Dirk Schnappinger

Also affiliated with Weill Cornell Medicine

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 38 papers. Top paper: “Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant Mycobacterium tuberculosis”.

Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant Mycobacterium tuberculosis

EMBO Molecular Medicine(2020)10.15252/emmm.202013207

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2.0DataRank · unranked

98 citations

Kiel Hards, Curtis A. Engelhart, Erik Hasenoehrl, Nitin Pal Kalia, Jared S. Mackenzie +16 more

Tissue Distribution of Doxycycline in Animal Models of Tuberculosis

Antimicrobial Agents and Chemotherapy(2020)10.1128/aac.02479-19

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0DataRank · unranked

44 citations

Matthew Zimmerman, Jansy P. Sarathy, Firat Kaya, Han Wang, Marizel Mina +8 more

Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA‐damage response and leads to cell death

Molecular Microbiology(2020)10.1111/mmi.14571

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0DataRank · unranked

30 citations

Ruojun Wang, Laure Botella, Ritu Sharma, Linnan Zhu, Joshua B. Wallach +6 more

Host-pathogen genetic interactions underlie tuberculosis susceptibility

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.01.405514

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0DataRank · unranked

6 citations

Richard E. Baker, Megan K. Proulx, Bibhuti B. Mishra, Jarukit E. Long, Sae Woong Park +21 more

The Tuberculosis Drug Accelerator at year 10: what have we learned?

Nature Medicine(2021)10.1038/s41591-021-01442-2

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0DataRank · unranked

62 citations

David Barros-Aguirre, Clifton E. Barry, Robert H. Bates, Steven J. Berthel, Helena I. Boshoff +32 more

Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.1c01586

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0DataRank · unranked

37 citations

Peter C. Ray, Fabio Zuccotto, Jorge Hernández, Anup Aggarwal, Claire J. Mackenzie +35 more

Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth

ACS Omega(2021)10.1021/acsomega.0c05589

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0DataRank · unranked

33 citations

Margaret Huggett, Penelope A. Turner, Malcolm Taylor, Laura A. T. Cleghorn, Julie V. Early +32 more

Antitubercular 2-Pyrazolylpyrimidinones: Structure–Activity Relationship and Mode-of-Action Studies

Journal of Medicinal Chemistry(2021)10.1021/acs.jmedchem.0c01727

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0DataRank · unranked

21 citations

Vinayak Singh, Alissa Myrick, Sandile B. Simelane, Dale Taylor, Christel Brunschwig +21 more

Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity

The Journal of Experimental Medicine(2021)10.1084/jem.20210332

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0DataRank · unranked

17 citations

Kan Lin, Divya Tiwari, Claire Healy, Carolina Trujillo, Yao Liu +4 more

A chemical-genetic map of the pathways controlling drug potency in Mycobacterium tuberculosis

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.11.27.469863

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0DataRank · unranked

4 citations

Nicholas C. Poulton, Jesseon S. Chang, Zachary A. Azadian, Michael A. DeJesus, Nadine Ruecker +10 more

Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.08.439092

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0DataRank · unranked

2 citations

Peter O. Oluoch, Nadine Ruecker, Megan K. Proulx, Vijay Soni, Kenan C. Murphy +19 more

Genetic models of latent tuberculosis in mice reveal differential control by adaptive immunity

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.02.08.430271

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0DataRank · unranked

0 citations

Kan Lin, Divya Tiwari, Claire Healy, Carolina Trujillo, Yao Liu +4 more

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis

Nature Microbiology(2022)10.1038/s41564-022-01130-y

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0DataRank · unranked

234 citations

Nicholas C. Poulton, Jesseon S. Chang, Zachary A. Azadian, Michael A. DeJesus, Nadine Ruecker +10 more

CinA mediates multidrug tolerance in Mycobacterium tuberculosis

Nature Communications(2022)10.1038/s41467-022-29832-1

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0DataRank · unranked

52 citations

Robert S. Jansen, Travis Hartman, Alexandre Gouzy, Ruojun Wang, Inna V. Krieger +10 more

Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs

Nature Communications(2022)10.1038/s41467-022-33736-5

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0DataRank · unranked

34 citations

Susan H. Davis, Sebastian Damerow, Curtis A. Engelhart, Michael Mathieson, Beatriz Baragaña +40 more

Two‐way regulation of protein expression for identification and validation of on‐target inhibitors of Mycobacterium tuberculosis

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.l7723

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0DataRank · unranked

0 citations

Curtis A. Engelhart, Esther Perez‐Herran, Divya Tiwari, Wei Li, Katherine A. Abrahams +9 more

Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity

Figshare(2022)10.5281/zenodo.6533839

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0DataRank · unranked

0 citations

Rudolf Müller, Kawaljit Singh, Virsinha Reddy, Charles J. Eyermann, Stephen E. Fienberg +12 more

Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity

Journal of Medicinal Chemistry(2023)10.1021/acs.jmedchem.3c01514

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0DataRank · unranked

21 citations

Caroline Wilson, T.C. Eadsforth, Avinash S. Punekar, Fábio K. Tamaki, Gavin Wood +18 more

Cyclic AMP is a critical mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis

eLife(2023)10.7554/elife.81177

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0DataRank · unranked

25 citations

Tiago Beites, Kyle Planck, Rachael A Fieweger, Kathryn A. Eckartt, Shuqi Li +7 more

Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation

mBio(2023)10.1128/mbio.01045-23

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0DataRank · unranked

9 citations

Sabine Ehrt, Dirk Schnappinger, Tiago Beites, Yuanyuan Xu

CpsA mediates infection of recruited lung myeloid cells by Mycobacterium tuberculosis

Cell Reports(2023)10.1016/j.celrep.2023.113607

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0DataRank · unranked

8 citations

Gauri Prasad, Joshua B. Wallach, Ekansh Mittal, Fong‐Fu Hsu, Dirk Schnappinger +2 more

Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis

mBio(2023)10.1128/mbio.00340-23

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0DataRank · unranked

10 citations

Travis Hartman, Tiago Beites, Jeehyun Kim, Hyungjin Eoh, Curtis A. Engelhart +7 more

Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.11.19.567569

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0DataRank · unranked

5 citations

Hong-Wei Su, Joshua B. Wallach, Jeffrey C. Wagner, Benjamin J. Braunecker, Michelle Gardner +19 more

A “suicide” BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.11.22.568105

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0DataRank · unranked

3 citations

Hongwei Su, Joshua D. Wallach, Yao Liu, Pauline Maiello, H. Jacob Borish +12 more

Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.10.536268

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0DataRank · unranked

2 citations

Sabine Ehrt, Dirk Schnappinger, Tiago Beites, Yuanyuan Xu

A dose-response model for statistical analysis of chemical genetic interactions in CRISPRi screens

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.03.551759

N/A

0DataRank · unranked

0 citations

Michael A. DeJesus, Aarthi Srinivasan, Jeremy M. Rock, Dirk Schnappinger, Thomas R. Ioerger +1 more

Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin

Nature Communications(2024)10.1038/s41467-024-48448-1

N/A

0DataRank · unranked

9 citations

Peng Ge, Laure Botella, Sae Woong Park, Ha-Na Lee, Natalie Thornton +7 more

Interruption of mycothiol synthesis and intracellular redox status impact iron-regulated reporter activation in Mycobacterium smegmatis

Microbiology Spectrum(2024)10.1128/spectrum.00487-24

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0DataRank · unranked

3 citations

Frances Marks, Luming Chan, Hélène Botella, Dirk Schnappinger, Sabine Ehrt +1 more

A dose-response model for statistical analysis of chemical genetic interactions in CRISPRi screens

PLoS Computational Biology(2024)10.1371/journal.pcbi.1011408

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0DataRank · unranked

4 citations

Michael A. DeJesus, Aarthi Srinivasan, Jeremy M. Rock, Dirk Schnappinger, Thomas R. Ioerger +1 more

Engineered Mycobacterium tuberculosis triple-kill-switch strain provides controlled tuberculosis infection in animal models

Nature Microbiology(2025)10.1038/s41564-024-01913-5

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0DataRank · unranked

19 citations

Hong-Wei Su, Joshua B. Wallach, Jeffrey C. Wagner, Benjamin J. Braunecker, Michelle Gardner +20 more

SuFEx-based antitubercular compound irreversibly inhibits Pks13

Nature(2025)10.1038/s41586-025-09286-3

N/A

0DataRank · unranked

19 citations

Paridhi Sukheja, Baiyuan Yang, Su Tang, Daniel Selle, Ashley Woods +40 more

A BCG kill switch strain protects against Mycobacterium tuberculosis in mice and non-human primates with improved safety and immunogenicity

Nature Microbiology(2025)10.1038/s41564-024-01895-4

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0DataRank · unranked

12 citations

Hong-Wei Su, Joshua D. Wallach, Yao Liu, Pauline Maiello, H. Jacob Borish +12 more

Common Biological Properties of Mycobacterium tuberculosis MmpL3 Inhibitors

ACS Infectious Diseases(2025)10.1021/acsinfecdis.5c00394

N/A

0DataRank · unranked

6 citations

R. H. Allen, Helena I. Boshoff, Laura A. T. Cleghorn, Curtis A. Engelhart, Dirk Schnappinger +2 more

Identification of a Series Containing a Pentafluorophenyl Moiety That Targets Pks13 to Inhibit Growth of Mycobacterium tuberculosis

ACS Infectious Diseases(2025)10.1021/acsinfecdis.4c00808

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0DataRank · unranked

4 citations

Justin R. Harrison, Stephen Thompson, Dinakaran Murugesan, M. Daben J. Libardo, Curtis A. Engelhart +18 more

Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action

Cell Systems(2025)10.1016/j.cels.2025.101348

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0DataRank · unranked

3 citations

A. Paul Alivisatos, Trever C. Smith, Nhi Van, Vijay Soni, Joshua B. Wallach +10 more

Validating Conditionally Essential Targets: Discovery of the First Orally Effective Biotin Inhibitor against Mycobacterium Tuberculosis

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.24.678246

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0DataRank · unranked

2 citations

Joshua B. Wallach, Yahani P. Jayasinghe, Mark R. Sullivan, Julianna Proietto, Suyapa Rodriguez +14 more

Metabolically Stable Adenylation Inhibitors of Biotin Protein Ligase as Antibacterial Agents

Journal of Medicinal Chemistry(2025)10.1021/acs.jmedchem.4c02299

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0DataRank · unranked

0 citations

Curtis A. Engelhart, Joshua B. Wallach, Divya Tiwari, Peng Ge, Adhar C. Manna +14 more

The Mycobacterium tuberculosis long-chain fatty acid resistome reveals the universal stress protein TB15.3 as essential for infection

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.14.648703

N/A

0DataRank · unranked

0 citations

Marco Silva, Joana A. Santos, Brian C. VanderVen, Dirk Schnappinger, Sabine Ehrt +2 more