Helena I. Boshoff

Also affiliated with National Institute of Allergy and Infectious Diseases

MedicineChemistry

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 50 papers. Top paper: “Sanfetrinem, an oral β-lactam antibiotic repurposed for the treatment of tuberculosis”.

Sanfetrinem, an oral β-lactam antibiotic repurposed for the treatment of tuberculosis

Drug Resistance Updates(2025)10.1016/j.drup.2025.101213

N/A

0.425DataRank · unranked

9 citations

Rubén González del Río, María Pilar Arenaz-Callao, Helena I. Boshoff, Joaquín Rullás, Sara Anca +10 more

The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition

Journal of the American Chemical Society(2023)10.1021/jacs.2c08816

N/A

0.405DataRank · unranked

9 citations

Ullrich Scheid, Teresa Kösel, Jennifer Herrmann, Daniel Krug, Helena I. Boshoff +28 more

Sanfetrinem, an oral β-lactam antibiotic repurposed for the treatment of tuberculosis

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.10.10.617558

N/A

0.108DataRank · unranked

1 citations

Rubén González del Río, María Pilar Arenaz-Callao, Helena I. Boshoff, Joaquín Rullás, Sara Anca +10 more

Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents

European Journal of Medicinal Chemistry(2020)10.1016/j.ejmech.2020.112450

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0DataRank · unranked

17 citations

Fabian Hulpia, Martijn Risseeuw, Harriet Forbes, Hélène Munier‐Lehmann, Guy Caljon +3 more

2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F420)-Dependent Nitroreductase (Ddn)

Journal of Medicinal Chemistry(2020)10.1021/acs.jmedchem.0c01374

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0DataRank · unranked

17 citations

Harriet Forbes, Fabian Hulpia, Martijn Risseeuw, Guy Caljon, Hélène Munier‐Lehmann +3 more

Development of small-molecule inhibitors of fatty acyl-AMP and fatty acyl-CoA ligases in Mycobacterium tuberculosis

European Journal of Medicinal Chemistry(2020)10.1016/j.ejmech.2020.112408

N/A

0DataRank · unranked

30 citations

Kimberly D. Grimes, Paul A. Sibbald, Peng Fu, Helena I. Boshoff, Daniel J. Wilson +2 more

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

Nucleic Acids Research(2020)10.1093/nar/gkaa539

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0DataRank · unranked

25 citations

Andrew Whitehouse, Karen Brown, Sophie Burbaud, Juan M. Belardinelli, Jasper Sangen +12 more

1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors

Molecules(2020)10.3390/molecules25122805

N/A

0DataRank · unranked

6 citations

Fabian Hulpia, Martijn Risseeuw, Harriet Forbes, Guy Caljon, Hélène Munier‐Lehmann +3 more

Tissue specific diversification, virulence and immune response to Mycobacterium bovis BCG in a patient with an IFN-γ R1 deficiency

Virulence(2020)10.1080/21505594.2020.1848108

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0DataRank · unranked

5 citations

Shamira J. Shallom, Kriti Arora, Helena I. Boshoff, Alexandra F. Freeman, Alejandra King +13 more

The Tuberculosis Drug Accelerator at year 10: what have we learned?

Nature Medicine(2021)10.1038/s41591-021-01442-2

N/A

0DataRank · unranked

62 citations

David Barros-Aguirre, Clifton E. Barry, Robert H. Bates, Steven J. Berthel, Helena I. Boshoff +32 more

Tuberculosis Drug Discovery: A Decade of Hit Assessment for Defined Targets

Frontiers in Cellular and Infection Microbiology(2021)10.3389/fcimb.2021.611304

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0DataRank · unranked

54 citations

Lena Trifonov, Veena Yadav, Clifton E. Barry, Helena I. Boshoff, Sangmi Oh

1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c00837

N/A

0DataRank · unranked

24 citations

Rudolf Müller, Grant A. Boyle, Virsinha Reddy, Aloysius T. Nchinda, Charles J. Eyermann +19 more

Antitubercular 2-Pyrazolylpyrimidinones: Structure–Activity Relationship and Mode-of-Action Studies

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.0c01727

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0DataRank · unranked

21 citations

Vinayak Singh, Alissa Myrick, Sandile B. Simelane, Dale Taylor, Christel Brunschwig +21 more

Structure–Activity Relationships of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Antitubercular Agents

ACS Infectious Diseases(2021)10.1021/acsinfecdis.0c00851

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0DataRank · unranked

20 citations

M. Daben J. Libardo, Shaik Azeeza, Gary T. Pauly, José Santinni Roma, Andaleeb Sajid +10 more

Reinvestigation of the structure-activity relationships of isoniazid

Tuberculosis(2021)10.1016/j.tube.2021.102100

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0DataRank · unranked

15 citations

Helena I. Boshoff, Yudi Rusman, Wassihun Wedajo Aragaw, Christine Salomon, Thomas Dick +2 more

Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis

Cell chemical biology(2021)10.1016/j.chembiol.2021.02.023

N/A

0DataRank · unranked

16 citations

Caroline J. Duncombe, Simon R. Green, Paul G. Wyatt, Stephen Thompson, Peter C. Ray +6 more

Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors

European Journal of Medicinal Chemistry(2021)10.1016/j.ejmech.2021.113784

N/A

0DataRank · unranked

11 citations

Romain Merceron, Fabian Hulpia, Ainhoa Lucía, Begoña Gracia, Yanlin Jian +9 more

Determining Minimum Inhibitory Concentrations in Liquid Cultures or on Solid Medium

Methods in molecular biology(2021)10.1007/978-1-0716-1460-0_26

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0DataRank · unranked

7 citations

Helena I. Boshoff, Qinglan Wang

Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site

Nature Communications(2021)10.1038/s41467-020-20224-x

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0DataRank · unranked

17 citations

Simon R. Green, Joanna C. Evans, Jeannine Hess, M. Blasz̧czyk, Christina Spry +21 more

6-Fluorophenylbenzohydrazides inhibit Mycobacterium tuberculosis growth through alteration of tryptophan biosynthesis

European Journal of Medicinal Chemistry(2021)10.1016/j.ejmech.2021.113843

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0DataRank · unranked

3 citations

G Venditti, Junhao Zhu, Helena I. Boshoff, Kriti Arora, Alessandro De Logu +5 more

Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs

Nature Communications(2022)10.1038/s41467-022-33736-5

N/A

0DataRank · unranked

34 citations

Susan H. Davis, Sebastian Damerow, Curtis A. Engelhart, Michael Mathieson, Beatriz Baragaña +40 more

Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions

ACS Infectious Diseases(2022)10.1021/acsinfecdis.1c00570

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0DataRank · unranked

25 citations

Jun Zhang, Landys Lopez Quezada, Julia Roberts, Yan Ling, Madeleine Wood +39 more

DNA-Dependent Binding of Nargenicin to DnaE1 Inhibits Replication in Mycobacterium tuberculosis

ACS Infectious Diseases(2022)10.1021/acsinfecdis.1c00643

N/A

0DataRank · unranked

24 citations

Mandy K. Mason, Alessandro Borsellini, R. Tassoni, Garth L. Abrahams, Sasha Lynch +11 more

Synthesis and biological evaluation of orally active prodrugs and analogs of para-aminosalicylic acid (PAS)

European Journal of Medicinal Chemistry(2022)10.1016/j.ejmech.2022.114201

N/A

0DataRank · unranked

14 citations

Michael D. Howe, Matthew Zimmerman, Helena I. Boshoff, Sachin Sharma, Brianna Remache +6 more

Molecular insights into Mmpl3 lead to the development of novel indole-2-carboxamides as antitubercular agents

Molecular Systems Design & Engineering(2022)10.1039/d1me00122a

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0DataRank · unranked

6 citations

Sumit Birangal, Fajeelath Fathima, Helena I. Boshoff, Harriet Forbes, Raghu Chandrashekar Hariharapura +2 more

Nonhydrolyzable d‑phenylalanine-benzoxazole derivatives retain antitubercular activity

Bioorganic & Medicinal Chemistry Letters(2022)10.1016/j.bmcl.2022.129116

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0DataRank · unranked

2 citations

Shibin Chacko, Nicole Kopetz, Helena I. Boshoff, Gregory D. Cuny, Lizbeth Hedstrom +1 more

GSK2556286 is a novel antitubercular drug candidate effective in vivo with the potential to shorten tuberculosis treatment

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.02.04.479214

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0DataRank · unranked

11 citations

Maria Santos Martínez, Olalla Sanz, Beatriz Urones, Jorge Esquivias, Heena Soni +25 more

A d-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of Mycobacterium tuberculosis

Zenodo (CERN European Organization for Nuclear Research)(2022)10.5281/zenodo.6512980

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0DataRank · unranked

0 citations

Shibin Chacko, Gary M. Marqus, Vinayak Singh, Zhe Wang, Kyle Planck +9 more

The myxobacterial antibiotic myxovalargin: Biosynthesis, structural revision, total synthesis and molecular characterization of ribosomal inhibition

ChemRxiv(2022)10.26434/chemrxiv-2022-vr3hn

N/A

0DataRank · unranked

0 citations

Ullrich Scheid, Teresa Kösel, Jennifer Herrmann, Daniel Krug, Helena I. Boshoff +22 more

Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c01514

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0DataRank · unranked

21 citations

Caroline Wilson, T.C. Eadsforth, Avinash S. Punekar, Fábio K. Tamaki, Gavin Wood +18 more

Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis

Chemistry - A European Journal(2023)10.1002/chem.202203868

N/A

0DataRank · unranked

10 citations

M. Snee, Richard B. Tunnicliffe, Madeline E. Kavanagh, Helena I. Boshoff, Cecilia Nwadiuto Amadi +7 more

Synthesis and Structure–Activity Relationships of a New Class of Oxadiazoles Targeting DprE1 as Antitubercular Agents

ACS Medicinal Chemistry Letters(2023)10.1021/acsmedchemlett.3c00295

N/A

0DataRank · unranked

9 citations

Helena I. Boshoff, Lena Trifonov, José Santinni Roma, Thomas R. Ioerger, Clifton E. Barry +2 more

MEPicides: α,β-unsaturated Fosmidomycin N-Acyl Analogs as Efficient Inhibitors of Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate reductoisomerase

ACS Infectious Diseases(2023)10.1021/acsinfecdis.3c00132

N/A

0DataRank · unranked

9 citations

Rachel L. Edwards, Haley Ball, Kenneth M. Heidel, Robert C. Brothers, Claire Johnson +11 more

Chemical approaches to unraveling the biology of mycobacteria

Cell chemical biology(2023)10.1016/j.chembiol.2023.04.014

N/A

0DataRank · unranked

7 citations

Raymond Khan, Sangmi Oh, Helena I. Boshoff, Clifton E. Barry, Peter Finin

Editorial: Drug-resistant Mycobacterium tuberculosis

Frontiers in Cellular and Infection Microbiology(2023)10.3389/fcimb.2023.1215294

N/A

0DataRank · unranked

12 citations

Digby F. Warner, Ben Gold, Helena I. Boshoff

The Antitubercular Activities of Natural Products with Fused-Nitrogen-Containing Heterocycles

Pharmaceuticals(2024)10.3390/ph17020211

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0DataRank · unranked

22 citations

Neha Malhotra, Clifton E. Barry, Sangmi Oh, Helena I. Boshoff

Inhibition of DXR in the MEP pathway with lipophilic N -alkoxyaryl FR900098 analogs

RSC Medicinal Chemistry(2024)10.1039/d3md00642e

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0DataRank · unranked

9 citations

Ruiqin Wang, Dana M. Hodge, Marwa O. Mikati, José Santinni Roma, Helena I. Boshoff +6 more

Developing novel indoles as antitubercular agents and simulated annealing-based analysis of their binding with MmpL3

Future Medicinal Chemistry(2024)10.1080/17568919.2024.2444872

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0DataRank · unranked

3 citations

Salil K. Das, Sumit Birangal, Helena I. Boshoff, José Santinni Roma, Manisha Joshel Lobo +3 more

Environmental fungi target thiol homeostasis to compete with Mycobacterium tuberculosis

PLoS Biology(2024)10.1371/journal.pbio.3002852

N/A

0DataRank · unranked

1 citations

Sangmi Oh, Peter Finin, Jessica Medrano, Jenna Andrews, Michael Goodwin +5 more

Environmental sphagnum-associated fungi target thiol homeostasis to compete with Mycobacterium tuberculosis

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.09.23.614403

N/A

0DataRank · unranked

0 citations

Sangmi Oh, Peter Finin, Jessica Medrano, Jenna Andrews, Michael Goodwin +5 more

Fragment-based development of small molecule inhibitors targeting Mycobacterium tuberculosis cholesterol metabolism

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.10.28.620643

N/A

0DataRank · unranked

0 citations

Kirsty J. McLean, Sophie H. Gilbert, Cecilia Nwadiuto Amadi, M. Snee, Richard B. Tunnicliffe +11 more

SuFEx-based antitubercular compound irreversibly inhibits Pks13

Nature(2025)10.1038/s41586-025-09286-3

N/A

0DataRank · unranked

19 citations

Paridhi Sukheja, Baiyuan Yang, Su Tang, Daniel Selle, Ashley Woods +40 more

Common Biological Properties of Mycobacterium tuberculosis MmpL3 Inhibitors

ACS Infectious Diseases(2025)10.1021/acsinfecdis.5c00394

N/A

0DataRank · unranked

6 citations

R. H. Allen, Helena I. Boshoff, Laura A. T. Cleghorn, Curtis A. Engelhart, Dirk Schnappinger +2 more

Identification of a Series Containing a Pentafluorophenyl Moiety That Targets Pks13 to Inhibit Growth of Mycobacterium tuberculosis

ACS Infectious Diseases(2025)10.1021/acsinfecdis.4c00808

N/A

0DataRank · unranked

4 citations

Justin R. Harrison, Stephen Thompson, Dinakaran Murugesan, M. Daben J. Libardo, Curtis A. Engelhart +18 more

Thioquinazolinones as Antituberculosis Agents Targeting Phosphopantetheinyl Transferase

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.5c00856

N/A

0DataRank · unranked

1 citations

Logan T. Zwerneman, Kyle Planck, Takushi Kaneko, Andrew J. Perkowski, Christine M. Suh +18 more

A Systematic Approach to Discover New Natural Product Scaffolds Using Database-Derived Relative Mass Spectral Defects and Molecular Networking

JACS Au(2025)10.1021/jacsau.4c00889

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0DataRank · unranked

1 citations

Eleonora Boccia, Rahim Rajwani, Robert D. O’Connor, Helena I. Boshoff, Clifton E. Barry +3 more

PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis

Science(2020)10.1126/science.aav5912

N/A

0DataRank · unranked

206 citations

Helena I. Boshoff, Justin R. Harrison, Peter C. Ray, Simon R. Green, Paul G. Wyatt +2 more

Validating Conditionally Essential Targets: Discovery of the First Orally Effective Biotin Inhibitor against Mycobacterium Tuberculosis

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.24.678246

N/A

0DataRank · unranked

2 citations

Joshua B. Wallach, Yahani P. Jayasinghe, Mark R. Sullivan, Julianna Proietto, Suyapa Rodriguez +14 more

Development and Optimization of Chromosomally-Integrated Fluorescent Mycobacterium tuberculosis Reporter Constructs

Frontiers in Microbiology(2020)10.3389/fmicb.2020.591866

N/A

0DataRank · unranked

28 citations

Alice C. Bell, Gareth A. Prosser, Maike Assmann, Hee‐Jeong Yang, Harriet Forbes +5 more

Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents

European Journal of Medicinal Chemistry(2020)10.1016/j.ejmech.2020.112659

N/A

0DataRank · unranked

19 citations

Romain Merceron, Steven De Munck, Harriet Forbes, Fabian Hulpia, Martijn Risseeuw +6 more