Alexander Hoffmann

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 7%percentile

0.104Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Clinical and molecular characterization of AXL in colorectal cancer, CALGB (Alliance)/SWOG 80405 and real-world data

Journal for ImmunoTherapy of Cancer(2025)10.1136/jitc-2025-013186

Top 78%

0.104DataRank

Top 78%1 citations

Joshua Millstein, Yan YANG, Joanne Xiu, Shivani Soni, Pooja Mittal +18 more

Papers

Driven by 52 papers — median percentile 22. Top paper: “An incoherent feedforward loop interprets NFκB/RelA dynamics to determine TNF‐induced necroptosis decisions”.

An incoherent feedforward loop interprets NFκB/RelA dynamics to determine TNF‐induced necroptosis decisions

Molecular Systems Biology(2020)10.15252/msb.20209677

N/A

0.948DataRank · unranked

32 citations

Ying Tang, Simon Mitchell, Brooks Taylor, Rob Foreman, Roy Wollman +2 more

Clinical and molecular characterization of AXL in colorectal cancer, CALGB (Alliance)/SWOG 80405 and real-world data

Journal for ImmunoTherapy of Cancer(2025)10.1136/jitc-2025-013186

Top 78%

0.104DataRank

Top 78%1 citations

Joshua Millstein, Yan YANG, Joanne Xiu, Shivani Soni, Pooja Mittal +18 more

IκBα Nuclear Export Enables 4-1BB–Induced cRel Activation and IL-2 Production to Promote CD8 T Cell Immunity

The Journal of Immunology(2020)10.4049/jimmunol.2000039

N/A

0DataRank · unranked

12 citations

Cheng Zhang, Melba Marie Tejera, Brandon Neldner, Jay W. Warrick, Shelly M. Wuerzberger‐Davis +4 more

NFκB dynamics determine the stimulus-specificity of epigenomic reprogramming in macrophages

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.02.18.954602

N/A

0DataRank · unranked

11 citations

Sho Ohta, Katherine M. Sheu, Roberto Spreafico, Adewunmi Adelaja, Brooks Taylor +2 more

Identification and physiological significance of temporal NFκB signaling codewords deployed by macrophages to classify immune threats

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.23.112862

N/A

0DataRank · unranked

2 citations

Adewunmi Adelaja, Yi Liu, Stefanie Luecke, Alexander Hoffmann, Brooks Taylor

An incoherent feedforward loop interprets NFκB/RelA dynamics to determine TNF-induced necroptosis decisions

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.04.30.070888

N/A

0DataRank · unranked

0 citations

Ying Tang, Simon Mitchell, Brooks Taylor, Rob Foreman, Roy Wollman +2 more

High dose IFN- β activates GAF to enhance expression of ISGF3 target genes in epithelial cells

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.10.28.358366

N/A

0DataRank · unranked

0 citations

Catera L. Wilder, Justin Buchanan, Minh Anh Nguyen, Chidera Okeke, Alexander Hoffmann +2 more

Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses

Immunity(2021)10.1016/j.immuni.2021.04.011

N/A

0DataRank · unranked

117 citations

Brooks Taylor, Katherine M. Sheu, Yi Liu, Stefanie Luecke, Alexander Hoffmann +1 more

Stimulus-specific responses in innate immunity: Multilayered regulatory circuits

Immunity(2021)10.1016/j.immuni.2021.08.018

N/A

0DataRank · unranked

54 citations

Katherine M. Sheu, Alexander Hoffmann, Stefanie Luecke

Quantifying information accumulation encoded in the dynamics of biochemical signaling

Nature Communications(2021)10.1038/s41467-021-21562-0

N/A

0DataRank · unranked

42 citations

Adewunmi Adelaja, Felix X.-F. Ye, Eric J. Deeds, Roy Wollman, Alexander Hoffmann +1 more

NK and CD8+ T cell phenotypes predict onset and control of CMV viremia after kidney transplant

JCI Insight(2021)10.1172/jci.insight.153175

N/A

0DataRank · unranked

27 citations

Subha Sen, Janice Arakawa‐Hoyt, Kenichi Ishiyama, Yumeng Sun, Rajesh Parmar +13 more

Identifying the combinatorial control of signal-dependent transcription factors

PLoS Computational Biology(2021)10.1371/journal.pcbi.1009095

N/A

0DataRank · unranked

26 citations

Diane Lefaudeux, Anup Mazumder, Jingyi Jessica Li, Alexander Hoffmann, Ning Wang

IκBα is required for full transcriptional induction of some NFκB-regulated genes in response to TNF in MCF-7 cells

npj Systems Biology and Applications(2021)10.1038/s41540-021-00204-7

N/A

0DataRank · unranked

16 citations

Shigeyuki Magi, Masahide Seki, Yutaka Suzuki, Takeya Kasukawa, Diane Lefaudeux +3 more

Acute and Chronic Changes in Gene Expression After CMV DNAemia in Kidney Transplant Recipients

Frontiers in Immunology(2021)10.3389/fimmu.2021.750659

N/A

0DataRank · unranked

13 citations

Joanna Schaenman, Z. Qian, Harry Pickering, Victoria Groysberg, Maura Rossetti +8 more

High Dose IFN-β Activates GAF to Enhance Expression of ISGF3 Target Genes in MLE12 Epithelial Cells

Frontiers in Immunology(2021)10.3389/fimmu.2021.651254

N/A

0DataRank · unranked

6 citations

Catera L. Wilder, Justin Buchanan, Minh Anh Nguyen, Chidera Okeke, Alexander Hoffmann +2 more

Functional Hallmarks of Healthy Macrophage Responses: Their Regulatory Basis and Disease Relevance

Annual Review of Immunology(2022)10.1146/annurev-immunol-101320-031555

N/A

0DataRank · unranked

183 citations

Alexander Hoffmann, Katherine M. Sheu

Pathogenic TNF-α drives peripheral nerve inflammation in an Aire-deficient model of autoimmunity

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2114406119

N/A

0DataRank · unranked

41 citations

Lily Guo, Xihui Yin, Ethan C. McCarthy, Mandy I. Cheng, Aline T. Hoang +12 more

Controlling Cancer Cell Death Types to Optimize Anti-Tumor Immunity

Biomedicines(2022)10.3390/biomedicines10050974

N/A

0DataRank · unranked

6 citations

Alexander Hoffmann, Marie Oliver-Metzig

Stochastic models of nucleosome dynamics reveal regulatory rules of stimulus-induced epigenome remodeling

Cell Reports(2022)10.1016/j.celrep.2022.111076

N/A

0DataRank · unranked

8 citations

Katherine M. Sheu, Quen J. Cheng, Alexander Hoffmann, German Enciso, Jinsu Kim

From Antibody Repertoires to Cell-Cell Interactions to Molecular Networks: Bridging Scales in the Germinal Center

Frontiers in Immunology(2022)10.3389/fimmu.2022.898078

N/A

0DataRank · unranked

7 citations

Alexander Hoffmann, Haripriya Vaidehi Narayanan

Optogenetic control of RelA reveals effect of transcription factor dynamics on downstream gene expression

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.08.03.502739

N/A

0DataRank · unranked

4 citations

Alain R. Bonny, Seesha Takagishi, Stefanie Luecke, Nina Riehs, Alexander Hoffmann +2 more

Cytokine-expression patterns reveal coordinated immunological programs associated with persistent MRSA bacteremia

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.12.28.521386

N/A

0DataRank · unranked

4 citations

Zhixin Cyrillus Tan, Liana C. Chan, Felicia Ruffin, Rajesh Parmar, Richard Ahn +9 more

The NF-κB multidimer system model: A knowledge base to explore diverse biological contexts

Science Signaling(2023)10.1126/scisignal.abo2838

N/A

0DataRank · unranked

33 citations

Rachel Tsui, Zhixin Cyrillus Tan, Arran Pack, Alexander Hoffmann, Simon Mitchell

Quantifying stimulus-response specificity to probe the functional state of macrophages

Cell Systems(2023)10.1016/j.cels.2022.12.012

N/A

0DataRank · unranked

21 citations

Aditya A. Guru, Alexander Hoffmann, Katherine M. Sheu

Tonic TNF conditioning of macrophages safeguards stimulus‐specific inflammatory responses

EMBO Reports(2023)10.15252/embr.202255986

N/A

0DataRank · unranked

15 citations

Adewunmi Adelaja, Xiaolu Guo, Supriya Sen, Roberto Spreafico, Apeksha Singh +6 more

RelB-deficient autoinflammatory pathology presents as interferonopathy, but in mice is interferon-independent

Journal of Allergy and Clinical Immunology(2023)10.1016/j.jaci.2023.06.024

N/A

0DataRank · unranked

15 citations

Yi Liu, Anna Fraser, Diane Lefaudeux, Dennis J. Chia, Linda Vong +3 more

A biochemical necroptosis model explains cell-type-specific responses to cell death cues

Biophysical Journal(2023)10.1016/j.bpj.2023.01.035

N/A

0DataRank · unranked

13 citations

Marie Oliver-Metzig, Alexander Hoffmann, Leonard A. Harris, Carlos F. Lopez, Geena V. Ildefonso

Use of Transcriptional Signatures to Differentiate Pathogen-Specific and Treatment-Specific Host Responses in Patients With Bacterial Bloodstream Infections

The Journal of Infectious Diseases(2023)10.1093/infdis/jiad498

N/A

0DataRank · unranked

5 citations

Richard Ahn, Felicia Ruffin, David W. Gjertson, Alexander Hoffmann, Vance G. Fowler +2 more

Designer genes courtesy of artificial intelligence

Genes & Development(2023)10.1101/gad.350783.123

N/A

0DataRank · unranked

3 citations

Alexander Hoffmann

Stimulus-response signaling dynamics characterize macrophage polarization states

Cell Systems(2024)10.1016/j.cels.2024.05.002

N/A

0DataRank · unranked

25 citations

Supriya Sen, Michael Iter, Adewunmi Adelaja, Stefanie Luecke, Xiaolu Guo +2 more

The noncanonical NFκB pathway: Regulatory mechanisms in health and disease

WIREs Mechanisms of Disease(2024)10.1002/wsbm.1646

N/A

0DataRank · unranked

20 citations

Helen J. Huang, Dennis J. Chia, Alexander Hoffmann, Benancio N. Rodriguez

Dynamical and combinatorial coding by MAPK p38 and NFκB in the inflammatory response of macrophages

Molecular Systems Biology(2024)10.1038/s44320-024-00047-4

N/A

0DataRank · unranked

19 citations

Xiaolu Guo, Katherine M. Sheu, Apeksha Singh, Sarina C. Lowe, Minhao Han +5 more

Co-imaging of RelA and c-Rel reveals features of NF-κB signaling for ligand discrimination

Cell Reports(2024)10.1016/j.celrep.2024.113940

N/A

0DataRank · unranked

17 citations

Apeksha Singh, S. W. Lowe, Mohammad Aqdas, Kevin Jiang, Haripriya Vaidehi Narayanan +3 more

Direct observation correlates NFκB cRel in B cells with activating and terminating their proliferative program

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2309686121

N/A

0DataRank · unranked

9 citations

Mark Y. Xiang, Yijia Chen, Helen J. Huang, Sukanya Roy, Himani Makkar +3 more

Tracking of lineage mass via quantitative phase imaging and confinement in low refractive index microwells

Lab on a Chip(2024)10.1039/d4lc00389f

N/A

0DataRank · unranked

2 citations

Justin Griffin, Koushik Roy, Alexander Hoffmann, Thomas A. Zangle, Jingzhou Zhang

Tracking of Lineage Mass via Quantitative Phase Imaging and Confinement in Low Refractive Index Microwells

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.03.27.587085

N/A

0DataRank · unranked

1 citations

Justin Griffin, Koushik Roy, Alexander Hoffmann, Thomas A. Zangle, Jingzhou Zhang

NF-κB RelB suppresses the inflammatory gene expression programs of dendritic cells by competing with RelA for binding to target gene promoters

Cell Discovery(2025)10.1038/s41421-024-00767-9

N/A

0DataRank · unranked

20 citations

Allison E. Daly, Benancio N. Rodriguez, Sunny Z. Wu, Kim A. Ngo, Anna Fraser +6 more

Population dynamics modeling reveals that myeloid bias involves both HSC differentiation and progenitor proliferation biases

Blood(2025)10.1182/blood.2024025598

N/A

0DataRank · unranked

18 citations

Dennis J. Chia, Dinesh S. Rao, Alexander Hoffmann, Apeksha Singh

Macrophage memory emerges from coordinated transcription factor and chromatin dynamics

Cell Systems(2025)10.1016/j.cels.2025.101171

N/A

0DataRank · unranked

10 citations

Minjun Son, Aleksandr Gorin, Emma Kenna, Abinash Padhi, Bijentimala Keisham +4 more

A computational workflow for assessing drug effects on temporal signaling dynamics reveals robustness in stimulus-specific NFκB signaling

PLoS Computational Biology(2025)10.1371/journal.pcbi.1013344

N/A

0DataRank · unranked

7 citations

Xiaolu Guo, Jennifer L. Wilson, Alexander Hoffmann, Emily R. Bozich

Modeling heterogeneous signaling dynamics of macrophages reveals principles of information transmission in stimulus responses

Nature Communications(2025)10.1038/s41467-025-60901-3

N/A

0DataRank · unranked

9 citations

Adewunmi Adelaja, Apeksha Singh, Roy Wollman, Alexander Hoffmann, Xiaolu Guo

Early cytokine signatures and clinical phenotypes discriminate persistent from resolving MRSA bacteremia

BMC Infectious Diseases(2025)10.1186/s12879-025-10620-3

N/A

0DataRank · unranked

7 citations

Ying Zheng, Maura Rossetti, Felicia Ruffin, Harry Pickering, Rajesh Parmar +12 more

Distinct roles for NF-κB in hematopoietic stem cells and the bone marrow milieu in promoting hematopoietic aging

Cell Reports(2025)10.1016/j.celrep.2025.116193

N/A

0DataRank · unranked

5 citations

Apeksha Singh, Yusheng Lin, Noa Popko, David Mastro, Yi Liu +5 more

Gene regulatory logic of the interferon-β enhancer is characterized by two selectively deployed modes of transcription factor synergy

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2502800122

N/A

0DataRank · unranked

3 citations

Cheng Zhang, Diana Ourthiague, Alexander Hoffmann, Allison Schiffman

Systems biology-enabled targeting of NF-κΒ and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL

Cell Death and Disease(2025)10.1038/s41419-025-07942-0

N/A

0DataRank · unranked

1 citations

Haripriya Vaidehi Narayanan, H. Brent Clark, Eleanor Jayawant, Hui Zhou, Yi Liu +8 more

A data-driven model of macrophage polarization states reveals an IFN macrophage signature in active Crohn’s disease

Frontiers in Immunology(2025)10.3389/fimmu.2025.1707719

N/A

0DataRank · unranked

1 citations

Madelaine Leitman, Noah Yan, Alexander Hoffmann, Sarina C. Lowe

Gene regulatory logic of the interferon-β enhancer contains multiple selectively deployed modes of transcription factor synergy

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.02.04.636520

N/A

0DataRank · unranked

1 citations

Cheng Zhang, Diana Ourthiague, Alexander Hoffmann, Allison Schiffman

Phased epigenetic fragility and stability accelerate the genetic evolution of B-cells

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.06.24.661408

N/A

0DataRank · unranked

0 citations

Haripriya Vaidehi Narayanan, Vaibhava Kesarwani, Tiffany Wang, Alexander Hoffmann, Mark Y. Xiang

Topological measures on phylogenetic trees of the antibody repertoire reveal the underlying kinetics of B cell fate decisions 4844

The Journal of Immunology(2025)10.1093/jimmun/vkaf283.2459

N/A

0DataRank · unranked

0 citations

Chengyuan Li, Jianche Liu, Mark Y. Xiang, Helen J. Huang, Alexander Hoffmann +1 more

Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics

Cell Reports(2020)10.1016/j.celrep.2020.01.108

N/A

0DataRank · unranked

74 citations

Kensei Kishimoto, Jeremy Davis‐Turak, Aditya Pimplaskar, Cheng Zhang, Roberto Spreafico +6 more

Macrophage reprogramming regulated by temporal and combinatorial signaling codes 2382

The Journal of Immunology(2025)10.1093/jimmun/vkaf283.307

N/A

0DataRank · unranked

0 citations

Alexander Hoffmann

Gene Regulatory Strategies that Decode the Duration of NFκB Dynamics Contribute to LPS- versus TNF-Specific Gene Expression

Cell Systems(2020)10.1016/j.cels.2019.12.004

N/A

0DataRank · unranked

73 citations

Cheng Zhang, Katherine M. Sheu, Yu Hsin Chen, Alexander Hoffmann, Supriya Sen

Alexander Hoffmann

Indexed papers

Top data-sharing exemplar

Papers