Brian M. Hoffman

Also affiliated with Division of Molecular & Cellular Biosciences, Northwestern University

Materials ScienceEnergyChemistryBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 40 papers. Top paper: “13 C Electron Nuclear Double Resonance Spectroscopy Shows Acetyl-CoA Synthase Binds Two Substrate CO in Multiple Binding Modes and Reveals the Importance of a CO-Binding “Alcove””.

13 C Electron Nuclear Double Resonance Spectroscopy Shows Acetyl-CoA Synthase Binds Two Substrate CO in Multiple Binding Modes and Reveals the Importance of a CO-Binding “Alcove”

Journal of the American Chemical Society(2020)10.1021/jacs.0c05950

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15 citations

Seth Wiley, Stephen W. Ragsdale, Brian M. Hoffman, Christopher D. James

13 C Electron Nuclear Double Resonance Spectroscopy Shows Acetyl-CoA Synthase Binds Two Substrate CO in Multiple Binding Modes and Reveals the Importance of a CO-Binding ‘Alcove’

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.06.23.165407

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0 citations

Seth Wiley, Stephen W. Ragsdale, Brian M. Hoffman, Christopher D. James

Metal ion fluxes controlling amphibian fertilization

Nature Chemistry(2021)10.1038/s41557-021-00705-2

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47 citations

Ajay Sharma, Nestor J. Zaluzec, Reiner Bleher, Barry Lai, Emma G. Schultz +5 more

An ecophysiological explanation for manganese enrichment in rock varnish

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2025188118

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44 citations

Chris M. Yeager, Ajay Sharma, N. Lanza, Demosthenes Morales, Gary Xie +9 more

Coordination of the Copper Centers in Particulate Methane Monooxygenase: Comparison between Methanotrophs and Characterization of the CuCSite by EPR and ENDOR Spectroscopies

Journal of the American Chemical Society(2021)10.1021/jacs.1c07018

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47 citations

Matthew O. Ross, Christopher Koo, Peter E. Doan, Amy C. Rosenzweig, Brian M. Hoffman +1 more

Exploring the Role of the Central Carbide of the Nitrogenase Active-Site FeMo-cofactor through Targeted13C Labeling and ENDOR Spectroscopy

Journal of the American Chemical Society(2021)10.1021/jacs.1c04152

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22 citations

Zhi‐Yong Yang, Dmitriy Lukoyanov, Dennis R. Dean, Lance C. Seefeldt, Brian M. Hoffman +1 more

Interplays of electron and nuclear motions along CO dissociation trajectory in myoglobin revealed by ultrafast X-rays and quantum dynamics calculations

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2018966118

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17 citations

Andrew Wildman, Dugan Hayes, Michael W. Mara, Patrick J. Lestrange, Marco Cammarata +9 more

A New Reaction for Improved Calibration of EPR Rapid-Freeze Quench Times: Kinetics of Ethylene Diamine Tetraacetate (EDTA) Transfer from Calcium(II) to Copper(II)

Applied Magnetic Resonance(2021)10.1007/s00723-021-01448-6

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1 citations

Hao Yang, Christopher D. James, Brian M. Hoffman, Peter E. Doan, Abigail L. Schroeter

Effects of Desiccation and Freezing on Microbial Ionizing Radiation Survivability: Considerations for Mars Sample Return

Astrobiology(2022)10.1089/ast.2022.0065

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62 citations

Robert P. Volpe, George Korza, Sarah DePratti, Isabel H. Conze, Igor Shuryak +11 more

A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2123566119

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46 citations

Richard J. Jodts, Jeffrey W. Slater, Reyvin M. Reyes, Valerie J. Winton, Rana Montaser +9 more

End-On Copper(I) Superoxo and Cu(II) Peroxo and Hydroperoxo Complexes Generated by Cryoreduction/Annealing and Characterized by EPR/ENDOR Spectroscopy

Journal of the American Chemical Society(2022)10.1021/jacs.1c10252

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36 citations

Austin E. Herzog, Richard J. Jodts, Kenneth D. Karlin, Brian M. Hoffman, Roman Davydov

[FeFe]‐Hydrogenase: Defined Lysate‐Free Maturation Reveals a Key Role for Lipoyl‐H‐Protein in DTMA Ligand Biosynthesis

Angewandte Chemie International Edition(2022)10.1002/anie.202203413

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27 citations

Batuhan Balci, Eric M. Shepard, Hao Yang, Douglas M. Warui, Stella Impano +5 more

Characterization by ENDOR Spectroscopy of the Iron–Alkyl Bond in a Synthetic Counterpart of Organometallic Intermediates in Radical SAM Enzymes

Journal of the American Chemical Society(2022)10.1021/jacs.2c07155

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10 citations

Richard J. Jodts, Youngsuk Kim, Alex McSkimming, Daniel L. M. Suess, Brian M. Hoffman +1 more

[FeFe]‐Hydrogenase: Defined Lysate‐Free Maturation Reveals a Key Role for Lipoyl‐H‐Protein in DTMA Ligand Biosynthesis

Angewandte Chemie(2022)10.1002/ange.202203413

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6 citations

Batuhan Balci, Eric M. Shepard, Hao Yang, Douglas M. Warui, Stella Impano +5 more

Connecting the Geometric and Electronic Structures of the Nitrogenase Iron–Molybdenum Cofactor through Site-selective Labeling

ChemRxiv(2022)10.26434/chemrxiv-2022-m57j9

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3 citations

Suppachai Srisantitham, Dmitriy Lukoyanov, Brian M. Hoffman, Daniel L. M. Suess, Edward D. Badding

Mechanism of Radical Initiation in the Radical SAM Enzyme Superfamily

Annual Review of Biochemistry(2023)10.1146/annurev-biochem-052621-090638

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47 citations

William E. Broderick, Joan Broderick, Brian M. Hoffman

Product analogue binding identifies the copper active site of particulate methane monooxygenase

Nature Catalysis(2023)10.1038/s41929-023-01051-x

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43 citations

Richard J. Jodts, Brian M. Hoffman, Amy C. Rosenzweig, Frank J. Tucci

Pyruvate formate-lyase activating enzyme: The catalytically active 5′-deoxyadenosyl radical caught in the act of H-atom abstraction

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2314696120

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18 citations

Hao Yang, William E. Broderick, Brian M. Hoffman, Joan Broderick, Maike N. Lundahl

Connecting the geometric and electronic structures of the nitrogenase iron–molybdenum cofactor through site-selective 57Fe labelling

Nature Chemistry(2023)10.1038/s41557-023-01154-9

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27 citations

Suppachai Srisantitham, Dmitriy Lukoyanov, Brian M. Hoffman, Daniel L. M. Suess, Edward D. Badding

Characterization of Methyl- and Acetyl-Ni Intermediates in Acetyl CoA Synthase Formed during Anaerobic CO2 and CO Fixation

Journal of the American Chemical Society(2023)10.1021/jacs.3c01772

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22 citations

Macon J. Abernathy, Seth Wiley, Claire Griffith, Christopher D. James, Jin Xiong +5 more

Computational Description of Alkylated Iron–Sulfur Organometallic Clusters

Journal of the American Chemical Society(2023)10.1021/jacs.3c03062

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8 citations

M Wittkop, Madeline B. Ho, William E. Broderick, Joan Broderick, Brian M. Hoffman +2 more

13C Electron Nuclear Double Resonance Spectroscopy-Guided Molecular Dynamics Computations Reveal the Structure of the Enzyme–Substrate Complex of an Active, N-Linked Glycosylated Lipoxygenase

Biochemistry(2023)10.1021/acs.biochem.3c00119

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9 citations

Chris Whittington, Mohammed A. Jabed, S. Gage Hill, Anastasiia Kostenko, Tao Yu +5 more

Discovery of a New Class of Aminoacyl Radical Enzymes Expands Nature’s Known Radical Chemistry

Journal of the American Chemical Society(2024)10.1021/jacs.4c10348

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11 citations

Hao Yang, Duncan J. Kountz, Maike N. Lundahl, Harry R. Beller, William E. Broderick +4 more

ENDOR Spectroscopy Reveals the “Free” 5′-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe–4S]2+ Cluster

Journal of the American Chemical Society(2024)10.1021/jacs.3c09428

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10 citations

Madeline B. Ho, Maike N. Lundahl, Martín A. Mosquera, William E. Broderick, Joan Broderick +2 more

Impact of N-Glycosylation on Protein Structure and Dynamics Linked to Enzymatic C–H Activation in the M. oryzae Lipoxygenase

Biochemistry(2024)10.1021/acs.biochem.4c00109

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8 citations

Ajay Sharma, S. Gage Hill, Anthony T. Iavarone, Brian M. Hoffman, Adam R. Offenbacher +1 more

The ternary complex of Mn 2+ , synthetic decapeptide DP1 (DEHGTAVMLK), and orthophosphate is a superb antioxidant

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2417389121

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6 citations

Ajay Sharma, Michael J. Daly, Brian M. Hoffman, Hao Yang

Role of ammonia-lyases in the synthesis of the dithiomethylamine ligand during [FeFe]-hydrogenase maturation

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.107760

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5 citations

Batuhan Balci, Eric M. Shepard, Hao Yang, Alex Drena, Gemma L. Holliday +4 more

Initial Steps in Methanobactin Biosynthesis: Substrate Binding by the Mixed-Valent Diiron Enzyme MbnBC

Biochemistry(2024)10.1021/acs.biochem.4c00011

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10 citations

Madeline B. Ho, Reyvin M. Reyes, Yun Ji Park, Peter E. Doan, Amy C. Rosenzweig +2 more

The Challenges and Opportunities of High-Spin Mn(II) EPR and ENDOR

Applied Magnetic Resonance(2024)10.1007/s00723-024-01680-w

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2 citations

Alex Drena, Ajay Sharma, Brian M. Hoffman, Peter E. Doan

Borrelia burgdorferi radiosensitivity and Mn antioxidant content: antigenic preservation and pathobiology

mBio(2024)10.1128/mbio.03131-24

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1 citations

Ajay Sharma, Jared Sealy, Vipin Singh Rana, Shelby D. Foor, Vera Y. Matrosova +7 more

Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome

Research Square(2024)10.21203/rs.3.rs-4131804/v1

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3 citations

Marianne B. Palczewski, Hannah Petraitis Kuschman, Brian M. Hoffman, Hao Yang, Sharon A. Glynn +15 more

Correction to “Terminal Hydride Complex of High-Spin Mn”

Journal of the American Chemical Society(2024)10.1021/jacs.4c11609

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1 citations

Addison Fraker, Niklas B. Thompson, Peter E. Doan, Brian M. Hoffman, Alex McSkimming +1 more

Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome

Nature Communications(2025)10.1038/s41467-025-56928-1

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12 citations

Hannah Petraitis Kuschman, Brian M. Hoffman, Venkatesan Kathiresan, Hao Yang, Sharon A. Glynn +16 more

Nitric Oxide restricts iron availability and induces quorum sensing in Streptococcus pyogenes

Redox Biology(2025)10.1016/j.redox.2025.103699

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6 citations

Venkatesan Kathiresan, Brian M. Hoffman, Jennifer C. Chang, Michael J. Federle, Douglas D. Thomas +1 more

Cryo-EM captures the coordination of asymmetric electron transfer through a di-copper site in DPOR

Nature Communications(2025)10.1038/s41467-025-59158-7

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5 citations

Natalie Walsh, Jaigeeth Deveryshetty, Monika Tokmina‐Lukaszewska, Kehan Zhao, Yunqiao J. Gan +6 more

Proton transfer during reduction of the catalytic metallo-cofactors of the three nitrogenase isozymes

Chemical Science(2025)10.1039/d5sc05488e

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5 citations

Dmitriy Lukoyanov, Derek F. Harris, Dennis R. Dean, Lance C. Seefeldt, Brian M. Hoffman +1 more

In vitro maturation of fully active [FeFe]-hydrogenase in a defined system including the iron carrier NfuA

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2517347122

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4 citations

Adrien Pagnier, Eric M. Shepard, Batuhan Balci, Abraham Teye, Douglas M. Warui +7 more

Simultaneous occupancy of Cu C and Cu D in the ammonia monooxygenase active site

Chemical Science(2025)10.1039/d5sc08447d

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1 citations

Madeline B. Ho, Aaron A. B. Turner, Lisa Y. Stein, Brian M. Hoffman, Amy C. Rosenzweig +1 more

Prophylactically Feeding Manganese to Drosophila Confers Sex-Specific Protection from Acute Ionizing Radiation Independent of MnSOD2 Levels

Antioxidants(2025)10.3390/antiox14020134

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4 citations

Aditya Sen, Ajay Sharma, Venkatesan Kathiresan, Brian M. Hoffman, Rachel T. Cox +1 more

Spectroscopic Interrogation of Thiolate Hydrogen Bonding in the CO Sensor Protein CooA: Implications for Thiolate Ligation Stability and Cytochrome P450 Function

Chemistry - A European Journal(2025)10.1002/chem.202404504

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1 citations

Richard J. Jodts, Brian M. Hoffman, Joshua Telser, Judith N. Burstyn, Brian R. Weaver