David A. Wink

Also affiliated with Frederick National Laboratory for Cancer Research, National Cancer Institute, Center for Cancer Research

MedicineBiochemistry, Genetics and Molecular Biology

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 33 papers. Top paper: “Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase”.

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase

Nature Communications(2020)10.1038/s41467-020-14433-7

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0DataRank · unranked

452 citations

Marieli Gonzalez-Cotto, Walter A. Baseler, Luke C. Davies, Bart Ghesquière, Nunziata Maio +9 more

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Journal of Visualized Experiments(2020)10.3791/60316

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11 citations

Nimit L. Patel, Timothy Back, Debashree Basudhar, Veena Somasundaram, Joseph D. Kalen +3 more

A divergent mode of activation of a nitrosyl iron complex with unusual antiangiogenic activity

Journal of Inorganic Biochemistry(2020)10.1016/j.jinorgbio.2020.111133

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8 citations

Lisa A. Ridnour, Florêncio Sousa Gouveia Júnior, Pedro Henrique Bezerra Cabral, Nilberto Robson Falcão do Nascimento, David A. Wink +10 more

Metabolic characterization of aggressive breast cancer cells exhibiting invasive phenotype: impact of non-cytotoxic doses of 2-DG on diminishing invasiveness

BMC Cancer(2020)10.1186/s12885-020-07414-y

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32 citations

Kaori Imadome, Veena Somasundaram, Miki Kawanishi, Kumiko Karasawa, David A. Wink +1 more

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Journal of Visualized Experiments(2020)10.3791/60316-v

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6 citations

Nimit L. Patel, Timothy Back, Debashree Basudhar, Veena Somasundaram, Joseph D. Kalen +3 more

Metabolic characterization of aggressive breast cancer cells exhibiting invasive phenotype: Impact of non-cytotoxic doses of 2-DG on diminishing invasiveness

Research Square(2020)10.21203/rs.3.rs-36631/v3

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1 citations

Kaori Imadome, Veena Somasundaram, Miki Kawanishi, Kumiko Karasawa, David A. Wink +1 more

An in vitro tumorigenesis model based on live cell-generated oxygen and nutrient gradients

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.24.264580

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0 citations

Sarah J. Flaherty, Veena Somasundaram, David A. Scheiblin, Stephen Lockett, David A. Wink +2 more

Metabolic characterization of aggressive breast cancer cells exhibiting invasive phenotype: Impact of non-cytotoxic doses of 2-DG on diminishing invasiveness

Research Square(2020)10.21203/rs.3.rs-36631/v2

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0DataRank · unranked

0 citations

Kaori Imadome, Veena Somasundaram, Miki Kawanishi, Kumiko Karasawa, David A. Wink +1 more

Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment

International Journal of Molecular Sciences(2021)10.3390/ijms22137068

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35 citations

Erika M. Palmieri, Veena Somasundaram, Dibyangana D. Bhattacharyya, Lisa A. Ridnour, Robert Y.S. Cheng +9 more

An in vitro tumorigenesis model based on live-cell-generated oxygen and nutrient gradients

Communications Biology(2021)10.1038/s42003-021-01954-0

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22 citations

Sarah J. Flaherty, Veena Somasundaram, David A. Scheiblin, Stephen Lockett, David A. Wink +2 more

Comment on “Evidence that the ProPerDP method is inadequate for protein persulfidation detection due to lack of specificity”

Science Advances(2021)10.1126/sciadv.abe7006

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4 citations

Elias S.J. Arnér, Edward E. Schmidt, Tobias P. Dick, Albert van der Vliet, Jing Yang +14 more

Targeting Nitric Oxide: Say NO to Metastasis

Clinical Cancer Research(2022)10.1158/1078-0432.ccr-22-2791

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64 citations

Sharon A. Glynn, Timothy R. Billiar, David A. Wink, Jenny C. Chang, T. P. Reddy

Systemic Nos2 Depletion and Cox inhibition limits TNBC disease progression and alters lymphoid cell spatial orientation and density

Redox Biology(2022)10.1016/j.redox.2022.102529

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24 citations

Lisa A. Ridnour, Robert Y.S. Cheng, Abigail J. Walke, Noémi Kedei, Dibyangana D. Bhattacharyya +21 more

HNO Protects the Myocardium against Reperfusion Injury, Inhibiting the mPTP Opening via PKCε Activation

Antioxidants(2022)10.3390/antiox11020382

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20 citations

Pasquale Pagliaro, Lisa A. Ridnour, Carlo G. Tocchetti, Katrina M. Miranda, Magdalena Juhaszova +4 more

Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming

Nature Communications(2023)10.1038/s41467-023-40738-4

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52 citations

Ronald J. Holewinski, Christopher McGinity, Ciro Leonardo Pierri, Nunziata Maio, Jonathan M. Weiss +7 more

Interferon-gamma is quintessential for NOS2 and COX2 expression in ER- breast tumors that lead to poor outcome

Cell Death and Disease(2023)10.1038/s41419-023-05834-9

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17 citations

Lisa A. Ridnour, Adelaide L. Wink, Ana L. González, Elise L. Femino, Helene Rittscher +20 more

The Chemical Biology of NO that Regulates Oncogenic Signaling and Metabolism: NOS2 and Its Role in Inflammatory Disease

Critical Reviews™ in Oncogenesis(2023)10.1615/critrevoncog.2023047302

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12 citations

Lisa A. Ridnour, Robert Y.S. Cheng, David A. Wink, Douglas D. Thomas, Katrina M. Miranda

IL-27 induces an IFN-like signature in murine macrophages which in turn modulate colonic epithelium

Frontiers in Immunology(2023)10.3389/fimmu.2023.1021824

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9 citations

Mairi H McLean, Julie A. Hixon, Sergio M. Pontejo, Tregei Starr, Courtney S. Malo +10 more

New nitrosyl ruthenium complexes with combined activities for multiple cardiovascular disorders

Dalton Transactions(2023)10.1039/d3dt00059a

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14 citations

João Alison de Moraes Silveira, Thaís Muratori Holanda, Aline Diogo Marinho, Lisa A. Ridnour, David A. Wink +5 more

Chronic Exposure to Nitric Oxide Induces P53 Mutations and Malignant-like Features in Human Breast Epithelial Cells

Biomolecules(2023)10.3390/biom13020311

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7 citations

Sandra Burkett, Stefan Ambs, Terry W. Moody, David A. Wink, Lisa A. Ridnour +1 more

Spatial analysis of NOS2 and COX2 interaction with T-effector cells reveals immunosuppressive landscapes associated with poor outcome in ER- breast cancer patients

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.21.572867

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2 citations

Robert Y.S. Cheng, William F. Heinz, Milind Pore, Ana L. González, Elise L. Femino +22 more

Pyruvate Dehydrogenase Operates as an Intramolecular Nitroxyl Generator During Macrophage Metabolic Reprogramming

Research Square(2023)10.21203/rs.3.rs-2238134/v1

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1 citations

Ronald J. Holewinski, Christopher McGinity, Ciro Leonardo Pierri, Nunziata Maio, Vincenzo Tragni +6 more

NOS2 and COX2 Provide Key Spatial Targets that Determine Outcome in ER-Breast Cancer

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.12.21.572859

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1 citations

William F. Heinz, Robert Y.S. Cheng, Adelaide L. Wink, Noémi Kedei, Milind Pore +21 more

Data from A Mitochondrial Target Sequence Polymorphism in Manganese Superoxide Dismutase Predicts Inferior Survival in Breast Cancer Patients Treated with Cyclophosphamide

(2023)10.1158/1078-0432.c.6517732

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0 citations

Brenda J. Boersma, Tiffany M. Howe, Hege Edvardsen, Stephanie Geisler, Julie E. Goodman +9 more

Data from A Mitochondrial Target Sequence Polymorphism in Manganese Superoxide Dismutase Predicts Inferior Survival in Breast Cancer Patients Treated with Cyclophosphamide

(2023)10.1158/1078-0432.c.6517732.v1

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0 citations

Brenda J. Boersma, Tiffany M. Howe, Hege Edvardsen, Stephanie Geisler, Julie E. Goodman +9 more

Interferon-gamma is Quintessential for NOS2 and COX2 Expression in ER - Breast Tumors that Lead to Poor Outcome

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.06.535916

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0DataRank · unranked

0 citations

Lisa A. Ridnour, Adelaide L. Wink, Ana L. González, Elise L. Femino, Helene Rittscher +20 more

NOS2 and COX-2 Co-Expression Promotes Cancer Progression: A Potential Target for Developing Agents to Prevent or Treat Highly Aggressive Breast Cancer

International Journal of Molecular Sciences(2024)10.3390/ijms25116103

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31 citations

Elise L. Femino, Ana L. González, Rebecca L. Moffat, William F. Heinz, Robert Y.S. Cheng +5 more

Adjuvant COX inhibition augments STING signaling and cytolytic T cell infiltration in irradiated 4T1 tumors

JCI Insight(2024)10.1172/jci.insight.165356

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8 citations

Robert Y.S. Cheng, Noémi Kedei, Veena Somasundaram, Dibyangana D. Bhattacharyya, Debashree Basudhar +25 more

TRAIL-induced cytokine production via NFKB2 pathway promotes neutrophil chemotaxis and immune suppression in triple negative breast cancers

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.07.19.604341

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3 citations

Yoshimi Endo Greer, Alexei Lobanov, Lisa A. Ridnour, Renee N. Donahue, Yeap Ng +11 more

TRAIL induces cytokine production via the NFkB2 pathway promoting neutrophil chemotaxis and neutrophil-mediated immune-suppression in triple negative breast cancer cells

Cancer Letters(2025)10.1016/j.canlet.2025.217692

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10 citations

Yoshimi Endo Greer, Alexei Lobanov, Lisa A. Ridnour, Renee N. Donahue, Yeap Ng +12 more

Elevated tumor NOS2/COX2 promotes immunosuppressive phenotypes associated with poor survival in ER– breast cancer

JCI Insight(2025)10.1172/jci.insight.193091

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5 citations

Robert Y.S. Cheng, William F. Heinz, Milind Pore, Ana L. González, Elise L. Femino +22 more

SPAC: a scalable, integrated enterprise platform for end-to-end single cell spatial analysis of multiplexed tissue imaging

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.02.646782

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3 citations

Rui He, Thomas Sheeley, David A. Scheiblin, Stephen Lockett, Lisa A. Ridnour +5 more

Fundamental inorganic chemistry and cancer and inflammatory mechanism of NO. kinetic approach to revealing insights into Cancer and other diseases

Polyhedron(2025)10.1016/j.poly.2025.117866

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0 citations

Leandro L. Coutinho, Robert Y.S. Cheng, Lisa A. Ridnour, Jon M. Fukuto, David A. Wink