Wilfred A. van der Donk

Also affiliated with University of Illinois Urbana-Champaign

Agricultural and Biological SciencesMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 54 papers. Top paper: “Sequence controlled secondary structure is important for the site-selectivity of lanthipeptide cyclization”.

Sequence controlled secondary structure is important for the site-selectivity of lanthipeptide cyclization

Chemical Science(2023)10.1039/d2sc06546k

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0.521DataRank · unranked

16 citations

Emily K. Desormeaux, Tung Le, Wilfred A. van der Donk, Diwakar Shukla, Xuenan Mi

MicroED in natural product and small molecule research

Natural Product Reports(2020)10.1039/d0np00035c

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51 citations

Steve Halaby, Wilfred A. van der Donk, Tamir Gonen, Emma Danelius

Bacteroidetes can be a rich source of novel lanthipeptides: The case study of Pedobacter lusitanus

Microbiological Research(2020)10.1016/j.micres.2020.126441

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39 citations

Wilfred A. van der Donk, Sónia Mendo, Tânia Caetano

Structural determinants of macrocyclization in substrate-controlled lanthipeptide biosynthetic pathways

Chemical Science(2020)10.1039/d0sc01651a

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38 citations

Lingyang Zhu, Jeella Z. Acedo, Weixin Tang, Wilfred A. van der Donk, Silvia C. Bobeica

Ribosomally Synthesized and Post-Translationally Modified Peptide Natural Products: New Insights into the Role of Leader and Core Peptides during Biosynthesis

UNC Libraries(2020)10.17615/ky38-za91

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2 citations

Wilfred A. van der Donk, Yang, Xiao

Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.03.13.990614

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12 citations

Douglas A. Mitchell, Wilfred A. van der Donk, Mark C. Walker

Engineering of new-to-nature ribosomally synthesized and post-translationally modified peptide natural products

Current Opinion in Biotechnology(2021)10.1016/j.copbio.2020.12.022

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63 citations

Wilfred A. van der Donk, Chunyu Wu

LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome

Cell(2021)10.1016/j.cell.2021.04.001

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59 citations

Sébastien R. G. Galan, Yibo Zeng, Tianhui Zhou, Chang He, Ritu Raj +13 more

Structure–Activity Relationships of the Enterococcal Cytolysin

ACS Infectious Diseases(2021)10.1021/acsinfecdis.1c00197

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25 citations

Alondra Sanchez, Weixin Tang, Wilfred A. van der Donk, Imran R. Rahman

Structural and mechanistic investigations of protein S-glycosyltransferases

Cell chemical biology(2021)10.1016/j.chembiol.2021.06.009

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20 citations

Chantal V. Garcia De Gonzalo, Subhanip Biswas, Yue Hao, Huan Wang, Neha Garg +4 more

Peptide backbone modifications in lanthipeptides

Methods in enzymology on CD-ROM/Methods in enzymology(2021)10.1016/bs.mie.2021.04.012

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15 citations

Wilfred A. van der Donk, Richard Ayikpoe

Overall Retention of Methyl Stereochemistry during B12-Dependent Radical SAM Methyl Transfer in Fosfomycin Biosynthesis

Biochemistry(2021)10.1021/acs.biochem.1c00113

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9 citations

Katharina Pallitsch, Gabriele Wallner, Wilfred A. van der Donk, Friedrich Hammerschmidt, Martin I. McLaughlin

A scalable platform to discover antimicrobials of ribosomal origin

Nature Communications(2022)10.1038/s41467-022-33890-w

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105 citations

Chengyou Shi, Alexander J. Battiste, Sara M. Eslami, Sangeetha Ramesh, Max A. Simon +14 more

Substrate Specificity of the Flavoenzyme BhaC1 That Converts a C-Terminal Trp to a Hydroxyquinone

Biochemistry(2022)10.1021/acs.biochem.2c00206

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5 citations

Wilfred A. van der Donk, Page N. Daniels

Macrocyclization and Backbone Rearrangement During RiPP Biosynthesis by a SAM-Dependent Domain-of-Unknown-Function 692

ACS Central Science(2023)10.1021/acscentsci.3c00160

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56 citations

Lingyang Zhu, Jeff Y. Chen, Chi P. Ting, Wilfred A. van der Donk, Richard Ayikpoe

Proteases Involved in Leader Peptide Removal during RiPP Biosynthesis

ACS Bio & Med Chem Au(2023)10.1021/acsbiomedchemau.3c00059

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33 citations

Wilfred A. van der Donk, Sara M. Eslami

Improved production of class I lanthipeptides in Escherichia coli

Chemical Science(2023)10.1039/d2sc06597e

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17 citations

Chunyu Wu, Emily K. Desormeaux, Raymond Sarksian, Wilfred A. van der Donk, Hyunji Lee

The mechanism of thia-Michael addition catalyzed by LanC enzymes

Proceedings of the National Academy of Sciences(2023)10.1073/pnas.2217523120

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14 citations

Shi Liu, Youran Luo, Satish K. Nair, Wilfred A. van der Donk, Chayanid Ongpipattanakul

A Novel Pathway for Biosynthesis of the Herbicidal Phosphonate Natural Product Phosphonothrixin Is Widespread in Actinobacteria

Journal of Bacteriology(2023)10.1128/jb.00485-22

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12 citations

Ryuichi Hirota, Michelle N. Goettge, Jerry Cui, David T. Krist, Lingyang Zhu +5 more

Investigation into the mechanism of action of the antimicrobial peptide epilancin 15X

Frontiers in Microbiology(2023)10.3389/fmicb.2023.1247222

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6 citations

B. Alexis Lower, Ryan Moreira, Darian Dorantes, Tung Le, Constantin Giurgiu +3 more

Synthesis of Fluorescent Lanthipeptide Cytolysin S Analogues by Late-Stage Sulfamidate Ring Opening

Organic Letters(2023)10.1021/acs.orglett.3c00122

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4 citations

Imran R. Rahman, Claudio D. Navo, Jesús M. Peregrina, Jesús H. Busto, Wilfred A. van der Donk +2 more

Exposure and resistance to lantibiotics impact microbiota composition and function

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.30.573728

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4 citations

Cody G. Cole, Huaiying Lin, Chunyu Wu, Fidel Haro, Emma McSpadden +3 more

Biosynthesis of macrocyclic peptides with C-terminal β-amino-α-keto acid groups by three different metalloenzymes

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.30.564719

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2 citations

Lingyang Zhu, Danielle L. Gray, Toby J. Woods, Chandrashekhar Padhi, Kristen M. Flatt +3 more

PEARL-catalyzed peptide bond formation after chain reversal during the biosynthesis of non-ribosomal peptides

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.23.573212

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2 citations

Wilfred A. van der Donk, Yue Yu

A remarkable transformation catalyzed by a domain-of-unknown-function 692 during the biosynthesis of a new RiPP natural product

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.02.06.527370

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0 citations

Lingyang Zhu, Jeff Y. Chen, Chi P. Ting, Wilfred A. van der Donk, Richard Ayikpoe

Expression of Lanthipeptides in Human Cells

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.19.563208

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0 citations

Imran R. Rahman, Wilfred A. van der Donk, Sara M. Eslami

A Facile Method for Determining Lanthipeptide Stereochemistry

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.10.26.564210

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0 citations

Shuyun Xu, Wilfred A. van der Donk, Youran Luo

Genome Mining for New Enzyme Chemistry

ACS Catalysis(2024)10.1021/acscatal.3c06322

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48 citations

Douglas A. Mitchell, Wilfred A. van der Donk, Dinh Thanh Nguyen

Biosynthesis of Macrocyclic Peptides with C-Terminal β-Amino-α-keto Acid Groups by Three Different Metalloenzymes

ACS Central Science(2024)10.1021/acscentsci.4c00088

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44 citations

Lingyang Zhu, Danielle L. Gray, Toby J. Woods, Chandrashekhar Padhi, Kristen M. Flatt +3 more

Multinuclear non-heme iron dependent oxidative enzymes (MNIOs) involved in unusual peptide modifications

Current Opinion in Chemical Biology(2024)10.1016/j.cbpa.2024.102467

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32 citations

Wilfred A. van der Donk, Jeff Y. Chen

Unexpected Transformations during Pyrroloiminoquinone Biosynthesis

Journal of the American Chemical Society(2024)10.1021/jacs.4c03677

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14 citations

Lingyang Zhu, Wilfred A. van der Donk, Josseline S. Ramos‐Figueroa

PEARL-Catalyzed Peptide Bond Formation after Chain Reversal by Ureido-Forming Condensation Domains

ACS Central Science(2024)10.1021/acscentsci.4c00044

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13 citations

Wilfred A. van der Donk, Yue Yu

Use of a head-to-tail peptide cyclase to prepare hybrid RiPPs

Chemical Communications(2024)10.1039/d3cc04919a

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5 citations

Dongtianyu Zhang, Rachel M. Martini, Subhanip Biswas, Wilfred A. van der Donk, Tung Le

Bibacillin 1: a two-component lantibiotic from Bacillus thuringiensis

RSC Chemical Biology(2024)10.1039/d4cb00192c

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4 citations

Yi Yang, Youran Luo, Michael S. Gilmore, Wilfred A. van der Donk, Ryan Moreira

Substrate Specificity of a Methyltransferase Involved in the Biosynthesis of the Lantibiotic Cacaoidin

Biochemistry(2024)10.1021/acs.biochem.4c00150

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4 citations

Youran Luo, Wilfred A. van der Donk, Haoqian Liang

Expression and Subcellular Localization of Lanthipeptides in Human Cells

ACS Synthetic Biology(2024)10.1021/acssynbio.4c00178

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1 citations

Chandrashekhar Padhi, Imran R. Rahman, Wilfred A. van der Donk, Sara M. Eslami

Kinetic Analysis of Lanthipeptide Cyclization by Substrate-Tolerant ProcM

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.05.16.594612

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1 citations

Wilfred A. van der Donk, Emily K. Desormeaux

Bibacillin 1: A two-component lantibiotic from Bacillus thuringiensis

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.08.13.607848

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1 citations

Yi Yang, Youran Luo, Michael S. Gilmore, Wilfred A. van der Donk, Ryan Moreira

Unexpected transformations during pyrroloiminoquinone biosynthesis

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.03.12.584671

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0 citations

Lingyang Zhu, Wilfred A. van der Donk, Josseline S. Ramos‐Figueroa

Characterization of S-glycosylated glycocins containing three disulfides

Journal of Industrial Microbiology & Biotechnology(2024)10.1093/jimb/kuaf028

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0 citations

Chandrashekhar Padhi, Wilfred A. van der Donk, Rachel M. Martini

Biosynthesis of Biphenomycin-like Macrocyclic Peptides by Formation and Cross-Linking of Ortho-Tyrosines

Journal of the American Chemical Society(2025)10.1021/jacs.5c06044

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19 citations

Lingyang Zhu, Jeff Y. Chen, Chuan Huang, Ryan Moreira, Gregory L. Challis +3 more

Genome mining for natural products made by multinuclear iron-dependent oxidation enzymes (MNIOs)

Methods in enzymology on CD-ROM/Methods in enzymology(2025)10.1016/bs.mie.2025.01.060

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7 citations

Wilfred A. van der Donk, Yue Yu

Aminoacyl-tRNA Specificity of a Ligase Catalyzing Non-ribosomal Peptide Extension

Journal of the American Chemical Society(2025)10.1021/jacs.5c12610

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4 citations

Josseline S. Ramos‐Figueroa, Alexander A. Vinogradov, Yuki Goto, Mayuresh G. Gadgil, Rebecca A. Splain +4 more

Combatting virulent gut bacteria by inhibiting the biosynthesis of a two-component lanthipeptide toxin

Nature Communications(2025)10.1038/s41467-025-62161-7

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3 citations

Bidisha Chakraborty, Yi Yang, Chandrashekhar Padhi, Michael S. Gilmore, Satish K. Nair +2 more

Large protein-like leader peptides engage differently with RiPP halogenases and lanthionine synthetases

Nature Communications(2025)10.1038/s41467-025-64365-3

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3 citations

Youran Luo, Hongwei Wu, Wilfred A. van der Donk, Andrew C. McShan, Vinayak Agarwal +1 more

The Biosynthetic Pathway to the Pyrroloiminoquinone Marine Natural Product Ammosamide C

Journal of the American Chemical Society(2025)10.1021/jacs.5c15504

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1 citations

Lingyang Zhu, Matthew Halliman, Wilfred A. van der Donk, Josseline S. Ramos‐Figueroa

Co-opting the bacterial lipoprotein pathway for the biosynthesis of lipidated macrocyclic peptides

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.10.31.685832

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3 citations

Lingyang Zhu, K. Zhang, Deborah A. Berthold, Wilfred A. van der Donk, Jeff Y. Chen

Biosynthesis of Macrocyclic Peptides by Formation and Crosslinking of ortho -Tyrosines

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.04.647296

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2 citations

Lingyang Zhu, Jeff Y. Chen, Ryan Moreira, Wilfred A. van der Donk, Chandrashekhar Padhi

The Biosynthetic Pathway to the Pyrroloiminoquinone Marine Natural Product Ammosamide C

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.03.674030

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2 citations

Lingyang Zhu, Matthew Halliman, Wilfred A. van der Donk, Josseline S. Ramos‐Figueroa

Characterization of a novel glycocin from a thermophile

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.05.19.655019

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1 citations

Wilfred A. van der Donk, Rachel M. Martini

An unusual ring pattern in the Rosβ lanthipeptide of the two-component lantibiotic roseocin

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.10.27.684949

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1 citations

Lingyang Zhu, Youran Luo, Dipti Sareen, Wilfred A. van der Donk, Emily K. Desormeaux

Oxidative Peptide Backbone Cleavage by a HEXXH Enzyme During RiPP Biosynthesis

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.10.30.685615

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1 citations

Yue Yu, Lingyang Zhu, Dinh Thanh Nguyen, Wilfred A. van der Donk, Yao Ouyang

Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family

BMC Genomics(2020)10.1186/s12864-020-06785-7

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157 citations

Sara M. Eslami, Kenton J. Hetrick, Sarah E. Ackenhusen, Douglas A. Mitchell, Wilfred A. van der Donk +1 more

Aminoacyl-tRNA specificity of a ligase catalyzing non-ribosomal peptide extension

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.09.13.676032

N/A

0DataRank · unranked

0 citations

Josseline S. Ramos‐Figueroa, Alexander A. Vinogradov, Yuki Goto, Mayuresh G. Gadgil, Rebecca A. Splain +4 more