🏆 Finalist — NIH Data Sharing Index (“S-Index”) Challenge

Adam B. Keeton

Auburn University

ORCID: 0000-0002-3053-341X

Biochemistry, Genetics and Molecular BiologyMedicineChemistry

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 15 papers. Top paper: “PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity”.

PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity

Drug Discovery Today(2020)10.1016/j.drudis.2020.06.008

N/A

0DataRank · unranked

68 citations

Antonio Ward, Xi Chen, Yulia Maxuitenko, Alexander B. Coley, Nada S. Aboelella +5 more

Discovery of trisubstituted pyrazolines as a novel scaffold for the development of selective phosphodiesterase 5 inhibitors

Bioorganic Chemistry(2020)10.1016/j.bioorg.2020.104322

N/A

0DataRank · unranked

13 citations

Heather N. Tinsley, Adam B. Keeton, Mohammed Weam, Noha H. Atta, Mennatallah A. Hammam +6 more

Targeting cGMP/PKG signaling for the treatment or prevention of colorectal cancer with novel sulindac derivatives lacking cyclooxygenase inhibitory activity

Oncology Signaling(2020)10.1016/j.onsig.2020.04.001

N/A

0DataRank · unranked

6 citations

Xi Chen, Antonio Ward, Alexander B. Coley, Gang Zhou, Donald J. Buchsbaum +3 more

Suppression of Colon Tumorigenesis in Mutant Apc Mice by a Novel PDE10 Inhibitor that Reduces Oncogenic β-Catenin

Cancer Prevention Research(2021)10.1158/1940-6207.capr-21-0208

N/A

0DataRank · unranked

18 citations

Wen‐Chi Chang, Xi Chen, Jacob Valiyaveettil, Verónica Ramírez‐Alcántara, Elaine Gavin +24 more

The path to the clinic: a comprehensive review on direct KRASG12C inhibitors

Journal of Experimental & Clinical Cancer Research(2022)10.1186/s13046-021-02225-w

N/A

0DataRank · unranked

179 citations

Gary A. Piazza, Adam B. Keeton, Caio A. Leite, Albert K. Kwan

Pan-RAS inhibitors: Hitting multiple RAS isozymes with one stone

Advances in cancer research(2022)10.1016/bs.acr.2021.07.009

N/A

0DataRank · unranked

32 citations

Antonio Ward, Adam B. Keeton, Xi Chen, Yulia Maxuitenko, Aishwarya Prakash +5 more

Novel Non-Cyclooxygenase Inhibitory Derivative of Sulindac Inhibits Breast Cancer Cell Growth In Vitro and Reduces Mammary Tumorigenesis in Rats

Cancers(2023)10.3390/cancers15030646

N/A

0DataRank · unranked

10 citations

Bini Mathew, Xi Chen, Yulia Maxuitenko, Li Nan, Whitney M. Lowe +9 more

Novel sulindac derivatives for colorectal cancer chemoprevention that target cGMP phosphodiesterases to suppress Wnt/β-catenin transcriptional activity

Cancer Insight(2023)10.58567/ci02020003

N/A

0DataRank · unranked

2 citations

Peyton Johnson, Khalda Fadlalla, Austin Moore, Chung-Hui Huang, Kristy Berry +6 more

Novel sulindac derivatives for colorectal cancer chemoprevention that target cGMP phosphodiesterases to suppress Wnt/β-catenin transcriptional activity

Cancer Insight(2023)10.58567/ci03010003

N/A

0DataRank · unranked

1 citations

Peyton Johnson, Khalda Fadlalla, Austin Moore, Chung-Hui Huang, Kristy Berry +6 more

A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer

Cancer Research(2024)10.1158/0008-5472.can-24-0323

N/A

0DataRank · unranked

22 citations

Tyler Mattox, Adam B. Keeton, Xi Chen, Forrest Smith, Kristy Berry +30 more

Novel Celecoxib Derivative, RF26, Blocks Colon Cancer Cell Growth by Inhibiting PDE5, Activating cGMP/PKG Signaling, and Suppressing β-catenin-dependent Transcription

Anti-Cancer Agents in Medicinal Chemistry(2024)10.2174/0118715206318802240821114353

N/A

0DataRank · unranked

3 citations

Mohammad Abdel‐Halim, Reem K. Fathalla, Luciana Madeira da Silva, Adam B. Keeton, Yulia Maxuitenko +6 more

Cyclic nucleotide phosphodiesterases as drug targets

Pharmacological Reviews(2025)10.1016/j.pharmr.2025.100042

N/A

0DataRank · unranked

28 citations

Viacheslav O. Nikolaev, Leila Gobejishvili, Claire Lugnier, Christian Heßlinger, Peter Nickolaus +24 more

ADT-1004: a first-in-class, oral pan-RAS inhibitor with robust antitumor activity in preclinical models of pancreatic ductal adenocarcinoma

Molecular Cancer(2025)10.1186/s12943-025-02288-9

N/A

0DataRank · unranked

17 citations

Ganji Purnachandra Nagaraju, Sujith Sarvesh, Julienne L. Carstens, Jeremy B. Foote, Emily C. Graff +17 more

Novel Disulfiram-Loaded Metal–Organic Nanoparticles Inhibit Tumor Growth and Induce Immunogenic Cell Death of Triple-Negative Breast Cancer Cells

Pharmaceutics(2025)10.3390/pharmaceutics17111448

N/A

0DataRank · unranked

0 citations

Xuejia Kang, Lang Zhou, Junwei Wang, Ssu-Yun Wu, Peizhen Sun +5 more

Targeting phosphodiesterase 10 unleashes antitumor immunity by inhibiting the RAS-MAPK signaling in cancer cells and myeloid-derived suppressor cells 3553

The Journal of Immunology(2025)10.1093/jimmun/vkaf283.1344

N/A

0DataRank · unranked

0 citations

Ogacheko Okoko, Xin Wang, Ye Yan, Khalda Fadlalla, Xi Chen +6 more