Richard C. Boucher

University of North Carolina at Chapel Hill

Also affiliated with Lung Institute, Cystic Fibrosis Research Foundation

Medicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 100%percentile

0Author DataRank

Indexed papers

0in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Papers

Driven by 125 papers. Top paper: “Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers”.

Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers

American Journal of Respiratory and Critical Care Medicine(2020)10.1164/rccm.202006-2248oc

N/A

7.3DataRank · unranked

184 citations

Brett M. Elicker, Travis S. Henry, David S. Gierada, Mark L. Schiebler, Wayne H. Anderson +29 more

Prevalence and Mechanisms of Mucus Accumulation in COVID-19 Lung Disease

American Journal of Respiratory and Critical Care Medicine(2022)10.1164/rccm.202111-2606oc

N/A

1.9DataRank · unranked

75 citations

Takanori Asakura, Caitlin E. Edwards, Hong Dang, Yu Mikami, Kenichi Okuda +20 more

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

Cell(2020)10.1016/j.cell.2020.05.042

N/A

1.1DataRank · unranked

1647 citations

Kenichi Okuda, Caitlin E. Edwards, David R. Martinez, Takanori Asakura, Kenneth H. Dinnon +38 more

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

Science(2020)10.1126/science.abe8499

N/A

1.0DataRank · unranked

998 citations

S. Chiba, Peter Halfmann, Camille Ehré, Makoto Kuroda, Kenneth H. Dinnon +21 more

A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.02.15.480515

N/A

0.598DataRank · unranked

17 citations

Sarah R. Leist, Kenichi Okuda, Hong Dang, Ethan J. Fritch, Kendra L. Gully +40 more

201 SCGB3A2-positive distal airway secretory cells are a therapeutic target for CFTR function restoration

Journal of Cystic Fibrosis(2023)10.1016/s1569-1993(23)01131-1

N/A

0.208DataRank · unranked

3 citations

S. Nakano, A. Singh, Z. Wiśniewski, Hong Dang, Lisa C. Morton +13 more

Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene

JCI Insight(2020)10.1172/jci.insight.139813

N/A

0DataRank · unranked

36 citations

Alessandra Livraghi-Butrico, Xia Hou, Carthic Rajagopalan, Jifeng Zhang, Jun Song +30 more

Breaking the In Vitro Alveolar Type II Cell Proliferation Barrier while Retaining Ion Transport Properties

UNC Libraries(2020)10.17615/pbng-by47

N/A

0DataRank · unranked

4 citations

Xuefeng Liu, Lisa C. Jones, Richard Schlegel, Scott H. Randell, Peter F. Bove +4 more

Normal and Cystic Fibrosis Airway Surface Liquid Homeostasis: THE EFFECTS OF PHASIC SHEAR STRESS AND VIRAL INFECTIONS

UNC Libraries(2020)10.17615/ak4t-v309

N/A

0DataRank · unranked

10 citations

Richard C. Boucher, Raymond J. Pickles, Anthony M. Paradiso, Peter L. Collins, Robert Tarran +6 more

CFTR Delivery to 25% of Surface Epithelial Cells Restores Normal Rates of Mucus Transport to Human Cystic Fibrosis Airway Epithelium

UNC Libraries(2020)10.17615/shw8-yj37

N/A

0DataRank · unranked

9 citations

Tristan R. McKay, Yu Yan, Brian Button, Yan L. Dang, Leatrice Vogel +8 more

Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation

UNC Libraries(2020)10.17615/sfd3-pt41

N/A

0DataRank · unranked

4 citations

Roshi Afshar, Morris Ling, Ramnik J. Xavier, James Moon, Daniel L. Hamilos +16 more

Future Directions in Early Cystic Fibrosis Lung Disease Research: An NHLBI Workshop Report

UNC Libraries(2020)10.17615/5b7f-j030

N/A

0DataRank · unranked

3 citations

Frank J. Accurso, Michael R. Knowles, John F. Engelhardt, Bonnie W. Ramsey, Susan V. Lynch +12 more

Osmotic water permeabilities of cultured, well-differentiated normal and cystic fibrosis airway epithelia

UNC Libraries(2020)10.17615/ayfg-3264

N/A

0DataRank · unranked

5 citations

Robert Tarran, Hirotoshi Matsui, C. William Davis, Richard C. Boucher

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

UNC Libraries(2020)10.17615/1qs8-pe15

N/A

0DataRank · unranked

2 citations

Hong Dang, Takafumi Kato, Sarah R. Leist, Aravinda de Silva, Mark J. Cameron +38 more

Mathematical Model of Nucleotide Regulation on Airway Epithelia: IMPLICATIONS FOR AIRWAY HOMEOSTASIS

UNC Libraries(2020)10.17615/n14t-n208

N/A

0DataRank · unranked

2 citations

Timothy C. Elston, Peiying Zuo, Richard C. Boucher, Maryse Picher, Brian Button +2 more

Airway Mucin Concentration as a Marker of Chronic Bronchitis

UNC Libraries(2020)10.17615/1qtb-n109

N/A

0DataRank · unranked

2 citations

Richard C. Boucher, Richard E. Kanner, Agathe Ceppe, Claire M. Doerschuk, Wayne H. Anderson +19 more

Development of Chronic Bronchitis and Emphysema in β-Epithelial Na + Channel–Overexpressing Mice

UNC Libraries(2020)10.17615/gnd0-0h79

N/A

0DataRank · unranked

1 citations

Alessandra Livraghi, Zhe Zhou, Marcus Mall, Stephen L. Tilley, Silvia M. Kreda +7 more

SARS-CoV-2 D614G Variant Exhibits Enhanced Replication ex vivo and Earlier Transmission in vivo

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.09.28.317685

N/A

0DataRank · unranked

67 citations

S. Chiba, Peter Halfmann, Camille Ehré, Makoto Kuroda, Kenneth H. Dinnon +15 more

Integrated Single-Cell Atlases Reveal an Oral SARS-CoV-2 Infection and Transmission Axis

medRxiv(2020)10.1101/2020.10.26.20219089

N/A

0DataRank · unranked

48 citations

Paola Pérez, Takafumi Kato, Yu Mikami, Kenichi Okuda, Rodney C. Gilmore +44 more

Nucleotide Release Provides a Mechanism for Airway Surface Liquid Homeostasis

UNC Libraries(2020)10.17615/2wf1-t474

N/A

0DataRank · unranked

1 citations

Catharina A. van Heusden, Robert Tarran, Eduardo R. Lazarowski, Seiko F. Okada, Richard C. Boucher +1 more

Roles of mucus adhesion and cohesion in cough clearance

UNC Libraries(2020)10.17615/an1y-4z26

N/A

0DataRank · unranked

0 citations

Michael Rubinstein, Richard C. Boucher, Robert G. Dennis, Eyad Atieh, Nathan T. Shenkute +7 more

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

UNC Libraries(2020)10.17615/dsyq-qr93

N/A

0DataRank · unranked

0 citations

Rachel L. Graham, Rhianna E. Lee, Richard C. Boucher, Noriko Nakajima, Kenneth H. Dinnon +21 more

Neonatal Pulmonary Macrophage Depletion Coupled to Defective Mucus Clearance Increases Susceptibility to Pneumonia and Alters Pulmonary Immune Responses

UNC Libraries(2020)10.17615/jqkg-4m13

N/A

0DataRank · unranked

0 citations

Kristy A. Terrell, Kristen J. Wilkinson, Kimberlie A. Burns, Richard C. Boucher, Alessandra Livraghi-Butrico +3 more

The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis

UNC Libraries(2020)10.17615/3v68-0a83

N/A

0DataRank · unranked

0 citations

Bahjat F. Qaqish, Michael Rubinstein, Wayne H. Anderson, Neil E. Alexis, C. William Davis +13 more

Airway drug pharmacokinetics via analysis of exhaled breath condensate

Carolina Digital Repository (University of North Carolina at Chapel Hill)(2020)10.17615/9rhk-kn38

N/A

0DataRank · unranked

0 citations

John H. Ansede, Melissa Johnson, Donn, Karl H., Charles R. Esther, Andrew J. Hirsh +3 more

Lung Microbiota and Bacterial Abundance in Patients with Bronchiectasis when Clinically Stable and during Exacerbation

UNC Libraries(2020)10.17615/1ea4-2231

N/A

0DataRank · unranked

0 citations

Máire Drain, Michael M. Tunney, J.S. Elborn, Chris R. Cardwell, Richard C. Boucher +5 more

Biophysical Model of Ion Transport across Human Respiratory Epithelia Allows Quantification of Ion Permeabilities

UNC Libraries(2020)10.17615/hdjw-vy25

N/A

0DataRank · unranked

0 citations

Guilherme J. M. Garcia, Timothy C. Elston, Richard C. Boucher

Thrombin Promotes Release of ATP from Lung Epithelial Cells through Coordinated Activation of Rho- and Ca 2+ -dependent Signaling Pathways

UNC Libraries(2020)10.17615/kps6-vk67

N/A

0DataRank · unranked

0 citations

Richard C. Boucher, Jo Ann Trejo, Lucia Seminario‐Vidal, Lisa C. Jones, Wanda K. O’Neal +2 more

Characterization of Rat Meibomian Gland Ion and Fluid Transport

UNC Libraries(2020)10.17615/jrqv-vk07

N/A

0DataRank · unranked

0 citations

Dongfang Yu, Richard Schlegel, Rodney C. Gilmore, Phillip W. Clapp, Michael Chua +6 more

Significance of the microbiome in obstructive lung disease

UNC Libraries(2020)10.17615/ay17-z315

N/A

0DataRank · unranked

0 citations

John R. Erb‐Downward, Gary B. Huffnagle, Vincent B. Young, Yvonne J. Huang, Jeffrey L. Curtis +10 more

Transmembrane Protein 16A (TMEM16A) Is a Ca 2+ -regulated Cl – Secretory Channel in Mouse Airways

UNC Libraries(2020)10.17615/3s0t-9h68

N/A

0DataRank · unranked

0 citations

Brian D. Harfe, Richard C. Boucher, Jason R. Rock, Sherif E. Gabriel, Wanda K. O’Neal +2 more

Metabolomic Evaluation of Neutrophilic Airway Inflammation in Cystic Fibrosis

UNC Libraries(2020)10.17615/ygx3-ng73

N/A

0DataRank · unranked

0 citations

Richard C. Boucher, Charles R. Esther, Yi Zhou, Raymond D. Coakley, Fred A. Wright +1 more

Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure

UNC Libraries(2020)10.17615/n4ex-wt40

N/A

0DataRank · unranked

0 citations

Brian Button, Margaret W. Leigh, Mehmet Kesımer, John K. Sheehan, Li‐Heng Cai +8 more

Rho Signaling Regulates Pannexin 1-mediated ATP Release from Airway Epithelia

UNC Libraries(2020)10.17615/a0pp-nn68

N/A

0DataRank · unranked

0 citations

Dale W. Laird, Silvia Peñuela, Lisa C. Jones, Wanda K. O’Neal, Richard C. Boucher +7 more

Similarities between UDP-Glucose and Adenine Nucleotide Release in Yeast: Involvement of the Secretory Pathway

UNC Libraries(2020)10.17615/cega-p736

N/A

0DataRank · unranked

0 citations

Charles R. Esther, Richard C. Boucher, Eduardo R. Lazarowski, Marién L. Clas, Henrik Dohlman +1 more

Mucin concentrations and peripheral airway obstruction in chronic obstructive pulmonary disease

UNC Libraries(2020)10.17615/470q-mz77

N/A

0DataRank · unranked

0 citations

R. Paine, E.A. Hoffman, Amina A. Ford, W.K. O apos Neal, Mehmet Kesımer +11 more

A Biophysical Basis for Mucus Solids Concentration as a Candidate Biomarker for Airways Disease

UNC Libraries(2020)10.17615/250q-7d45

N/A

0DataRank · unranked

0 citations

John Mellnik, M. Gregory Forest, Frank Mu, Aaron Vose, Scott H. Donaldson +6 more

Retrovirus-mediated gene transfer to cystic fibrosis airway epithelial cells: effect of selectable marker sequences on long-term expression

UNC Libraries(2020)10.17615/7whx-m241

N/A

0DataRank · unranked

0 citations

Richard C. Boucher, Larry G. Johnson, Ronald Swanstrom, K. L. Moore, Mabel L. Wong-sun +1 more

The Adult Cystic Fibrosis Airway Microbiota Is Stable over Time and Infection Type, and Highly Resilient to Antibiotic Treatment of Exacerbations

UNC Libraries(2020)10.17615/qr98-s086

N/A

0DataRank · unranked

0 citations

J.S. Elborn, D.F. Gilpin, Anthony A. Fodor, Erich Klem, Michael M. Tunney +2 more

Mathematical model reveals role of nucleotide signaling in airway surface liquid homeostasis and its dysregulation in cystic fibrosis

UNC Libraries(2020)10.17615/yrj4-6273

N/A

0DataRank · unranked

0 citations

Timothy C. Elston, Richard C. Boucher, Conner I. Sandefur

Soluble Mediators, Not Cilia, Determine Airway Surface Liquid Volume in Normal and Cystic Fibrosis Superficial Airway Epithelia

UNC Libraries(2020)10.17615/a31p-ej46

N/A

0DataRank · unranked

0 citations

Robert Tarran, Scott H. Donaldson, Richard C. Boucher, Laura Trout

Physiological Regulation of ATP Release at the Apical Surface of Human Airway Epithelia

UNC Libraries(2020)10.17615/7bbd-n197

N/A

0DataRank · unranked

0 citations

Robert A. Nicholas, Richard C. Boucher, Silvia M. Kreda, Eduardo R. Lazarowski, Seiko F. Okada

Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography

UNC Libraries(2020)10.17615/2f3v-hs32

N/A

0DataRank · unranked

0 citations

Andrew D. Luster, Mehmet Kesımer, Benjamin D. Medoff, Cho, Josalyn L., Margit V. Szabari +5 more

Characterization of Wild-Type and F508 Cystic Fibrosis Transmembrane Regulator in Human Respiratory Epithelia

UNC Libraries(2020)10.17615/gh8t-k880

N/A

0DataRank · unranked

0 citations

John R. Riordan, April Mengos, James R. Yankaskas, Richard C. Boucher, Marcus Mall +2 more

The Mitochondrial Barriers Segregate Agonist-induced Calcium-dependent Functions in Human Airway Epithelia

UNC Libraries(2020)10.17615/f744-4992

N/A

0DataRank · unranked

0 citations

Anthony M. Paradiso, Carla M. P. Ribeiro, Alessandra Livraghi, Richard C. Boucher

Airway Surface Liquid Volume Regulation Determines Different Airway Phenotypes in Liddle Compared with βENaC-overexpressing Mice

UNC Libraries(2020)10.17615/g7w0-jv62

N/A

0DataRank · unranked

0 citations

Wanda K. O’Neal, Carsten Schultz, Alessandra Livraghi, Ray A. Caldwell, Marcus Mall +9 more

Human Alveolar Type II Cells Secrete and Absorb Liquid in Response to Local Nucleotide Signaling

UNC Libraries(2020)10.17615/2rby-tr22

N/A

0DataRank · unranked

0 citations

Barbara R. Grubb, Richard C. Boucher, Carla M. P. Ribeiro, Scott H. Randell, Troy D. Rogers +3 more

Touch induces ATP release in Arabidopsis roots that is modulated by the heterotrimeric G-protein complex

UNC Libraries(2020)10.17615/ncyd-fp53

N/A

0DataRank · unranked

0 citations

Sung‐Yong Kim, Sarah J. Swanson, Seiko F. Okada, Ravisha R. Weerasinghe, Simon Gilroy +4 more

Modelling Dysregulated Na + Absorption in Airway Epithelial Cells with Mucosal Nystatin Treatment

UNC Libraries(2020)10.17615/mrmz-9f76

N/A

0DataRank · unranked

0 citations

Marcus Mall, Richard C. Boucher, Alessandra Livraghi, Carla M. P. Ribeiro, Anthony M. Paradiso

X-Box–Binding Protein 1 and Innate Immune Responses of Human Cystic Fibrosis Alveolar Macrophages

UNC Libraries(2020)10.17615/j48y-2c37

N/A

0DataRank · unranked

0 citations

Wanda K. O’Neal, Lisa C. Jones, Carla M. P. Ribeiro, Richard C. Boucher, Bob Lubamba

Mucus clearance as a primary innate defense mechanism for mammalian airways

UNC Libraries(2020)10.17615/r02t-5h69

N/A

0DataRank · unranked

0 citations

Richard C. Boucher, Michael R. Knowles

Inflammation Promotes Airway Epithelial ATP Release via Calcium-Dependent Vesicular Pathways

UNC Libraries(2020)10.17615/gsjm-sg72

N/A

0DataRank · unranked

0 citations

Seiko F. Okada, Lubna H. Abdullah, Catharina van Heusden, Carla M. P. Ribeiro, Eduardo R. Lazarowski +3 more

In Vivo Airway Surface Liquid Cl − Analysis with Solid-State Electrodes

UNC Libraries(2020)10.17615/dc4z-gg69

N/A

0DataRank · unranked

0 citations

Barbara R. Grubb, Pierre Barker, Robert Tarran, Richard C. Boucher, Ray A. Caldwell +1 more

Elevated Airway Purines in COPD

UNC Libraries(2020)10.17615/b289-zn40

N/A

0DataRank · unranked

0 citations

Elena Bordonali, Aili L. Lazaar, Bahjat F. Qaqish, Charles R. Esther, Richard C. Boucher

The Cystic Fibrosis Transmembrane Conductance Regulator Impedes Proteolytic Stimulation of the Epithelial Na + Channel

UNC Libraries(2020)10.17615/q3pw-dg97

N/A

0DataRank · unranked

0 citations

Richard C. Boucher, Agustı́n Garcı́a-Caballero, Martina Gentzsch, Yan L. Dang, Hamsa Suchindran +2 more

Polarized Signaling via Purinoceptors in Normal and Cystic Fibrosis Airway Epithelia

UNC Libraries(2020)10.17615/xjwh-s186

N/A

0DataRank · unranked

0 citations

Carla M. P. Ribeiro, Anthony M. Paradiso, Richard C. Boucher

SARS-CoV-2 infection of the oral cavity and saliva

Nature Medicine(2021)10.1038/s41591-021-01296-8

N/A

0DataRank · unranked

827 citations

Paola Pérez, Takafumi Kato, Yu Mikami, Kenichi Okuda, Rodney C. Gilmore +85 more

Evidence for Periciliary Liquid Layer Depletion, Not Abnormal Ion Composition, in the Pathogenesis of Cystic Fibrosis Airways Disease

UNC Libraries(2021)10.17615/4e6v-xz24

N/A

0DataRank · unranked

57 citations

Scott H. Randell, C.William Davis, Barbara R. Grubb, John T. Gatzy, Hirotoshi Matsui +2 more

Identification of Sputum Biomarkers Predictive of Pulmonary Exacerbations in COPD

CHEST Journal(2021)10.1016/j.chest.2021.10.049

N/A

0DataRank · unranked

41 citations

Wanda K. O’Neal, Wayne H. Anderson, Mehmet Kesımer, Agathe Ceppe, Claire M. Doerschuk +52 more

Purinergic receptors in airway hydration

Biochemical Pharmacology(2021)10.1016/j.bcp.2020.114387

N/A

0DataRank · unranked

22 citations

Richard C. Boucher, Eduardo R. Lazarowski

Inhaled gene therapy of preclinical muco-obstructive lung diseases by nanoparticles capable of breaching the airway mucus barrier

Thorax(2021)10.1136/thoraxjnl-2020-215185

N/A

0DataRank · unranked

19 citations

Gijung Kwak, Jason Rodriguez, Alessandra Livraghi-Butrico, Xinyuan Zuo, Valentina Simon +11 more

Molecular dynamics simulations to explore the structure and rheological properties of normal and hyperconcentrated airway mucus

Studies in Applied Mathematics(2021)10.1111/sapm.12433

N/A

0DataRank · unranked

14 citations

Xue‐Zheng Cao, Micah Papanikolas, Takafumi Kato, Richard C. Boucher, Matthew R. Markovetz +4 more

Ecto 5′-Nucleotidase and Nonspecific Alkaline Phosphatase: TWO AMP-HYDROLYZING ECTOENZYMES WITH DISTINCT ROLES IN HUMAN AIRWAYS

UNC Libraries(2021)10.17615/7d9b-1p97

N/A

0DataRank · unranked

16 citations

Josef Spychała, Richard C. Boucher, Lauranell H. Burch, Maryse Picher, Andrew J. Hirsh

An improved inhaled mucolytic to treat airway muco-obstructive diseases

UNC Libraries(2021)10.17615/cjma-5x97

N/A

0DataRank · unranked

5 citations

D. Villalon, Barbara R. Grubb, Nicholas C. Fontana, B. Wang, David B. Hill +12 more

Metabolism of P2 Receptor Agonists in Human Airways: IMPLICATIONS FOR MUCOCILIARY CLEARANCE AND CYSTIC FIBROSIS

UNC Libraries(2021)10.17615/exnf-2597

N/A

0DataRank · unranked

5 citations

Lauranell H. Burch, Richard C. Boucher, Maryse Picher

Loss of Binding and Entry of Liposome-DNA Complexes Decreases Transfection Efficiency in Differentiated Airway Epithelial Cells

UNC Libraries(2021)10.17615/xny4-vm57

N/A

0DataRank · unranked

5 citations

Scott H. Randell, Richard C. Boucher, Hirotoshi Matsui, Larry G. Johnson

Constitutive Release of ATP and Evidence for Major Contribution of Ecto-nucleotide Pyrophosphatase and Nucleoside Diphosphokinase to Extracellular Nucleotide Concentrations

UNC Libraries(2021)10.17615/dddg-bj46

N/A

0DataRank · unranked

4 citations

T. Kendall Harden, Eduardo R. Lazarowski, Richard C. Boucher

Identification of Dynein Heavy Chain 7 as an Inner Arm Component of Human Cilia That Is Synthesized but Not Assembled in a Case of Primary Ciliary Dyskinesia

UNC Libraries(2021)10.17615/gawj-k181

N/A

0DataRank · unranked

0 citations

Mary B. Moyer, Kevin Blackburn, Wanda K. O’Neal, Richard C. Boucher, Scott H. Randell +2 more

Thiol-based mucolytics exhibit antiviral activity against SARS-CoV-2 through allosteric disulfide disruption in the spike glycoprotein

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.07.01.450701

N/A

0DataRank · unranked

2 citations

Ari Zeida, Caitlin E. Edwards, Michael L. Mallory, Santiago Sastre, Matías Machado +9 more

Pharmacokinetic-based failure of a detergent virucidal for SARS-COV-2 nasal infections

Research Square(2021)10.21203/rs.3.rs-500168/v1

N/A

0DataRank · unranked

0 citations

Kyle S. Kimura, Yu Mikami, Caitlin E. Edwards, Suman R. Das, M.H. Freeman +17 more

pH-dependent Intraluminal Organization of Mucin Granules in Live Human Mucous/Goblet Cells

UNC Libraries(2021)10.17615/bznv-ar87

N/A

0DataRank · unranked

0 citations

Michael Chua, Richard C. Boucher, Juan Pérez-Vilar, John C. Olsen

Hyperconcentrated Mucus Unifies Submucosal Gland and Superficial Airway Dysfunction in Cystic Fibrosis

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.09.22.461306

N/A

0DataRank · unranked

0 citations

Giorgia Radicioni, Micah Papanikolas, Georgi Stoychev, Matthew R. Markovetz, Kazuhiro Aoki +25 more

Yes-Associated Protein 65 Localizes P62 c-Yes to the Apical Compartment of Airway Epithelia by Association with Ebp50

UNC Libraries(2021)10.17615/bhxr-9k10

N/A

0DataRank · unranked

0 citations

Sharon L. Milgram, Marius Sudol, M. Jackson Stutts, Richard C. Boucher, Silvia M. Kreda +1 more

Regulation of the Epithelial Sodium Channel by Serine Proteases in Human Airways

UNC Libraries(2021)10.17615/etqs-0g59

N/A

0DataRank · unranked

0 citations

Ginger Holloway, Sherif E. Gabriel, Andrew J. Hirsh, Julie Chao, Dong Chen Li +2 more

Effect of Loss of P2Y 2 Receptor Gene Expression on Nucleotide Regulation of Murine Epithelial Cl − Transport

UNC Libraries(2021)10.17615/1qrc-3z19

N/A

0DataRank · unranked

0 citations

László Homolya, Victoria L. Cressman, Richard C. Boucher, Eduardo R. Lazarowski, Barbara R. Grubb +1 more

Mucin Granule Intraluminal Organization in Living Mucous/Goblet Cells: ROLES OF PROTEIN POST-TRANSLATIONAL MODIFICATIONS AND SECRETION

UNC Libraries(2021)10.17615/6ff1-yc21

N/A

0DataRank · unranked

0 citations

Juan Pérez-Vilar, Carolyn R. Bertozzi, Raean Mabolo, Cheryl T. McVaugh, Richard C. Boucher

Role of mechanical stress in regulating airway surface hydration and mucus clearance rates

UNC Libraries(2021)10.17615/vy7s-yd16

N/A

0DataRank · unranked

0 citations

Richard C. Boucher, Brian Button

Differential effects of cyclic and constant stress on ATP release and mucociliary transport by human airway epithelia: Role of cyclic stress in airway mucociliary transport

UNC Libraries(2021)10.17615/4883-bm69

N/A

0DataRank · unranked

0 citations

Maryse Picher, Richard C. Boucher, Brian Button

Permeabilization via the P2X 7 Purinoreceptor Reveals the Presence of a Ca 2+ -activated Cl − Conductance in the Apical Membrane of Murine Tracheal Epithelial Cells

UNC Libraries(2021)10.17615/n8z0-gh70

N/A

0DataRank · unranked

0 citations

E. S. Martsen, Sherif E. Gabriel, Mariya Makhlina, Richard C. Boucher, Mike I. Lethem +1 more

Chronic Airway Infection/Inflammation Induces a Ca 2+ i -dependent Hyperinflammatory Response in Human Cystic Fibrosis Airway Epithelia

UNC Libraries(2021)10.17615/s0y6-wp82

N/A

0DataRank · unranked

0 citations

Lisa C. Jones, Ute Schwab, Anthony M. Paradiso, Juan Pérez-Vilar, Carla M. P. Ribeiro +2 more

An Apical PDZ Protein Anchors the Cystic Fibrosis Transmembrane Conductance Regulator to the Cytoskeleton

UNC Libraries(2021)10.17615/ka33-r314

N/A

0DataRank · unranked

0 citations

Silvia M. Kreda, Anthony Bretscher, M. Jackson Stutts, Richard C. Boucher, Sharon L. Milgram +3 more

Cystic Fibrosis Transmembrane Regulator-independent Release of ATP: ITS IMPLICATIONS FOR THE REGULATION OF P2Y2RECEPTORS IN AIRWAY EPITHELIA

UNC Libraries(2021)10.17615/w82f-jb16

N/A

0DataRank · unranked

0 citations

Eduardo R. Lazarowski, W. C. Watt, Richard C. Boucher

Cell to Cell Communication in Response to Mechanical Stress via Bilateral Release of Atp and Utp in Polarized Epithelia

UNC Libraries(2021)10.17615/rnet-h984

N/A

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0 citations

Thomas H. Steinberg, László Homolya, Richard C. Boucher

Human distal lung maps and lineage hierarchies reveal a bipotent progenitor

Nature(2022)10.1038/s41586-022-04541-3

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Vishwaraj Sontake, Aleksandra Tata, Yoshihiko Kobayashi, Lauren Macadlo, Kenichi Okuda +11 more

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection

Nature Genetics(2022)10.1038/s41588-022-01131-x

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Sylvia A. Sarnik, Eleanor Wang, James Zengel, Sarah R. Leist, Alexandra Schäfer +45 more

An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2

Cell Host & Microbe(2022)10.1016/j.chom.2022.12.005

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Yuying Xie, Takanori Asakura, Dingka Song, Kaixin Liang, Sharon Taft-Benz +13 more

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JCI Insight(2022)10.1172/jci.insight.159491

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Agnieszka Korzeniowska, Cynthia C. Aguilar, Jingwen Gu, Eric Karlins, Andrew J. Oler +35 more

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Journal of Dental Research(2022)10.1177/00220345221110768

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Human Cell Atlas Oral and Craniofacial Bionetwork, Inês Sequeira, Kevin M. Byrd, Ana Célia Caetano, Paul T. Sharpe +43 more

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Biophysical Journal(2022)10.1016/j.bpj.2022.04.003

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Timothy Wessler, Katherine Daftari, Kameryn Y. Hinton, Richard C. Boucher, Raymond J. Pickles +4 more

A Multitrait Locus Regulates Sarbecovirus Pathogenesis

mBio(2022)10.1128/mbio.01454-22

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Sarah R. Leist, Lisa E. Gralinski, David R. Martinez, Emma S. Winkler, Kenichi Okuda +27 more

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CHEST Journal(2022)10.1016/j.chest.2022.11.009

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P. Miguel Quibrera, Alejandro P. Comellas, Surya P. Bhatt, Donald P Tashkin, Eric A. Hoffman +52 more

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Journal of Cystic Fibrosis(2022)10.1016/j.jcf.2022.04.008

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Ian C. Garbarine, Cameron B. Morrison, William J. Kissner, Ian Seim, M. Gregory Forest +12 more

Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein

UNC Libraries(2022)10.17615/6hdp-b372

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Rafael Radí, Richard C. Boucher, Kate S. Carroll, Ling Fu, Ari Zeida +9 more

Protease-anti-protease compartmentalization in SARS-CoV-2 ARDS: Therapeutic implications

Carolina Digital Repository (University of North Carolina at Chapel Hill)(2022)10.17615/7ee9-9s90

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Richard C. Boucher, Kenichi Okuda, R.E. Zumwalt, C. Gabillard, J.L. Torres-Castillo +19 more

Development of a novel air–liquid interface airway tissue equivalent model for in vitro respiratory modeling studies

Scientific Reports(2023)10.1038/s41598-023-36863-1

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Uma Gandhi, Kimberly D. Reeves, Kristina Stumpf, Kenichi Okuda, Frank C. Marini +7 more

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The Lancet Infectious Diseases(2023)10.1016/s1473-3099(23)00271-2

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Naoki Kishida, Kenichi Okuda, Keisuke Kamada, Masami Iwama, Masaru Suzuki +6 more

Inflammatory Activity of Epithelial Stem Cell Variants from Cystic Fibrosis Lungs Is Not Resolved by CFTR Modulators

American Journal of Respiratory and Critical Care Medicine(2023)10.1164/rccm.202305-0818oc

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18 citations

Suchan Niroula, Ashley Hoffman, Melika Khorrami, Melina Khorrami, Feng Yuan +17 more

Longitudinal changes in the cystic fibrosis airway microbiota with time and treatment

Journal of Cystic Fibrosis(2023)10.1016/j.jcf.2023.11.010

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Laura J. Sherrard, Joseph Hatch, Bryan Zorn, E. Johnston, Clodagh McGettigan +13 more

Modeling identifies variability in SARS-CoV-2 uptake and eclipse phase by infected cells as principal drivers of extreme variability in nasal viral load in the 48 h post infection

Journal of Theoretical Biology(2023)10.1016/j.jtbi.2023.111470

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9 citations

Timothy Wessler, Alex Chen, Richard C. Boucher, Ronit Freeman, Samuel K. Lai +3 more

Associations of COVID-19 Symptoms with Omicron Subvariants BA.2 and BA.5, Host Status, and Clinical Outcomes: A Registry-Based Observational Study in Sapporo, Japan

medRxiv(2023)10.1101/2023.02.02.23285393

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5 citations

Naoki Kishida, Kenichi Okuda, Keisuke Kamada, Masami Iwama, Masaru Suzuki +6 more

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Journal of Cystic Fibrosis(2023)10.1016/s1569-1993(23)01123-2

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Taraneh Sadritabrizi, Liou Y. Sun, Richard C. Boucher, G. Chen, K. Hasegawa

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Cell Reports(2024)10.1016/j.celrep.2024.114076

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Caitlin E. Edwards, Michael L. Mallory, Rhianna E. Lee, Hong Dang, Alexis B. Bailey +20 more

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Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation(2024)10.15326/jcopdf.2023.0490

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Lori A. Bateman, Susan Murray, David Couper, Wassim W. Labaki, Christine M. Freeman +31 more

Prolonged airway explant culture enables study of health, disease, and viral pathogenesis

bioRxiv (Cold Spring Harbor Laboratory)(2024)10.1101/2024.02.03.578756

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1 citations

Kenichi Okuda, Jacob R. Galiger, Stephen A. Schworer, Troy D. Rogers, Hong Dang +15 more

A Multitrait Locus Regulates Sarbecovirus Pathogenesis

UNC Libraries(2024)10.17615/q0t7-5r51

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0 citations

Shu Dong, L. Gralinski, Pablo Hock, Victoria K. Baxter, Jennifer F. Loome +27 more

Human distal lung maps and lineage hierarchies reveal a bipotent progenitor

UNC Libraries(2024)10.17615/fv5b-sn92

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0 citations

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Molecular dynamics simulations to explore the structure and rheological properties of normal and hyperconcentrated airway mucus

UNC Libraries(2024)10.17615/tmqe-f823

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0 citations

Richard C. Boucher, Micah Papanikolas, Ronit Freeman, Andrew G. Ford, M. Gregory Forest +4 more

Associations of COVID-19 symptoms with omicron subvariants BA.2 and BA.5, host status, and clinical outcomes in Japan: a registry-based observational study

UNC Libraries(2024)10.17615/8g7r-xc27

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0DataRank · unranked

0 citations

Yoichi M. Ito, Naoki Kishida, Yasuyuki Nasuhara, Isao Yokota, Satoshi Konno +6 more

Airway epithelial heterogeneity and mucus plugging in asthmatic bronchioles

American Journal of Respiratory and Critical Care Medicine(2025)10.1164/rccm.202409-1849oc

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Hiroaki Murano, Hong Dang, Matthew R. Markovetz, Minako Saito, Takafumi Kato +28 more

Prolonged airway explant culture enables study of health, disease, and viral pathogenesis

Science Advances(2025)10.1126/sciadv.adp0451

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Kenichi Okuda, Jacob R. Galiger, Stephen A. Schworer, Troy D. Rogers, Hong Dang +16 more

STAT3-Dependent Regulation of CFTR and Ciliogenesis Is Essential for Mucociliary Clearance and Innate Airway Defense in Hyper-IgE Syndrome

American Journal of Respiratory and Critical Care Medicine(2025)10.1164/rccm.202407-1415oc

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Samantha A. Walls, Hong Dang, Nancy L. Quinney, Patrick R Sears, Taraneh Sadritabrizi +35 more

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Nature Microbiology(2025)10.1038/s41564-025-02090-9

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American Journal of Respiratory Cell and Molecular Biology(2025)10.1165/rcmb.2024-0130oc

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Stephen A. Schworer, Rodney C. Gilmore, Fatima Khan, Alane Blythe C. Dy, Adam L. Haber +5 more

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mSphere(2025)10.1128/msphere.00951-24

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Alexandra Schäfer, Kenichi Okuda, Sarah R. Leist, Jacob Kocher, Adam S. Cockrell +17 more

Dysregulation of lung epithelial cell homeostasis and immunity contributes to Middle East respiratory syndrome coronavirus disease severity

UNC Libraries(2025)10.17615/tntp-7z55

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0 citations

Carrie D. Niccora, Katrina M. Waters, Kristin Burnum-Johnson, Padraig Hawkins, Alexandra Schäfer +17 more

Longitudinal changes in the cystic fibrosis airway microbiota with time and treatment

UNC Libraries(2025)10.17615/kj0z-w326

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Inflammatory Activity of Epithelial Stem Cell Variants from Cystic Fibrosis Lungs Is Not Resolved by CFTR Modulators

UNC Libraries(2025)10.17615/fy1h-1150

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Development of a novel air–liquid interface airway tissue equivalent model for in vitro respiratory modeling studies

UNC Libraries(2025)10.17615/r4az-7m97

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Laura A. Cox, Uma Gandhi, Sean V. Murphy, Anthony Atala, Kristina Stumpf +7 more

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Canadian Journal of Respiratory Critical Care and Sleep Medicine(2025)10.1080/24745332.2025.2483843

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0DataRank · unranked

0 citations

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Modeling identifies variability in SARS-CoV-2 uptake and eclipse phase by infected cells as principal drivers of extreme variability in nasal viral load in the 48 h post infection

UNC Libraries(2025)10.17615/j0np-5206

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0 citations

Raymond J. Pickles, Alex Chen, M. Gregory Forest, Jason Pearson, Richard C. Boucher +3 more

Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis

Cell(2020)10.1016/j.cell.2020.03.047

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172 citations

Wang Shan, Marcin Dulęba, Suchan Niroula, Kristina Göller, Jingzhong Xie +21 more

Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction

Cell stem cell(2020)10.1016/j.stem.2020.10.005

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0DataRank · unranked

425 citations

Vishwaraj Sontake, Aleksandra Tata, Yoshihiko Kobayashi, Caitlin E. Edwards, Brook E. Heaton +11 more

Mucus Hyperconcentration as a Unifying Aspect of the Chronic Bronchitic Phenotype

UNC Libraries(2020)10.17615/0rky-5784

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0DataRank · unranked

57 citations

Wayne H. Anderson, Brian Button, Richard C. Boucher

Associations Among 25-Hydroxyvitamin D Levels, Lung Function, and Exacerbation Outcomes in COPD

CHEST Journal(2020)10.1016/j.chest.2019.11.047

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53 citations

Agathe Ceppe, Claire M. Doerschuk, David Couper, Eric A. Hoffman, Alejandro P. Comellas +53 more

Current smoking with or without chronic bronchitis is independently associated with goblet cell hyperplasia in healthy smokers and COPD subjects

Scientific Reports(2020)10.1038/s41598-020-77229-1

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0DataRank · unranked

11 citations

Stephanie Jeong, Huaqing Zhao, Mehmet Kesımer, Richard C. Boucher, J. Michael Wells +15 more