Hassane S. Mchaourab

Biochemistry, Genetics and Molecular BiologyMedicineChemistry

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 49 papers. Top paper: “Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling”.

Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling

Nature Communications(2024)10.1038/s41467-024-53420-0

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0.462DataRank · unranked

11 citations

Kevin L. Jagessar, Matthew Brownd, Adithya Polasa, Richard A. Stein, Mahmoud Moradi +3 more

A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl–/H+ transport cycle

eLife(2020)10.7554/elife.53479

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0DataRank · unranked

50 citations

Ricky C. Cheng, Tao Jiang, Irimpan I. Mathews, Richard A. Stein, Antoine Koehl +4 more

Sequence and structural determinants of ligand-dependent alternating access of a MATE transporter

Proceedings of the National Academy of Sciences(2020)10.1073/pnas.1917139117

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44 citations

Derek P. Claxton, Richard A. Stein, Hassane S. Mchaourab, Kevin L. Jagessar

Structure and assembly of CAV1 8S complexes revealed by single particle electron microscopy

Science Advances(2020)10.1126/sciadv.abc6185

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40 citations

Jason C. Porta, Jessica L. Hanks, Yelena Peskova, Elad Binshtein, Kelly A. Dryden +6 more

The Multidrug Transporter MdfA Deviates from the Canonical Model of Alternating Access of MFS Transporters

Journal of Molecular Biology(2020)10.1016/j.jmb.2020.08.017

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29 citations

Smriti Mishra, Richard A. Stein, Eitan Bibi, Hassane S. Mchaourab, Eliane Hadas Yardeni

Structure and assembly of CAV1 8S complexes revealed by single particle electron microscopy

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.06.04.133678

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2 citations

Jason C. Porta, Jessica L. Hanks, Yelena Peskova, Elad Binshtein, Kelly A. Dryden +6 more

AlphaFold2 predicts the inward‐facing conformation of the multidrug transporter LmrP

Proteins Structure Function and Bioinformatics(2021)10.1002/prot.26138

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33 citations

Cédric Govaerts, Hassane S. Mchaourab, Diego del Alamo

Principles of Alternating Access in Multidrug and Toxin Extrusion (MATE) Transporters

Journal of Molecular Biology(2021)10.1016/j.jmb.2021.166959

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30 citations

Kevin L. Jagessar, Hassane S. Mchaourab, Derek P. Claxton

Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations

The Journal of General Physiology(2021)10.1085/jgp.201711954

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30 citations

Richard A. Stein, Hassane S. Mchaourab, Eric J. Hustedt

Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter

Nature Chemical Biology(2021)10.1038/s41589-021-00936-x

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30 citations

Smriti Mishra, Wenchang Zhou, Michael J. Mohan, Qingyu Tang, José D. Faraldo‐Gómez +3 more

Methodology for rigorous modeling of protein conformational changes by Rosetta using DEER distance restraints

PLoS Computational Biology(2021)10.1371/journal.pcbi.1009107

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25 citations

Kevin L. Jagessar, Jens Meiler, Hassane S. Mchaourab, Diego del Alamo

Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia

eLife(2021)10.7554/elife.68039

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23 citations

Mary Hongying Cheng, Josep Font, Alexandra C. Schwartz, Kaitlyn V. Ledwitch, Amanda M. Duran +14 more

Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.101534

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18 citations

Karin J. Bosma, Derek P. Claxton, James K. Oeser, Kritika Singh, Lindsay B. Breidenbach +4 more

Conserved binding site in the N-lobe of prokaryotic MATE transporters suggests a role for Na+ in ion-coupled drug efflux

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100262

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11 citations

Derek P. Claxton, Emel Ficici, Tsukasa Kusakizako, Robyn Stix, Wenchang Zhou +4 more

Sampling the conformational landscapes of transporters and receptors with AlphaFold2

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.11.22.469536

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11 citations

Davide Sala, Hassane S. Mchaourab, Jens Meiler, Diego del Alamo

Cryo-EM structure of an elusive pre-transport intermediate of the multidrug ABC transporter BmrCD reveals modes of asymmetric drug binding

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.03.13.435271

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3 citations

Smriti Mishra, Wenchang Zhou, José D. Faraldo‐Gómez, Hassane S. Mchaourab, Thomas Tomasiak +1 more

Psychomotor Impairments and Therapeutic Implications Revealed by a Mutation Associated with Infantile Parkinsonism-Dystonia

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.03.09.434693

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0DataRank · unranked

0 citations

Mary Hongying Cheng, Josep Font, Alexandra C. Schwartz, Kaitlyn V. Ledwitch, Amanda M. Duran +14 more

Sampling alternative conformational states of transporters and receptors with AlphaFold2

eLife(2022)10.7554/elife.75751

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546 citations

Davide Sala, Hassane S. Mchaourab, Jens Meiler, Diego del Alamo

SPEACH_AF: Sampling protein ensembles and conformational heterogeneity with Alphafold2

PLoS Computational Biology(2022)10.1371/journal.pcbi.1010483

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262 citations

Hassane S. Mchaourab, Richard A. Stein

Molecular architecture of the human caveolin-1 complex

Science Advances(2022)10.1126/sciadv.abn7232

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124 citations

Bing Han, Alican Gulsevin, Jeong Min Chung, Yelena Peskova, Sarah M. Connolly +6 more

Integrated AlphaFold2 and DEER investigation of the conformational dynamics of a pH-dependent APC antiporter

Proceedings of the National Academy of Sciences(2022)10.1073/pnas.2206129119

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39 citations

Lillian DeSousa, Rahul Nair, Suhaila Rahman, Jens Meiler, Hassane S. Mchaourab +1 more

Modeling of protein conformational changes with Rosetta guided by limited experimental data

Structure(2022)10.1016/j.str.2022.04.013

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31 citations

Diego del Alamo, Hassane S. Mchaourab, Jens Meiler, Davide Sala

Principles of Alternating Access in LeuT-fold Transporters: Commonalities and Divergences

Journal of Molecular Biology(2022)10.1016/j.jmb.2022.167746

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33 citations

Jens Meiler, Hassane S. Mchaourab, Diego del Alamo

Template-free prediction of a new monotopic membrane protein fold and assembly by AlphaFold2

Biophysical Journal(2022)10.1016/j.bpj.2022.11.011

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16 citations

Bing Han, Jason C. Porta, Hassane S. Mchaourab, Jens Meiler, Anne K. Kenworthy +1 more

Adamts10 controls transforming growth factor β family signaling that contributes to retinal ganglion cell development

Frontiers in Molecular Biosciences(2022)10.3389/fmolb.2022.989851

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2 citations

Amy E. Whitener, Hang‐Jing Wu, Shu-Yu Wu, Hassane S. Mchaourab, Douglas P. Mortlock +3 more

Principles of Alternating Access in LeuT-fold Transporters: Commonalities and Divergences

ChemRxiv(2022)10.26434/chemrxiv-2022-nk6h3

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5 citations

Jens Meiler, Hassane S. Mchaourab, Diego del Alamo

First crystal structure of a non-canonical amino acid linked to a paramagnetic lanthanide tag facilitates protein structure determination using NMR-derived restraints

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.04.10.487812

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3 citations

Soumya Ganguly, Heather L. Darling, Joel M. Harp, Alican Gulsevin, Irene Coin +5 more

Integrated AlphaFold2 and DEER investigation of the conformational dynamics of a pH-dependent APC antiporter

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.04.13.488180

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0DataRank · unranked

2 citations

Lillian DeSousa, Rahul Nair, Suhaila Rahman, Jens Meiler, Hassane S. Mchaourab +1 more

Template-free prediction of a new monotopic membrane protein fold and oligomeric assembly by Alphafold2

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.07.12.499809

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2 citations

Bing Han, Jason C. Porta, Hassane S. Mchaourab, Jens Meiler, Anne K. Kenworthy +1 more

Modeling of protein conformational changes with Rosetta guided by limited experimental data

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.02.14.480383

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1 citations

Diego del Alamo, Hassane S. Mchaourab, Jens Meiler, Davide Sala

Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter

Nature Communications(2023)10.1038/s41467-023-42937-5

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31 citations

Matt Sinclair, Hale S. Hasdemir, Richard A. Stein, Erkan Karakaş, Emad Tajkhorshid +2 more

Generation and characterization of a zebrafish knockout model of abcb4, a homolog of the human multidrug efflux transporter P-glycoprotein

Human Genomics(2023)10.1186/s40246-023-00530-3

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23 citations

Hyosung Kim, Leen Alabdalla, Smriti Mishra, Hassane S. Mchaourab, Jinhee Park

Structural analysis of the P132L disease mutation in caveolin-1 reveals its role in the assembly of oligomeric complexes

Journal of Biological Chemistry(2023)10.1016/j.jbc.2023.104574

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11 citations

Alican Gulsevin, Sarah M. Connolly, Ting Wang, Brigitte Meyer, Jason C. Porta +10 more

Cucurbit[7]uril Enhances Distance Measurements of Spin-Labeled Proteins

Journal of the American Chemical Society(2023)10.1021/jacs.3c09184

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9 citations

Richard A. Stein, Maren Pink, Peter Madzelan, Thacien Ngendahimana, Suchada Rajca +6 more

Interplay between Nrf2 and αB-crystallin in the lens and heart of zebrafish under proteostatic stress

Frontiers in Molecular Biosciences(2023)10.3389/fmolb.2023.1185704

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4 citations

Samantha MacGavin, Laurie Niederbrach, Hassane S. Mchaourab, Jinhee Park

Approximating conformational Boltzmann distributions with AlphaFold2 predictions

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.06.552168

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6 citations

Richard A. Stein, Jens Meiler, Hassane S. Mchaourab, Benjamin P. Brown

Interplay between Nrf2 and αB-crystallin in the lens and heart of zebrafish under proteostatic stress

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.04.04.535454

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1 citations

Samantha MacGavin, Laurie Niederbrach, Hassane S. Mchaourab, Jinhee Park

Cucurbit[7]uril Enhances Distance Measurements of Spin-Labeled Proteins

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.22.554361

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1 citations

Richard A. Stein, Maren Pink, Peter Madzelan, Thacien Ngendahimana, Suchada Rajca +6 more

Generation and characterization of a zebrafish knockout model of abcb4, a homolog of the human multidrug efflux transporter P-glycoprotein

Research Square(2023)10.21203/rs.3.rs-3192988/v1

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0DataRank · unranked

0 citations

Hyosung Kim, Leen Alabdalla, Smriti Mishra, Hassane S. Mchaourab, Jinhee Park

Defining unique structural features in the MAFA and MAFB transcription factors that control Insulin gene activity

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.08.23.554429

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0DataRank · unranked

0 citations

Xin Tong, Katie C. Coate, Min Guo, Jinhua Liu, Garrett Reynolds +5 more

Approximating Projections of Conformational Boltzmann Distributions with AlphaFold2 Predictions: Opportunities and Limitations

Journal of Chemical Theory and Computation(2024)10.1021/acs.jctc.3c01081

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32 citations

Richard A. Stein, Jens Meiler, Hassane S. Mchaourab, Benjamin P. Brown

Alternating access of a bacterial homolog of neurotransmitter: sodium symporters determined from AlphaFold2 ensembles and DEER spectroscopy

Proceedings of the National Academy of Sciences(2024)10.1073/pnas.2406063121

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4 citations

Richard A. Stein, Eva Gil‐Iturbe, Matthias Quick, Hassane S. Mchaourab, Alexandra C. Schwartz

Defining unique structural features in the MAFA and MAFB transcription factors that control Insulin gene activity

Journal of Biological Chemistry(2024)10.1016/j.jbc.2024.107938

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3 citations

Xin Tong, Katie C. Coate, Min Guo, Jinhua Liu, Garrett Reynolds +5 more

Alternating Access of a Neurotransmitter:Sodium Symporter Bacterial Homolog Determined from AlphaFold2 Ensembles and DEER Spectroscopy

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.04.08.587957

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0DataRank · unranked

3 citations

Richard A. Stein, Eva Gil‐Iturbe, Matthias Quick, Hassane S. Mchaourab, Alexandra C. Schwartz

Conformational cycle of a protease-containing ABC transporter in lipid nanodiscs reveals the mechanism of cargo-protein coupling

Research Square(2024)10.21203/rs.3.rs-4087134/v1

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0DataRank · unranked

0 citations

Ruojing Zhang, Kevin L. Jagessar, Adithya Polasa, Matthew Brownd, Richard A. Stein +3 more

Modeling protein conformational ensembles by guiding AlphaFold2 with Double Electron Electron Resonance (DEER) distance distributions

Nature Communications(2025)10.1038/s41467-025-62582-4

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18 citations

Richard A. Stein, Te‐Yu Kao, Benjamin P. Brown, Hassane S. Mchaourab, Tianqi Wu

Drug-bound outward-facing conformation of a heterodimeric ABC exporter suggests a putative mechanism of drug translocation

Nature Communications(2025)10.1038/s41467-025-65318-6

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4 citations

Matt Sinclair, Paola Bisignano, Yunsen Zhang, Emad Tajkhorshid, Hassane S. Mchaourab +1 more

An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity

Nature Structural & Molecular Biology(2020)10.1038/s41594-020-0464-y

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80 citations

Andrew Hutchin, Matthieu Masureel, Emel Ficici, Chloé Martens, Pierre Legrand +6 more

Data-Independent Acquisition Parallel Accumulation–Serial Fragmentation (diaPASEF) Analysis of the Separated Zebrafish Lens Improves Identifications

Journal of the American Society for Mass Spectrometry(2025)10.1021/jasms.5c00087

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1 citations

W. Hayes McDonald, Kristie L. Rose, Hassane S. Mchaourab, Kevin L. Schey, Sarah R. Zelle