Charles A. Dinarello

University of Colorado Anschutz Medical Campus

Immunology and MicrobiologyBiochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 38 papers. Top paper: “Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment”.

Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

Cancer Research Communications(2023)10.1158/2767-9764.crc-23-0065

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0.488DataRank · unranked

16 citations

Adrian T.A. Dominguez, Shaikh M. Atif, Alberto Dinarello, Tania Azam, Kibrom M. Alula +11 more

IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8

Theranostics(2020)10.7150/thno.47435

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59 citations

Stéphanie Zandee, Jesús Amo‐Aparicio, Marc Charabati, Alexandre Prat, Cecília Garlanda +4 more

Extracellular and nuclear roles of IL-37 after spinal cord injury

Brain Behavior and Immunity(2020)10.1016/j.bbi.2020.09.026

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16 citations

Alba Sánchez‐Fernández, Suzhao Li, Elan Eisenmesser, Cecília Garlanda, Charles A. Dinarello +2 more

Reduced concentrations of the B cell cytokine interleukin 38 are associated with cardiovascular disease risk in overweight subjects

European Journal of Immunology(2020)10.1002/eji.201948390

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33 citations

Martin Jaeger, Inge van den Munckhof, Rob ter Horst, Kiki Schraa, Jelle Zwaag +13 more

PASylation of IL-1 receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis

Journal of Biological Chemistry(2020)10.1016/s0021-9258(17)49941-8

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30 citations

Benjamin J. Swartzwelter, Carlo Marchetti, Dennis M. de Graaf, Alexandra Lerchner, Martin Schlapschy +6 more

Inflammasome Sensor NLRP1 Confers Acquired Drug Resistance to Temozolomide in Human Melanoma

Cancers(2020)10.3390/cancers12092518

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28 citations

Jenny Mae Samson, Takeshi Yamauchi, Prasanna K. Vaddi, Yuko Matsumoto, Charles A. Dinarello +3 more

Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease

Cytokine(2020)10.1016/j.cyto.2020.155334

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26 citations

Ralph J. A. Maas, Sanne P. Smeekens, Elan Eisenmesser, Jasmina S. Redzic, Monique M. Helsen +8 more

IL-37 Expression Is Downregulated in Lesional Psoriasis Skin

ImmunoHorizons(2020)10.4049/immunohorizons.2000083

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25 citations

Ane Langkilde‐Lauesen Nielsen, Claus Johansen, Christian Vestergaard, Astrid Fauerbye, Rubén López‐Vales +3 more

Impact of rare and common genetic variation in the Interleukin-1 pathway on human cytokine responses

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.02.14.949602

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2 citations

Peer Arts, Giulio Cavalli, Martin Jaeger, Marloes Steehouwer, Maartje van de Vorst +9 more

Abrogation of Anti-Inflammatory Transcription Factor LKLF in Neutrophil-Dominated Airways

UNC Libraries(2020)10.17615/q9an-am72

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0 citations

Abby D. Patterson, Milene T. Saavedra, Jerry A. Nick, Kenneth C. Malcolm, Charles A. Dinarello +4 more

Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion

Proceedings of the National Academy of Sciences(2021)10.1073/pnas.2000915118

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194 citations

Dinoop Ravindran Menon, Douglas G. Osborne, C. Preston Neff, Nicholas E. Powers, Fabia Gamboni +17 more

Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression

Frontiers in Immunology(2021)10.3389/fimmu.2021.661323

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127 citations

Alberto Dinarello, Nicholas E. Powers, Matthew A. Burchill, Leo A. B. Joosten, Carlo Marchetti +2 more

The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity

Cell Reports(2021)10.1016/j.celrep.2021.108955

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72 citations

Isak W. Tengesdal, Mark S. Gresnigt, Travis Nemkov, Rob J.W. Arts, Jorge Domínguez‐Andrés +16 more

Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells

JCI Insight(2021)10.1172/jci.insight.145928

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69 citations

Lisa Van de Wijer, Farid Keramati, Wim Trypsteen, Sofie Rutsaert, Rob ter Horst +13 more

IL-1 family cytokines as drivers and inhibitors of trained immunity

Cytokine(2021)10.1016/j.cyto.2021.155773

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69 citations

Rob J.W. Arts, Mihai G. Netea, Charles A. Dinarello, Leo A. B. Joosten, Lisa U. Teufel

IL‐37 regulates allergic inflammation by counterbalancing pro‐inflammatory IL‐1 and IL‐33

Allergy(2021)10.1111/all.15072

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49 citations

Lars Lunding, Ulrich M. Zissler, Christina Vock, Sina Webering, Johanna C. Ehlers +10 more

Single-cell RNA-seq reveals a critical role of novel pro-inflammatory EndMT in mediating adverse remodeling in coronary artery–on–a–chip

Science Advances(2021)10.1126/sciadv.abg1694

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47 citations

Qingzhou Yao, Peijian Zhang, Erlinda The, Yufeng Zhai, Lihua Ao +5 more

Urate-induced epigenetic modifications in myeloid cells

Arthritis Research & Therapy(2021)10.1186/s13075-021-02580-1

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46 citations

Orsolya I. Gaal, Maartje C. P. Cleophas, Viola Klück, Robab Davar, Ehsan Habibi +14 more

Inhibition of the NLRP3 inflammasome by OLT1177 induces functional protection and myelin preservation after spinal cord injury

Experimental Neurology(2021)10.1016/j.expneurol.2021.113889

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43 citations

Joana Garcia-Garcia, María Puigdomenech, Isaac Francos-Quijorna, Damaris B. Skouras, Charles A. Dinarello +2 more

Interleukin‐37 improves T‐cell‐mediated immunity and chimeric antigen receptor T‐cell therapy in aged backgrounds

Aging Cell(2021)10.1111/acel.13309

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34 citations

Miyoung Lee, Rae Hunter, Raira S. Ank, Jamie Y. Story, Ganesh R. Talekar +10 more

Modulation of Liver Inflammation and Fibrosis by Interleukin-37

Frontiers in Immunology(2021)10.3389/fimmu.2021.603649

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54 citations

Maria Effenberger, Heidi Noll‐Puchta, Lucas Griessmair, Andrea Ringleb, Sonja Haas +7 more

IL-38 prevents induction of trained immunity by inhibition of mTOR signaling

Journal of Leukocyte Biology(2021)10.1002/jlb.3a0220-143rrr

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39 citations

Lisa U. Teufel, Frank L. van de Veerdonk, Leo A. B. Joosten, Mihai G. Netea, Charles A. Dinarello +2 more

A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100630

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25 citations

Liqiong Jiang, Karsten Beckmann, Jesper Falkesgaard Højen, Ulrich Pessara, Nicholas E. Powers +7 more

Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy

Journal of Clinical Investigation(2021)10.1172/jci144983

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20 citations

Giorgia Renga, Marilena Pariano, Marina Maria Bellet, Giuseppe Servillo, Francesca Fallarino +25 more

Interleukin-38 in Health and Disease

Cytokine(2022)10.1016/j.cyto.2022.155824

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38 citations

Lisa U. Teufel, Leo A. B. Joosten, Charles A. Dinarello, Dennis M. de Graaf

IL-37 expression reduces acute and chronic neuroinflammation and rescues cognitive impairment in an Alzheimer’s disease mouse model

eLife(2022)10.7554/elife.75889

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31 citations

Shirin Hosseini, Melanie Ohm, Robert Geffers, Karsten Hiller, Charles A. Dinarello +2 more

Activation of Host-NLRP3 Inflammasome in Myeloid Cells Dictates Response to Anti-PD-1 Therapy in Metastatic Breast Cancers

Pharmaceuticals(2022)10.3390/ph15050574

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23 citations

Suzhao Li, Nicholas E. Powers, Makenna May, C. Preston Neff, Leo A. B. Joosten +3 more

IL-38 Gene Deletion Worsens Murine Colitis

Frontiers in Immunology(2022)10.3389/fimmu.2022.840719

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16 citations

Ruth X. Wang, Jesús Amo‐Aparicio, J. Scott Lee, Alexander S. Dowdell, Isak W. Tengesdal +5 more

Circulating interleukin-38 concentrations in healthy adults

Frontiers in Immunology(2022)10.3389/fimmu.2022.964365

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11 citations

Dennis M. de Graaf, Mihai G. Netea, Charles A. Dinarello, Leo A. B. Joosten, Rob J.W. Arts +1 more

Human and Bacterial Toll-Interleukin Receptor Domains Exhibit Distinct Dynamic Features and Functions

Molecules(2022)10.3390/molecules27144494

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5 citations

Jasmina S. Redzic, Travis Nemkov, Anthony J. Saviola, Monika Dzieciątkowska, Kirk C. Hansen +4 more

Exploratory analysis of interleukin‐38 in hospitalized COVID‐19 patients

Immunity Inflammation and Disease(2022)10.1002/iid3.712

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1 citations

Lisa U. Teufel, Aline H. de Nooijer, Adriaan J. van Gammeren, Antonius A.M. Ermens, Ildikó O. Gaál +7 more

Pharmacologic inhibition of NLRP3 reduces the levels of α-synuclein and protects dopaminergic neurons in a model of Parkinson’s disease

Journal of Neuroinflammation(2023)10.1186/s12974-023-02830-w

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57 citations

Jonathan Daly, Jesper Falkesgaard Højen, Charles A. Dinarello, Jesús Amo‐Aparicio

NLRP3 and cancer: Pathogenesis and therapeutic opportunities

Pharmacology & Therapeutics(2023)10.1016/j.pharmthera.2023.108545

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49 citations

Charles A. Dinarello, Carlo Marchetti, Isak W. Tengesdal

Metabolic reprogramming of the inflammatory response in the nervous system: the crossover between inflammation and metabolism

Neural Regeneration Research(2023)10.4103/1673-5374.391330

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19 citations

Charles A. Dinarello, Rubén López‐Vales, Jesús Amo‐Aparicio

IL-38 regulates intestinal stem cell homeostasis by inducing WNT signaling and beneficial IL-1β secretion

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2306476120

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7 citations

Makenna May, Jesús Amo‐Aparicio, Tania Azam, Joseph M. Gaballa, Carlo Marchetti +10 more

Micro- and nano-plastics induce inflammation and cell death in human cells

Frontiers in Immunology(2025)10.3389/fimmu.2025.1528502

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19 citations

William S. Webber, Shaikh M. Atif, Ashley Ley, Karl A. Pankratz, Rachael Kostelecky +5 more

Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial

The Lancet Rheumatology(2020)10.1016/s2665-9913(20)30065-5

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0DataRank · unranked

296 citations

Tim Jansen, M. Janssen, Antoaneta Comarniceanu, M. Efdé, Isak W. Tengesdal +8 more

Interleukin-38 is a negative regulator of trained immunity—A retrospective multi-omics study

iScience(2025)10.1016/j.isci.2025.113758

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2 citations

Vasiliki Matzaraki, Lukas Folkman, Dennis M. de Graaf, Rob ter Horst, Simone J.C.F.M. Moorlag +8 more