Andrew E. Aplin

Also affiliated with Sidney Kimmel Cancer Center, Cancer Research Center

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

3in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 3 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma

UNC Libraries(2020)10.17615/a8zp-dq08

Top 100%

0DataRank

Top 100%0 citations

Andrew E. Aplin, Yiling Lu, Sébastien Jeay, Carol L. Shields, Michal Barzily-Rokni +49 more

Papers

Driven by 47 papers — median percentile 0. Top paper: “Gene signature reveals decreased SOX10-dependent transcripts in malignant cells from immune checkpoint inhibitor-resistant cutaneous melanomas”.

Gene signature reveals decreased SOX10-dependent transcripts in malignant cells from immune checkpoint inhibitor-resistant cutaneous melanomas

iScience(2023)10.1016/j.isci.2023.107472

N/A

0.438DataRank · unranked

11 citations

Signe Caksa, Ahmet Saçan, Claudia Capparelli, Andrew E. Aplin, Timothy J. Purwin

BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors

Oncogene(2020)10.1038/s41388-020-01554-y

N/A

0DataRank · unranked

48 citations

Timothy J. Purwin, Nelisa Bechtel, Connie Liao, Vivian Chua, Erin L. Seifert +6 more

Activation of CD8+ T Cells Contributes to Antitumor Effects of CDK4/6 Inhibitors plus MEK Inhibitors

Cancer Immunology Research(2020)10.1158/2326-6066.cir-19-0743

N/A

0DataRank · unranked

20 citations

Dan A. Erkes, Phil F. Cheng, Manoela Tiago, Nicole A. Wilski, Conroy O. Field +6 more

Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma

Molecular Cancer Therapeutics(2020)10.1158/1535-7163.mct-19-1016

N/A

0DataRank · unranked

32 citations

Timothy J. Purwin, Anna Han, Vivian Chua, Prem Patel, Usman Baqai +7 more

Targeting BRD/BET proteins inhibits adaptive kinome upregulation and enhances the effects of BRAF/MEK inhibitors in melanoma

British Journal of Cancer(2020)10.1038/s41416-019-0724-y

N/A

0DataRank · unranked

27 citations

Claudia Capparelli, Dan A. Erkes, Timothy J. Purwin, Shea A. Heilman, Adam C. Berger +3 more

Role of serine 365 in BRAF V600E sensitivity to RAF inhibition

Pigment Cell & Melanoma Research(2020)10.1111/pcmr.12932

N/A

0DataRank · unranked

6 citations

Justin Rock, Andrew E. Aplin, Michael J. Vido

A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma

UNC Libraries(2020)10.17615/a8zp-dq08

Top 100%

0DataRank

Top 100%0 citations

Andrew E. Aplin, Yiling Lu, Sébastien Jeay, Carol L. Shields, Michal Barzily-Rokni +49 more

Melanoma models for the next generation of therapies

Cancer Cell(2021)10.1016/j.ccell.2021.01.011

N/A

0DataRank · unranked

228 citations

Kristen L. Mueller, David J. Adams, Niroshana Anandasabapathy, Andrew E. Aplin, Corine Bertolotto +31 more

Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ -Driven Uveal Melanoma

Clinical Cancer Research(2021)10.1158/1078-0432.ccr-20-3363

N/A

0DataRank · unranked

77 citations

Monica Acosta, Robert Saddawi‐Konefka, Ayush Kishore, Simone Lubrano, Frederico Gomes +13 more

Roles of the BAP1 Tumor Suppressor in Cell Metabolism

Cancer Research(2021)10.1158/0008-5472.can-20-3430

N/A

0DataRank · unranked

59 citations

Timothy J. Purwin, Andrew E. Aplin, Anna Han

SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects

Cell Reports(2021)10.1016/j.celrep.2021.110085

N/A

0DataRank · unranked

39 citations

Manoela Tiago, Signe Caksa, Claudia Capparelli, Timothy J. Purwin, Gaurav Kumar +6 more

Metabolic Alterations and Therapeutic Opportunities in Rare Forms of Melanoma

Trends in cancer(2021)10.1016/j.trecan.2021.05.005

N/A

0DataRank · unranked

30 citations

Zachary T. Schug, Andrew E. Aplin, Anna Han

Prognostic Values of G-Protein Mutations in Metastatic Uveal Melanoma

Cancers(2021)10.3390/cancers13225749

N/A

0DataRank · unranked

22 citations

Ayako Shimada, Inna Chervoneva, Liam Hulse, Meggie Danielson, Jeffrey Swensen +6 more

Anchorage-dependent Regulation of the Mitogen-activated Protein Kinase Cascade by Growth Factors Is Supported by a Variety of Integrin α Chains

UNC Libraries(2021)10.17615/1tfd-p108

N/A

0DataRank · unranked

0 citations

Sarah M. Short, Andrew E. Aplin, R. L. Juliano

Integrin-mediated Activation of MAP Kinase Is Independent of FAK: Evidence for Dual Integrin Signaling Pathways in Fibroblasts

UNC Libraries(2021)10.17615/jwqx-8z41

N/A

0DataRank · unranked

9 citations

Qiming Chen, Michael D. Schaller, Ikramuddin Aukhil, Yu Shen, Tsung H. Lin +3 more

Integrin-Mediated Adhesion Regulates ERK Nuclear Translocation and Phosphorylation of Elk-1

UNC Libraries(2021)10.17615/e3bk-dk25

N/A

0DataRank · unranked

1 citations

Andrew E. Aplin, Sheryl A. Stewart, R. L. Juliano, Richard K. Assoian

Correction to: BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors

Oncogene(2021)10.1038/s41388-021-01645-4

N/A

0DataRank · unranked

2 citations

Timothy J. Purwin, Nelisa Bechtel, Connie Liao, Vivian Chua, Erin L. Seifert +6 more

Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma

Nature Communications(2022)10.1038/s41467-022-28801-y

N/A

0DataRank · unranked

100 citations

Timothy J. Purwin, McKenna Q. Glasheen, Signe Caksa, Manoela Tiago, Nicole A. Wilski +17 more

The future of targeted kinase inhibitors in melanoma

Pharmacology & Therapeutics(2022)10.1016/j.pharmthera.2022.108200

N/A

0DataRank · unranked

33 citations

Usman Baqai, Andrew E. Aplin, Signe Caksa

A Genome-Wide Screen Identifies PDPK1 as a Target to Enhance the Efficacy of MEK1/2 Inhibitors in NRAS Mutant Melanoma

Cancer Research(2022)10.1158/0008-5472.can-21-3217

N/A

0DataRank · unranked

26 citations

Mai Q. Nguyen, Nicole A. Wilski, Timothy J. Purwin, Mégane Vernon, Manoela Tiago +2 more

Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma

Oncogene(2022)10.1038/s41388-021-02154-0

N/A

0DataRank · unranked

16 citations

Vivian Chua, Usman Baqai, Timothy J. Purwin, Nelisa Bechtel, Emily Hunter +7 more

IGF1R Inhibition Enhances the Therapeutic Effects of Gq/11 Inhibition in Metastatic Uveal Melanoma Progression

Molecular Cancer Therapeutics(2022)10.1158/1535-7163.mct-22-0147

N/A

0DataRank · unranked

6 citations

Bao Lam, Mizue Terai, Takahito Sugase, Ryota Tanaka, Eduardo Farias +9 more

Multi‐omics profiling shows BAP1 loss is associated with upregulated cell adhesion molecules in uveal melanoma

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.l7442

N/A

0DataRank · unranked

0 citations

Timothy J. Purwin, Vivian Chua, Anna Han, Nelisa Bechtel, Edward J. Hartsough +4 more

Lysosomal lipid peroxidation regulates tumor immunity

Journal of Clinical Investigation(2023)10.1172/jci164596

N/A

0DataRank · unranked

56 citations

Jennifer J. Lee, Amanda M. Versace, Sandra L. Harper, Aaron R. Goldman, Mary Ann S. Crissey +11 more

MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping

Nature Cell Biology(2023)10.1038/s41556-023-01208-7

N/A

0DataRank · unranked

28 citations

Saul Carcamo, Aman Agarwal, Navpreet Tung, Étienne Humblin, Matthew S. Goldberg +14 more

High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma

Cell Reports Medicine(2023)10.1016/j.xcrm.2023.101244

N/A

0DataRank · unranked

25 citations

Simone Lubrano, Michele Ceribelli, Damiano Cosimo Rigiracciolo, Robert Saddawi‐Konefka, Farhoud Faraji +18 more

Targeting Upregulated cIAP2 in SOX10-Deficient Drug Tolerant Melanoma

Molecular Cancer Therapeutics(2023)10.1158/1535-7163.mct-23-0025

N/A

0DataRank · unranked

13 citations

Signe Caksa, Amelia G. Young, Nicole A. Wilski, Connor A. Ott, Inna Chervoneva +6 more

SOX10 Loss Sensitizes Melanoma Cells to Cytokine-Mediated Inflammatory Cell Death

Molecular Cancer Research(2023)10.1158/1541-7786.mcr-23-0290

N/A

0DataRank · unranked

13 citations

Signe Caksa, Casey D. Stefanski, Isabella V. Trachtenberg, Haley P. Wilson, Nicole A. Wilski +9 more

Kinome profiling identifies MARK3 and STK10 as potential therapeutic targets in uveal melanoma

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.105418

N/A

0DataRank · unranked

7 citations

Alison Kurimchak, Isabella V. Trachtenberg, Timothy J. Purwin, Jelan I. Haj, Anna Han +10 more

Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth

Cancers(2023)10.3390/cancers15133451

N/A

0DataRank · unranked

10 citations

Dzmitry Mukha, Vivian Chua, Timothy J. Purwin, Manoela Tiago, Bhavik Modasia +15 more

Data from Rnd3 Regulation of the Actin Cytoskeleton Promotes Melanoma Migration and Invasive Outgrowth in Three Dimensions

(2023)10.1158/0008-5472.c.6499431

N/A

0DataRank · unranked

0 citations

Andrew E. Aplin, Richard M. Klein

Data from Rnd3 Regulation of the Actin Cytoskeleton Promotes Melanoma Migration and Invasive Outgrowth in Three Dimensions

(2023)10.1158/0008-5472.c.6499431.v1

N/A

0DataRank · unranked

0 citations

Andrew E. Aplin, Richard M. Klein

Merged pdf from ErbB3 Targeting Enhances the Effects of MEK Inhibitor in Wild-Type BRAF/NRAS Melanoma

(2023)10.1158/0008-5472.22419945

Top 100%

0DataRank

Top 100%0 citations

Timothy J. Purwin, Shea A. Heilman, Inna Chervoneva, Peter A. McCue, Adam C. Berger +5 more

Merged pdf from ErbB3 Targeting Enhances the Effects of MEK Inhibitor in Wild-Type BRAF/NRAS Melanoma

INDIGO (University of Illinois at Chicago)(2023)10.1158/0008-5472.22419945.v1

Top 100%

0DataRank

Top 100%0 citations

Timothy J. Purwin, Shea A. Heilman, Inna Chervoneva, Peter A. McCue, Adam C. Berger +5 more

Data from Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma

(2023)10.1158/1078-0432.c.6529851

N/A

0DataRank · unranked

0 citations

Monica Acosta, Robert Saddawi‐Konefka, Ayush Kishore, Simone Lubrano, Frederico Gomes +13 more

Data from Response and Resistance to Paradox-Breaking BRAF Inhibitor in Melanomas In Vivo and Ex Vivo

(2023)10.1158/1535-7163.c.6539317

N/A

0DataRank · unranked

0 citations

Curtis H. Kugel, Michael J. Vido, Adam C. Berger, Timothy J. Purwin, Allison Goldberg +6 more

Site matters in metastatic melanoma

Trends in cancer(2023)10.1016/j.trecan.2023.05.007

N/A

0DataRank · unranked

0 citations

Andrew E. Aplin, Haley P. Wilson

Slow proliferation of BAP1-deficient uveal melanoma cells is associated with reduced S6 signaling and resistance to nutrient stress

Science Signaling(2024)10.1126/scisignal.adn8376

N/A

0DataRank · unranked

6 citations

Melisa Lopez-Anton, Mizue Terai, Ryota Tanaka, Usman Baqai, Timothy J. Purwin +13 more

Mcl-1 mediates intrinsic resistance to RAF inhibitors in mutant BRAF papillary thyroid carcinoma

Cell Death Discovery(2024)10.1038/s41420-024-01945-0

N/A

0DataRank · unranked

9 citations

Jacob Yo, Kayla C. Gallant, Camille J. Cunanan, Amirali Amirfallah, Marzieh Daniali +5 more

Lineage commitment pathways epigenetically oppose oncogenic Gαq/11-YAP1 signaling in dormant disseminated uveal melanoma

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.03.05.583565

N/A

0DataRank · unranked

1 citations

Melisa Lopez Anton, Timothy J. Purwin, Lornella Seeneevassen, Vivian Chua, Francis Waltrich +10 more

Aqueous humor biomarkers in ocular oncology: Insights and advances

Cell Reports Medicine(2025)10.1016/j.xcrm.2025.102447

N/A

0DataRank · unranked

4 citations

Signe Caksa, Rachel E Cain, Scott A. Waldman, Andrew E. Aplin, Lara Cheslow

Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4+ T Cells

Cancer Research(2025)10.1158/0008-5472.can-24-3267

N/A

0DataRank · unranked

2 citations

Timothy J. Purwin, Dan A. Erkes, Kristen M. DeRosa, Erica Kitterman, Samantha M. Barnada +13 more

Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma models

Nature Communications(2025)10.1038/s41467-025-64682-7

N/A

0DataRank · unranked

2 citations

Timothy J. Purwin, Panyu Chen, Somenath Chowdhury, George L. Mellor, K.X. Luo +10 more

Pyroptosis Modulates Multiple Immune Cell Populations in Targeted Therapy–Treated Melanoma

Cancer Immunology Research(2025)10.1158/2326-6066.cir-25-0444

N/A

0DataRank · unranked

2 citations

Dan A. Erkes, Timothy J. Purwin, Diana S. Melissaratos, Casey D. Stefanski, Signe Caksa +7 more

Inhibition of anti-apoptotic BCL2 overcomes adaptive resistance to co-targeting of the protein kinase FAK and MEK in GNAQ-driven uveal melanoma

Journal of Biological Chemistry(2025)10.1016/j.jbc.2025.110712

N/A

0DataRank · unranked

1 citations

Rodolfo Daniel Cervantes‐Villagrana, Nadia Arang, Adam Officer, Sendi Rafael Adame-Garcia, Gabriela Cuesta-Margolles +3 more

Targeting PHGDH Upregulation Reduces Glutathione Levels and Resensitizes Resistant NRAS-Mutant Melanoma to MAPK Kinase Inhibition

Journal of Investigative Dermatology(2020)10.1016/j.jid.2020.02.047

N/A

0DataRank · unranked

43 citations

Jessica L.F. Teh, Timothy J. Purwin, Inna Chervoneva, Michael A. Davies, Katherine L. Nathanson +5 more

Modelling Acral Melanoma in Admixed Brazilians Uncovers Genomic Drivers and Targetable Pathways

medRxiv(2025)10.1101/2025.08.08.25332963

N/A

0DataRank · unranked

0 citations

Sara Santos Bernardes, Flavia C. Aguiar, Antonio C. Facciolo, Martín del Castillo Velasco Herrera, J. Rene C. Wong-Ramirez +25 more

Andrew E. Aplin

Indexed papers

Top data-sharing exemplar

Papers