Eugene I. Shakhnovich

Biochemistry, Genetics and Molecular BiologyMaterials Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 41 papers. Top paper: “Empowering drug off-target discovery with metabolic and structural analysis”.

Empowering drug off-target discovery with metabolic and structural analysis

Nature Communications(2023)10.1038/s41467-023-38859-x

N/A

1.0DataRank · unranked

28 citations

Daniel C. Zielinski, Christopher Dalldorf, João V. Rodrigues, Bernhard Ø. Palsson, Eugene I. Shakhnovich +1 more

Effect of Protein Structure on Evolution of Cotranslational Folding

Biophysical Journal(2020)10.1016/j.bpj.2020.06.037

N/A

0DataRank · unranked

21 citations

William M. Jacobs, Eugene I. Shakhnovich, Victor Y. Zhao

Expanding protein universe and its origin from the biological Big Bang

UNC Libraries(2020)10.17615/sskb-4g65

N/A

0DataRank · unranked

14 citations

Nikolay V. Dokholyan, Eugene I. Shakhnovich, B. Shakhnovich

Validation of DBFOLD: An efficient algorithm for computing folding pathways of complex proteins

PLoS Computational Biology(2020)10.1371/journal.pcbi.1008323

N/A

0DataRank · unranked

28 citations

William M. Jacobs, Eugene I. Shakhnovich, Amir Bitran

Imprint of evolution on protein structures

UNC Libraries(2020)10.17615/0sad-c810

N/A

0DataRank · unranked

4 citations

Eugene I. Shakhnovich, Boris E. Shakhnovich, G. Tiana, Nikolay V. Dokholyan

DBFOLD: An efficient algorithm for computing folding pathways of complex proteins

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.09.09.289116

N/A

0DataRank · unranked

0 citations

William M. Jacobs, Eugene I. Shakhnovich, Amir Bitran

Development of antibacterial compounds that block evolutionary pathways to resistance

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.30.362582

N/A

0DataRank · unranked

0 citations

Sourav Chowdhury, João V. Rodrigues, Eugene I. Shakhnovich, Yanmin Zhang

Avoidance of protein unfolding constrains protein stability in long-term evolution

Biophysical Journal(2021)10.1016/j.bpj.2021.03.042

N/A

0DataRank · unranked

9 citations

Pouria Dasmeh, Adrian W.R. Serohijos, Eugene I. Shakhnovich, Rostam M. Razban

Switching an active site helix in dihydrofolate reductase reveals limits to subdomain modularity

Biophysical Journal(2021)10.1016/j.bpj.2021.09.032

N/A

0DataRank · unranked

2 citations

João V. Rodrigues, Elena R. Lozovsky, Daniel L. Hartl, Eugene I. Shakhnovich, Victor Y. Zhao

Effect of RNA on morphology and dynamics of membraneless organelles

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.16.440139

N/A

0DataRank · unranked

3 citations

Eugene I. Shakhnovich, Srivastav Ranganathan

Empowering systems-guided drug target discovery with metabolic and structural analysis

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.05.17.444532

N/A

0DataRank · unranked

3 citations

Daniel C. Zielinski, Christopher Dalldorf, João V. Rodrigues, Bernhard Ø. Palsson, Eugene I. Shakhnovich +1 more

Switching an active site helix in dihydrofolate reductase reveals limits to sub-domain modularity

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.06.18.448971

N/A

0DataRank · unranked

1 citations

João V. Rodrigues, Elena R. Lozovsky, Daniel L. Hartl, Eugene I. Shakhnovich, Victor Y. Zhao

The physics of liquid-to-solid transitions in multi-domain protein condensates

Biophysical Journal(2022)10.1016/j.bpj.2022.06.013

N/A

0DataRank · unranked

55 citations

Eugene I. Shakhnovich, Srivastav Ranganathan

A native chemical chaperone in the human eye lens

eLife(2022)10.7554/elife.76923

N/A

0DataRank · unranked

22 citations

Sourav Chowdhury, Christopher N. Woods, David C. Thorn, Nicki Watson, Arthur McClelland +3 more

Domain‐swapped dimeric γ‐crystallin: the missing link in the evolution of oligomeric β‐crystallins

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.r3926

N/A

0DataRank · unranked

1 citations

Eugene Serebryany, Gabriel Birrane, Ali İ. Kaya, Eugene I. Shakhnovich, David C. Thorn

Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.21.517316

N/A

0DataRank · unranked

3 citations

Bharat V. Adkar, Sanchari Bhattacharyya, Dorit Levy, Marija Iljina, Inbal Riven +4 more

Systematic conformation-to-phenotype mapping via limited deep-sequencing of proteins

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.04.12.488104

N/A

0DataRank · unranked

0 citations

Victor Y. Zhao, Kibum Park, Amir Bitran, Sunia A. Trauger, Bogdan Budnik +2 more

Systematic Conformation‐to‐Phenotype Mapping via Limited Protein Sequencing

The FASEB Journal(2022)10.1096/fasebj.2022.36.s1.l7930

N/A

0DataRank · unranked

0 citations

Sunia A. Trauger, Bogdan Budnik, Eugene I. Shakhnovich, Eugene Serebryany

Systematic Conformation-to-Phenotype Mapping via Limited Deep-Sequencing of Proteins

SSRN Electronic Journal(2022)10.2139/ssrn.4087714

N/A

0DataRank · unranked

0 citations

Victor Y. Zhao, Kibum Park, Amir Bitran, Sunia A. Trauger, Bogdan Budnik +2 more

Cotranslational formation of disulfides guides folding of the SARS COV-2 receptor binding domain

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.11.10.516025

N/A

0DataRank · unranked

0 citations

Kibum Park, Eugene Serebryany, Eugene I. Shakhnovich, Amir Bitran

Phosphorylation sites are evolutionary checkpoints against liquid–solid transition in protein condensates

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2215828120

N/A

0DataRank · unranked

43 citations

Pouria Dasmeh, Seth T. E. Furniss, Eugene I. Shakhnovich, Srivastav Ranganathan

Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2219855120

N/A

0DataRank · unranked

20 citations

Bharat V. Adkar, Sanchari Bhattacharyya, Dorit Levy, Marija Iljina, Inbal Riven +4 more

Enzymatic metabolons dramatically enhance metabolic fluxes of low-efficiency biochemical reactions

Biophysical Journal(2023)10.1016/j.bpj.2023.10.033

N/A

0DataRank · unranked

10 citations

Junlang Liu, Eugene I. Shakhnovich, Srivastav Ranganathan

Systematic conformation-to-phenotype mapping via limited deep sequencing of proteins

Molecular Cell(2023)10.1016/j.molcel.2023.05.006

N/A

0DataRank · unranked

9 citations

Victor Y. Zhao, Kibum Park, Amir Bitran, Sunia A. Trauger, Bogdan Budnik +2 more

Co-translational formation of disulfides guides folding of the SARS-CoV-2 receptor binding domain

Biophysical Journal(2023)10.1016/j.bpj.2023.07.002

N/A

0DataRank · unranked

5 citations

Kibum Park, Eugene Serebryany, Eugene I. Shakhnovich, Amir Bitran

The critical role of co-translational folding: An evolutionary and biophysical perspective

Current Opinion in Systems Biology(2023)10.1016/j.coisb.2023.100485

N/A

0DataRank · unranked

6 citations

William M. Jacobs, Eugene I. Shakhnovich, Amir Bitran

Epistasis and pleiotropy shape biophysical protein subspaces associated with drug resistance

Physical review. E(2023)10.1103/physreve.108.054408

N/A

0DataRank · unranked

3 citations

Rafael F. Guerrero, Miles D. Miller-Dickson, Eugene I. Shakhnovich, Matthew D. Shoulders, C. Brandon Ogbunugafor

Epistasis meets pleiotropy in shaping biophysical protein subspaces associated with antimicrobial resistance

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.09.535490

N/A

0DataRank · unranked

4 citations

Rafael F. Guerrero, Eugene I. Shakhnovich, Matthew D. Shoulders, C. Brandon Ogbunugafor

Separation of sticker-spacer energetics governs the coalescence of metastable condensates

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.03.560747

N/A

0DataRank · unranked

3 citations

Eugene I. Shakhnovich, Aniruddha Chattaraj

Biophysical principles predict fitness of SARS-CoV-2 variants

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.07.23.549087

N/A

0DataRank · unranked

1 citations

Marian Huot, Vaibhav Mohanty, Eugene I. Shakhnovich, D. I. C. Wang

Separation of sticker-spacer energetics governs the coalescence of metastable condensates

Biophysical Journal(2024)10.1016/j.bpj.2024.12.017

N/A

0DataRank · unranked

13 citations

Eugene I. Shakhnovich, Aniruddha Chattaraj

Biophysical principles predict fitness of SARS-CoV-2 variants

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2314518121

N/A

0DataRank · unranked

20 citations

Marian Huot, Vaibhav Mohanty, Eugene I. Shakhnovich, D. I. C. Wang

Multi-condensate state as a functional strategy to optimize the cell signaling output

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.01.14.575571

N/A

0DataRank · unranked

1 citations

Eugene I. Shakhnovich, Aniruddha Chattaraj

Protein Quality Control is a Master Modulator of Molecular Evolution in Bacteria

Genome Biology and Evolution(2025)10.1093/gbe/evaf010

N/A

0DataRank · unranked

10 citations

Maristella Alvarez, Robert H. Wilson, Eugene I. Shakhnovich, C. Brandon Ogbunugafor, Carolina Díaz Arenas

Predicting high-fitness viral protein variants with Bayesian active learning and biophysics

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2503742122

N/A

0DataRank · unranked

7 citations

D. I. C. Wang, Jiacheng Liu, Eugene I. Shakhnovich, Marian Huot

A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A

Nature Communications(2025)10.1038/s41467-025-56489-3

N/A

0DataRank · unranked

8 citations

Dvir Reif, Kibum Park, Alexander J. McQuown, Anjali R. Nelliat, Charlotte Trejtnar +5 more

The Eye Lens Protein, γS Crystallin, Undergoes Glutathionylation-Induced Disulfide Bonding Between Cysteines 22 and 26

Biomolecules(2025)10.3390/biom15030402

N/A

0DataRank · unranked

6 citations

David C. Thorn, Martin E. Tovar‐Ramírez, Eugene I. Shakhnovich, Larry L. David, Kirsten J. Lampi +1 more

Entropy-driven denaturation enables sustainable protein regeneration through rapid gel-solid transition

Nature Communications(2025)10.1038/s41467-025-61959-9

N/A

0DataRank · unranked

2 citations

Junlang Liu, Michael M. Peters, Ryoma Ishii, D. I. C. Wang, Sourav Chowdhury +3 more

BPS2025 - Pursuit of the elusive disulfide crosslink in oxidized γS-crystallin from the eye lens

Biophysical Journal(2025)10.1016/j.bpj.2024.11.1179

N/A

0DataRank · unranked

0 citations

Constance Kraay, Kate Halverson-Kolkind, David C. Thorn, Eugene I. Shakhnovich, Larry L. David +1 more

Dynamic metastable long-living droplets formed by sticker-spacer proteins

eLife(2020)10.7554/elife.56159

N/A

0DataRank · unranked

196 citations

Eugene I. Shakhnovich, Srivastav Ranganathan

Cotranslational Protein Folding Through Non-Native Structural Intermediates

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.09.648002

N/A

0DataRank · unranked

0 citations

Amir Bitran, Ekaterina Samatova, Eugene I. Shakhnovich, Marina V. Rodnina, Siyu Wang