Alex S. Holehouse

Also affiliated with Living Systems (United States)

Biochemistry, Genetics and Molecular BiologyMaterials Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 64 papers. Top paper: “Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions”.

Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions

Annual Review of Biophysics(2020)10.1146/annurev-biophys-121219-081629

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9.6DataRank · unranked

994 citations

Alex S. Holehouse, Rohit V. Pappu, Jeong‐Mo Choi

Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain

Genome Research(2024)10.1101/gr.279415.124

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0.554DataRank · unranked

17 citations

David M. Granas, Jie Li, Zara Shariff, Stephen P. Plassmeyer, Alex S. Holehouse +3 more

Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation

Molecular Cell(2020)10.1016/j.molcel.2020.01.025

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0DataRank · unranked

250 citations

Tu Anh Nguyen, Michelle H. Lee, Alex S. Holehouse, Ammon E. Posey, Rohit V. Pappu +2 more

Connecting Coil-to-Globule Transitions to Full Phase Diagrams for Intrinsically Disordered Proteins

Biophysical Journal(2020)10.1016/j.bpj.2020.06.014

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0DataRank · unranked

127 citations

Alex S. Holehouse, Ashutosh Chilkoti, Tanja Mittag, Rohit V. Pappu, Xiangze Zeng

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.06.17.158121

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0DataRank · unranked

81 citations

Jhullian J. Alston, J. Jeremías Incicco, Sukrit Singh, Melissa D. Stuchell‐Brereton, Michael D. Ward +9 more

Hydration-dependent phase separation of a prion-like protein regulates seed germination during water stress

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.07.242172

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0DataRank · unranked

8 citations

Steven Boeynaems, Benjamin Jin, Flavia Bossi, Eduardo Flores, Elena Lazarus +8 more

Design principles of acidic transcriptional activation domains

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.28.359026

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0DataRank · unranked

7 citations

Eddie Ramirez, Alex S. Holehouse, Rohit V. Pappu, Barak A. Cohen, Max V. Staller

Probing the Hidden Sensitivity of Intrinsically Disordered Proteins to their Chemical Environment

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.17.252478

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0DataRank · unranked

2 citations

Feng Yu, Garrett M. Ginell, Nora M. Shamoon, Patrick Koenig, Alex S. Holehouse +2 more

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

Nature Communications(2021)10.1038/s41467-021-21953-3

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0DataRank · unranked

593 citations

Jhullian J. Alston, J. Jeremías Incicco, Sukrit Singh, Melissa D. Stuchell‐Brereton, Michael D. Ward +9 more

A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation

Cell(2021)10.1016/j.cell.2021.06.009

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0DataRank · unranked

240 citations

Steven Boeynaems, Eduardo Flores, Benjamin Jin, Shannon Hateley, Flavia Bossi +14 more

Integrating single-molecule spectroscopy and simulations for the study of intrinsically disordered proteins

Methods(2021)10.1016/j.ymeth.2021.03.018

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0DataRank · unranked

34 citations

Andrea Soranno, Alex S. Holehouse, Jhullian J. Alston

Sequence determinants of in cell condensate morphology, dynamics, and oligomerization as measured by number and brightness analysis

Cell Communication and Signaling(2021)10.1186/s12964-021-00744-9

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0DataRank · unranked

20 citations

Alex S. Holehouse, Lucia C. Strader, Ryan J. Emenecker

Protein products of nonstop mRNA disrupt nucleolar homeostasis

Cell Stress and Chaperones(2021)10.1007/s12192-021-01200-w

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0DataRank · unranked

13 citations

Laura Mediani, Francesco Antoniani, Jonathan Vinet, Shuangxi Li, Simon Alberti +5 more

A modular platform for engineering function of natural and synthetic biomolecular condensates

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.02.03.429226

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0DataRank · unranked

32 citations

Steven Boeynaems, Vinson Lam, Emma Stainton, Maarten Jacquemyn, Dirk Daelemans +5 more

Tardigrade CAHS Proteins Act as Molecular Swiss Army Knives to Mediate Desiccation Tolerance Through Multiple Mechanisms

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.08.16.456555

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0DataRank · unranked

25 citations

Kenny H. Nguyen, Sourav Biswas, Charles A. Childs, KC Shraddha, Bryan X. Medina +10 more

Structural biases in disordered proteins are prevalent in the cell

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.11.24.469609

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0DataRank · unranked

20 citations

Karina Guadalupe, Feng Yu, Eduardo Flores, Anthony Perez, Ralph McAnelly +7 more

Conformational buffering underlies functional selection in intrinsically disordered protein regions

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.14.444182

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0DataRank · unranked

9 citations

Wade M. Borcherds, Juliana Glavina, Susana Barrera-Vilarmau, Amin Sagar, Alejandro Estaña +12 more

Shelterin components modulate nucleic acids condensation and phase separation in the context of telomeric DNA

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.30.442189

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0DataRank · unranked

3 citations

J. Jeremías Incicco, Paolo De Bona, Eric J. Tomko, Eric A. Galburt, Alex S. Holehouse +2 more

Sequence determinants of in cell condensate assembly morphology, dynamics, and oligomerization as measured by number and brightness analysis

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.18.440340

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0DataRank · unranked

1 citations

Alex S. Holehouse, Lucia C. Strader, Ryan J. Emenecker

The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems

Nature Communications(2022)10.1038/s41467-022-33221-z

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0DataRank · unranked

132 citations

Steven Boeynaems, Vinson Lam, Daniel Scholl, Emma Stainton, Adam Briner +8 more

Conformational buffering underlies functional selection in intrinsically disordered protein regions

Nature Structural & Molecular Biology(2022)10.1038/s41594-022-00811-w

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0DataRank · unranked

129 citations

Juliana Glavina, Wade M. Borcherds, Matías Safranchik, Susana Barrera-Vilarmau, Amin Sagar +14 more

Shelterin Components Modulate Nucleic Acids Condensation and Phase Separation in the Context of Telomeric DNA

Journal of Molecular Biology(2022)10.1016/j.jmb.2022.167685

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0DataRank · unranked

21 citations

J. Jeremías Incicco, Paolo De Bona, Eric J. Tomko, Eric A. Galburt, Alex S. Holehouse +2 more

The formation of a fuzzy complex in the negative arm regulates the robustness of the circadian clock

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.01.04.474980

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0DataRank · unranked

13 citations

Daniel Griffith, Divya G. Shastry, Jacqueline F. Pelham, Garrett M. Ginell, Joshua Thomas +4 more

The kinetic landscape of human transcription factors

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.06.01.494187

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0DataRank · unranked

7 citations

Nader Alerasool, Daniel Griffith, Alex S. Holehouse, Mikko Taipale, Timothée Lionnet +1 more

A condensate forming tether for lariat debranching enzyme is defective in non-photosensitive trichothiodystrophy

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.03.515106

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0DataRank · unranked

1 citations

Luke Buerer, Albino Bacolla, Timur Rusanov, Nicolas Schmidt, Sridhar Nonavinkere Srivatsan +13 more

A fuzzy complex in the negative arm regulates circadian clock robustness.

Research Square(2022)10.21203/rs.3.rs-1328618/v1

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0DataRank · unranked

0 citations

Meaghan S. Jankowski, Daniel Griffith, Divya G. Shastry, Jacqueline F. Pelham, Garrett M. Ginell +4 more

The molecular basis for cellular function of intrinsically disordered protein regions

Nature Reviews Molecular Cell Biology(2023)10.1038/s41580-023-00673-0

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0DataRank · unranked

690 citations

Birthe B. Kragelund, Alex S. Holehouse

Intrinsically disordered regions are poised to act as sensors of cellular chemistry

Trends in Biochemical Sciences(2023)10.1016/j.tibs.2023.08.001

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0DataRank · unranked

136 citations

Garrett M. Ginell, Alex S. Holehouse, Shahar Sukenik, David Moses

The disordered N-terminal tail of SARS-CoV-2 Nucleocapsid protein forms a dynamic complex with RNA

Nucleic Acids Research(2023)10.1093/nar/gkad1215

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0DataRank · unranked

44 citations

Jhullian J. Alston, J. Jeremías Incicco, Alex S. Holehouse, Kathleen B. Hall, Melissa D. Stuchell‐Brereton +2 more

Dissecting the biophysics and biology of intrinsically disordered proteins

Trends in Biochemical Sciences(2023)10.1016/j.tibs.2023.10.002

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0DataRank · unranked

21 citations

Alex S. Holehouse, Richard W. Kriwacki, Paul Robustelli, Hao Jiang, Alexander I. Sobolevsky +3 more

Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates

Molecular Cell(2023)10.1016/j.molcel.2023.05.025

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0DataRank · unranked

35 citations

Yanniv Dorone, Yanrong Zhuang, Victoria Shabardina, Guozhong Huang, Anca Marian +13 more

FIREBALL: A tool to fit protein phase diagrams based on mean-field theories for polymer solutions

Biophysical Journal(2023)10.1016/j.bpj.2023.05.007

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0DataRank · unranked

16 citations

Alex S. Holehouse, Xiangze Zeng, Rohit V. Pappu, Mina Farag

A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy

Molecular Cell(2023)10.1016/j.molcel.2023.06.011

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0DataRank · unranked

14 citations

Luke Buerer, Ning Tsao, Albino Bacolla, Fadhel Mansoori, Timur Rusanov +17 more

SOURSOP: A Python Package for the Analysis of Simulations of Intrinsically Disordered Proteins

Journal of Chemical Theory and Computation(2023)10.1021/acs.jctc.3c00190

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0DataRank · unranked

41 citations

Alex T. Keeley, Kiersten M. Ruff, Rohit V. Pappu, Alex S. Holehouse, Jared M. Lalmansingh

Rational design of disordered proteins for systematic sequence-to-function investigation

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.29.564547

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0DataRank · unranked

24 citations

Trevor Brandt, Karina Guadalupe, Kavindu Kolamunna, Jeffrey M. Lotthammer, Nora M. Shamoon +7 more

SOURSOP: A Python package for the analysis of simulations of intrinsically disordered proteins

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.16.528879

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0DataRank · unranked

17 citations

Alex T. Keeley, Kiersten M. Ruff, Rohit V. Pappu, Alex S. Holehouse, Jared M. Lalmansingh

Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.09.531820

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0DataRank · unranked

15 citations

X. Rosa, Vivian Yeong, Garrett M. Ginell, Jian-Hua Chen, Jacob A. Blum +18 more

Labile assembly of a tardigrade protein induces biostasis

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.06.30.547219

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0DataRank · unranked

8 citations

Ky‐Anh Nguyen, Saikat Biswas, Vincent Nicholson, Andrey Romanyuk, Jorge Ramı́rez +19 more

FIREBALL: A tool to fit protein phase diagrams based on mean-field theories for polymer solutions

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.19.533322

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0DataRank · unranked

2 citations

Alex S. Holehouse, Xiangze Zeng, Rohit V. Pappu, Mina Farag

Sequence-ensemble-function relationships for disordered proteins in live cells

Research Square(2023)10.21203/rs.3.rs-3501110/v1

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0DataRank · unranked

1 citations

Ryan J. Emenecker, Karina Guadalupe, Nora M. Shamoon, Shahar Sukenik, Alex S. Holehouse

Structural biases in disordered proteins are prevalent in the cell

Nature Structural & Molecular Biology(2024)10.1038/s41594-023-01148-8

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0DataRank · unranked

68 citations

Karina Guadalupe, Feng Yu, Eduardo Flores, Anthony R. Perez, Ralph McAnelly +8 more

Identification of plant transcriptional activation domains

Nature(2024)10.1038/s41586-024-07707-3

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0DataRank · unranked

61 citations

Lisa Van den Broeck, C. P. MILLER, Ryan J. Emenecker, John A. Bryant, T.M. Lee +14 more

Labile assembly of a tardigrade protein induces biostasis

Protein Science(2024)10.1002/pro.4941

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0DataRank · unranked

26 citations

Ky‐Anh Nguyen, Saikat Biswas, Vincent Nicholson, Andrey Romanyuk, Jorge Ramı́rez +20 more

Phosphorylation of disordered proteins tunes local and global intramolecular interactions

Biophysical Journal(2024)10.1016/j.bpj.2024.10.021

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0DataRank · unranked

23 citations

Martin J. Fossat, Alex S. Holehouse, Emery T. Usher

Partial wrapping of single-stranded DNA by replication protein A and modulation through phosphorylation

Nucleic Acids Research(2024)10.1093/nar/gkae584

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0DataRank · unranked

13 citations

Vikas Kaushik, Iram Munir Ahmad, Jaigeeth Deveryshetty, Alex S. Holehouse, Snorri Th. Sigurdsson +9 more

Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator

Nature Communications(2024)10.1038/s41467-024-47761-z

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0DataRank · unranked

11 citations

Daniel Griffith, Divya G. Shastry, Jacqueline F. Pelham, Garrett M. Ginell, Joshua Thomas +4 more

Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors

Cancer Discovery(2024)10.1158/2159-8290.cd-23-1393

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0DataRank · unranked

10 citations

Jack H. Landmann, Tien-Ching Chang, Mehmet Emrah Selli, Yangdon Tenzin, John M. Warrington +8 more

Molecular insights into the interaction between a disordered protein and a folded RNA

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2409139121

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0DataRank · unranked

9 citations

Emery T. Usher, Selin Dedeoğlu, Matthew J. Crotteau, Olivia A. Fraser, Neela H. Yennawar +7 more

Direct prediction of intermolecular interactions driven by disordered regions

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.03.597104

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0DataRank · unranked

26 citations

Ryan J. Emenecker, Jeffrey M. Lotthammer, Emery T. Usher, Alex S. Holehouse, Garrett M. Ginell

Disordered proteins interact with the chemical environment to tune their protective function during drying

eLife(2024)10.7554/elife.97231

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0DataRank · unranked

5 citations

Kenny Nguyen, Vincent Nicholson, Annie Walgren, Tony Trent, Edith Gollub +5 more

Disordered proteins interact with the chemical environment to tune their protective function during drying

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.28.582506

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0DataRank · unranked

4 citations

Kenny Nguyen, Vincent Nicholson, Annie Walgren, Tony Trent, Edith Gollub +5 more

Protein surface chemistry encodes an adaptive tolerance to desiccation

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.07.28.604841

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0DataRank · unranked

4 citations

Haley M. Moran, Azeem Horani, Alexander Truong, Edgar Manriquez-Sandoval, John F. Ramirez +12 more

Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.03.21.585809

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0DataRank · unranked

2 citations

David M. Granas, Jie Li, Zara Shariff, Stephen P. Plassmeyer, Alex S. Holehouse +3 more

Structural dynamics of the intrinsically disordered linker region of cardiac troponin T

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.05.30.596451

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0DataRank · unranked

1 citations

Lina Greenberg, Akiva E. Greenberg, Ryan J. Emenecker, Melissa D. Stuchell‐Brereton, Alex S. Holehouse +3 more

Molecular insights into the interaction between a disordered protein and a folded RNA

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.12.598678

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0DataRank · unranked

1 citations

Emery T. Usher, Selin Dedeoğlu, Matthew J. Crotteau, Olivia A. Fraser, Neela H. Yennawar +7 more

The dimerization domain of SARS CoV 2 Nucleocapsid protein is partially disordered as a monomer and forms a high affinity dynamic complex

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.09.25.614883

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0DataRank · unranked

1 citations

J. Jeremías Incicco, Kathleen B. Hall, Alex S. Holehouse, Melissa D. Stuchell‐Brereton, Andrea Soranno +1 more

Wrapping of single-stranded DNA by Replication Protein A and modulation through phosphorylation

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.03.28.587234

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0DataRank · unranked

0 citations

Vikas Kaushik, Iram Munir Ahmad, Jaigeeth Deveryshetty, Alex S. Holehouse, Snorri Th.d Sigurdsson +5 more

Reviewer #1 (Public Review): Disordered proteins interact with the chemical environment to tune their protective function during drying

(2024)10.7554/elife.97231.1.sa1

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0DataRank · unranked

0 citations

Kenny Nguyen, Vincent Nicholson, Annie Walgren, Tony Trent, Edith Gollub +5 more

Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms

Molecular Cell(2025)10.1016/j.molcel.2025.03.004

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0DataRank · unranked

35 citations

Kaia Mattioli, Clarissa Santoso, Gloria Sheynkman, Sachi Inukai, Babita Kaundal +33 more

The dimerization domain of SARS-CoV-2 nucleocapsid protein is partially disordered and forms a dynamic high-affinity dimer

Cell Reports Physical Science(2025)10.1016/j.xcrp.2025.102695

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0DataRank · unranked

9 citations

J. Jeremías Incicco, Kathleen B. Hall, Alex S. Holehouse, Melissa D. Stuchell‐Brereton, Andrea Soranno +1 more

A phase transition modulates the protective function of a tardigrade disordered protein during desiccation

Protein Science(2025)10.1002/pro.70300

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0DataRank · unranked

4 citations

Sourav Biswas, Shraddha KC, Annie Walgren, Vincent Nicholson, Charles A. Childs +6 more

Protein surface chemistry encodes an adaptive tolerance to desiccation

Cell Systems(2025)10.1016/j.cels.2025.101407

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0DataRank · unranked

1 citations

Haley M. Moran, David P Cordone, Azeem Horani, Alexander Truong, Edgar Manriquez-Sandoval +14 more

Direct Optical Quantification of Chain Collapse, Reduced Dielectric, and Water Release Driving Protein Phase Separation

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.11.04.686660

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0DataRank · unranked

1 citations

Jacob A. Spies, Justin Cheong, Lixue Shi, DeeAnn K. Asamoto, Alex S. Holehouse +5 more

Emerging Roles for Phase Separation in Plants

Developmental Cell(2020)10.1016/j.devcel.2020.09.010

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0DataRank · unranked

163 citations

Alex S. Holehouse, Lucia C. Strader, Ryan J. Emenecker