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0DataRank · unranked

0 citations

Maen Abdelrahim, Ala Abudayyeh, Ping Lei, Stephen Safe, Xinyi Liu

Data from 1,1-Bis(3′-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth

(2023)10.1158/1535-7163.c.6530925.v1

N/A

0DataRank · unranked

0 citations

Sabitha Papineni, Sudhakar Chintharlapalli, Sung‐Dae Cho, Stephen Safe, Ashish M. Kamat +1 more

Bis-Indole Derivatives as Dual Nuclear Receptor 4A1 (NR4A1) and NR4A2 Ligands

Biomolecules(2024)10.3390/biom14030284

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0DataRank · unranked

15 citations

Amanuel Hailemariam, Fuada Mariyam, Zahin Hafiz, Gregory G. Martin, Jainish Kothari +6 more

Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach

Exploration of Drug Science(2024)10.37349/eds.2024.00054

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0DataRank · unranked

12 citations

Stephen Safe

Dual nuclear receptor 4A1 (NR4A1/NR4A2) ligands inhibit glioblastoma growth and target TWIST1

Molecular Pharmacology(2024)10.1016/j.molpha.2024.100009

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0DataRank · unranked

12 citations

Mi‐Ok Lee, Lei Zhang, Arafat Rahman Oany, Svetlana A. Mikheeva, Andrei M. Mikheev +3 more

Natural products and synthetic analogs as selective orphan nuclear receptor 4A (NR4A) modulators.

PubMed(2024)10.14670/hh-18-689

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0DataRank · unranked

8 citations

Stephen Safe

TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) induces depression-like phenotype

NeuroToxicology(2024)10.1016/j.neuro.2024.05.010

N/A

0DataRank · unranked

6 citations

Paula L. Gallegos, Alexandra C. Ojeda, Andrea M. Perttula, Ashley Lucio, Robert S. Chapkin +3 more

1,4-dihydroxy-2-naphthoic acid prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced motor function deficits

Behavioural Pharmacology(2024)10.1097/fbp.0000000000000806

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0DataRank · unranked

0 citations

Roanna A. Debler, Paula L. Gallegos, Lauren Hillbrick, Robert S. Chapkin, Stephen Safe +2 more

Targeting Lineage-Specific Functions of NR4A1 for Cancer Immunotherapy

International Journal of Molecular Sciences(2025)10.3390/ijms26115266

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0DataRank · unranked

8 citations

Akhila Nataraj, Yufeng Xiao, Bristy Rani Podder, Zeng Jin, Tanzia Islam Tithi +8 more

Orphan nuclear receptor transcription factors as drug targets

Transcription(2025)10.1080/21541264.2025.2521766

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0DataRank · unranked

6 citations

Arafat Rahman Oany, Wai Ning Tiffany Tsui, Mi‐Ok Lee, Vinod K. Srivastava, Srijana Upadhyay +6 more

Orphan nuclear receptor 4A1 (NR4A1) and NR4A2 are endogenous regulators of CD71 and their ligands induce ferroptosis in breast cancer

Cell Death and Disease(2025)10.1038/s41419-025-08143-5

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2 citations

Srijana Upadhyay, Wai Ning Tiffany Tsui, Amanuel Hailemariam, Sarah Latka, John D. Landua +6 more

Activation of Genes by Nuclear Receptor/Specificity Protein (Sp) Interactions in Cancer

Cancers(2025)10.3390/cancers17020284

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0DataRank · unranked

5 citations

Evan Farkas, Amanuel Hailemariam, Arafat Rahman Oany, Gargi Sivaram, Wai Ning Tiffany Tsui +1 more

A Chalcone Synthase-like Bacterial Protein Catalyzes Heterocyclic C-Ring Cleavage of Naringenin to Alter Bioactivity Against Nuclear Receptors in Colonic Epithelial Cells

Metabolites(2025)10.3390/metabo15030146

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3 citations

Farrhin Nowshad, Meredith Davis Leigh, Jimmy W. Crott, Hyejin Park, Greg Martin +5 more

Expression of Prooncogenic Nuclear Receptor 4A (NR4A)-Regulated Genes β1-Integrin and G9a Inhibited by Dual NR4A1/2 Ligands

International Journal of Molecular Sciences(2025)10.3390/ijms26083909

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0DataRank · unranked

1 citations

Victoria Gatlin, Shreyan Gupta, Michael L. Salinas, Selim Romero, James J. Cai +3 more

Orphan Nuclear Receptor 4A1 (NR4A1) and NR4A2 are Endogenous Regulators of CD71 and Their Ligands Induce Ferroptosis in Breast Cancer

Research Square(2025)10.21203/rs.3.rs-6214709/v1

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0DataRank · unranked

0 citations

Arafat Rahman Oany, Srijana Upadhyay, Wai Ning Tiffany Tsui, Amanuel Hailemariam, Sarah Latka +6 more

The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer

Molecular Cancer Research(2020)10.1158/1541-7786.mcr-20-0707

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0DataRank · unranked

145 citations

Keshav Karki, Stephen Safe

NR4A nuclear receptor expression in human macrophages mediates apoptosis and controls Mycobacterium tuberculosis growth

The Journal of Immunology(2025)10.1093/jimmun/vkaf252

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0DataRank · unranked

0 citations

Natalie Jarvis, Susanta Pahari, D. Ortega, Abul Azad, Stephen Safe +3 more