David A. Largaespada

Also affiliated with University of Minnesota System

MedicineMathematics

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 27 papers. Top paper: “APOBEC3A catalyzes mutation and drives carcinogenesis in vivo”.

APOBEC3A catalyzes mutation and drives carcinogenesis in vivo

The Journal of Experimental Medicine(2020)10.1084/jem.20200261

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0DataRank · unranked

154 citations

Rena Levin-Klein, Matthew C. Jarvis, Hyoung Kim, Prokopios P. Argyris, Michael A. Carpenter +14 more

ZBTB20 regulates WNT/CTNNB1 signalling pathway by suppressing PPARG during hepatocellular carcinoma tumourigenesis

JHEP Reports(2020)10.1016/j.jhepr.2020.100223

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0DataRank · unranked

50 citations

Amy P. Chiu, Barbara R. Tschida, Lilian H. Lo, Cynthia H. Chiu, Xiao-Xiao Li +9 more

Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K–AKT Signaling for the Treatment of Metastatic Osteosarcoma

Molecular Cancer Therapeutics(2020)10.1158/1535-7163.mct-20-0369

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15 citations

Garrett M. Draper, Nicholas J. Slipek, Alex T. Larsson, Natalie Stratton, Emily J. Pomeroy +14 more

Overexpression of HGF/MET axis along with p53 inhibition induces de novo glioma formation in mice

Neuro-Oncology Advances(2020)10.1093/noajnl/vdaa067

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0DataRank · unranked

12 citations

Anna Musket, Jianqun Kou, Johanna Preiszner, Barbara R. Tschida, Anna Qin +9 more

New Model Systems and the Development of Targeted Therapies for the Treatment of Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors

Genes(2020)10.3390/genes11050477

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43 citations

David A. Largaespada, Kyle Williams

PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma

Bone(2020)10.1016/j.bone.2020.115353

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0DataRank · unranked

35 citations

Nicholas J. Slipek, Emily J. Pomeroy, Kanut Laoharawee, Sara H. Osum, Alex T. Larsson +13 more

Transposon Mutagenesis-Guided CRISPR/Cas9 Screening Strongly Implicates Dysregulation of Hippo/YAP Signaling in Malignant Peripheral Nerve Sheath Tumor Development

Cancers(2021)10.3390/cancers13071584

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14 citations

Nicholas Koes, Ji Hae Ryu, Gabriel Kaufmann, Mariah J. Berner, Madison T. Weg +6 more

Spontaneous and Engineered Large Animal Models of Neurofibromatosis Type 1

International Journal of Molecular Sciences(2021)10.3390/ijms22041954

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0DataRank · unranked

17 citations

Adrienne L. Watson, David A. Largaespada, Sara H. Osum

Selumetinib normalizes Ras/MAPK signaling in clinically relevant neurofibromatosis type 1 minipig tissues in vivo

Neuro-Oncology Advances(2021)10.1093/noajnl/vdab020

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8 citations

Alexander Coutts, Dylan Duerre, Barbara R. Tschida, Mark N. Kirstein, James Fisher +8 more

Flow Assisted Mutation Enrichment (FAME): A highly efficacious and efficient method to enrich Double Knockouts (DKO) after gene editing

PLoS ONE(2021)10.1371/journal.pone.0247375

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1 citations

Xiaopin Cai, Sara Bowen, David A. Largaespada, Ming V. Li, Michael J. Hansen

Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.04.29.490078

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0DataRank · unranked

1 citations

Alex T. Larsson, Ana Calizo, Kai Pollard, Xiaochun Zhang, Eric Conniff +16 more

In vivo functional genomics identifies essentiality of potassium homeostasis in medulloblastoma

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.07.23.501234

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0DataRank · unranked

0 citations

Xin Wang, Anders W. Erickson, Patryk Skowron, Xian Wang, Xin Chen +29 more

RAD-TGTs: Measurement of cellular tensions via flow cytometry and DNA sequencing enabled by force-dependent rupture and delivery of DNA tension probes

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.08.515662

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0DataRank · unranked

0 citations

Adam T. Smiley, Marcus D. Kelly, Ghaidan A. Shamsan, Sarah M. Anderson, Branden A. Smeester +4 more

Radiation Therapy and Myeloid-Derived Suppressor Cells: Breaking Down Their Cancerous Partnership

International Journal of Radiation Oncology*Biology*Physics(2023)10.1016/j.ijrobp.2023.11.050

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0DataRank · unranked

44 citations

Matthew Berkseth, Drew M. Pardoll, Sudipto Ganguly, Lawrence Kleinberg, Jessica Lawrence +5 more

RAD-TGTs: high-throughput measurement of cellular mechanotype via rupture and delivery of DNA tension probes

Nature Communications(2023)10.1038/s41467-023-38157-6

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30 citations

Adam T. Smiley, María Paz Ramírez, Marcus D. Kelly, Ghaidan A. Shamsan, Sarah M. Anderson +5 more

Cutaneous Neurofibroma Heterogeneity: Factors that Influence Tumor Burden in Neurofibromatosis Type 1

Journal of Investigative Dermatology(2023)10.1016/j.jid.2022.12.027

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0DataRank · unranked

20 citations

Renée M. McKay, Sang Yong Lee, Carlos G. Romo, Jaishri O. Blakeley, Muzlifah Haniffa +5 more

Sex differences in methylation profiles are apparent in medulloblastoma, particularly among SHH tumors

Frontiers in Oncology(2023)10.3389/fonc.2023.1113121

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7 citations

Natali Sorajja, Lauren J. Mills, Christopher L. Moertel, Thanh T. Hoang, Logan G. Spector +3 more

CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon restoration of RB function in malignant peripheral nerve sheath tumors

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.02.526674

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0DataRank · unranked

5 citations

Ana Calizo, Lindy Zhang, James C. Pino, Yang Lyu, Kai Pollard +11 more

Evolution of the clinical-stage hyperactive TcBuster transposase as a platform for robust non-viral production of adoptive cellular therapies

Molecular Therapy(2024)10.1016/j.ymthe.2024.04.024

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0DataRank · unranked

27 citations

Emily J. Pomeroy, Nicholas J. Slipek, Bryan J. Jones, Bryce Wick, Jae‐Woong Chang +19 more

Conditionally replicative adenovirus as a therapy for malignant peripheral nerve sheath tumors

Molecular Therapy Oncology(2024)10.1016/j.omton.2024.200783

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2 citations

Robert Galvin, M. Sheehy, Ethan L. Novacek, Kari Jacobsen, Stanislas Corbiere +5 more

NF1-dependent disruption of the blood-nerve-barrier is improved by blockade of P2RY14

iScience(2024)10.1016/j.isci.2024.110294

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0DataRank · unranked

0 citations

Eric P. Rahrmann, Tilat A. Rizvi, Katherine C Scheffer, Timothy N. Phoenix, David A. Largaespada +2 more

CREB5 promotes tumorigenicity and upregulates druggable cell surface modalities in basal-like breast cancer

npj Precision Oncology(2025)10.1038/s41698-025-01051-z

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3 citations

Ella Boytim, Ava Gustafson, Megan Ludwig, Liangjun Wang, Atef Ali +18 more

Pharmacogenomic Synthetic Lethal Screens Reveal Hidden Vulnerabilities and New Therapeutic Approaches for Treatment of NF1-Associated Tumors

Molecular Cancer Therapeutics(2025)10.1158/1535-7163.mct-24-1053

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0DataRank · unranked

2 citations

Alex T. Larsson, Bryant J. Keller, Katherine E. Chaney, Rory L. Williams, Minu Bhunia +8 more

Sleeping Beauty mutagenesis identifies BACH2 and other regulators of CD8 + T cell exhaustion, persistence in vivo , and CAR-T function under tumor-associated chronic antigen stimulation

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.08.18.670666

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1 citations

Alex T. Larsson, Tyler Jubenville, Wendy A. Hudson, Carli M. Stewart, Alexander K. Tsai +16 more

Techniques for Validating CRISPR Changes Using RNA-Sequencing Data

Genes(2025)10.3390/genes16040369

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0DataRank · unranked

0 citations

Tracy A. Marko, Elizabeth N. Edwards, Paige Hazelton Ridder, Jyotika Varshney, Kyle Williams +4 more

A modular, immunopeptidogenomic (iPepGen) analysis pipeline for discovery, verification, and prioritization of cancer peptide neoantigen candidates

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.07.647596

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0DataRank · unranked

0 citations

Reid Wagner, Katherine Do, James E. Johnson, Fengchao Yu, Tyler Jubenville +8 more

Non-viral TcBuster transposon engineering of CD70-CAR natural killer cells for the treatment of osteosarcoma

Molecular Therapy Oncology(2025)10.1016/j.omton.2025.201119

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0DataRank · unranked

0 citations

Jae‐Woong Chang, Joshua Krueger, Young Vue, Alexandria K. Gilkey, Timothy D. Folsom +11 more