Lei Guo

Also affiliated with First Affiliated Hospital of Wenzhou Medical University, Southwestern Medical Center, The University of Texas Southwestern Medical Center

Biochemistry, Genetics and Molecular BiologyMedicine

Pilot corpus only

This score is computed over theSindex pilot corpus and does not cover the full scientific literature. Scores are relative to papers we have ingested — papers, authors, and institutions outside the pilot are not represented. Methodology.

Top 5%percentile

0.494Author DataRank

Indexed papers

2in pilot corpus

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Why this DataRank?

An author's DataRank is the sum of the DataRanks of all 2 indexed papers attributed to them. A prolific author with many moderate-impact papers can outrank one with a single high-impact paper.

Author scores recompute whenever paper DataRanks are refreshed, so this number lags the underlying paper scores by at most one batch run.

Read the full methodology →

The highest-impact dataset this researcher has shared, ranked by DataRank — the single contribution doing the most to lift their data-sharing standing.

Genome‐wide methylomic regulation of multiscale gene networks in Alzheimer's disease

Alzheimer s & Dementia(2023)10.1002/alz.12969

Top 39%

0.494DataRank

Top 39%26 citations

Minghui Wang, Lei Guo, John F. Fullard, Courtney Micallef, Jaroslav Bendl +12 more

Papers

Driven by 39 papers — median percentile 31. Top paper: “Dysbiosis of gut microbiome affecting small intestine morphology and immune balance: a rhesus macaque model”.

Dysbiosis of gut microbiome affecting small intestine morphology and immune balance: a rhesus macaque model

Zool. Res.(2020)10.24272/j.issn.2095-8137.2020.004

N/A

0.951DataRank · unranked

25 citations

Li Nan, Wang Jing-Jing, Huang Xing, Zheng Hui-Wen, He Zhan-Long +19 more

Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

Cancer Research(2024)10.1158/0008-5472.can-24-1388

N/A

0.924DataRank · unranked

36 citations

Shaked Nir Heyman, Lei Guo, Lydia Flores, Trisha K. Savage, Juan Villarreal +6 more

The altered gut virome community in rhesus monkeys is correlated with the gut bacterial microbiome and associated metabolites

Virology Journal(2019)10.1186/s12985-019-1211-z

N/A

0.630DataRank · unranked

13 citations

Hongzhe Li, Jingjing Wang, Lei Guo, Haitao Fan, Huiwen Zheng +11 more

Genome‐wide methylomic regulation of multiscale gene networks in Alzheimer's disease

Alzheimer s & Dementia(2023)10.1002/alz.12969

Top 39%

0.494DataRank

Top 39%26 citations

Minghui Wang, Lei Guo, John F. Fullard, Courtney Micallef, Jaroslav Bendl +12 more

Correction: A Novel Neutralizing Antibody Specific to the DE Loop of VP1 Can Inhibit EV-D68 Infection in Mice

The Journal of Immunology(2019)10.4049/jimmunol.1801658

N/A

0.365DataRank · unranked

3 citations

Jingjing Wang, Bingxiang Li, Lei Guo, Alexandra P. Lewis, Jie Song +21 more

Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2

Nature Neuroscience(2020)10.1038/s41593-020-0597-7

N/A

0DataRank · unranked

289 citations

Shalaka Wahane, Marie-Sophie Friedl, Michael Kluge, Caroline C. Friedel, Kleopatra Avrampou +7 more

MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer’s disease pathogenesis

Molecular Psychiatry(2020)10.1038/s41380-020-0824-3

N/A

0DataRank · unranked

84 citations

Min Huang, Lei Guo, Li Zhu, Jianwei Hou, Larry Zhang +11 more

Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets

Science Advances(2021)10.1126/sciadv.abb5398

N/A

0DataRank · unranked

335 citations

Minghui Wang, Sezen Vatansever, Lei Guo, Ming Chen, Qian Wang +19 more

Sex Differences in Alzheimer’s Disease: Insights From the Multiomics Landscape

Biological Psychiatry(2021)10.1016/j.biopsych.2021.02.968

N/A

0DataRank · unranked

176 citations

Margaret B. Zhong, Larry Zhang, Bin Zhang, Dongming Cai, Lei Guo

Targeting epigenetic regulatory machinery to overcome cancer therapy resistance

Seminars in Cancer Biology(2021)10.1016/j.semcancer.2020.12.022

N/A

0DataRank · unranked

88 citations

Yi‐Tsang Lee, Yubin Zhou, Yun Huang, Lei Guo

Diversified transcriptional responses of myeloid and glial cells in spinal cord injury shaped by HDAC3 activity

Science Advances(2021)10.1126/sciadv.abd8811

N/A

0DataRank · unranked

69 citations

Xianxiao Zhou, Xiang Zhou, Lei Guo, Marie-Sophie Friedl, Michael Kluge +7 more

Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer

Nature Communications(2021)10.1038/s41467-021-25650-z

N/A

0DataRank · unranked

44 citations

Aundrietta D. Duncan, Shiming Jiang, Sabrina A. Stratton, Kendra Allton, Clinton Yam +28 more

Evaluation of an EZH2 inhibitor in patient-derived orthotopic xenograft models of pediatric brain tumors alone and in combination with chemo- and radiation therapies

Laboratory Investigation(2021)10.1038/s41374-021-00700-8

N/A

0DataRank · unranked

26 citations

Holly B. Lindsay, Mari Kogiso, Yuchen Du, Frank Braun, Huiyuan Zhang +12 more

Numb is required for optimal contraction of skeletal muscle

bioRxiv (Cold Spring Harbor Laboratory)(2021)10.1101/2021.09.03.453960

N/A

0DataRank · unranked

6 citations

Chenglin Mo, Daniella Azulai, Zhiying Wang, Lauren M. Harlow, Yating Du +13 more

14-3-3ζ Captures SET in the Cytoplasm, Mediating Tau Pathology and Cognitive Impairments

Research Square(2021)10.21203/rs.3.rs-744907/v1

N/A

0DataRank · unranked

0 citations

Qing Zhang, Gang Wu, Erming Wang, Minghui Wang, Fang Huang +16 more

De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

Cancer Cell(2022)10.1016/j.ccell.2022.07.011

N/A

0DataRank · unranked

131 citations

Milan R. Savani, Michael M. Levitt, Adam C. Wang, Jennifer E. Endress, Cylaina Bird +46 more

The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development

Nature Genetics(2022)10.1038/s41588-022-01063-6

N/A

0DataRank · unranked

88 citations

Dapeng Hao, Junsung Woo, Teng-Wei Huang, Lei Guo, Xueqiu Lin +10 more

Synergistic anti-tumor efficacy of mutant isocitrate dehydrogenase 1 inhibitor SYC-435 with standard therapy in patient-derived xenograft mouse models of glioma

Translational Oncology(2022)10.1016/j.tranon.2022.101368

N/A

0DataRank · unranked

24 citations

Lin Qi, Yuchen Du, Frank Braun, Huiyuan Zhang, Lei Huang +19 more

Numb is required for optimal contraction of skeletal muscle

Journal of Cachexia Sarcopenia and Muscle(2022)10.1002/jcsm.12907

N/A

0DataRank · unranked

17 citations

Chenglin Mo, Daniella Azulai, Zhiying Wang, Lauren M. Harlow, Yating Du +13 more

Cross-Talk Between Histone Methyltransferases and Demethylases Regulate REST Transcription During Neurogenesis

Frontiers in Oncology(2022)10.3389/fonc.2022.855167

N/A

0DataRank · unranked

11 citations

Shinji Maegawa, Shavali Shaik, Ajay Sharma, Javiera Bravo‐Alegria, Lei Guo +4 more

Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms

Clinical Epigenetics(2022)10.1186/s13148-022-01297-5

N/A

0DataRank · unranked

5 citations

Tingting Hong, Yue Wei, Lei Guo, Minjung Lee, Hui Yang +10 more

Telomere dysfunction impairs intestinal differentiation and predisposes to diet-induced colitis

bioRxiv (Cold Spring Harbor Laboratory)(2022)10.1101/2022.07.14.499988

N/A

0DataRank · unranked

0 citations

Lei Guo, Won‐Suk Song, Christopher Chronowski, Viktor Akhanov, Navish Bosquez +17 more

Sex specific molecular networks and key drivers of Alzheimer’s disease

Molecular Neurodegeneration(2023)10.1186/s13024-023-00624-5

N/A

0DataRank · unranked

46 citations

Jiqing Cao, Jianwei Hou, Yonghe Li, Min Huang, Li Zhu +14 more

Dissecting embryonic and extraembryonic lineage crosstalk with stem cell co-culture

Cell(2023)10.1016/j.cell.2023.11.008

N/A

0DataRank · unranked

44 citations

Enbo Zhang, Leqian Yu, Baiquan Ci, Masahiro Sakurai, Lei Guo +19 more

Itaconate-producing neutrophils regulate local and systemic inflammation following trauma

JCI Insight(2023)10.1172/jci.insight.169208

N/A

0DataRank · unranked

37 citations

Sonya Ostashevskaya-Gohstand, Stefano Comazzetto, Jessica S. Hook, Lei Guo, Neda Vishlaghi +8 more

Molecular differences in brain regional vulnerability to aging between males and females

Frontiers in Aging Neuroscience(2023)10.3389/fnagi.2023.1153251

N/A

0DataRank · unranked

17 citations

Jiqing Cao, Li Zhu, Kurt Farrell, Minghui Wang, Lei Guo +7 more

Comprehensive characterization of patient-derived xenograft models of pediatric leukemia

iScience(2023)10.1016/j.isci.2023.108171

N/A

0DataRank · unranked

8 citations

Laura J. Klesse, Erin Butler, Jiwoong Kim, He Zhang, Xue Xiao +25 more

Dissecting embryonic and extra-embryonic lineage crosstalk with stem cell co-culture

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.03.07.531525

N/A

0DataRank · unranked

5 citations

Enwei Zhang, Leqian Yu, Baiquan Ci, Lei Guo, Masahiro Sakurai +13 more

Mapping Cellular Interactions from Spatially Resolved Transcriptomics Data

bioRxiv (Cold Spring Harbor Laboratory)(2023)10.1101/2023.09.18.558298

N/A

0DataRank · unranked

3 citations

Yunguan Wang, Woo Yong Chang, Alicia Malewska, Fabiana Napolitano, Jeffrey Gahan +20 more

Mapping cellular interactions from spatially resolved transcriptomics data

Nature Methods(2024)10.1038/s41592-024-02408-1

N/A

0DataRank · unranked

55 citations

Yunguan Wang, Woo Yong Chang, Alicia Malewska, Fabiana Napolitano, Jeffrey Gahan +20 more

iIMPACT: integrating image and molecular profiles for spatial transcriptomics analysis

Genome biology(2024)10.1186/s13059-024-03289-5

N/A

0DataRank · unranked

25 citations

Shidan Wang, Lei Guo, Bencong Zhu, Zhuoyu Wen, Liwei Jia +4 more

An interpretable Bayesian clustering approach with feature selection for analyzing spatially resolved transcriptomics data

Biometrics(2024)10.1093/biomtc/ujae066

N/A

0DataRank · unranked

6 citations

Bencong Zhu, Xi Jiang, Lei Guo, Yang Xie, Lin Xu +2 more

CD8+ T cells in the tumor microenvironment modulate the response to endocrine therapy in breast cancer

Journal of Clinical Investigation(2025)10.1172/jci188458

N/A

0DataRank · unranked

4 citations

Yunguan Wang, Dhivya R. Sudhan, Paula I. González-Ericsson, Luigi Formisano, Nisha Unni +26 more

A regularized Bayesian Dirichlet-multinomial regression model for integrating single-cell-level omics and patient-level clinical study data

Biometrics(2025)10.1093/biomtc/ujaf005

N/A

0DataRank · unranked

0 citations

Lei Yu, Lei Guo, Lin Xu, Qiwei Li, Yanghong Guo

ARHGEF2 Isoform Switching Couples Intestinal Epithelial Barrier Function with Autophagic Response to Pathogens

Research Square(2025)10.21203/rs.3.rs-8252764/v1

N/A

0DataRank · unranked

0 citations

Shuyuan Chen, Alka Diwaker, Zhiheng Li, Abdulmajeed Salamah, Lei Guo +12 more

Additional file 5: of The altered gut virome community in rhesus monkeys is correlated with the gut bacterial microbiome and associated metabolites

Figshare(2019)10.6084/m9.figshare.9692027

N/A

0DataRank · unranked

0 citations

Hongzhe Li, Jingjing Wang, Lei Guo, Haitao Fan, Huiwen Zheng +11 more

Additional file 8: of The altered gut virome community in rhesus monkeys is correlated with the gut bacterial microbiome and associated metabolites

Figshare(2019)10.6084/m9.figshare.9692051

Top 100%

0DataRank

Top 100%0 citations

Hongzhe Li, Jingjing Wang, Lei Guo, Haitao Fan, Huiwen Zheng +11 more

Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease

Neuron(2020)10.1016/j.neuron.2020.11.002

N/A

0DataRank · unranked

215 citations

Aiqun Li, Michiko Sekiya, Noam D. Beckmann, Xiuming Quan, Nadine Schrode +37 more

The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease

Nature(2020)10.1038/s41586-020-2681-2

N/A

0DataRank · unranked

397 citations

Georgia Frost, Xianzhong Wu, Christina J. Crump, Si Pan, Eitan Wong +26 more

Lei Guo

Indexed papers

Top data-sharing exemplar

Papers