Alfred L. George

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 63 papers. Top paper: “A randomized pilot clinical trial of pravastatin versus placebo in pregnant patients at high risk of preeclampsia”.

A randomized pilot clinical trial of pravastatin versus placebo in pregnant patients at high risk of preeclampsia

American Journal of Obstetrics and Gynecology(2021)10.1016/j.ajog.2021.05.018

N/A

3.3DataRank · unranked

90 citations

Holly West, Katherine L. Wisner, Steve N. Caritis, Shannon Clark, Raman Venkataramanan +20 more

Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state

eLife(2020)10.7554/elife.53901

N/A

1.2DataRank · unranked

59 citations

Po Wei Kang, Panpan Hou, Nien-Du Yang, Georg Kuenze, Jarrod A. Smith +10 more

Arrhythmia Variant Associations and Reclassifications in the eMERGE-III Sequencing Study

Circulation(2021)10.1161/circulationaha.121.055562

N/A

1.2DataRank · unranked

49 citations

Giovanni Davogustto, Christian M. Shaffer, Carlos G. Vanoye, Reshma R. Desai, Eric Farber‐Eger +46 more

Cellular and behavioral effects of altered NaV1.2 sodium channel ion permeability in Scn2a K1422E mice

Human Molecular Genetics(2022)10.1093/hmg/ddac087

N/A

0.524DataRank · unranked

32 citations

Nicole A. Hawkins, Sunita N. Misra, Alexandra M Huffman, Tyler Thaxton, Christopher H. Thompson +7 more

Neuronal modeling of alternating hemiplegia of childhood reveals transcriptional compensation and replicates a trigger-induced phenotype

Neurobiology of Disease(2020)10.1016/j.nbd.2020.104881

N/A

0.464DataRank · unranked

21 citations

Grant Westlake, Lindsay K. Klofas, Soyoun Jeon, Laura Armstrong, Kathryn J. Swoboda +3 more

TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD

Nature Neuroscience(2025)10.1038/s41593-025-02096-w

N/A

0.442DataRank · unranked

18 citations

Kelly A. Marshall, Peter Harley, Jacob R. Mann, Francesco Alessandrini, Carlos G. Vanoye +32 more

Transient titin-dependent ventricular defects during development lead to adult atrial arrhythmia and impaired contractility

iScience(2024)10.1016/j.isci.2024.110395

N/A

0.406DataRank · unranked

14 citations

Olivia T Ly, Hanna Chen, Ziwei Zhang, Beatriz Ibarra, Mahmud Arif Pavel +14 more

Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 2: Population and Clinical Considerations

Circulation Arrhythmia and Electrophysiology(2021)10.1161/circep.121.010190

N/A

0.385DataRank · unranked

12 citations

Alfred L. George, Jeanne M. Nerbonne, Joseph Bass, Crystal M. Ripplinger, Mukesh K. Jain +15 more

Disease-linked supertrafficking of a potassium channel

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100423

N/A

0.330DataRank · unranked

8 citations

Laura M. Chamness, Carlos G. Vanoye, Georg Kuenze, Jens Meiler, Alfred L. George +3 more

Genetic Testing and Hospital Length of Stay in Neonates With Epilepsy

Pediatric Neurology(2022)10.1016/j.pediatrneurol.2022.05.011

N/A

0.292DataRank · unranked

6 citations

Ashwin Sunderraj, L. Nelson Sanchez‐Pinto, Anne T. Berg, Alfred L. George, Andrea C. Pardo +1 more

Pathogenic SCN2A variants are associated with familial and sporadic hemiplegic migraine

Research Square(2023)10.21203/rs.3.rs-3215189/v1

N/A

0.241DataRank · unranked

4 citations

Christopher H. Thompson, Jean‐Marc DeKeyser, Tatiana Abramova, Steven Gazal, Thierry Moulin +7 more

Cellular and behavioral effects of altered Na V 1.2 sodium channel ion permeability in Scn2a K1422E mice

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.07.19.452930

N/A

0.208DataRank · unranked

3 citations

Nicole A. Hawkins, Sunita N. Misra, Alexandra M Huffman, Tyler Thaxton, Christopher H. Thompson +7 more

387. Advantageous Properties of the piggyBac Transposon System for Gene Transfer in Human Cells

Molecular Therapy(2006)10.1016/j.ymthe.2006.08.448

N/A

0.104DataRank · unranked

1 citations

Craig J. Coates, Edward J. Rebar, Alfred L. George, Matthew H. Wilson

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.09.515866

N/A

0.104DataRank · unranked

1 citations

Marc Dos Santos, Nicolas H. Piguel, Yizhi Wang, Nicole A. Hawkins, Vikram A. Bagchi +12 more

The impact of damaging epilepsy and cardiac genetic variant burden in sudden death in the young

medRxiv(2023)10.1101/2023.03.27.23287711

N/A

0.104DataRank · unranked

1 citations

Lorenzo L. Pesce, Edgar J. Hernández, Gregory Webster, Lisa Dellefave‐Castillo, Mark W. Russell +17 more

High Throughput Screening Identifies a Small Molecule Trafficking Corrector for Long-QT Syndrome Associated KCNQ1 Variants

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.10.13.682066

N/A

0.104DataRank · unranked

1 citations

Carlos G. Vanoye, Ana C Chang-Gonzalez, Ian M. Romaine, Katherine M. Stefanski, Mason C. Wilkinson +12 more

Structural Requirements for the Stability and Trafficking of the KCNQ1 Potassium Channel

Biophysical Journal(2021)10.1016/j.bpj.2020.11.1592

N/A

0DataRank · unranked

0 citations

Alfred L. George, Charles R. Sanders, Hui Huang

High-throughput Evaluation of Epilepsy-associated KCNQ2 Variants Reveals Functional and Pharmacological Heterogeneity

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.10.18.464842

N/A

0DataRank · unranked

0 citations

Reshma R. Desai, Zhigang Ji, Sneha Adusumilli, Nirvani Jairam, Nora F. Ghabra +10 more

Precision medicine for genetic epilepsy on the horizon: Recent advances, present challenges, and suggestions for continued progress

Epilepsia(2022)10.1111/epi.17332

N/A

0DataRank · unranked

144 citations

Ingo Helbig, Cameron S. Metcalf, Laura S. Lubbers, Lori L. Isom, Scott Demarest +8 more

High-throughput evaluation of epilepsy-associated KCNQ2 variants reveals functional and pharmacological heterogeneity

JCI Insight(2022)10.1172/jci.insight.156314

N/A

0DataRank · unranked

66 citations

Reshma R. Desai, Zhigang Ji, Sneha Adusumilli, Nirvani Jairam, Nora F. Ghabra +10 more

‘Channeling’ therapeutic discovery for epileptic encephalopathy through iPSC technologies

Trends in Pharmacological Sciences(2022)10.1016/j.tips.2022.03.001

N/A

0DataRank · unranked

29 citations

Christina M. Ambrosi, Kelly A. Marshall, Luis A. Williams, Jordyn Eisenberg, Mennat Gharib +5 more

Predicting the functional impact of KCNQ1 variants with artificial neural networks

PLoS Computational Biology(2022)10.1371/journal.pcbi.1010038

N/A

0DataRank · unranked

9 citations

Georg Kuenze, Carlos G. Vanoye, Charles R. Sanders, Alfred L. George, Jens Meiler +1 more

Cholesterol-induced suppression of Kir2 channels is mediated by decoupling at the inter-subunit interfaces

iScience(2022)10.1016/j.isci.2022.104329

N/A

0DataRank · unranked

11 citations

Sara T. Granados, Carlos G. Vanoye, Т. В. Абрамова, Danielle Kulbak, Sang Joon Ahn +4 more

Molecular simulations reveal a mechanism for enhanced allosteric coupling between voltage-sensor and pore domains in KCNQ1 explaining its activation by ML277

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.05.31.494217

N/A

0DataRank · unranked

0 citations

Carlos G. Vanoye, Mason C. Wilkinson, Reshma R. Desai, Sneha Adusumilli, Charles R. Sanders +3 more

Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties

The Journal of General Physiology(2023)10.1085/jgp.202313375

N/A

0DataRank · unranked

62 citations

F Potet, Tatiana V Abramova, Jean‐Marc DeKeyser, Nora F. Ghabra, Carlos G. Vanoye +3 more

RNA-based translation activators for targeted gene upregulation

Nature Communications(2023)10.1038/s41467-023-42252-z

N/A

0DataRank · unranked

46 citations

Huachun Liu, Shannon S. Lu, Krysten A. Jones, Anitha P. Govind, Okunola Jeyifous +8 more

Outlining cardiac ion channel protein interactors and their signature in the human electrocardiogram

Nature Cardiovascular Research(2023)10.1038/s44161-023-00294-y

N/A

0DataRank · unranked

22 citations

Robert W. Mills, Konstantin Kahnert, David Y. Chiang, Giorgia Bertoli, Pia R. Lundegaard +8 more

Exome sequencing of ATP1A3-negative cases of alternating hemiplegia of childhood reveals SCN2A as a novel causative gene

European Journal of Human Genetics(2023)10.1038/s41431-023-01489-4

N/A

0DataRank · unranked

8 citations

Francesco Danilo Tiziano, Mohamad A. Mikati, Lisanne S. Vijfhuizen, Sophie Nicole, Gaëtan Lesca +19 more

Epilepsy-associated SCN2A (Na V 1.2) Variants Exhibit Diverse and Complex Functional Properties

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.23.529757

N/A

0DataRank · unranked

2 citations

F Potet, Tatiana Abramova, Jean‐Marc DeKeyser, Nora F. Ghabra, Carlos G. Vanoye +3 more

Engineered cocultures of iPSC-derived atrial cardiomyocytes and atrial fibroblasts for modeling atrial fibrillation

Science Advances(2024)10.1126/sciadv.adg1222

N/A

0DataRank · unranked

35 citations

Yong Duk Han, Ashlin R. Michell, Olivia T Ly, Carlos G. Vanoye, Emanuele Spanghero +4 more

Susceptibility to innate immune activation in genetically mediated myocarditis

Journal of Clinical Investigation(2024)10.1172/jci180254

N/A

0DataRank · unranked

29 citations

Dominic E. Fullenkamp, Ivana A. Chychula, Binjie Li, Lisa Dellefave‐Castillo, Adi D. Dubash +14 more

The impact of damaging epilepsy and cardiac genetic variant burden in sudden death in the young

Genome Medicine(2024)10.1186/s13073-024-01284-w

N/A

0DataRank · unranked

13 citations

Lorenzo L. Pesce, Edgar J. Hernández, Gregory Webster, Lisa Dellefave‐Castillo, Mark W. Russell +18 more

Reduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias

Journal of the American Heart Association(2024)10.1161/jaha.123.030467

N/A

0DataRank · unranked

12 citations

Lisa Dellefave‐Castillo, Garima Tomar, Lisa D. Wilsbacher, Lubna Choudhury, David Y. Barefield +11 more

Altered neurological and neurobehavioral phenotypes in a mouse model of the recurrent KCNB1-p.R306C voltage-sensor variant

Neurobiology of Disease(2024)10.1016/j.nbd.2024.106470

N/A

0DataRank · unranked

7 citations

Nicole A. Hawkins, Christopher H. Thompson, Erin M. Baker, Dennis M. Echevarria-Cooper, Levi Barse +6 more

Novel mouse model of alternating hemiplegia of childhood exhibits prominent motor and seizure phenotypes

Neurobiology of Disease(2024)10.1016/j.nbd.2024.106751

N/A

0DataRank · unranked

5 citations

Jean‐Marc DeKeyser, Jennifer A. Kearney, Alfred L. George, Nicole A. Hawkins

Concentrations of Fluoxetine Enantiomers Decline During Pregnancy and Increase After Birth

Journal of Clinical Psychopharmacology(2024)10.1097/jcp.0000000000001821

N/A

0DataRank · unranked

3 citations

Michael J. Avram, Alfred L. George, Tatiana V Abramova, Amy Yang, Steve N. Caritis +3 more

The Need for Speed; Investigating Channelopathy-Associated Epilepsy Using High Throughput Electrophysiological Approaches

Epiliepsy currents/Epilepsy currents(2024)10.1177/15357597241280484

N/A

0DataRank · unranked

1 citations

Evangelos Kiskinis, Alfred L. George

Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy

eLife(2024)10.7554/elife.91204

N/A

0DataRank · unranked

3 citations

Emma C. Thompson, Anuraag Madabushi, Kristen Park, Heun Soh, Nissi Varghese +20 more

In vivo prime editing rescues alternating hemiplegia of childhood in mice

Cell(2025)10.1016/j.cell.2025.06.038

N/A

0DataRank · unranked

33 citations

Markus Terrey, Holt A. Sakai, Christine Q. Simmons, Elena Arystarkhova, Natalia S. Morsci +14 more

Characterization of the functional and clinical impacts of CACNA1A missense variants found in neurodevelopmental disorders

Science Translational Medicine(2025)10.1126/scitranslmed.adr0024

N/A

0DataRank · unranked

3 citations

Lei Cui, Nikita Budnik, Siwei Chen, Erick Olivares, David Báez-Nieto +14 more

Functional Profiling of KCNE1 Variants Informs Population Carrier Frequency of Jervell and Lange-Nielsen Syndrome Type 2

Circulation Genomic and Precision Medicine(2025)10.1161/circgen.125.005219

N/A

0DataRank · unranked

2 citations

Reshma R. Desai, Jordan John, Steven C. Hoffman, Nicolas Fink, Yue Zhang +8 more

Changes in S‐Citalopram Plasma Concentrations Across Pregnancy and Postpartum

Clinical Pharmacology & Therapeutics(2025)10.1002/cpt.3642

N/A

0DataRank · unranked

5 citations

Michael J. Avram, Alfred L. George, Amy Yang, Jody D. Ciolino, Hyunyoung Jeong +5 more

Genotype‐function‐phenotype correlations for SCN1A variants identified by clinical genetic testing

Annals of Clinical and Translational Neurology(2025)10.1002/acn3.52297

N/A

0DataRank · unranked

1 citations

Christopher H. Thompson, Dillon Scott, Tatiana V Abramova, Bethany Stieve, Abigail Freeman +2 more

Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability

eLife(2025)10.7554/elife.105696

N/A

0DataRank · unranked

6 citations

Chenyu Wang, Ryan P.D. Alexander, Emmie Banks, Tim R. Fenton, Jean‐Marc DeKeyser +6 more

Characterization of the functional and clinical impacts of CACNA1A missense variants found in neurodevelopmental disorders

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.23.650298

N/A

0DataRank · unranked

0 citations

Lei Cui, Nikita Budnik, Siwei Chen, Erick Olivares, David Báez-Nieto +11 more

Heterogeneous Genotype-Phenotype Associations in TRIO-Related Neurodevelopmental Disorder Revealed by Meta-Analysis

medRxiv(2025)10.1101/2025.10.17.25338222

N/A

0DataRank · unranked

0 citations

Alfred L. George, Sarah Ann Duck

Classification models distinguish functional and trafficking effects of KCNQ1 variants to enhance variant interpretation

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.10.31.685955

N/A

0DataRank · unranked

0 citations

Eric W. Bell, Carlos G. Vanoye, Eduardo Guadarrama, Reshma R. Desai, Jean-Marc DeKeyser +7 more

Neurodevelopmental features in KCNQ2 developmental and epileptic encephalopathy may have limited associations with K V 7 .2 dysfunction

Epilepsia Open(2025)10.1002/epi4.70192

N/A

0DataRank · unranked

1 citations

Carlos G. Vanoye, Reshma R. Desai, Anne T. Berg, Alfred L. George, Jessa Bidwell

Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants

The Journal of General Physiology(2020)10.1085/jgp.201912442

N/A

0DataRank · unranked

55 citations

Roy Ben‐Shalom, Kevin J. Bender, Alfred L. George, Christopher H. Thompson

Reengineering an Antiarrhythmic Drug Using Patient hiPSC Cardiomyocytes to Improve Therapeutic Potential and Reduce Toxicity

Cell stem cell(2020)10.1016/j.stem.2020.08.003

N/A

0DataRank · unranked

51 citations

Dries Feyen, Arne A.N. Bruyneel, Karl J. Okolotowicz, Daniel A. J. Ryan, Kevin J. Sampson +10 more

Impact of CYP2C9‐Interacting Drugs on Warfarin Pharmacogenomics

Clinical and Translational Science(2020)10.1111/cts.12781

N/A

0DataRank · unranked

20 citations

Meredith S. Heiss, Remington B. Fenter, Tatiana Abramova, Minoli A. Perera, Jennifer A. Pacheco +4 more

Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation

The Journal of General Physiology(2020)10.1085/jgp.202012667

N/A

0DataRank · unranked

18 citations

Seojin Park, Duncan F. Muir, Ryan L. Woltz, Lu Ren, Phuong T. Nguyen +10 more

Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation

eLife(2020)10.7554/elife.57680

N/A

0DataRank · unranked

41 citations

Carlos G. Vanoye, Reshma R. Desai, Sneha Adusumilli, Kathryn R. Brewer, Hope Woods +5 more

Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome

Frontiers in Pharmacology(2020)10.3389/fphar.2020.00550

N/A

0DataRank · unranked

39 citations

Georg Kuenze, Carlos G. Vanoye, Alfred L. George, Jens Meiler, Charles R. Sanders +1 more

Striatal Kir2 K+ channel inhibition mediates the antidyskinetic effects of amantadine

Journal of Clinical Investigation(2020)10.1172/jci133398

N/A

0DataRank · unranked

38 citations

Wenjie Ren, Shenyu Zhai, Ben Yang, Carlos G. Vanoye, Ananya Mitra +3 more

Cryptic prokaryotic promoters explain instability of recombinant neuronal sodium channels in bacteria

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.11.05.370429

N/A

0DataRank · unranked

3 citations

Christopher H. Thompson, Alfred L. George, Jean‐Marc DeKeyser

Stabilization of the KCNQ1 Potassium Channel Causes Disease

Biophysical Journal(2020)10.1016/j.bpj.2019.11.740

N/A

0DataRank · unranked

0 citations

Laura M. Chamness, Jonathan P. Schlebach, Arina Hadziselimovic, Georg Kuenze, Jens Meiler +3 more

Neuronal Modeling of Alternating Hemiplegia of Childhood Reveals Transcriptional Compensation and Replicates a Trigger-Induced Phenotype

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.04.08.031732

N/A

0DataRank · unranked

0 citations

Grant Westlake, Lindsay K. Klofas, Soyoun Jeon, Laura Armstrong, Kathryn J. Swoboda +3 more

Disease-Linked Super-Trafficking of a Mutant Potassium Channel

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.07.29.227231

N/A

0DataRank · unranked

0 citations

Laura M. Chamness, Carlos G. Vanoye, Georg Kuenze, Jens Meiler, Alfred L. George +3 more

Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy

eLife(2021)10.7554/elife.64434

N/A

0DataRank · unranked

50 citations

Kelly A. Marshall, Carlos G. Vanoye, Reshma R. Desai, Bernabé I. Bustos, Brandon N Piyevsky +10 more

Cryptic prokaryotic promoters explain instability of recombinant neuronal sodium channels in bacteria

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100298

N/A

0DataRank · unranked

38 citations

Christopher H. Thompson, Alfred L. George, Jean-Marc DeKeyser

Targeting the Microtubule EB1-CLASP2 Complex Modulates Na V 1.5 at Intercalated Discs

Circulation Research(2021)10.1161/circresaha.120.318643

N/A

0DataRank · unranked

38 citations

Mariam Jouni, David Y. Chiang, Marta Pérez-Hernández, Svitlana Podliesna, Nuo Yu +21 more

Functional evaluation of human ion channel variants using automated electrophysiology

Methods in enzymology on CD-ROM/Methods in enzymology(2021)10.1016/bs.mie.2021.02.011

N/A

0DataRank · unranked

22 citations

Christopher H. Thompson, Reshma R. Desai, Jean‐Marc DeKeyser, Liqi Chen, Laura J. Rasmussen‐Torvik +3 more