Patrick E. MacDonald

Also affiliated with University of Alberta, Lund University, Michigan Medicine

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 5%percentile

0.364Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

HumanIslets: An integrated platform for human islet data access and analysis

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.19.599613

Top 49%

0.364DataRank

Top 49%9 citations

Yao Lu, Cara E. Ellis, Jessica Worton, Jelena Kolic, Shugo Sasaki +27 more

Papers

Driven by 43 papers — median percentile 51. Top paper: “Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D”.

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D

Nature Communications(2020)10.1038/s41467-020-18581-8

N/A

2.4DataRank · unranked

164 citations

Arushi Varshney, Martijn van de Bunt, Rashmi B. Prasad, Olof Asplund, Amanda J. Bennett +31 more

Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes

Nature Genetics(2023)10.1038/s41588-023-01397-9

N/A

1.9DataRank · unranked

82 citations

Joshua Chiou, Chun Zeng, Michael Miller, Ileana Matta, Jee Yun Han +16 more

MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation

Nucleic Acids Research(2024)10.1093/nar/gkae253

N/A

1.1DataRank · unranked

2073 citations

Yao Lü, Guangyan Zhou, Fiona Hui, Lei Xu, Charles Viau +6 more

Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice

Nature Communications(2024)10.1038/s41467-024-53127-2

N/A

0.821DataRank · unranked

37 citations

Amanda Cambraia, Shristi Shrestha, Melanie Cutler, Matthew A. Cottam, Guy Perkins +12 more

Modulation of insulin secretion by RBFOX2-mediated alternative splicing

Nature Communications(2023)10.1038/s41467-023-43605-4

N/A

0.666DataRank · unranked

26 citations

Kristen L. Wells, Alexandra Theis, Yong-Kyung Kim, Aliya F Spigelman, Xiong Liu +3 more

Combinatorial transcription factor profiles predict mature and functional human islet α and β cells

JCI Insight(2021)10.1172/jci.insight.151621

N/A

0.581DataRank · unranked

47 citations

Diane C. Saunders, John T. Walker, Joan Camuñas-Soler, Xiao-Qing Dai, Rachana Haliyur +12 more

A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding

Nature Communications(2024)10.1038/s41467-023-44589-x

N/A

0.560DataRank · unranked

18 citations

Kunimasa Suzuki, Nancy Smith, Xi Li, Lisa Nalbach, Sonia Fuentes +11 more

β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice

Diabetes(2021)10.2337/db20-1235

N/A

0.537DataRank · unranked

18 citations

Nancy Smith, Aliya F Spigelman, Kunimasa Suzuki, Mourad Ferdaoussi, Tamadher A. Alghamdi +9 more

Molecular and functional profiling of human islets: from heterogeneity to human phenotypes

Diabetologia(2020)10.1007/s00125-020-05159-8

N/A

0.477DataRank · unranked

23 citations

Birbickram Roy, Patrick E. MacDonald, Rafael Arrojo e Drigo

HumanIslets: An integrated platform for human islet data access and analysis

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.06.19.599613

Top 49%

0.364DataRank

Top 49%9 citations

Yao Lu, Cara E. Ellis, Jessica Worton, Jelena Kolic, Shugo Sasaki +27 more

HNF1α maintains pancreatic α and β cell functions in primary human islets

JCI Insight(2023)10.1172/jci.insight.170884

N/A

0.360DataRank · unranked

10 citations

Romina J. Bevacqua, Vy M. N. Coykendall, Xiong Liu, Weichen Zhao, Charles Chang +5 more

Heterogeneity of Diabetes: β-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research’s Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases

Canadian Journal of Diabetes(2021)10.1016/j.jcjd.2021.09.126

N/A

0.313DataRank · unranked

3 citations

Dana K. Andersen, Guillermo Arreaza-Rubín, Christopher L. Pin, Sheryl Sato, C. Bruce Verchere +56 more

Multiplexed Deep Visual Proteomics Unveils Spatial Heterogeneity and Rare Endocrine States in Human Adult Pancreatic Islets

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.27.650857

N/A

0.241DataRank · unranked

4 citations

Nicolai Dorka, Marvin Thielert, Frida Björklund, Frederic Ballllosera Navarro, Anna Martinez Casals +7 more

A new hypothesis for type 1 diabetes risk: The at-risk allele at rs3842753 associates with increased beta cell INS mRNA in a meta-analysis of single cell RNA sequencing data

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.12.06.413971

N/A

0.104DataRank · unranked

1 citations

Stephane Flibotte, Joan Camuñas-Soler, Patrick E. MacDonald, James D. Johnson, Su Wang

Molecular correlates of glycine receptor activity in human β cells

Molecular Metabolism(2025)10.1016/j.molmet.2025.102156

N/A

0.104DataRank · unranked

1 citations

Cara E. Ellis, Aliya F Spigelman, Theodore dos Santos, Jasmine Maghera, Kunimasa Suzuki +2 more

HNF1α transcriptional activation and repression maintain human islet α and β cell function

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.09.25.509394

N/A

0DataRank · unranked

0 citations

Romina J. Bevacqua, Vy Nguyen, Xiong Liu, Weichen Zhao, Charles Chang +5 more

Deletion of carboxypeptidase E in beta cells disrupts proinsulin processing and alters beta cell identity in mice

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.10.20.512925

N/A

0DataRank · unranked

0 citations

Austin J. Taylor, James Fulcher, Adam Swensen, Xiao-Qing Dai, Mitsuhiro Komba +8 more

Metabolic Messengers: glucagon

Nature Metabolism(2023)10.1038/s42255-022-00725-3

N/A

0DataRank · unranked

50 citations

Patrik Rorsman, Patrick E. MacDonald

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

Diabetologia(2023)10.1007/s00125-022-05856-6

N/A

0DataRank · unranked

20 citations

Nicole A. J. Krentz, Christoph Metzendorf, Fernando Abaitua, Aliya F Spigelman, Han Sun +17 more

RFX6 Maintains Gene Expression and Function of Adult Human Islet α-Cells

Diabetes(2023)10.2337/db23-0483

N/A

0DataRank · unranked

11 citations

Mollie F. Qian, Krissie Tellez, Austin Bautista, Romina J. Bevacqua, Xueying Gu +7 more

Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease

medRxiv(2023)10.1101/2023.05.24.23290298

N/A

0DataRank · unranked

9 citations

WenQing Grace Sun, Haoning Howard Cen, Jessica Ewald, Jason C. Rogalski, Shugo Sasaki +16 more

Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes

週刊教育資料(2023)10.1101/2022.12.31.522386

N/A

0DataRank · unranked

8 citations

Joshua Chiou, Chun Zeng, Michael Miller, Ileana Matta, Jee Yun Han +16 more

Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.23.554369

N/A

0DataRank · unranked

4 citations

Shristi Shrestha, Matthew A. Cottam, Guy Perkins, Varda Lev‐Ram, Birbickram Roy +11 more

Caloric restriction promotes beta cell longevity and delays aging and senescence signatures.

Research Square(2023)10.21203/rs.3.rs-3311459/v1

N/A

0DataRank · unranked

3 citations

Cristiane dos Santos, Shristi Shrestha, Matthew A. Cottam, Guy Perkins, Varda Lev‐Ram +11 more

HumanIslets.com: Improving accessibility, integration, and usability of human research islet data

Cell Metabolism(2024)10.1016/j.cmet.2024.09.001

N/A

0DataRank · unranked

42 citations

Yao Lü, Cara E. Ellis, Jessica Worton, Jelena Kolic, Shugo Sasaki +27 more

Peptidylglycine alpha-amidating monooxygenase is important in mice for beta-cell cilia formation and insulin secretion but promotes diabetes risk through beta-cell independent mechanisms

Molecular Metabolism(2025)10.1016/j.molmet.2025.102123

N/A

0DataRank · unranked

6 citations

Nils Bäck, Jenicia Zhen, L. Xiong, Mitsuhiro Komba, Anna L. Gloyn +5 more

Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes

Journal of Clinical Investigation(2025)10.1172/jci195267

N/A

0DataRank · unranked

6 citations

Xiao-Qing Dai, Robert C. Jones, Aliya F Spigelman, Hannah M Mummey, Jessica Ewald +15 more

Spatially bound functional heterogeneity drives modular organization in β-cell networks

Biophysical Journal(2025)10.1016/j.bpj.2025.07.043

N/A

0DataRank · unranked

4 citations

Marko Šterk, Lidija Križančić Bombek, Patrick E. MacDonald, Andraž Stožer, Marko Gosak +1 more

Deletion of Carboxypeptidase E in β-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice

Diabetes(2023)10.2337/db22-0945

N/A

0DataRank · unranked

20 citations

Austin J. Taylor, James Fulcher, Adam Swensen, Xiao-Qing Dai, Mitsuhiro Komba +8 more

Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes

Cell Metabolism(2020)10.1016/j.cmet.2020.04.005

N/A

0DataRank · unranked

301 citations

Xiao-Qing Dai, Yan Hang, Austin Bautista, James Lyon, Kunimasa Suzuki +4 more

A role for alternative splicing in circadian control of exocytosis and glucose homeostasis

Genes & Development(2020)10.1101/gad.338178.120

N/A

0DataRank · unranked

31 citations

Mark Perelis, Benjamin J. Weidemann, Akihiko Taguchi, Haopeng Lin, Chiaki Omura +13 more

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.15.338160

N/A

0DataRank · unranked

2 citations

Evgeniy Panzhinskiy, Jelena Kolic, Haoning Howard Cen, Derek A. Dionne, Xiao-Qing Dai +31 more

CRISPR-based genome editing in primary human pancreatic islet cells

Nature Communications(2021)10.1038/s41467-021-22651-w

N/A

0DataRank · unranked

53 citations

Xiao-Qing Dai, Jonathan Y. Lam, Xueying Gu, M. Friedländer, Krissie Tellez +11 more

A New Hypothesis for Type 1 Diabetes Risk: The At-Risk Allele at rs3842753 Associates With Increased Beta-Cell INS Messenger RNA in a Meta-Analysis of Single-Cell RNA-Sequencing Data

Canadian Journal of Diabetes(2021)10.1016/j.jcjd.2021.03.007

N/A

0DataRank · unranked

17 citations

Stéphane Flibotte, Joan Camuñas-Soler, Patrick E. MacDonald, James D. Johnson, Su Wang

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.04.08.435504

N/A

0DataRank · unranked

8 citations

Joan Camuñas-Soler, Linford J.B. Briant, Theodore dos Santos, Aliya F Spigelman, Emily M. Walker +13 more

Combinatorial transcription factor profiles predict mature and functional human islet α and β cells

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.02.23.432522

N/A

0DataRank · unranked

3 citations

Diane C. Saunders, John T. Walker, Joan Camuñas-Soler, Xiao-Qing Dai, Rachana Haliyur +12 more

Ca 2+ oscillations, waves, and networks in islets from human donors with and without type 2 diabetes

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.12.08.471749

N/A

0DataRank · unranked

2 citations

Richard Yan‐Do, Haopeng Lin, Patrick E. MacDonald, Andraž Stožer, Marko Gosak

Pharmacologic rescue of circadian β-cell failure through P2Y1 purinergic receptor identified by small-molecule screen

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.11.05.467499

N/A

0DataRank · unranked

0 citations

Benjamin J. Weidemann, Akihiko Taguchi, Mark Perelis, Kathryn Moynihan Ramsey, Marsha Newman +7 more

Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state

Cell Metabolism(2022)10.1016/j.cmet.2021.12.021

N/A

0DataRank · unranked

84 citations

Joan Camuñas-Soler, Linford J.B. Briant, Theodore dos Santos, Aliya F Spigelman, Emily M. Walker +19 more

A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk

Nature Genetics(2022)10.1038/s41588-022-01261-2

N/A

0DataRank · unranked

59 citations

Yingying Ye, Elena Navarro‐Guerrero, Varsha Rajesh, Alina Pollner, Romina J. Bevacqua +16 more

Ca2+ Oscillations, Waves, and Networks in Islets From Human Donors With and Without Type 2 Diabetes

Diabetes(2022)10.2337/db22-0004

N/A

0DataRank · unranked

37 citations

Richard Yan‐Do, Haopeng Lin, Patrick E. MacDonald, Andraž Stožer, Marko Gosak

Cryopreservation and post-thaw characterization of dissociated human islet cells

PLoS ONE(2022)10.1371/journal.pone.0263005

N/A

0DataRank · unranked

26 citations

Xiao-Qing Dai, Yan Hang, Jonathan Y. Lam, James Lyon, Jocelyn E. Manning Fox +5 more

β-cell responses to high fat feeding: A role and mechanism for redox sensing by SENP1

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.04.05.487203

N/A

0DataRank · unranked

1 citations

Kunimasa Suzuki, Nancy Smith, Xi Li, Lisa Nalbach, Sonia Fuentes +11 more

Patrick E. MacDonald

Indexed papers

Top data-sharing exemplar

Papers