Michael S. Wolfe

MedicineComputer ScienceBiochemistry, Genetics and Molecular BiologyMaterials Science

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

1in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 1 indexed paper attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

Papers

Driven by 30 papers. Top paper: “A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain”.

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

Nature(1999)10.1038/19083

N/A

1.1DataRank · unranked

2101 citations

Wim Annaert, Philippe Cupers, Paul Saftig, Katleen Craessaerts, Jeffrey S. Mumm +7 more

Unraveling the complexity of γ-secretase

Seminars in Cell and Developmental Biology(2020)10.1016/j.semcdb.2020.01.005

N/A

0.587DataRank · unranked

49 citations

Michael S. Wolfe

Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein

Communications Biology(2023)10.1038/s42003-023-04539-1

N/A

0.505DataRank · unranked

28 citations

Sujan Devkota, Apurba Bhattarai, Michael S. Wolfe, Yinglong Miao, N. Hung

Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

eLife(2024)10.7554/elife.102274

N/A

0.330DataRank · unranked

8 citations

Sujan Devkota, Emily L. Williams, Masato Maesako, Michael S. Wolfe, Parnian Arafi

Discovery of aryl aminothiazole γ-secretase modulators with novel effects on amyloid β-peptide production

Bioorganic & Medicinal Chemistry Letters(2021)10.1016/j.bmcl.2021.128446

N/A

0.241DataRank · unranked

4 citations

Lei Liu, Michael S. Wolfe, Sanjay Bhattarai

Discovery of aryl aminothiazole γ-secretase modulators with novel effects on amyloid β-peptide production

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.08.09.455471

N/A

0.104DataRank · unranked

1 citations

Lei Liu, Michael S. Wolfe, Sanjay Bhattarai

Design of Transmembrane Mimetic Structural Probes to Trap Different Stages of γ-Secretase-Substrate Interaction

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.08.05.455313

N/A

0DataRank · unranked

0 citations

Sujan Devkota, Michael S. Wolfe, Sanjay Bhattarai

Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer's disease

Alzheimer s & Dementia(2022)10.1002/alz.12646

N/A

0DataRank · unranked

53 citations

Bianca M. Lauro, Amy He, Hyo Lee, Sanjay Bhattarai, Michael S. Wolfe +6 more

Verteporfin is a substrate-selective γ-secretase inhibitor that binds the amyloid precursor protein transmembrane domain

Journal of Biological Chemistry(2022)10.1016/j.jbc.2022.101792

N/A

0DataRank · unranked

13 citations

Kristine F. Parson, Ilyas Beg, Mason C. Wilkinson, Kamila Nurmakova, Iliana Levesque +5 more

Effects of Presenilin-1 Familial Alzheimer’s Disease Mutations on γ-Secretase Activation for Cleavage of Amyloid Precursor Protein

Research Square(2022)10.21203/rs.3.rs-1910553/v1

N/A

0DataRank · unranked

0 citations

Sujan Devkota, Apurba Bhattarai, Michael S. Wolfe, Yinglong Miao, Hung D. Nguyen

A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer’s disease

Nature Communications(2023)10.1038/s41467-023-42704-6

N/A

0DataRank · unranked

18 citations

Chenxi Qiu, Zhen‐Kai Ngian, Marianna Liang, Derek Drake, Jaejoon Choi +11 more

Molecular Dynamics Activation of γ-Secretase for Cleavage of the Notch1 Substrate

ACS Chemical Neuroscience(2023)10.1021/acschemneuro.3c00594

N/A

0DataRank · unranked

7 citations

Shweta R. Malvankar, Michael S. Wolfe, Yinglong Miao, N. Hung

Molecular Dynamics Activation of γ-Secretase for Cleavage of Notch1 Substrate

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.26.559539

N/A

0DataRank · unranked

0 citations

Shweta R. Malvankar, Michael S. Wolfe, Yinglong Miao, N. Hung

Familial Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes

Cell Reports(2024)10.1016/j.celrep.2024.113761

N/A

0DataRank · unranked

39 citations

Rui Zhou, Vaishnavi Nagarajan, Masato Maesako, N. Hung, Arshad Ali Noorani +9 more

Emerging structures and dynamic mechanisms of γ-secretase for Alzheimer’s disease

Neural Regeneration Research(2024)10.4103/nrr.nrr-d-23-01781

N/A

0DataRank · unranked

11 citations

Michael S. Wolfe, Yinglong Miao

Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

eLife(2024)10.7554/elife.102274.1

N/A

0DataRank · unranked

1 citations

Sujan Devkota, Masato Maesako, Michael S. Wolfe, Parnian Arafi

Effects of transmembrane phenylalanine residues on γ-secretase-mediated Notch-1 proteolysis

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.12.11.628002

N/A

0DataRank · unranked

1 citations

Michael S. Wolfe, Shweta R. Malvankar

Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.08.30.610520

N/A

0DataRank · unranked

0 citations

Sujan Devkota, Emily L. Williams, Masato Maesako, Michael S. Wolfe, Parnian Arafi

Presenilin, γ-Secretase, and the Search for Pathogenic Triggers of Alzheimer’s Disease

Biochemistry(2025)10.1021/acs.biochem.4c00830

N/A

0DataRank · unranked

18 citations

Michael S. Wolfe

Presenilin-1 Familial Alzheimer Mutations Impair γ-Secretase Cleavage of APP Through Stabilized Enzyme–Substrate Complex Formation

Biomolecules(2025)10.3390/biom15070955

N/A

0DataRank · unranked

7 citations

Masato Maesako, Michael S. Wolfe, Sujan Devkota

Effects of Transmembrane Phenylalanine Residues on γ-Secretase-Mediated Notch-1 Proteolysis

ACS Chemical Neuroscience(2025)10.1021/acschemneuro.4c00790

N/A

0DataRank · unranked

4 citations

Michael S. Wolfe, Shweta R. Malvankar

γ-Secretase-mediated endoproteolysis of neuregulin-1 and E-cadherin

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.04.19.649652

N/A

0DataRank · unranked

0 citations

Michael S. Wolfe, Shweta R. Malvankar

Familial Alzheimer Mutations in Presenilin-1 Decrease APP Substrate Proteolysis by γ-Secretase via Stable Enzyme-Substrate Complex Formation

Preprints.org(2025)10.20944/preprints202505.1338.v1

N/A

0DataRank · unranked

0 citations

Masato Maesako, Michael S. Wolfe, Sujan Devkota

A C. elegans model of familial Alzheimer’s disease shows age-dependent synaptic degeneration independent of amyloid β-peptide

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.07.16.665161

N/A

0DataRank · unranked

0 citations

Caitlin L. Libowitz, Brian D. Ackley, Michael S. Wolfe, Vaishnavi Nagarajan

AHA1 regulates Aβ production via modulation of APP expression and γ-secretase assembly

bioRxiv (Cold Spring Harbor Laboratory)(2025)10.1101/2025.11.03.686106

N/A

0DataRank · unranked

0 citations

Sadequl Islam, Kevin Catalfano, Heather Wilkins, Brian S. J. Blagg, Kun Zou +2 more

Mechanisms of γ-Secretase Activation and Substrate Processing

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.03.09.984534

N/A

0DataRank · unranked

2 citations

Sujan Devkota, Sanjay Bhattarai, Michael S. Wolfe, Yinglong Miao, Apurba Bhattarai

Mechanisms of γ-Secretase Activation and Substrate Processing

ACS Central Science(2020)10.1021/acscentsci.0c00296

N/A

0DataRank · unranked

45 citations

Sujan Devkota, Sanjay Bhattarai, Michael S. Wolfe, Yinglong Miao, Apurba Bhattarai

Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100281

N/A

0DataRank · unranked

71 citations

Todd D. Williams, Michael S. Wolfe, Sujan Devkota

Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons

Journal of Neuroscience(2021)10.1523/jneurosci.1698-21.2021

N/A

0DataRank · unranked

51 citations

Mei CQ Houser, Yuliia Turchyna, Michael S. Wolfe, Oksana Berezovska, Masato Maesako

Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides

Journal of Biological Chemistry(2021)10.1016/j.jbc.2021.100393

N/A

0DataRank · unranked

45 citations

Bianca M. Lauro, Michael S. Wolfe, Dennis J. Selkoe, Lei Liu